Malabaricone B (BioDeep_00000180630)

Main id: BioDeep_00000233643

 

human metabolite PANOMIX_OTCML-2023 blood metabolite Antitumor activity natural product


代谢物信息卡片


1-(2,6-dihydroxyphenyl)-9-(4-hydroxyphenyl)nonan-1-one

化学式: C21H26O4 (342.18309960000005)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=C(C(=C1)O)C(=O)CCCCCCCCC2=CC=C(C=C2)O)O
InChI: InChI=1S/C21H26O4/c22-17-14-12-16(13-15-17)8-5-3-1-2-4-6-9-18(23)21-19(24)10-7-11-20(21)25/h7,10-15,22,24-25H,1-6,8-9H2

描述信息

Malabaricone B, a naturally occurring plant phenolic, is an orally active α-glucosidase inhibitor with an IC50 of 63.7 μM. Malabaricone B has anticancer, antimicrobial, anti-oxidation and antidiabetic activities[1][2][3].
Malabaricone B, a naturally occurring plant phenolic, is an orally active α-glucosidase inhibitor with an IC50 of 63.7 μM. Malabaricone B has anticancer, antimicrobial, anti-oxidation and antidiabetic activities[1][2][3].

同义名列表

2 个代谢物同义名

1-(2,6-dihydroxyphenyl)-9-(4-hydroxyphenyl)nonan-1-one; Malabaricone B



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

19 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Cai-Wei Li, Yi-Cheng Chu, Chun-Yi Huang, Shu-Ling Fu, Jih-Jung Chen. Evaluation of Antioxidant and Anti-α-glucosidase Activities of Various Solvent Extracts and Major Bioactive Components from the Seeds of Myristica fragrans. Molecules (Basel, Switzerland). 2020 Nov; 25(21):. doi: 10.3390/molecules25215198. [PMID: 33171671]
  • Muhamad Aqmal Othman, Kohei Yuyama, Yuta Murai, Yasuyuki Igarashi, Daisuke Mikami, Yasodha Sivasothy, Khalijah Awang, Kenji Monde. Malabaricone C as Natural Sphingomyelin Synthase Inhibitor against Diet-Induced Obesity and Its Lipid Metabolism in Mice. ACS medicinal chemistry letters. 2019 Aug; 10(8):1154-1158. doi: 10.1021/acsmedchemlett.9b00171. [PMID: 31413799]
  • Mrityunjay Tyagi, Biswanath Maity, Bhaskar Saha, Ajay Kumar Bauri, Mahesh Subramanian, Subrata Chattopadhyay, Birija Sankar Patro. Spice-derived phenolic, malabaricone B induces mitochondrial damage in lung cancer cells via a p53-independent pathway. Food & function. 2018 Nov; 9(11):5715-5727. doi: 10.1039/c8fo00624e. [PMID: 30318526]
  • B Prabha, S Neethu, S Lekshmy Krishnan, D R Sherin, M Madhukrishnan, R Ananthakrishnan, K B Rameshkumar, T K Manojkumar, P Jayamurthy, K V Radhakrishnan. Antidiabetic potential of phytochemicals isolated from the stem bark of Myristica fatua Houtt. var. magnifica (Bedd.) Sinclair. Bioorganic & medicinal chemistry. 2018 07; 26(12):3461-3467. doi: 10.1016/j.bmc.2018.05.020. [PMID: 29789207]
  • Ji-Young Park, Su Hwan Lim, Bo Ram Kim, Hyung Jae Jeong, Hyung-Jun Kwon, Gyu-Yong Song, Young Bae Ryu, Woo Song Lee. Sialidase inhibitory activity of diarylnonanoid and neolignan compounds extracted from the seeds of Myristica fragrans. Bioorganic & medicinal chemistry letters. 2017 07; 27(14):3060-3064. doi: 10.1016/j.bmcl.2017.05.055. [PMID: 28551100]
  • Muhamad Aqmal Othman, Yasodha Sivasothy, Chung Yeng Looi, Abdulwali Ablat, Jamaludin Mohamad, Marc Litaudon, Khalijah Awang. Acylphenols and dimeric acylphenols from Myristica maxima Warb. Fitoterapia. 2016 Jun; 111(?):12-7. doi: 10.1016/j.fitote.2016.04.004. [PMID: 27072985]
  • Debashish Banerjee, Biswanath Maity, Atmaram H Bandivdeker, Sandip K Bandyopadhyay, Subrata Chattopadhyay. Angiogenic and cell proliferating action of the natural diarylnonanoids, malabaricone B and malabaricone C during healing of indomethacin-induced gastric ulceration. Pharmaceutical research. 2008 Jul; 25(7):1601-9. doi: 10.1007/s11095-007-9512-0. [PMID: 18071876]
  • Debashish Banerjee, Ajay K Bauri, Ranjit K Guha, Sandip K Bandyopadhyay, Subrata Chattopadhyay. Healing properties of malabaricone B and malabaricone C, against indomethacin-induced gastric ulceration and mechanism of action. European journal of pharmacology. 2008 Jan; 578(2-3):300-12. doi: 10.1016/j.ejphar.2007.09.041. [PMID: 17977527]
  • Rupashree Sen, Ajay Kumar Bauri, Subrata Chattopadhyay, Mitali Chatterjee. Antipromastigote activity of the malabaricones of Myristica malabarica (rampatri). Phytotherapy research : PTR. 2007 Jun; 21(6):592-5. doi: 10.1002/ptr.2115. [PMID: 17335115]