Kakkalide (BioDeep_00000180244)

Main id: BioDeep_00000230482

 

human metabolite PANOMIX_OTCML-2023 blood metabolite


代谢物信息卡片


5-hydroxy-6-methoxy-3-(4-methoxyphenyl)-7-[(3,4,5-trihydroxy-6-{[(3,4,5-trihydroxyoxan-2-yl)oxy]methyl}oxan-2-yl)oxy]-4H-chromen-4-one

化学式: C28H32O15 (608.1741122)
中文名称: 葛花苷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=CC=C(C=C1)C1=COC2=CC(OC3OC(COC4OCC(O)C(O)C4O)C(O)C(O)C3O)=C(OC)C(O)=C2C1=O
InChI: InChI=1S/C28H32O15/c1-37-12-5-3-11(4-6-12)13-8-39-15-7-16(26(38-2)22(33)18(15)19(13)30)42-28-25(36)23(34)21(32)17(43-28)10-41-27-24(35)20(31)14(29)9-40-27/h3-8,14,17,20-21,23-25,27-29,31-36H,9-10H2,1-2H3

描述信息

同义名列表

4 个代谢物同义名

5-hydroxy-6-methoxy-3-(4-methoxyphenyl)-7-[(3,4,5-trihydroxy-6-{[(3,4,5-trihydroxyoxan-2-yl)oxy]methyl}oxan-2-yl)oxy]-4H-chromen-4-one; 5-hydroxy-6-methoxy-3-(4-methoxyphenyl)-7-[(3,4,5-trihydroxy-6-{[(3,4,5-trihydroxyoxan-2-yl)oxy]methyl}oxan-2-yl)oxy]chromen-4-one; CID 14037245; Kakkalide



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Hyo-Min Jang, Keon-Tae Park, Hyun-Deok Noh, So-Hyeon Lee, Dong-Hyun Kim. Kakkalide and irisolidone alleviate 2,4,6-trinitrobenzenesulfonic acid-induced colitis in mice by inhibiting lipopolysaccharide binding to toll-like receptor-4 and proteobacteria population. International immunopharmacology. 2019 Aug; 73(?):246-253. doi: 10.1016/j.intimp.2019.05.008. [PMID: 31112869]
  • Guozhe Zhang, Tianxing Gong, Yoshihiro Kano, Dan Yuan. Screening for in vitro metabolites of kakkalide and irisolidone in human and rat intestinal bacteria by ultra-high performance liquid chromatography/quadrupole time-of-flight mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2014 Feb; 947-948(?):117-24. doi: 10.1016/j.jchromb.2013.12.017. [PMID: 24412694]
  • Hong Wang, Xue Bai, Jiahong Sun, Yoshihiro Kano, Toshiaki Makino, Dan Yuan. Metabolism and excretion of kakkalide and its metabolites in rat urine, bile, and feces as determined by HPLC/UV and LC/MS/MS. Planta medica. 2013 Nov; 79(16):1552-7. doi: 10.1055/s-0033-1350832. [PMID: 24108437]
  • Xue Bai, Jialin Qu, Jing Lu, Yoshihiro Kano, Dan Yuan. Pharmacokinetics of kakkalide and its main metabolites in rat plasma determined by HPLC-DAD and LC-MSn. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2011 Feb; 879(5-6):395-402. doi: 10.1016/j.jchromb.2010.12.025. [PMID: 21256817]
  • Xue Bai, Yuanyuan Xie, Jia Liu, Jialin Qu, Yoshihiro Kano, Dan Yuan. Isolation and identification of urinary metabolites of kakkalide in rats. Drug metabolism and disposition: the biological fate of chemicals. 2010 Feb; 38(2):281-6. doi: 10.1124/dmd.109.028555. [PMID: 19910516]
  • Yi-cheng Fu, Xiao-jing Wang, Xian-hui Jia, Ling Zhou. [Primary studies on chemical constituents from butanol extraction of the thorny elaeagnus leaf and their cytotoxicity]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2009 Dec; 32(12):1848-50. doi: ". [PMID: 20432901]
  • Kyoung Ah Kang, Rui Zhang, Mei Jing Piao, Dong Ok Ko, Zhi Hong Wang, Bum Joon Kim, Jae Woo Park, Hee Sun Kim, Dong Hyun Kim, Jin Won Hyun. Protective effect of irisolidone, a metabolite of kakkalide, against hydrogen peroxide induced cell damage via antioxidant effect. Bioorganic & medicinal chemistry. 2008 Feb; 16(3):1133-41. doi: 10.1016/j.bmc.2007.10.085. [PMID: 17996449]
  • Ill-Min Chung, Min-Young Kim, Won-Hwan Park, Hyung-In Moon. Aldose reductase inhibitors from Viola hondoensis W. Becker et H Boss. The American journal of Chinese medicine. 2008; 36(4):799-803. doi: 10.1142/s0192415x08006247. [PMID: 18711775]
  • Sung-Won Min, Dong-Hyun Kim. Kakkalide and irisolidone: HMG-CoA reductase inhibitors isolated from the flower of Pueraria thunbergiana. Biological & pharmaceutical bulletin. 2007 Oct; 30(10):1965-8. doi: 10.1248/bpb.30.1965. [PMID: 17917273]
  • Ji-eun Shin, Eun-Ah Bae, Young Chul Lee, Jin-Youl Ma, Dong-Hyun Kim. Estrogenic effect of main components kakkalide and tectoridin of Puerariae Flos and their metabolites. Biological & pharmaceutical bulletin. 2006 Jun; 29(6):1202-6. doi: 10.1248/bpb.29.1202. [PMID: 16755017]
  • Yeo-Ok Han, Myung Joo Han, Sung-Hwan Park, Dong-Hyun Kim. Protective effects of kakkalide from Flos puerariae on ethanol-induced lethality and hepatic injury are dependent on its biotransformation by human intestinal microflora. Journal of pharmacological sciences. 2003 Nov; 93(3):331-6. doi: 10.1254/jphs.93.331. [PMID: 14646251]
  • T Yamazaki, Y Nakajima, Y Niho, T Hosono, T Kurashige, J Kinjo, T Nohara. Pharmacological studies on Puerariae flos III: protective effects of kakkalide on ethanol-induced lethality and acute hepatic injury in mice. The Journal of pharmacy and pharmacology. 1997 Aug; 49(8):831-3. doi: 10.1111/j.2042-7158.1997.tb06122.x. [PMID: 9379366]