Gelsenicine (BioDeep_00000179373)

Main id: BioDeep_00000231737

 

human metabolite PANOMIX_OTCML-2023 blood metabolite


代谢物信息卡片


6-ethyl-1-methoxy-1,2-dihydro-10-oxa-5-azaspiro[indole-3,2-tricyclo[5.3.1.0⁴,⁸]undecan]-5-en-2-one

化学式: C19H22N2O3 (326.16303419999997)
中文名称: 胡蔓藤碱
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC1=NC2CC3(C4CC1C2CO4)C(=O)N(OC)C1=CC=CC=C31
InChI: InChI=1S/C19H22N2O3/c1-3-14-11-8-17-19(9-15(20-14)12(11)10-24-17)13-6-4-5-7-16(13)21(23-2)18(19)22/h4-7,11-12,15,17H,3,8-10H2,1-2H3

描述信息

Humantenmine, a newalkaloid isolated from Gelsemium elegan Banth in China, has the potential for pain and rheumatic arthritis treatment[1][2].
Humantenmine, a newalkaloid isolated from Gelsemium elegan Banth in China, has the potential for pain and rheumatic arthritis treatment[1][2].

同义名列表

4 个代谢物同义名

6-ethyl-1-methoxy-1,2-dihydro-10-oxa-5-azaspiro[indole-3,2-tricyclo[5.3.1.0⁴,⁸]undecan]-5-en-2-one; 6-ethyl-1-methoxy-10-oxa-5-azaspiro[indole-3,2-tricyclo[5.3.1.0⁴,⁸]undecan]-5-en-2-one; Humantenmine; GELSENICINE



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jun-Jie Cao, Kun Yang, Chong-Yin Huang, Yu-Juan Li, Hui Yu, Yong Wu, Zhi-Liang Sun, Zhao-Ying Liu. Pharmacokinetic Study of Multiple Components of Gelsemium elegans in Goats by Ultra-Performance Liquid Chromatography Coupled to Tandem Mass Spectrometry. Journal of analytical toxicology. 2020 May; 44(4):378-390. doi: 10.1093/jat/bkz100. [PMID: 31993639]
  • Sha-Sha Liu, Kun Yang, Zhi-Liang Sun, Xiaofeng Zheng, Xia Bai, Zhao-Ying Liu. A novel two-dimensional liquid chromatography system for the simultaneous determination of three monoterpene indole alkaloids in biological matrices. Analytical and bioanalytical chemistry. 2019 Jul; 411(17):3857-3870. doi: 10.1007/s00216-019-01859-2. [PMID: 31073732]
  • Zi-Yuan Wang, Meng-Ting Zuo, Zhao-Ying Liu. The Metabolism and Disposition of Koumine, Gelsemine and Humantenmine from Gelsemium. Current drug metabolism. 2019; 20(7):583-591. doi: 10.2174/1389200220666190614152304. [PMID: 31203797]
  • Kun Yang, Xue-Ming Long, Yan-Chun Liu, Fu-Hua Chen, Xiao-Feng Liu, Zhi-Liang Sun, Zhao-Ying Liu. Development and in-house validation of a sensitive LC-MS/MS method for simultaneous quantification of gelsemine, koumine and humantenmine in porcine plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2018 Feb; 1076(?):54-60. doi: 10.1016/j.jchromb.2018.01.019. [PMID: 29406028]
  • Yanxian Hu, Minghao Chen, Zhaoyu Wang, Yao Lan, Lan Tang, Menghua Liu, Jie Zhao, Ming Hu, Lulu Zhang, Ling Ye. Development of a validated UPLC-MS/MS method for determination of humantenmine in rat plasma and its application in pharmacokinetics and bioavailability studies. Biomedical chromatography : BMC. 2017 Dec; 31(12):. doi: 10.1002/bmc.4017. [PMID: 28557019]