CID 9844747 (BioDeep_00000179081)

   

human metabolite blood metabolite


代谢物信息卡片


4-fluoro-N-(2-{4-[2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-5-yl]piperazin-1-yl}ethyl)benzamide

  化学式: C22H26FN3O4 (415.1907)
中文名称: 氟辛克生
  谱图信息: 最多检出来源 not specific(not specific) %

分子结构信息

SMILES: C1CN(CCN1CCNC(=O)C2=CC=C(C=C2)F)C3=C4C(=CC=C3)OC(CO4)CO
InChI: InChI=1S/C22H26FN3O4/c23-17-6-4-16(5-7-17)22(28)24-8-9-25-10-12-26(13-11-25)19-2-1-3-20-21(19)29-15-18(14-27)30-20/h1-7,18,27H,8-15H2,(H,24,28)


描述信息

D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014151 - Anti-Anxiety Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D017366 - Serotonin Receptor Agonists
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
Flesinoxan is a hypotensive agent and a potent, high affinity and selective 5-hydroxytryptamine1A (5-HT1A) receptor agonist with an EC50 value of 24 nM. Flesinoxan also has effective anxiolytic/antidepressant effects[1][2][3].

同义名列表

5 个代谢物同义名

4-fluoro-N-(2-{4-[2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-5-yl]piperazin-1-yl}ethyl)benzamide; p-Fluoro-N-(2-(4-(2-(hydroxymethyl)-1,4-benzodioxan-5-yl)-1-piperazinyl)ethyl)benzamide; (R)-Flesinoxan; CID 9844747; Flesinoxan



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome()

BioCyc()

PlantCyc()

代谢反应

个相关的代谢反应过程信息。

Reactome()

BioCyc()

WikiPathways()

Plant Reactome()

INOH()

PlantCyc()

COVID-19 Disease Map()

PathBank()

PharmGKB()

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Minoru Tsuji, Tomoko Takeuchi, Kazuya Miyagawa, Daisuke Ishii, Taro Imai, Kotaro Takeda, Masaki Kitajima, Hiroshi Takeda. Yokukansan, a traditional Japanese herbal medicine, alleviates the emotional abnormality induced by maladaptation to stress in mice. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2014 Feb; 21(3):363-71. doi: 10.1016/j.phymed.2013.08.025. [PMID: 24129119]
  • Cécile Bétry, Alan L Pehrson, Adeline Etiévant, Bjarke Ebert, Connie Sánchez, Nasser Haddjeri. The rapid recovery of 5-HT cell firing induced by the antidepressant vortioxetine involves 5-HT(3) receptor antagonism. The international journal of neuropsychopharmacology. 2013 Jun; 16(5):1115-27. doi: 10.1017/s1461145712001058. [PMID: 23089374]
  • Ivan Skelin, Fumitaka Yamane, Mirko Diksic. Flesinoxan challenge suggests that chronic treatment with paroxetine in rats does not desensitize receptors controlling 5-HT synthesis. Neurochemistry international. 2008 Dec; 53(6-8):236-43. doi: 10.1016/j.neuint.2008.04.005. [PMID: 18786747]
  • Jocelien D A Olivier, Alexander R Cools, Berend Olivier, Judith R Homberg, Edwin Cuppen, Bart A Ellenbroek. Stress-induced hyperthermia and basal body temperature are mediated by different 5-HT(1A) receptor populations: a study in SERT knockout rats. European journal of pharmacology. 2008 Aug; 590(1-3):190-7. doi: 10.1016/j.ejphar.2008.06.008. [PMID: 18606402]
  • T Pattij, T H Hijzen, L Groenink, R S Oosting, J van der Gugten, R A Maes, R Hen, B Olivier. Stress-induced hyperthermia in the 5-HT(1A) receptor knockout mouse is normal. Biological psychiatry. 2001 Apr; 49(7):569-74. doi: 10.1016/s0006-3223(00)01022-2. [PMID: 11297713]
  • J A Bouwknecht, J van der Gugten, T H Hijzen, R A Maes, R Hen, B Olivier. Corticosterone responses in 5-HT1B receptor knockout mice to stress or 5-HT1A receptor activation are normal. Psychopharmacology. 2001 Feb; 153(4):484-90. doi: 10.1007/s002130000598. [PMID: 11243496]
  • R M Sibug, J C Compaan, O C Meijer, J Van der Gugten, B Olivier, E R De Kloet. Flesinoxan treatment reduces 5-HT1A receptor mRNA in the dentate gyrus independently of high plasma corticosterone levels. European journal of pharmacology. 1998 Jul; 353(2-3):207-14. doi: 10.1016/s0014-2999(98)00417-8. [PMID: 9726650]
  • L Groenink, J Van der Gugten, J C Compaan, R A Maes, B Olivier. Flesinoxan pretreatment differentially affects corticosterone, prolactin and behavioural responses to a flesinoxan challenge. Psychopharmacology. 1997 May; 131(1):93-100. doi: 10.1007/s002130050270. [PMID: 9181641]
  • J C Compaan, L Groenink, J Van der Gugten, R A Maes, B Olivier. Pretreatment with 5-HT1A receptor agonist flesinoxan attenuates Fos protein in rat hypothalamus. European journal of pharmacology. 1997 Apr; 324(2-3):161-8. doi: 10.1016/s0014-2999(97)00071-x. [PMID: 9145767]
  • J C Compaan, L Groenink, J van der Gugten, R A Maes, B Olivier. 5-HT1A receptor agonist flesinoxan enhances Fos immunoreactivity in rat central amygdala, bed nucleus of the stria terminalis and hypothalamus. The European journal of neuroscience. 1996 Nov; 8(11):2340-7. doi: 10.1111/j.1460-9568.1996.tb01197.x. [PMID: 8950098]
  • A L Chamienia, E J Johns. The cardiovascular and renal functional responses to the 5-HT1A receptor agonist flesinoxan in two rat models of hypertension. British journal of pharmacology. 1996 Aug; 118(8):1891-8. doi: 10.1111/j.1476-5381.1996.tb15621.x. [PMID: 8864520]
  • L Groenink, J van der Gugten, T J Zethof, J A van der Heyden, B Olivier. Neuroendocrine effects of diazepam and flesinoxan in the stress-induced hyperthermia test in mice. Pharmacology, biochemistry, and behavior. 1996 May; 54(1):249-54. doi: 10.1016/0091-3057(95)02177-9. [PMID: 8728565]
  • B Seletti, C Benkelfat, P Blier, L Annable, F Gilbert, C de Montigny. Serotonin1A receptor activation by flesinoxan in humans. Body temperature and neuroendocrine responses. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 1995 Oct; 13(2):93-104. doi: 10.1016/0893-133x(95)00025-9. [PMID: 8597527]
  • L Groenink, J Van der Gugten, P M Verdouw, R A Maes, B Olivier. The anxiolytic effects of flesinoxan, a 5-HT1A receptor agonist, are not related to its neuroendocrine effects. European journal of pharmacology. 1995 Jul; 280(2):185-93. doi: 10.1016/0014-2999(95)00209-4. [PMID: 7589185]
  • L Groenink, J Van der Gugten, J Mos, R A Maes, B Olivier. The corticosterone-enhancing effects of the 5-HT1A receptor antagonist, (S)-UH301, are not mediated by the 5-HT1A receptor. European journal of pharmacology. 1995 Jan; 272(2-3):177-83. doi: 10.1016/0014-2999(94)00645-n. [PMID: 7713161]
  • P de Koning, M H de Vries. A comparison of the neuro-endocrinological and temperature effects of DU 29894, flesinoxan, sulpiride and haloperidol in normal volunteers. British journal of clinical pharmacology. 1995 Jan; 39(1):7-14. doi: 10.1111/j.1365-2125.1995.tb04403.x. [PMID: 7756102]
  • A L Chamienia, E J Johns. The renal functional responses to 5-HT1A receptor agonist, flesinoxan, in anaesthetized, normotensive rat. British journal of pharmacology. 1994 May; 112(1):214-8. doi: 10.1111/j.1476-5381.1994.tb13054.x. [PMID: 8032644]
  • M J Millan, J M Rivet, A Gobert, H Canton, S Veiga, K Bervoets. 5-HT1A receptors and the tail-flick response. VI. Intrinsic alpha 1A-adrenoceptor antagonist properties can mask the actions of 5-HT1A receptor agonists in the spontaneous tail-flick paradigm. The Journal of pharmacology and experimental therapeutics. 1994 Apr; 269(1):121-31. doi: . [PMID: 7909555]
  • A L Chamienia, E J Johns. Renal functional responses to the 5-HT1A receptor agonist flesinoxan: effects of controlled renal perfusion pressure. The Journal of pharmacology and experimental therapeutics. 1994 Apr; 269(1):215-20. doi: NULL. [PMID: 8169828]
  • D J Critchley, V C Middlefell, C W Liddle, N D Foden, C T Dourish. Effects of the selective 5-HT1A receptor antagonist WAY100135 and its enantiomers on 8-OH-DPAT-induced hyperglycaemia in conscious rats. European journal of pharmacology. 1994 Mar; 254(1-2):133-9. doi: 10.1016/0014-2999(94)90380-8. [PMID: 8206109]
  • D Kelder, S B Ross. Long lasting attenuation of 8-OH-DPAT-induced corticosterone secretion after a single injection of a 5-HT1A receptor agonist. Naunyn-Schmiedeberg's archives of pharmacology. 1992 Aug; 346(2):121-6. doi: 10.1007/bf00165292. [PMID: 1448177]
  • A G Ramage, W Wouters, P Bevan. Evidence that the novel antihypertensive agent, flesinoxan, causes differential sympathoinhibition and also increases vagal tone by a central action. European journal of pharmacology. 1988 Jul; 151(3):373-9. doi: 10.1016/0014-2999(88)90533-x. [PMID: 3215269]