Eckol (BioDeep_00000178610)

Main id: BioDeep_00000364085

 

human metabolite PANOMIX_OTCML-2023 blood metabolite natural product


代谢物信息卡片


1-(3,5-dihydroxyphenoxy)-2,4,7,9-tetrahydroxydibenzo-1,4-dioxin

化学式: C18H12O9 (372.0481)
中文名称: 鹅掌菜酚
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=C(C=C(C=C1O)OC2=C(C=C(C3=C2OC4=C(C=C(C=C4O3)O)O)O)O)O
InChI: InChI=1S/C18H12O9/c19-7-1-8(20)3-10(2-7)25-16-12(23)6-13(24)17-18(16)27-15-11(22)4-9(21)5-14(15)26-17/h1-6,19-24H

描述信息

同义名列表

5 个代谢物同义名

1-(3,5-dihydroxyphenoxy)-2,4,7,9-tetrahydroxydibenzo-1,4-dioxin; 4-(3,5-dihydroxyphenoxy)-dibenzo(b,e)(1,4)dioxin-1,3,6,8-tetrol; 4-(3,5-dihydroxyphenoxy)dibenzo-p-dioxin-1,3,6,8-tetrol; 4-(3,5-dihydroxyphenoxy)oxanthrene-1,3,6,8-tetrol; Eckol



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

18 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Srijan Shrestha, Wei Zhang, Alexander J Begbie, Tara L Pukala, Scott D Smid. Ecklonia radiata extract containing eckol protects neuronal cells against Aβ1-42 evoked toxicity and reduces aggregate density. Food & function. 2020 Jul; 11(7):6509-6516. doi: 10.1039/d0fo01438a. [PMID: 32633748]
  • Eui Jeong Han, Hyun-Soo Kim, K K A Sanjeewa, K H I N M Herath, You-Jin Jeon, Youngheun Jee, Jeongjun Lee, Taehee Kim, Sun-Yup Shim, Ginnae Ahn. Eckol from Ecklonia cava Suppresses Immunoglobulin E-mediated Mast Cell Activation and Passive Cutaneous Anaphylaxis in Mice. Nutrients. 2020 05; 12(5):. doi: 10.3390/nu12051361. [PMID: 32397556]
  • Su Hui Seong, Pradeep Paudel, Hyun Ah Jung, Jae Sue Choi. Identifying Phlorofucofuroeckol-A as a Dual Inhibitor of Amyloid-β25-35 Self-Aggregation and Insulin Glycation: Elucidation of the Molecular Mechanism of Action. Marine drugs. 2019 Oct; 17(11):. doi: 10.3390/md17110600. [PMID: 31652867]
  • Meng-Ya Zhang, Jie Guo, Xian-Min Hu, Shu-Qi Zhao, Shu-Lan Li, Jun Wang. An in vivo anti-tumor effect of eckol from marine brown algae by improving the immune response. Food & function. 2019 Jul; 10(7):4361-4371. doi: 10.1039/c9fo00865a. [PMID: 31276149]
  • Manoj G Kulkarni, Kannan R R Rengasamy, Srinivasa C Pendota, Jiří Gruz, Lenka Plačková, Ondřej Novák, Karel Doležal, Johannes Van Staden. Bioactive molecules derived from smoke and seaweed Ecklonia maxima showing phytohormone-like activity in Spinacia oleracea L. New biotechnology. 2019 Jan; 48(?):83-89. doi: 10.1016/j.nbt.2018.08.004. [PMID: 30098416]
  • Shulan Li, Juan Liu, Mengya Zhang, Yuan Chen, Tianxing Zhu, Jun Wang. Protective Effect of Eckol against Acute Hepatic Injury Induced by Carbon Tetrachloride in Mice. Marine drugs. 2018 Aug; 16(9):. doi: 10.3390/md16090300. [PMID: 30150561]
  • Kannan R R Rengasamy, Manoj G Kulkarni, Srinivasa C Pendota, Johannes Van Staden. Enhancing growth, phytochemical constituents and aphid resistance capacity in cabbage with foliar application of eckol--a biologically active phenolic molecule from brown seaweed. New biotechnology. 2016 Mar; 33(2):273-9. doi: 10.1016/j.nbt.2015.11.002. [PMID: 26585339]
  • Adeyemi O Aremu, Nqobile A Masondo, Kannan R R Rengasamy, Stephen O Amoo, Jiří Gruz, Ondřej Bíba, Michaela Šubrtová, Aleš Pěnčík, Ondřej Novák, Karel Doležal, Johannes Van Staden. Physiological role of phenolic biostimulants isolated from brown seaweed Ecklonia maxima on plant growth and development. Planta. 2015 Jun; 241(6):1313-24. doi: 10.1007/s00425-015-2256-x. [PMID: 25672504]
  • Hyun Ah Jung, Hee Jin Jung, Hyun Young Jeong, Hyun Ju Kwon, Md Yousof Ali, Jae Sue Choi. Phlorotannins isolated from the edible brown alga Ecklonia stolonifera exert anti-adipogenic activity on 3T3-L1 adipocytes by downregulating C/EBPα and PPARγ. Fitoterapia. 2014 Jan; 92(?):260-9. doi: 10.1016/j.fitote.2013.12.003. [PMID: 24334103]
  • Min-Cheol Kang, Seon Heui Cha, W A J P Wijesinghe, Sung-Myung Kang, Seung-Hong Lee, Eun-A Kim, Choon Bok Song, You-Jin Jeon. Protective effect of marine algae phlorotannins against AAPH-induced oxidative stress in zebrafish embryo. Food chemistry. 2013 Jun; 138(2-3):950-5. doi: 10.1016/j.foodchem.2012.11.005. [PMID: 23411200]
  • Sung-Myung Kang, Seon-Heui Cha, Ju-Young Ko, Min-Cheol Kang, Daekyung Kim, Soo-Jin Heo, Jin-Soo Kim, Min Soo Heu, Yong-Tae Kim, Won-Kyo Jung, You-Jin Jeon. Neuroprotective effects of phlorotannins isolated from a brown alga, Ecklonia cava, against H2O2-induced oxidative stress in murine hippocampal HT22 cells. Environmental toxicology and pharmacology. 2012 Jul; 34(1):96-105. doi: 10.1016/j.etap.2012.03.006. [PMID: 22465981]
  • Mei Jing Piao, Nam Ho Lee, Sungwook Chae, Jin Won Hyun. Eckol inhibits ultraviolet B-induced cell damage in human keratinocytes via a decrease in oxidative stress. Biological & pharmaceutical bulletin. 2012; 35(6):873-80. doi: 10.1248/bpb.35.873. [PMID: 22687478]
  • Graciliana Lopes, Carla Sousa, Luís R Silva, Eugénia Pinto, Paula B Andrade, João Bernardo, Teresa Mouga, Patrícia Valentão. Can phlorotannins purified extracts constitute a novel pharmacological alternative for microbial infections with associated inflammatory conditions?. PloS one. 2012; 7(2):e31145. doi: 10.1371/journal.pone.0031145. [PMID: 22319609]
  • Kumiko Yokogawa, Isao Matsui-Yuasa, Akiko Tamura, Masaki Terada, Akiko Kojima-Yuasa. Inhibitory effects of Ecklonia cava extract on high glucose-induced hepatic stellate cell activation. Marine drugs. 2011 Dec; 9(12):2793-2808. doi: 10.3390/md9122793. [PMID: 22363250]
  • Ratih Pangestuti, Se-Kwon Kim. Neuroprotective effects of marine algae. Marine drugs. 2011; 9(5):803-818. doi: 10.3390/md9050803. [PMID: 21673890]
  • Yong Li, Sang-Hoon Lee, Quang-To Le, Moon-Moo Kim, Se-Kwon Kim. Anti-allergic effects of phlorotannins on histamine release via binding inhibition between IgE and Fc epsilonRI. Journal of agricultural and food chemistry. 2008 Dec; 56(24):12073-80. doi: 10.1021/jf802732n. [PMID: 19053379]
  • Na Young Yoon, Hyeung Rak Kim, Hae Young Chung, Jae Sue Choi. Anti-hyperlipidemic effect of an edible brown algae, Ecklonia stolonifera, and its constituents on poloxamer 407-induced hyperlipidemic and cholesterol-fed rats. Archives of pharmacal research. 2008 Dec; 31(12):1564-71. doi: 10.1007/s12272-001-2152-8. [PMID: 19099225]
  • Rui Zhang, Kyoung Ah Kang, Mei Jing Piao, Dong Ok Ko, Zhi Hong Wang, In Kyung Lee, Bum Joon Kim, Il Yun Jeong, Taekyun Shin, Jae Woo Park, Nam Ho Lee, Jin Won Hyun. Eckol protects V79-4 lung fibroblast cells against gamma-ray radiation-induced apoptosis via the scavenging of reactive oxygen species and inhibiting of the c-Jun NH(2)-terminal kinase pathway. European journal of pharmacology. 2008 Sep; 591(1-3):114-23. doi: 10.1016/j.ejphar.2008.06.086. [PMID: 18625217]
  • Jeongtae Kim, Changjong Moon, Heechul Kim, Jinwoo Jeong, Juyeon Lee, Jihoon Kim, Jin Won Hyun, Jae Woo Park, Mi Yeon Moon, Nam Ho Lee, Sung Ho Kim, Youngheun Jee, Taekyun Shin. The radioprotective effects of the hexane and ethyl acetate extracts of Callophyllis japonica in mice that undergo whole body irradiation. Journal of veterinary science. 2008 Sep; 9(3):281-4. doi: 10.4142/jvs.2008.9.3.281. [PMID: 18716448]
  • Kyoung Ah Kang, Kyoung Hwa Lee, Sungwook Chae, Rui Zhang, Myung Sun Jung, Youngki Lee, So Young Kim, Hee Sun Kim, Hong Gu Joo, Jae Woo Park, Young Min Ham, Nam Ho Lee, Jin Won Hyun. Eckol isolated from Ecklonia cava attenuates oxidative stress induced cell damage in lung fibroblast cells. FEBS letters. 2005 Nov; 579(28):6295-304. doi: 10.1016/j.febslet.2005.10.008. [PMID: 16253238]
  • Hye Sook Kang, Hae Young Chung, Ji Young Kim, Byeng Wha Son, Hyun Ah Jung, Jae Sue Choi. Inhibitory phlorotannins from the edible brown alga Ecklonia stolonifera on total reactive oxygen species (ROS) generation. Archives of pharmacal research. 2004 Feb; 27(2):194-8. doi: 10.1007/bf02980106. [PMID: 15022722]
  • Y Fukuyama, M Kodama, I Miura, Z Kinzyo, M Kido, H Mori, Y Nakayama, M Takahashi. Structure of an anti-plasmin inhibitor, eckol, isolated from the brown alga Ecklonia kurome Okamura and inhibitory activities of its derivatives on plasma plasmin inhibitors. Chemical & pharmaceutical bulletin. 1989 Feb; 37(2):349-53. doi: 10.1248/cpb.37.349. [PMID: 2525966]