N-[1-[[5-(Diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-4-methyl-2-(propanoylamino)pentanamide (BioDeep_00000175554)
human metabolite blood metabolite
代谢物信息卡片
N-(5-Carbamimidamido-1-oxopentan-2-yl)-2-({1-hydroxy-2-[(1-hydroxypropylidene)amino]-4-methylpentylidene}amino)-4-methylpentanimidate
化学式: C21H40N6O4 (440.3111)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 81.48%
分子结构信息
SMILES: CCC(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(CCCN=C(N)N)C=O
InChI: InChI=1S/C21H40N6O4/c1-6-18(29)26-16(10-13(2)3)20(31)27-17(11-14(4)5)19(30)25-15(12-28)8-7-9-24-21(22)23/h12-17H,6-11H2,1-5H3,(H,25,30)(H,26,29)(H,27,31)(H4,22,23,24)
描述信息
同义名列表
3 个代谢物同义名
N-(5-Carbamimidamido-1-oxopentan-2-yl)-2-({1-hydroxy-2-[(1-hydroxypropylidene)amino]-4-methylpentylidene}amino)-4-methylpentanimidate; N-[1-[[5-(Diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-4-methyl-2-(propanoylamino)pentanamide; N-(5-carbamimidamido-1-oxopentan-2-yl)-4-methyl-2-(4-methyl-2-propanamidopentanamido)pentanamide
相关代谢途径
Reactome()
BioCyc()
PlantCyc()
代谢反应
个相关的代谢反应过程信息。
Reactome()
BioCyc()
WikiPathways()
Plant Reactome()
INOH()
PlantCyc()
COVID-19 Disease Map()
PathBank()
PharmGKB()
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Chiara Magni, Fabio Sessa, Gabriella Tedeschi, Armando Negri, Alessio Scarafoni, Alessandro Consonni, Marcello Duranti. Identification in lupin seed of a serine-endopeptidase activity cleaving between twin arginine pairs and causing limited proteolysis of seed storage proteins.
Molecular plant.
2012 Sep; 5(5):1011-9. doi:
10.1093/mp/ssr116. [PMID: 22217442] - Xiaoqun Catherine Zhang, Antonella Piccini, Michael P Myers, Linda Van Aelst, Nicholas K Tonks. Functional analysis of the protein phosphatase activity of PTEN.
The Biochemical journal.
2012 Jun; 444(3):457-64. doi:
10.1042/bj20120098. [PMID: 22413754] - Jan Dimberg, Karin Ström, Sture Löfgren, Niklas Zar, Mikael Lindh, Andreas Matussek. DNA promoter methylation status and protein expression of interleukin-8 in human colorectal adenocarcinomas.
International journal of colorectal disease.
2012 Jun; 27(6):709-14. doi:
10.1007/s00384-011-1367-5. [PMID: 22108905] - Maura H Parker, Julia von Maltzahn, Nadine Bakkar, Ban Al-Joubori, Jeff Ishibashi, Denis Guttridge, Michael A Rudnicki. MyoD-dependent regulation of NF-κB activity couples cell-cycle withdrawal to myogenic differentiation.
Skeletal muscle.
2012 05; 2(1):6. doi:
10.1186/2044-5040-2-6. [PMID: 22541644] - Nobuo N Noda, Takafumi Kobayashi, Wakana Adachi, Yuko Fujioka, Yoshinori Ohsumi, Fuyuhiko Inagaki. Structure of the novel C-terminal domain of vacuolar protein sorting 30/autophagy-related protein 6 and its specific role in autophagy.
The Journal of biological chemistry.
2012 May; 287(20):16256-66. doi:
10.1074/jbc.m112.348250. [PMID: 22437838] - Margaret R Cunningham, Kathryn A McIntosh, John D Pediani, Joris Robben, Alexandra E Cooke, Mary Nilsson, Gwyn W Gould, Stuart Mundell, Graeme Milligan, Robin Plevin. Novel role for proteinase-activated receptor 2 (PAR2) in membrane trafficking of proteinase-activated receptor 4 (PAR4).
The Journal of biological chemistry.
2012 May; 287(20):16656-69. doi:
10.1074/jbc.m111.315911. [PMID: 22411985] - Hong Can Zhu, Jing Zhao, Chang Yue Luo, Qian Qian Li. Gastrointestinal dysfunction in a Parkinson's disease rat model and the changes of dopaminergic, nitric oxidergic, and cholinergic neurotransmitters in myenteric plexus.
Journal of molecular neuroscience : MN.
2012 May; 47(1):15-25. doi:
10.1007/s12031-011-9560-0. [PMID: 21647710] - Luis Izquierdo, Angela Mehlert, Michael A J Ferguson. The lipid-linked oligosaccharide donor specificities of Trypanosoma brucei oligosaccharyltransferases.
Glycobiology.
2012 May; 22(5):696-703. doi:
10.1093/glycob/cws003. [PMID: 22241825] - Azza Al-Tawashi, Sung Yun Jung, Dou Liu, Bing Su, Jun Qin. Protein implicated in nonsyndromic mental retardation regulates protein kinase A (PKA) activity.
The Journal of biological chemistry.
2012 Apr; 287(18):14644-58. doi:
10.1074/jbc.m111.261875. [PMID: 22375002] - Emanuela Esposito, Barbara Rinaldi, Emanuela Mazzon, Maria Donniacuo, Daniela Impellizzeri, Irene Paterniti, Annalisa Capuano, Placido Bramanti, Salvatore Cuzzocrea. Anti-inflammatory effect of simvastatin in an experimental model of spinal cord trauma: involvement of PPAR-α.
Journal of neuroinflammation.
2012 Apr; 9(?):81. doi:
10.1186/1742-2094-9-81. [PMID: 22537532] - Gon-Sup Kim, Hyoung Joon Park, Jong-Hwa Woo, Mi-Kyeong Kim, Phil-Ok Koh, Wongi Min, Yeoung-Gyu Ko, Chung-Hei Kim, Chung-Kil Won, Jae-Hyeon Cho. Citrus aurantium flavonoids inhibit adipogenesis through the Akt signaling pathway in 3T3-L1 cells.
BMC complementary and alternative medicine.
2012 Apr; 12(?):31. doi:
10.1186/1472-6882-12-31. [PMID: 22471389] - Eun Young Kim, Joon Seok Choi, Ko Eun Lee, Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Suhn Hee Kim, Jong Un Lee, Soo Wan Kim. Altered regulation of renal Acid base transporters in response to ammonium chloride loading in rats.
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology.
2012 Apr; 16(2):91-5. doi:
10.4196/kjpp.2012.16.2.91. [PMID: 22563253] - Li Li, Li Wang, Ruijing Xiao, Guoguo Zhu, Yan Li, Changxuan Liu, Ru Yang, Zhiqing Tang, Jie Li, Wei Huang, Lang Chen, Xiaoling Zheng, Yuling He, Jinquan Tan. The invasion of tobacco mosaic virus RNA induces endoplasmic reticulum stress-related autophagy in HeLa cells.
Bioscience reports.
2012 Apr; 32(2):171-86. doi:
10.1042/bsr20110069. [PMID: 21729006] - Antonio Galindo, Ana María Calcagno-Pizarelli, Herbert N Arst, Miguel Ángel Peñalva. An ordered pathway for the assembly of fungal ESCRT-containing ambient pH signalling complexes at the plasma membrane.
Journal of cell science.
2012 Apr; 125(Pt 7):1784-95. doi:
10.1242/jcs.098897. [PMID: 22344261] - Havva Keskin, Judit Garriga, Daphne Georlette, Xavier Graña. Complex effects of flavopiridol on the expression of primary response genes.
Cell division.
2012 Mar; 7(?):11. doi:
10.1186/1747-1028-7-11. [PMID: 22458775] - Sébastien Pyr Dit Ruys, Xuemin Wang, Ewan M Smith, Gaëtan Herinckx, Nusrat Hussain, Mark H Rider, Didier Vertommen, Christopher G Proud. Identification of autophosphorylation sites in eukaryotic elongation factor-2 kinase.
The Biochemical journal.
2012 Mar; 442(3):681-92. doi:
10.1042/bj20111530. [PMID: 22216903] - You-Chang Oh, Won-Kyung Cho, Jin Hui Oh, Ga Young Im, Yun Hee Jeong, Min Cheol Yang, Jin Yeul Ma. Fermentation by Lactobacillus enhances anti-inflammatory effect of Oyaksungisan on LPS-stimulated RAW 264.7 mouse macrophage cells.
BMC complementary and alternative medicine.
2012 Mar; 12(?):17. doi:
10.1186/1472-6882-12-17. [PMID: 22405334] - Aphrodite T Choumessi, Mathieu Danel, Stefan Chassaing, Isabelle Truchet, Véronique B Penlap, Anatole Constant Pieme, Tazoacha Asonganyi, Bernard Ducommun, Annie Valette. Characterization of the antiproliferative activity of Xylopia aethiopica.
Cell division.
2012 Mar; 7(1):8. doi:
10.1186/1747-1028-7-8. [PMID: 22409878] - Patricia Gangoiti, Caterina Bernacchioni, Chiara Donati, Francesca Cencetti, Alberto Ouro, Antonio Gómez-Muñoz, Paola Bruni. Ceramide 1-phosphate stimulates proliferation of C2C12 myoblasts.
Biochimie.
2012 Mar; 94(3):597-607. doi:
10.1016/j.biochi.2011.09.009. [PMID: 21945811] - Shaoqing Lei, Yanan Liu, Huimin Liu, Hong Yu, Hui Wang, Zhengyuan Xia. Effects of N-acetylcysteine on nicotinamide dinucleotide phosphate oxidase activation and antioxidant status in heart, lung, liver and kidney in streptozotocin-induced diabetic rats.
Yonsei medical journal.
2012 Mar; 53(2):294-303. doi:
10.3349/ymj.2012.53.2.294. [PMID: 22318816] - Detina Zalli, Richard Bayliss, Andrew M Fry. The Nek8 protein kinase, mutated in the human cystic kidney disease nephronophthisis, is both activated and degraded during ciliogenesis.
Human molecular genetics.
2012 Mar; 21(5):1155-71. doi:
10.1093/hmg/ddr544. [PMID: 22106379] - Anisuzzaman, M Khyrul Islam, M Abdul Alim, Takeharu Miyoshi, Takeshi Hatta, Kayoko Yamaji, Yasunobu Matsumoto, Kozo Fujisaki, Naotoshi Tsuji. Longistatin is an unconventional serine protease and induces protective immunity against tick infestation.
Molecular and biochemical parasitology.
2012 Mar; 182(1-2):45-53. doi:
10.1016/j.molbiopara.2011.12.002. [PMID: 22206819] - Marc Siegert, Heidi Pertl-Obermeyer, Gabriele Gadermaier, Fatima Ferreira, Gerhard Obermeyer. Expression of the major mugwort pollen allergen Art v 1 in tobacco plants and cell cultures: problems and perspectives for allergen production in plants.
Plant cell reports.
2012 Mar; 31(3):561-71. doi:
10.1007/s00299-011-1199-3. [PMID: 22159963] - Adriana Arita, Jingping Niu, Qingshan Qu, Najuan Zhao, Ye Ruan, Arthur Nadas, Yana Chervona, Fen Wu, Hong Sun, Richard B Hayes, Max Costa. Global levels of histone modifications in peripheral blood mononuclear cells of subjects with exposure to nickel.
Environmental health perspectives.
2012 Feb; 120(2):198-203. doi:
10.1289/ehp.1104140. [PMID: 22024396] - Sonia Giacometti, Claudia Adriana Marrano, Maria Cristina Bonza, Laura Luoni, Margherita Limonta, Maria Ida De Michelis. Phosphorylation of serine residues in the N-terminus modulates the activity of ACA8, a plasma membrane Ca2+-ATPase of Arabidopsis thaliana.
Journal of experimental botany.
2012 Feb; 63(3):1215-24. doi:
10.1093/jxb/err346. [PMID: 22090438] - Junqi Wang, Yu Chung Tse, Giselbert Hinz, David G Robinson, Liwen Jiang. Storage globulins pass through the Golgi apparatus and multivesicular bodies in the absence of dense vesicle formation during early stages of cotyledon development in mung bean.
Journal of experimental botany.
2012 Feb; 63(3):1367-80. doi:
10.1093/jxb/err366. [PMID: 22143915] - K M Habegger, B A Penque, W Sealls, L Tackett, L N Bell, E K Blue, P J Gallagher, M Sturek, M A Alloosh, H O Steinberg, R V Considine, J S Elmendorf. Fat-induced membrane cholesterol accrual provokes cortical filamentous actin destabilisation and glucose transport dysfunction in skeletal muscle.
Diabetologia.
2012 Feb; 55(2):457-67. doi:
10.1007/s00125-011-2334-y. [PMID: 22002007] - Michiko Sekine, Toshiaki Monkawa, Ryuji Morizane, Kunie Matsuoka, Choji Taya, Yoshiko Akita, Kensuke Joh, Hiroshi Itoh, Matsuhiko Hayashi, Yoshiaki Kikkawa, Kenji Kohno, Akemi Suzuki, Hiromichi Yonekawa. Selective depletion of mouse kidney proximal straight tubule cells causes acute kidney injury.
Transgenic research.
2012 Feb; 21(1):51-62. doi:
10.1007/s11248-011-9504-z. [PMID: 21431867] - Sarah Lebeer, Ingmar J J Claes, Crina I A Balog, Geert Schoofs, Tine L A Verhoeven, Kris Nys, Ingemar von Ossowski, Willem M de Vos, Hanne L P Tytgat, Patrizia Agostinis, Airi Palva, Els J M Van Damme, André M Deelder, Sigrid C J De Keersmaecker, Manfred Wuhrer, Jos Vanderleyden. The major secreted protein Msp1/p75 is O-glycosylated in Lactobacillus rhamnosus GG.
Microbial cell factories.
2012 Feb; 11(?):15. doi:
10.1186/1475-2859-11-15. [PMID: 22297095] - Andria P Medina, Jialing Lin, Paul H Weigel. Hyaluronan synthase mediates dye translocation across liposomal membranes.
BMC biochemistry.
2012 Jan; 13(?):2. doi:
10.1186/1471-2091-13-2. [PMID: 22276637] - Maja B Hoegg, Stephen M Robbins, James D McGhee. Characterization of the C. elegans erlin homologue.
BMC cell biology.
2012 Jan; 13(?):2. doi:
10.1186/1471-2121-13-2. [PMID: 22269071] - Sophie Doublier, Dimas C Belisario, Manuela Polimeni, Laura Annaratone, Chiara Riganti, Elena Allia, Dario Ghigo, Amalia Bosia, Anna Sapino. HIF-1 activation induces doxorubicin resistance in MCF7 3-D spheroids via P-glycoprotein expression: a potential model of the chemo-resistance of invasive micropapillary carcinoma of the breast.
BMC cancer.
2012 Jan; 12(?):4. doi:
10.1186/1471-2407-12-4. [PMID: 22217342] - Sameer B Shah, James M Love, Andrea O'Neill, Richard M Lovering, Robert J Bloch. Influences of desmin and keratin 19 on passive biomechanical properties of mouse skeletal muscle.
Journal of biomedicine & biotechnology.
2012; 2012(?):704061. doi:
10.1155/2012/704061. [PMID: 22287836] - Sayani Banerjee, Pratip Chakraborty, Piyali Saha, Soma Aditya Bandyopadhyay, Sutapa Banerjee, Syed N Kabir. Ovotoxic effects of galactose involve attenuation of follicle-stimulating hormone bioactivity and up-regulation of granulosa cell p53 expression.
PloS one.
2012; 7(2):e30709. doi:
10.1371/journal.pone.0030709. [PMID: 22319579] - Maria Luisa Sirico, Bruna Guida, Alfredo Procino, Andrea Pota, Maurizio Sodo, Giuseppe Grandaliano, Simona Simone, Giovanni Pertosa, Eleonora Riccio, Bruno Memoli. Human mature adipocytes express albumin and this expression is not regulated by inflammation.
Mediators of inflammation.
2012; 2012(?):236796. doi:
10.1155/2012/236796. [PMID: 22675238] - Ali A Alshatwi, Tarique N Hasan, Gowhar Shafi, Naveed Ahmed Syed, Abdullah H Al-Assaf, Mohammed S Alamri, Abdrohman S Al-Khalifa. Validation of the Antiproliferative Effects of Organic Extracts from the Green Husk of Juglans regia L. on PC-3 Human Prostate Cancer Cells by Assessment of Apoptosis-Related Genes.
Evidence-based complementary and alternative medicine : eCAM.
2012; 2012(?):103026. doi:
10.1155/2012/103026. [PMID: 22454652] - Fu-Lun Li, Rong Xu, Qing-Chun Zeng, Xin Li, Jie Chen, Yi-Fei Wang, Bin Fan, Lin Geng, Bin Li. Tanshinone IIA Inhibits Growth of Keratinocytes through Cell Cycle Arrest and Apoptosis: Underlying Treatment Mechanism of Psoriasis.
Evidence-based complementary and alternative medicine : eCAM.
2012; 2012(?):927658. doi:
10.1155/2012/927658. [PMID: 22203883] - Paola Brun, Paola Brun, Maria Vono, Paola Venier, Elena Tarricone, Velika Deligianni, Emilio Martines, Matteo Zuin, Silvia Spagnolo, Roberto Cavazzana, Romilda Cardin, Ignazio Castagliuolo, Alvise La Gloria Valerio, Andrea Leonardi. Disinfection of ocular cells and tissues by atmospheric-pressure cold plasma.
PloS one.
2012; 7(3):e33245. doi:
10.1371/journal.pone.0033245. [PMID: 22432007] - Bryan N Kahner, Hisashi Kato, Asoka Banno, Mark H Ginsberg, Sanford J Shattil, Feng Ye. Kindlins, integrin activation and the regulation of talin recruitment to αIIbβ3.
PloS one.
2012; 7(3):e34056. doi:
10.1371/journal.pone.0034056. [PMID: 22457811] - Xiao juan Wang, Dai lin Wei, Zhi gang Song, Hong chao Jiao, Hai Lin. Effects of fatty acid treatments on the dexamethasone-induced intramuscular lipid accumulation in chickens.
PloS one.
2012; 7(5):e36663. doi:
10.1371/journal.pone.0036663. [PMID: 22623960] - Jesper Olesen, Signe Larsson, Ninna Iversen, Simi Yousafzai, Ylva Hellsten, Henriette Pilegaard. Skeletal muscle PGC-1α is required for maintaining an acute LPS-induced TNFα response.
PloS one.
2012; 7(2):e32222. doi:
10.1371/journal.pone.0032222. [PMID: 22384185] - Emma Mormeneo, Cecilia Jimenez-Mallebrera, Xavier Palomer, Valeria De Nigris, Manuel Vázquez-Carrera, Anna Orozco, Andrés Nascimento, Jaume Colomer, Carles Lerín, Anna M Gómez-Foix. PGC-1α induces mitochondrial and myokine transcriptional programs and lipid droplet and glycogen accumulation in cultured human skeletal muscle cells.
PloS one.
2012; 7(1):e29985. doi:
10.1371/journal.pone.0029985. [PMID: 22272266] - Xiaoning Chen, Kara J Margolis, Michael D Gershon, Gary J Schwartz, Ji Y Sze. Reduced serotonin reuptake transporter (SERT) function causes insulin resistance and hepatic steatosis independent of food intake.
PloS one.
2012; 7(3):e32511. doi:
10.1371/journal.pone.0032511. [PMID: 22412882] - Shiteshu Shrimal, Arpita Saha, Sudha Bhattacharya, Alok Bhattacharya. Lipids induce expression of serum-responsive transmembrane kinase EhTMKB1-9 in an early branching eukaryote Entamoeba histolytica.
Scientific reports.
2012; 2(?):333. doi:
10.1038/srep00333. [PMID: 22451862] - Pinki Nandi, Swatilekha Ghosh, Kuladip Jana, Parimal C Sen. Elucidation of the involvement of p14, a sperm protein during maturation, capacitation and acrosome reaction of caprine spermatozoa.
PloS one.
2012; 7(1):e30552. doi:
10.1371/journal.pone.0030552. [PMID: 22291985] - Ju Wang, Ying Pan, Ye Hong, Qing-Yu Zhang, Xiao-Ning Wang, Ling-Dong Kong. Quercetin Protects against Cadmium-Induced Renal Uric Acid Transport System Alteration and Lipid Metabolism Disorder in Rats.
Evidence-based complementary and alternative medicine : eCAM.
2012; 2012(?):548430. doi:
10.1155/2012/548430. [PMID: 22690247] - Mohammad Moneruzzaman Khandaker, Amru Nasrulhaq Boyce, Normaniza Osman, Abm Sharif Hossain. Physiochemical and phytochemical properties of wax apple (Syzygium samarangense [Blume] Merrill & L. M. Perry var. Jambu Madu) as affected by growth regulator application.
TheScientificWorldJournal.
2012; 2012(?):728613. doi:
10.1100/2012/728613. [PMID: 22701370] - Chih-Ya Wang, An-Chi Tsai, Chieh-Yu Peng, Ya-Ling Chang, Kuo-Hsiung Lee, Che-Ming Teng, Shiow-Lin Pan. Dehydrocostuslactone suppresses angiogenesis in vitro and in vivo through inhibition of Akt/GSK-3β and mTOR signaling pathways.
PloS one.
2012; 7(2):e31195. doi:
10.1371/journal.pone.0031195. [PMID: 22359572] - Jun-Xiang Bao, Hui Chang, Yong-Gang Lv, Jin-Wen Yu, Yun-Gang Bai, Huan Liu, Yue Cai, Ling Wang, Jin Ma, Yao-Ming Chang. Lysosome-membrane fusion mediated superoxide production in hyperglycaemia-induced endothelial dysfunction.
PloS one.
2012; 7(1):e30387. doi:
10.1371/journal.pone.0030387. [PMID: 22253932] - Hua Sun, Linghong Yu, Huailing Wei, Gengtao Liu. A novel antihepatitis drug, bicyclol, prevents liver carcinogenesis in diethylnitrosamine-initiated and phenobarbital-promoted mice tumor model.
Journal of biomedicine & biotechnology.
2012; 2012(?):584728. doi:
10.1155/2012/584728. [PMID: 22500097] - Aristidis S Veskoukis, Antonios Kyparos, Michalis G Nikolaidis, Dimitrios Stagos, Nektarios Aligiannis, Maria Halabalaki, Konstantinos Chronis, Nikolaos Goutzourelas, Leandros Skaltsounis, Dimitrios Kouretas. The antioxidant effects of a polyphenol-rich grape pomace extract in vitro do not correspond in vivo using exercise as an oxidant stimulus.
Oxidative medicine and cellular longevity.
2012; 2012(?):185867. doi:
10.1155/2012/185867. [PMID: 22693650] - Eugene Tkachenko, Dan Tse, Olga Sideleva, Sophie J Deharvengt, Marcus R Luciano, Yan Xu, Caitlin L McGarry, John Chidlow, Paul F Pilch, William C Sessa, Derek K Toomre, Radu V Stan. Caveolae, fenestrae and transendothelial channels retain PV1 on the surface of endothelial cells.
PloS one.
2012; 7(3):e32655. doi:
10.1371/journal.pone.0032655. [PMID: 22403691] - Craig T Wallington-Beddoe, Anthony S Don, John Hewson, Qiao Qiao, Rachael A Papa, Richard B Lock, Kenneth F Bradstock, Linda J Bendall. Disparate in vivo efficacy of FTY720 in xenograft models of Philadelphia positive and negative B-lineage acute lymphoblastic leukemia.
PloS one.
2012; 7(5):e36429. doi:
10.1371/journal.pone.0036429. [PMID: 22570713] - Julien Giron-Michel, Sandy Azzi, Krystel Khawam, Erwan Mortier, Anne Caignard, Aurore Devocelle, Silvano Ferrini, Michela Croce, Hélène François, Lola Lecru, Bernard Charpentier, Salem Chouaib, Bruno Azzarone, Pierre Eid. Interleukin-15 plays a central role in human kidney physiology and cancer through the γc signaling pathway.
PloS one.
2012; 7(2):e31624. doi:
10.1371/journal.pone.0031624. [PMID: 22363690] - Rahul Checker, Santosh K Sandur, Deepak Sharma, Raghavendra S Patwardhan, S Jayakumar, Vineet Kohli, Gautam Sethi, Bharat B Aggarwal, Krishna B Sainis. Potent anti-inflammatory activity of ursolic acid, a triterpenoid antioxidant, is mediated through suppression of NF-κB, AP-1 and NF-AT.
PloS one.
2012; 7(2):e31318. doi:
10.1371/journal.pone.0031318. [PMID: 22363615] - Penelope Cipriani, Sunhye L Kim, Janet D Klein, Jae H Sim, Tobias N von Bergen, Mitsi A Blount. The role of nitric oxide in the dysregulation of the urine concentration mechanism in diabetes mellitus.
Frontiers in physiology.
2012; 3(?):176. doi:
10.3389/fphys.2012.00176. [PMID: 22685437] - Siham Yasari, Denis Prud'homme, Frédérique Tesson, Marek Jankowski, Jolanta Gutkowska, Emile Levy, Jean-Marc Lavoie. Effects of exercise training on molecular markers of lipogenesis and lipid partitioning in fructose-induced liver fat accumulation.
Journal of nutrition and metabolism.
2012; 2012(?):181687. doi:
10.1155/2012/181687. [PMID: 21860785] - Thomas Lundåsen, Eva-Marie Andersson, Michael Snaith, Helena Lindmark, Johanna Lundberg, Ann-Margret Östlund-Lindqvist, Bo Angelin, Mats Rudling. Inhibition of intestinal bile acid transporter Slc10a2 improves triglyceride metabolism and normalizes elevated plasma glucose levels in mice.
PloS one.
2012; 7(5):e37787. doi:
10.1371/journal.pone.0037787. [PMID: 22662222] - Giuseppe Procino, Lisa Mastrofrancesco, Grazia Tamma, Domenica Rita Lasorsa, Marianna Ranieri, Gilda Stringini, Francesco Emma, Maria Svelto, Giovanna Valenti. Calcium-sensing receptor and aquaporin 2 interplay in hypercalciuria-associated renal concentrating defect in humans. An in vivo and in vitro study.
PloS one.
2012; 7(3):e33145. doi:
10.1371/journal.pone.0033145. [PMID: 22403735] - M Raschid Hoda, Gerit Theil, Nasreldin Mohammed, Kersten Fischer, Paolo Fornara. The adipocyte-derived hormone leptin has proliferative actions on androgen-resistant prostate cancer cells linking obesity to advanced stages of prostate cancer.
Journal of oncology.
2012; 2012(?):280386. doi:
10.1155/2012/280386. [PMID: 22690216] - Gina M Whitaker, Francis C Lynn, Christopher H S McIntosh, Eric A Accili. Regulation of GIP and GLP1 receptor cell surface expression by N-glycosylation and receptor heteromerization.
PloS one.
2012; 7(3):e32675. doi:
10.1371/journal.pone.0032675. [PMID: 22412906] - Peter F Mount, Kurt Gleich, Shanna Tam, Scott A Fraser, Suet-Wan Choy, Karen M Dwyer, Bo Lu, Bryce Van Denderen, Günter Fingerle-Rowson, Richard Bucala, Bruce E Kemp, David A Power. The outcome of renal ischemia-reperfusion injury is unchanged in AMPK-β1 deficient mice.
PloS one.
2012; 7(1):e29887. doi:
10.1371/journal.pone.0029887. [PMID: 22253816] - Melania Kurdián, Inmaculada Herrero-Fresneda, Nuria Lloberas, Pepita Gimenez-Bonafe, Virginia Coria, María T Grande, José Boggia, Leonel Malacrida, Joan Torras, Miguel A Arévalo, Francisco González-Martínez, José M López-Novoa, Josep Grinyó, Oscar Noboa. Delayed mTOR inhibition with low dose of everolimus reduces TGFβ expression, attenuates proteinuria and renal damage in the renal mass reduction model.
PloS one.
2012; 7(3):e32516. doi:
10.1371/journal.pone.0032516. [PMID: 22427849] - Mario Bonomini, Annalisa Giardinelli, Caterina Morabito, Sara Di Silvestre, Moreno Di Cesare, Natalia Di Pietro, Vittorio Sirolli, Gloria Formoso, Luigi Amoroso, Maria Addolorata Mariggiò, Assunta Pandolfi. Calcimimetic R-568 and its enantiomer S-568 increase nitric oxide release in human endothelial cells.
PloS one.
2012; 7(1):e30682. doi:
10.1371/journal.pone.0030682. [PMID: 22295103] - Mehdi Shakibaei, David Allaway, Simone Nebrich, Ali Mobasheri. Botanical Extracts from Rosehip (Rosa canina), Willow Bark (Salix alba), and Nettle Leaf (Urtica dioica) Suppress IL-1β-Induced NF-κB Activation in Canine Articular Chondrocytes.
Evidence-based complementary and alternative medicine : eCAM.
2012; 2012(?):509383. doi:
10.1155/2012/509383. [PMID: 22474508] - Rodrigo Herrera-Molina, Renato Frischknecht, Horacio Maldonado, Constanze I Seidenbecher, Eckart D Gundelfinger, Claudio Hetz, María de la Luz Aylwin, Pascal Schneider, Andrew F G Quest, Lisette Leyton. Astrocytic αVβ3 integrin inhibits neurite outgrowth and promotes retraction of neuronal processes by clustering Thy-1.
PloS one.
2012; 7(3):e34295. doi:
10.1371/journal.pone.0034295. [PMID: 22479590] - Junyun He, Huafang Lai, Christopher Brock, Qiang Chen. A novel system for rapid and cost-effective production of detection and diagnostic reagents of West Nile virus in plants.
Journal of biomedicine & biotechnology.
2012; 2012(?):106783. doi:
10.1155/2012/106783. [PMID: 22187532] - Jorg Kotzka, Birgit Knebel, Jutta Haas, Lorena Kremer, Sylvia Jacob, Sonja Hartwig, Ulrike Nitzgen, Dirk Muller-Wieland. Preventing phosphorylation of sterol regulatory element-binding protein 1a by MAP-kinases protects mice from fatty liver and visceral obesity.
PloS one.
2012; 7(2):e32609. doi:
10.1371/journal.pone.0032609. [PMID: 22384276] - Qiang-Song Wang, Yaozu Xiang, Yuan-Lu Cui, Ke-Ming Lin, Xin-Fang Zhang. Dietary blue pigments derived from genipin, attenuate inflammation by inhibiting LPS-induced iNOS and COX-2 expression via the NF-κB inactivation.
PloS one.
2012; 7(3):e34122. doi:
10.1371/journal.pone.0034122. [PMID: 22479539] - Jueun Oh, Tao Yu, Soo Jeong Choi, Yanyan Yang, Heung Soo Baek, Soon Ae An, Lee Kyoung Kwon, Jinsol Kim, Ho Sik Rho, Song Seok Shin, Wahn Soo Choi, Sungyoul Hong, Jae Youl Cho. Syk/Src pathway-targeted inhibition of skin inflammatory responses by carnosic acid.
Mediators of inflammation.
2012; 2012(?):781375. doi:
10.1155/2012/781375. [PMID: 22577255] - Akiko Muroyama, Aya Fujita, Cheng Lv, Shota Kobayashi, Yoshiyasu Fukuyama, Yasuhide Mitsumoto. Magnolol Protects against MPTP/MPP(+)-Induced Toxicity via Inhibition of Oxidative Stress in In Vivo and In Vitro Models of Parkinson's Disease.
Parkinson's disease.
2012; 2012(?):985157. doi:
10.1155/2012/985157. [PMID: 22655218] - Chris Linehan, Sanjeev Gupta, Afshin Samali, Lynn O'Connor. Bisphenol A-mediated suppression of LPL gene expression inhibits triglyceride accumulation during adipogenic differentiation of human adult stem cells.
PloS one.
2012; 7(5):e36109. doi:
10.1371/journal.pone.0036109. [PMID: 22662114] - Heng Wang, Yongfei Fang, Yong Wang, Zhizhong Wang, Qinghua Zou, Ying Shi, Juerong Chen, Daizhi Peng. Inhibitory Effect of Curcumol on Jak2-STAT Signal Pathway Molecules of Fibroblast-Like Synoviocytes in Patients with Rheumatoid Arthritis.
Evidence-based complementary and alternative medicine : eCAM.
2012; 2012(?):746426. doi:
10.1155/2012/746426. [PMID: 22474524] - Alexander V Chibalin, Judith A Heiny, Boubacar Benziane, Alexander V Prokofiev, Alexander V Vasiliev, Violetta V Kravtsova, Igor I Krivoi. Chronic nicotine modifies skeletal muscle Na,K-ATPase activity through its interaction with the nicotinic acetylcholine receptor and phospholemman.
PloS one.
2012; 7(3):e33719. doi:
10.1371/journal.pone.0033719. [PMID: 22442718] - Thérèse Keravis, Fanny Monneaux, Issaka Yougbaré, Lucien Gazi, Jean-Jacques Bourguignon, Sylviane Muller, Claire Lugnier. Disease progression in MRL/lpr lupus-prone mice is reduced by NCS 613, a specific cyclic nucleotide phosphodiesterase type 4 (PDE4) inhibitor.
PloS one.
2012; 7(1):e28899. doi:
10.1371/journal.pone.0028899. [PMID: 22247763] - Ali Mobasheri, Elisa Trujillo, Mari-Francis Arteaga, Pablo Martín-Vasallo. Na(+), K(+)-ATPase subunit composition in a human chondrocyte cell line; evidence for the presence of α1, α3, β1, β2 and β3 isoforms.
International journal of molecular sciences.
2012; 13(4):5019-34. doi:
10.3390/ijms13045019. [PMID: 22606027] - Audrey Bergouignan, Wendolyn S Gozansky, Daniel W Barry, Wayne Leitner, Paul S MacLean, James O Hill, Boris Draznin, Edward L Melanson. Increasing dietary fat elicits similar changes in fat oxidation and markers of muscle oxidative capacity in lean and obese humans.
PloS one.
2012; 7(1):e30164. doi:
10.1371/journal.pone.0030164. [PMID: 22253914] - Guixian Wang, Weitang Yuan, Tae-Hwan Kwon, Zhenzhen Li, Jianguo Wen, Sukru Oguzkan Topcu, Jens Christian Djurhuus, Søren Nielsen, Jørgen Frøkiær. Age-related changes in expression in renal AQPs in response to congenital, partial, unilateral ureteral obstruction in rats.
Pediatric nephrology (Berlin, Germany).
2012 Jan; 27(1):83-94. doi:
10.1007/s00467-011-1878-x. [PMID: 22028046] - Sung A Jung, Miseon Choi, Sohee Kim, Rina Yu, Taesun Park. Cinchonine Prevents High-Fat-Diet-Induced Obesity through Downregulation of Adipogenesis and Adipose Inflammation.
PPAR research.
2012; 2012(?):541204. doi:
10.1155/2012/541204. [PMID: 22675336] - Setsuko Fukushima, Michiteru Yoshida, Hiroshi Takatsuji. Role of Linkers between Zinc Fingers in Spacing Recognition by Plant TFIIIA-Type Zinc-Finger Proteins.
Journal of amino acids.
2012; 2012(?):848037. doi:
10.1155/2012/848037. [PMID: 22312478] - Xin Wang, Zunji Ke, Gang Chen, Mei Xu, Kimberly A Bower, Jacqueline A Frank, Zhuo Zhang, Xianglin Shi, Jia Luo. Cdc42-dependent activation of NADPH oxidase is involved in ethanol-induced neuronal oxidative stress.
PloS one.
2012; 7(5):e38075. doi:
10.1371/journal.pone.0038075. [PMID: 22662267] - Alak Manna, Piu Saha, Avijit Sarkar, Debanjan Mukhopadhyay, Ajay K Bauri, Deepak Kumar, Padma Das, Subrata Chattopadhyay, Mitali Chatterjee. Malabaricone-A induces a redox imbalance that mediates apoptosis in U937 cell line.
PloS one.
2012; 7(5):e36938. doi:
10.1371/journal.pone.0036938. [PMID: 22590637] - Jodie M Fleming, Erika Ginsburg, Anita S Goldhar, Joshua Plant, Barbara K Vonderhaar. Progesterone receptor activates Msx2 expression by downregulating TNAP/Akp2 and activating the Bmp pathway in EpH4 mouse mammary epithelial cells.
PloS one.
2012; 7(3):e34058. doi:
10.1371/journal.pone.0034058. [PMID: 22457812] - Michael R Breen, Marta Camps, Francisco Carvalho-Simoes, Antonio Zorzano, Paul F Pilch. Cholesterol depletion in adipocytes causes caveolae collapse concomitant with proteosomal degradation of cavin-2 in a switch-like fashion.
PloS one.
2012; 7(4):e34516. doi:
10.1371/journal.pone.0034516. [PMID: 22493697] - Jyh-Horng Wang, Kao-Shang Shih, Jing-Ping Liou, Yi-Wen Wu, Anita Shin-Yuan Chang, Kang-Li Wang, Ching-Lin Tsai, Chia-Ron Yang. Anti-arthritic effects of magnolol in human interleukin 1β-stimulated fibroblast-like synoviocytes and in a rat arthritis model.
PloS one.
2012; 7(2):e31368. doi:
10.1371/journal.pone.0031368. [PMID: 22359588] - Nam-Hun Lee, Chang-Seob Seo, Ho-Young Lee, Da-Young Jung, Jun-Kyung Lee, Jin-Ah Lee, Kye Yong Song, Hyeun-Kyoo Shin, Mee-Young Lee, Young Bae Seo, Hokyoung Kim, Hyekyung Ha. Hepatoprotective and Antioxidative Activities of Cornus officinalis against Acetaminophen-Induced Hepatotoxicity in Mice.
Evidence-based complementary and alternative medicine : eCAM.
2012; 2012(?):804924. doi:
10.1155/2012/804924. [PMID: 21869901] - Huaying Fan, Liu Yang, Fenghua Fu, Hui Xu, Qinggang Meng, Haibo Zhu, Lirong Teng, Mingyan Yang, Leiming Zhang, Ziliang Zhang, Ke Liu. Cardioprotective effects of salvianolic Acid a on myocardial ischemia-reperfusion injury in vivo and in vitro.
Evidence-based complementary and alternative medicine : eCAM.
2012; 2012(?):508938. doi:
10.1155/2012/508938. [PMID: 21789047] - Daniel Laporte, Ema Olate, Paula Salinas, Marcela Salazar, Xavier Jordana, Loreto Holuigue. Glutaredoxin GRXS13 plays a key role in protection against photooxidative stress in Arabidopsis.
Journal of experimental botany.
2012 Jan; 63(1):503-15. doi:
10.1093/jxb/err301. [PMID: 21963612] - Rosaria Santangelo, Cesare Mancuso, Simona Marchetti, Enrico Di Stasio, Giovambattista Pani, Giovanni Fadda. Bilirubin: An Endogenous Molecule with Antiviral Activity in vitro.
Frontiers in pharmacology.
2012; 3(?):36. doi:
10.3389/fphar.2012.00036. [PMID: 22408623] - Robert J Walker, Nancy M Anderson, Suleiman Bahouth, Jena J Steinle. Silencing of insulin receptor substrate-1 increases cell death in retinal Müller cells.
Molecular vision.
2012; 18(?):271-9. doi:
NULL. [PMID: 22328823] - Diana L Esposito, Federica Aru, Rossano Lattanzio, Annalisa Morgano, Michela Abbondanza, Reza Malekzadeh, Faraz Bishehsari, Rosa Valanzano, Antonio Russo, Mauro Piantelli, Antonio Moschetta, Lavinia Vittoria Lotti, Renato Mariani-Costantini. The insulin receptor substrate 1 (IRS1) in intestinal epithelial differentiation and in colorectal cancer.
PloS one.
2012; 7(4):e36190. doi:
10.1371/journal.pone.0036190. [PMID: 22558377] - René Anour, Olena Andrukhova, Eva Ritter, Ute Zeitz, Reinhold G Erben. Klotho lacks a vitamin D independent physiological role in glucose homeostasis, bone turnover, and steady-state PTH secretion in vivo.
PloS one.
2012; 7(2):e31376. doi:
10.1371/journal.pone.0031376. [PMID: 22319626] - Naveen Sharma, Carlos M Castorena, Gregory D Cartee. Tissue-specific responses of IGF-1/insulin and mTOR signaling in calorie restricted rats.
PloS one.
2012; 7(6):e38835. doi:
10.1371/journal.pone.0038835. [PMID: 22701721] - Bombi Lee, Bong-Jun Sur, Sunoh Kwon, Euntaek Jung, Insop Shim, Hyejung Lee, Dae-Hyun Hahm. Acupuncture stimulation alleviates corticosterone-induced impairments of spatial memory and cholinergic neurons in rats.
Evidence-based complementary and alternative medicine : eCAM.
2012; 2012(?):670536. doi:
10.1155/2012/670536. [PMID: 22216057] - Sally J Gustafson, Kriya L Dunlap, Colin M McGill, Thomas B Kuhn. A nonpolar blueberry fraction blunts NADPH oxidase activation in neuronal cells exposed to tumor necrosis factor-α.
Oxidative medicine and cellular longevity.
2012; 2012(?):768101. doi:
10.1155/2012/768101. [PMID: 22530077] - Ming-Huei Chou, Jiin-Haur Chuang, Hock-Liew Eng, Po-Chin Tsai, Chih-Sung Hsieh, Hsiang-Chun Liu, Chiou-Huey Wang, Chih-Yun Lin, Tsun-Mei Lin. Effects of hepatocyte CD14 upregulation during cholestasis on endotoxin sensitivity.
PloS one.
2012; 7(4):e34903. doi:
10.1371/journal.pone.0034903. [PMID: 22511970] - Yi-Fang Li, Rong-Rong He, Bun Tsoi, Xiao-Di Li, Wei-Xi Li, Keiichi Abe, Hiroshi Kurihara. Anti-stress effects of carnosine on restraint-evoked immunocompromise in mice through spleen lymphocyte number maintenance.
PloS one.
2012; 7(4):e33190. doi:
10.1371/journal.pone.0033190. [PMID: 22511917] - Mingjun Li, Fengjuan Feng, Lailiang Cheng. Expression patterns of genes involved in sugar metabolism and accumulation during apple fruit development.
PloS one.
2012; 7(3):e33055. doi:
10.1371/journal.pone.0033055. [PMID: 22412983] - Yuki Wakayama, Koichi Miura, Hisataka Sabe, Naoki Mochizuki. EphrinA1-EphA2 signal induces compaction and polarization of Madin-Darby canine kidney cells by inactivating Ezrin through negative regulation of RhoA.
The Journal of biological chemistry.
2011 Dec; 286(51):44243-44253. doi:
10.1074/jbc.m111.267047. [PMID: 21979959]
