5-Methoxy-N,N-diisopropyltryptamine (BioDeep_00000174566)

 

Secondary id: BioDeep_00000272578

human metabolite blood metabolite


代谢物信息卡片


N-(1-Methylethyl)-N-{2-[5-(methyloxy)-1H-indol-3-yl]ethyl}propan-2-amine

化学式: C17H26N2O (274.2045026)
中文名称: 5-甲氧基-N,N-二异丙基色胺
谱图信息: 最多检出来源 Homo sapiens(blood) 12.5%

分子结构信息

SMILES: CC(C)N(CCC1=CNC2=C1C=C(C=C2)OC)C(C)C
InChI: InChI=1S/C17H26N2O/c1-12(2)19(13(3)4)9-8-14-11-18-17-7-6-15(20-5)10-16(14)17/h6-7,10-13,18H,8-9H2,1-5H3

描述信息

同义名列表

7 个代谢物同义名

N-(1-Methylethyl)-N-{2-[5-(methyloxy)-1H-indol-3-yl]ethyl}propan-2-amine; N-Isopropyl-N-[2-(5-methoxy-1H-indol-3-yl)ethyl]propan-2-amine; 5-Methoxy-N,N-bis(1-methylethyl)-1H-indole-3-ethanamine; [2-(5-methoxy-1H-indol-3-yl)ethyl]bis(propan-2-yl)amine; 5-Methoxy-N,N-diisopropyltryptamine monohydrochloride; 5-Methoxy-N,N-diisopropyltryptamine; 5-MeO-DIPT



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yoko Hagino, Frank Scott Hall, George R Uhl, Ichiro Sora, Kazutaka Ikeda. Dual actions of 5-MeO-DIPT at the serotonin transporter and serotonin 5-HT1A receptor in the mouse striatum and prefrontal cortex. Neuropsychopharmacology reports. 2021 03; 41(1):91-101. doi: 10.1002/npr2.12161. [PMID: 33547882]
  • Xiuying Yan, Shuai Yuan, Zhiguo Yu, Yunli Zhao, Sujing Zhang, Hejian Wu, Hui Yan, Ping Xiang. Development of an LC-MS/MS method for determining 5-MeO-DIPT in dried urine spots and application to forensic cases. Journal of forensic and legal medicine. 2020 May; 72(?):101963. doi: 10.1016/j.jflm.2020.101963. [PMID: 32452453]
  • Xiuying Yan, Ping Xiang, Yunli Zhao, Zhiguo Yu, Hui Yan. Determination of 5-MeO-DIPT in Human Urine Using Gas Chromatography Coupled with High-Resolution Orbitrap Mass Spectrometry. Journal of analytical toxicology. 2020 Apr; 44(5):461-469. doi: 10.1093/jat/bkaa005. [PMID: 32020169]
  • D Fabregat-Safont, M Barneo-Muñoz, F Martinez-Garcia, J V Sancho, F Hernández, M Ibáñez. Proposal of 5-methoxy-N-methyl-N-isopropyltryptamine consumption biomarkers through identification of in vivo metabolites from mice. Journal of chromatography. A. 2017 Jul; 1508(?):95-105. doi: 10.1016/j.chroma.2017.06.010. [PMID: 28602505]
  • Ming J Jin, Changbae Jin, Jin Y Kim, Moon K In, Oh S Kwon, Hye H Yoo. A quantitative method for simultaneous determination of 5-methoxy-N,N-diisopropyltryptamine and its metabolites in urine using liquid chromatography-electrospray ionization-tandem mass spectrometry. Journal of forensic sciences. 2011 Jul; 56(4):1044-8. doi: 10.1111/j.1556-4029.2011.01753.x. [PMID: 21418218]
  • Nicole R Herring, Tori L Schaefer, Peter H Tang, Matthew R Skelton, James P Lucot, Gary A Gudelsky, Charles V Vorhees, Michael T Williams. Comparison of time-dependent effects of (+)-methamphetamine or forced swim on monoamines, corticosterone, glucose, creatine, and creatinine in rats. BMC neuroscience. 2008 May; 9(?):49. doi: 10.1186/1471-2202-9-49. [PMID: 18513404]
  • Takayuki Nakagawa, Shuji Kaneko. Neuropsychotoxicity of abused drugs: molecular and neural mechanisms of neuropsychotoxicity induced by methamphetamine, 3,4-methylenedioxymethamphetamine (ecstasy), and 5-methoxy-N,N-diisopropyltryptamine (foxy). Journal of pharmacological sciences. 2008 Jan; 106(1):2-8. doi: 10.1254/jphs.fm0070141. [PMID: 18198474]
  • Michael T Williams, Nicole R Herring, Tori L Schaefer, Matthew R Skelton, Nicholas G Campbell, Jack W Lipton, Anne E McCrea, Charles V Vorhees. Alterations in body temperature, corticosterone, and behavior following the administration of 5-methoxy-diisopropyltryptamine ('foxy') to adult rats: a new drug of abuse. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2007 Jun; 32(6):1404-20. doi: 10.1038/sj.npp.1301232. [PMID: 17047665]
  • C Sogawa, N Sogawa, J Tagawa, A Fujino, K Ohyama, M Asanuma, M Funada, S Kitayama. 5-Methoxy-N,N-diisopropyltryptamine (Foxy), a selective and high affinity inhibitor of serotonin transporter. Toxicology letters. 2007 Apr; 170(1):75-82. doi: 10.1016/j.toxlet.2007.02.007. [PMID: 17382495]
  • Masanari Itokawa, Ken Iwata, Misako Takahashi, Gen-Ichi Sugihara, Takeshi Sasaki, Yu-Ichiro Abe, Minari Uno, Mizue Hobo, Daisuke Jitoku, Kikue Inoue, Makoto Arai, Ichiro Yasuda, Masahiro Shintani. Acute confusional state after designer tryptamine abuse. Psychiatry and clinical neurosciences. 2007 Apr; 61(2):196-9. doi: 10.1111/j.1440-1819.2007.01638.x. [PMID: 17362440]
  • Einosuke Tanaka, Tooru Kamata, Munehiro Katagi, Hitoshi Tsuchihashi, Katsuya Honda. A fatal poisoning with 5-methoxy-N,N-diisopropyltryptamine, Foxy. Forensic science international. 2006 Nov; 163(1-2):152-4. doi: 10.1016/j.forsciint.2005.11.026. [PMID: 16406422]
  • Tooru Kamata, Munehiro Katagi, Hiroe T Kamata, Akihiro Miki, Noriaki Shima, Kei Zaitsu, Mayumi Nishikawa, Einosuke Tanaka, Katsuya Honda, Hitoshi Tsuchihashi. Metabolism of the psychotomimetic tryptamine derivative 5-methoxy-N,N-diisopropyltryptamine in humans: identification and quantification of its urinary metabolites. Drug metabolism and disposition: the biological fate of chemicals. 2006 Feb; 34(2):281-7. doi: 10.1124/dmd.105.005835. [PMID: 16280455]
  • Tomomi Ishida, Keiko Kudo, Akiko Kiyoshima, Hiromasa Inoue, Akiko Tsuji, Noriaki Ikeda. Sensitive determination of alpha-methyltryptamine (AMT) and 5-methoxy-N,N-diisopropyltryptamine (5MeO-DIPT) in whole blood and urine using gas chromatography-mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2005 Aug; 823(1):47-52. doi: 10.1016/j.jchromb.2004.10.067. [PMID: 16055053]
  • John M Wilson, Frank McGeorge, Susan Smolinske, Robert Meatherall. A foxy intoxication. Forensic science international. 2005 Feb; 148(1):31-6. doi: 10.1016/j.forsciint.2004.04.017. [PMID: 15607587]
  • Shawn P Vorce, Jason H Sklerov. A general screening and confirmation approach to the analysis of designer tryptamines and phenethylamines in blood and urine using GC-EI-MS and HPLC-electrospray-MS. Journal of analytical toxicology. 2004 Sep; 28(6):407-10. doi: 10.1093/jat/28.6.407. [PMID: 15516287]
  • Robert Meatherall, Pankaj Sharma. Foxy, a designer tryptamine hallucinogen. Journal of analytical toxicology. 2003 Jul; 27(5):313-7. doi: 10.1093/jat/27.5.313. [PMID: 12908946]