4-Fluoroamphetamine (BioDeep_00000174380)
Secondary id: BioDeep_00000173281, BioDeep_00000272424
human metabolite blood metabolite Volatile Flavor Compounds
代谢物信息卡片
4-Fluoroamphetamine hydrochloride, (+-)-isomer
化学式: C9H12FN (153.0953724)
中文名称: 1-(4-氟苯基)丙胺, 4-氟苯丙胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(CC1=CC=C(C=C1)F)N
InChI: InChI=1S/C9H12FN/c1-7(11)6-8-2-4-9(10)5-3-8/h2-5,7H,6,11H2,1H3
描述信息
D002491 - Central Nervous System Agents > D000697 - Central Nervous System Stimulants
同义名列表
数据库引用编号
7 个数据库交叉引用编号
- PubChem: 9986
- HMDB: HMDB0246424
- ChEMBL: CHEMBL2009392
- CAS: 788123-23-9
- CAS: 72522-20-4
- CAS: 459-02-9
- KEGG: C22767
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Moritz Losacker, Stefan W Toennes, Elizabeth B de Sousa Fernandes Perna, Johannes G Ramaekers, Joerg Roehrich, Cornelius Hess. Chiral Serum Pharmacokinetics of 4-Fluoroamphetamine after Controlled Oral Administration: Can (R)/(S)-Concentration Ratios Help in Interpreting Forensic Cases?.
Journal of analytical toxicology.
2021 Nov; 45(9):985-992. doi:
10.1093/jat/bkaa156. [PMID: 33031519] - Sylvia I Meier, Silvana Petzel-Witt, Manfred Schubert-Zsilavecz, Elizabeth B de Sousa Fernandes Perna, Eef L Theunissen, Johannes G Ramaekers, Stefan W Toennes. Analysis of 4-fluoroamphetamine in cerumen after controlled oral application.
Drug testing and analysis.
2020 Jul; 12(7):968-974. doi:
10.1002/dta.2796. [PMID: 32246899] - Xun Zhou, Jamal Bouitbir, Matthias E Liechti, Stephan Krähenbühl, Riccardo V Mancuso. Para-Halogenation of Amphetamine and Methcathinone Increases the Mitochondrial Toxicity in Undifferentiated and Differentiated SH-SY5Y Cells.
International journal of molecular sciences.
2020 Apr; 21(8):. doi:
10.3390/ijms21082841. [PMID: 32325754] - Stefan W Toennes, David Schneider, Werner Pogoda, Alexander Paulke, Cora Wunder, Eef L Theunissen, Elizabeth B de Sousa Fernandes Perna, Johannes G Ramaekers. Excretion of 4-fluoroamphetamine and three metabolites in urine after controlled oral ingestion.
Journal of pharmaceutical and biomedical analysis.
2020 Feb; 179(?):113008. doi:
10.1016/j.jpba.2019.113008. [PMID: 31785931] - Stefan W Toennes, David Schneider, Werner Pogoda, Alexander Paulke, Cora Wunder, Eef L Theunissen, Kim P C Kuypers, Eliza de Sousa Fernandes Perna, Johannes G Ramaekers. Pharmacokinetic properties of 4-fluoroamphetamine in serum and oral fluid after oral ingestion.
Drug testing and analysis.
2019 Jul; 11(7):1028-1034. doi:
10.1002/dta.2595. [PMID: 30912312] - K P C Kuypers, E B De Sousa Fernandes Perna, E L Theunissen, S W Toennes, N L Mason, N R P W Hutten, J G Ramaekers. A First-in-Man Study with 4-Fluoroamphetamine Demonstrates it Produces a Mild Psychedelic State.
Journal of psychoactive drugs.
2019 Jul; 51(3):225-235. doi:
10.1080/02791072.2019.1569286. [PMID: 30676284] - Anne Zwartsen, Carlijn H C Litjens, Laura Hondebrink, Jeroen J M W van den Heuvel, Rick Greupink, Frans G M Russel, Dylan W de Lange, Juliette Legler, Jan B Koenderink, Remco H S Westerink. Differential effects of psychoactive substances on human wildtype and polymorphic T356M dopamine transporters (DAT).
Toxicology.
2019 06; 422(?):69-75. doi:
10.1016/j.tox.2019.04.012. [PMID: 31009648] - Patrick C Dolder, Elizabeth B de Sousa Fernandes Perna, Natasha L Mason, Nadia R P W Hutten, Stefan W Toennes, Eef L Theunissen, Johannes G Ramaekers, Kim P C Kuypers. Independent elevation of peripheral oxytocin concentrations and reduction in cognitive empathy during 4-fluoroamphetamine intoxication.
Human psychopharmacology.
2018 11; 33(6):e2680. doi:
10.1002/hup.2680. [PMID: 30357914] - K P C Kuypers, E B de Sousa Fernandes Perna, P C Dolder, S W Toennes, E L Theunissen, N L Mason, N R P W Hutten, J G Ramaekers. Drug liking and wanting, not impulsive action or reflection is increased by 4-fluoroamphetamine.
Psychopharmacology.
2018 08; 235(8):2349-2356. doi:
10.1007/s00213-018-4931-7. [PMID: 29855660] - Anja Begeman, Eric J F Franssen. Lack of Detection of New Amphetamine-Like Drugs Using Conventional Urinary Immunoassays.
Therapeutic drug monitoring.
2018 02; 40(1):135-139. doi:
10.1097/ftd.0000000000000475. [PMID: 29194289] - Anne Zwartsen, Anouk H A Verboven, Regina G D M van Kleef, Fiona M J Wijnolts, Remco H S Westerink, Laura Hondebrink. Measuring inhibition of monoamine reuptake transporters by new psychoactive substances (NPS) in real-time using a high-throughput, fluorescence-based assay.
Toxicology in vitro : an international journal published in association with BIBRA.
2017 Dec; 45(Pt 1):60-71. doi:
10.1016/j.tiv.2017.05.010. [PMID: 28506818] - Ana Causanilles, Juliet Kinyua, Christoph Ruttkies, Alexander L N van Nuijs, Erik Emke, Adrian Covaci, Pim de Voogt. Qualitative screening for new psychoactive substances in wastewater collected during a city festival using liquid chromatography coupled to high-resolution mass spectrometry.
Chemosphere.
2017 Oct; 184(?):1186-1193. doi:
10.1016/j.chemosphere.2017.06.101. [PMID: 28672699] - Suad Al-Abri, Kathryn H Meier, Jennifer M Colby, Craig G Smollin, Neal L Benowitz. Cardiogenic shock after use of fluoroamphetamine confirmed with serum and urine levels.
Clinical toxicology (Philadelphia, Pa.).
2014 Dec; 52(10):1292-5. doi:
10.3109/15563650.2014.974262. [PMID: 25350468] - Kristina Yasmin Rust, Markus R Baumgartner, Annika M Dally, Thomas Kraemer. Prevalence of new psychoactive substances: A retrospective study in hair.
Drug testing and analysis.
2012 Jun; 4(6):402-8. doi:
10.1002/dta.1338. [PMID: 22522922] - J Röhrich, J Becker, T Kaufmann, S Zörntlein, R Urban. Detection of the synthetic drug 4-fluoroamphetamine (4-FA) in serum and urine.
Forensic science international.
2012 Feb; 215(1-3):3-7. doi:
10.1016/j.forsciint.2011.04.004. [PMID: 21543168] - J F McElroy, J M Miller, J S Meyer. Fenfluramine, p-chloroamphetamine and p-fluoroamphetamine stimulation of pituitary-adrenocortical activity in rat: evidence for differences in site and mechanism of action.
The Journal of pharmacology and experimental therapeutics.
1984 Mar; 228(3):593-9. doi:
. [PMID: 6323674] - S Marklund. Determination of plasma or serum haemoglobin by peroxidase activity employing 2,2'-azino-di-(3-ethyl-benzthiazolinsulphonate-6) as chromogen.
Scandinavian journal of clinical and laboratory investigation.
1978 Oct; 38(6):543-7. doi:
10.1080/00365517809108817. [PMID: 30165] - M Nozaki. [Combined use of bucolome and pyrazolone derivatives (1). Pharmacological activities and blood concentration].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
1975 Sep; 71(6):609-29. doi:
NULL. [PMID: 281]