(2Z,6Z,10Z)-2,6,9,9-Tetramethylcycloundeca-2,6,10-trien-1-one (BioDeep_00000173606)

Main id: BioDeep_00000000986

 

human metabolite blood metabolite natural product


代谢物信息卡片


(2Z,6Z,10Z)-2,6,9,9-Tetramethylcycloundeca-2,6,10-trien-1-one

化学式: C15H22O (218.1670562)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 0.43%

分子结构信息

SMILES: C/C1=C/CC(C)(C)/C=C\C(=O)/C(C)=C\CC1
InChI: InChI=1S/C15H22O/c1-12-6-5-7-13(2)14(16)9-11-15(3,4)10-8-12/h7-9,11H,5-6,10H2,1-4H3

描述信息

同义名列表

3 个代谢物同义名

(2Z,6Z,10Z)-2,6,9,9-Tetramethylcycloundeca-2,6,10-trien-1-one; 2,6,9,9-tetramethylcycloundeca-2,6,10-trien-1-one; Zerumbone



数据库引用编号

6 个数据库交叉引用编号

  • PubChem: 5725
  • HMDB: HMDB0245523
  • chemspider: 5523
  • LOTUS: LTS0135758
  • wikidata: Q105008991
  • LOTUS: LTS0084812

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

17 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Haslinda Mohd Salleh, Abdulwali Ablat, Soon-Lim Chong, Hazrina Hazni, Norsita Tohar, Nurulwahidah Fauzi, Habibah A Wahab, Muhamad Aqmal Othman, Sook Yee Liew, Khalijah Awang. The protective effects of Zingiber zerumbet rhizome against fevers in rats. Die Naturwissenschaften. 2024 Apr; 111(2):20. doi: 10.1007/s00114-024-01907-7. [PMID: 38558027]
  • Dipak Biswas, Bharat Gopalrao Somkuwar, Jagat Chandra Borah, Pritish Kumar Varadwaj, Saurabh Gupta, Zeeshan Ahmad Khan, Gopinath Mondal, Asamanja Chattoraj, Lokesh Deb. Phytochemical mediated modulation of COX-3 and NFκB for the management and treatment of arthritis. Scientific reports. 2023 08; 13(1):13612. doi: 10.1038/s41598-023-37729-2. [PMID: 37604838]
  • Jutao Li, Lingying Wang, Yuxin Sun, Zhe Wang, Ye Qian, Vidhya Duraisamy, Tawfiq M Al Antary. Zerumbone-induced reactive oxygen species-mediated oxidative stress re-sensitizes breast cancer cells to paclitaxel. Biotechnology and applied biochemistry. 2023 Feb; 70(1):28-37. doi: 10.1002/bab.2326. [PMID: 35240000]
  • Shana Wuken, Junjun Li, Xiaoli Gao, Shungang Jiao, Xiaojing Ma, Suyile Chen, Pengfei Tu, Luqi Huang, Xingyun Chai. Zerumbone, a major sesquiterpene from Syringa pinnatifolia Hemsl., exerts the sedative effect by regulating GABAergic nervous system. Journal of ethnopharmacology. 2023 Jan; 301(?):115813. doi: 10.1016/j.jep.2022.115813. [PMID: 36220513]
  • Jin-Guo Wang, Da-Lei Li, Rong Fan, Meng-Jun Yan. Zerumbone combined with gefitinib alleviates lung cancer cell growth through the AKT/STAT3/SLC7A11 axis. Neoplasma. 2023 Jan; ?(?):. doi: 10.4149/neo_2022_220418n423. [PMID: 36637083]
  • Nurul Huda Alwakil, Mohamad Suffian Mohamad Annuar, Mahanom Jalil. Synergistic Effects of Plant Growth Regulators and Elicitors on α-Humulene and Zerumbone Production in Zingiber zerumbet Smith Adventitious Root Cultures. Molecules (Basel, Switzerland). 2022 Jul; 27(15):. doi: 10.3390/molecules27154744. [PMID: 35897918]
  • Junjun Li, Fuxing Ge, Shana Wuken, Shungang Jiao, Panlong Chen, Meiwen Huang, Xiaoli Gao, Juan Liu, Pengfei Tu, Xingyun Chai, Luqi Huang. Zerumbone, a humulane sesquiterpene from Syringa pinnatifolia, attenuates cardiac fibrosis by inhibiting of the TGF-β1/Smad signaling pathway after myocardial infarction in mice. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Jun; 100(?):154078. doi: 10.1016/j.phymed.2022.154078. [PMID: 35405613]
  • Julia Schnoell, Isabella Stanisz, Bernhard J Jank, Victoria Stanek, Rainer Schmid, Markus Brunner, Gregor Heiduschka, Ulana Kotowski. Zerumbone acts as a radiosensitizer in head and neck squamous cell carcinoma. Investigational new drugs. 2022 04; 40(2):224-231. doi: 10.1007/s10637-021-01190-7. [PMID: 34613571]
  • Shaymaa Fadhel Abbas Albaayit, Rasedee Abdullah, Mohd Hezmee Mohd Noor. Zerumbone-Loaded Nanostructured Lipid Carrier Gel Enhances Wound Healing in Diabetic Rats. BioMed research international. 2022; 2022(?):1129297. doi: 10.1155/2022/1129297. [PMID: 36124067]
  • Giovanni Schepici, Valentina Contestabile, Andrea Valeri, Emanuela Mazzon. Ginger, a Possible Candidate for the Treatment of Dementias?. Molecules (Basel, Switzerland). 2021 Sep; 26(18):. doi: 10.3390/molecules26185700. [PMID: 34577171]
  • Jasmine Siew Min Chia, Ahmad Akira Omar Farouk, Tengku Azam Shah Tengku Mohamad, Mohd Roslan Sulaiman, Hanis Zakaria, Nurul Izzaty Hassan, Enoch Kumar Perimal. Zerumbone Ameliorates Neuropathic Pain Symptoms via Cannabinoid and PPAR Receptors Using In Vivo and In Silico Models. Molecules (Basel, Switzerland). 2021 Jun; 26(13):. doi: 10.3390/molecules26133849. [PMID: 34202590]
  • Banulata Gopalsamy, Jasmine Siew Min Chia, Ahmad Akira Omar Farouk, Mohd Roslan Sulaiman, Enoch Kumar Perimal. Zerumbone-Induced Analgesia Modulated via Potassium Channels and Opioid Receptors in Chronic Constriction Injury-Induced Neuropathic Pain. Molecules (Basel, Switzerland). 2020 Aug; 25(17):. doi: 10.3390/molecules25173880. [PMID: 32858809]
  • Yuen Ping Tan, Andrei I Savchenko, Kylie A Agnew-Francis, Glen M Boyle, Paul V Bernhardt, James A Fraser, Craig M Williams. Kalparinol, a Salvialane (Isodaucane) Sesquiterpenoid Derived from Native Australian Dysphania Species That Suggests a Putative Biogenetic Link to Zerumbone. Journal of natural products. 2020 05; 83(5):1473-1479. doi: 10.1021/acs.jnatprod.9b01039. [PMID: 32302147]
  • Da-Seul Shin, Yong-Bin Eom. Efficacy of zerumbone against dual-species biofilms of Candida albicans and Staphylococcus aureus. Microbial pathogenesis. 2019 Dec; 137(?):103768. doi: 10.1016/j.micpath.2019.103768. [PMID: 31585154]
  • Nabilah Mohammad Yaqoob Akhtar, Ibrahim Jantan, Laiba Arshad, Md Areeful Haque. Standardized ethanol extract, essential oil and zerumbone of Zingiber zerumbet rhizome suppress phagocytic activity of human neutrophils. BMC complementary and alternative medicine. 2019 Nov; 19(1):331. doi: 10.1186/s12906-019-2748-5. [PMID: 31752812]
  • Soonjae Hwang, Minjeong Jo, Ju Eun Hong, Chan Oh Park, Chang Gun Lee, Miyong Yun, Ki-Jong Rhee. Zerumbone Suppresses Enterotoxigenic Bacteroides fragilis Infection-Induced Colonic Inflammation through Inhibition of NF-κΒ. International journal of molecular sciences. 2019 Sep; 20(18):. doi: 10.3390/ijms20184560. [PMID: 31540059]
  • Hye-Rim Kim, Ki-Jong Rhee, Yong-Bin Eom. Anti-biofilm and antimicrobial effects of zerumbone against Bacteroides fragilis. Anaerobe. 2019 Jun; 57(?):99-106. doi: 10.1016/j.anaerobe.2019.04.001. [PMID: 30953693]
  • Meilin Wang, Jingling Niu, Lina Ou, Bo Deng, Yingyi Wang, Sanqiang Li. Zerumbone Protects against Carbon Tetrachloride (CCl4)-Induced Acute Liver Injury in Mice via Inhibiting Oxidative Stress and the Inflammatory Response: Involving the TLR4/NF-κB/COX-2 Pathway. Molecules (Basel, Switzerland). 2019 May; 24(10):. doi: 10.3390/molecules24101964. [PMID: 31121820]
  • A Rosa, D Caprioglio, R Isola, M Nieddu, G Appendino, A M Falchi. Dietary zerumbone from shampoo ginger: new insights into its antioxidant and anticancer activity. Food & function. 2019 Mar; 10(3):1629-1642. doi: 10.1039/c8fo02395f. [PMID: 30834410]
  • Md Areeful Haque, Ibrahim Jantan, Hemavathy Harikrishnan, Shazliana Ghazalee. Standardized extract of Zingiber zerumbet suppresses LPS-induced pro-inflammatory responses through NF-κB, MAPK and PI3K-Akt signaling pathways in U937 macrophages. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 Feb; 54(?):195-205. doi: 10.1016/j.phymed.2018.09.183. [PMID: 30668369]
  • You-Cheng Hseu, Chih-Ting Chang, Yugandhar Vudhya Gowrisankar, Xuan-Zao Chen, Hui-Chang Lin, Hung-Rong Yen, Hsin-Ling Yang. Zerumbone Exhibits Antiphotoaging and Dermatoprotective Properties in Ultraviolet A-Irradiated Human Skin Fibroblast Cells via the Activation of Nrf2/ARE Defensive Pathway. Oxidative medicine and cellular longevity. 2019; 2019(?):4098674. doi: 10.1155/2019/4098674. [PMID: 31814875]
  • Min-Ju Kim, Jung-Mi Yun. Molecular Mechanism of the Protective Effect of Zerumbone on Lipopolysaccharide-Induced Inflammation of THP-1 Cell-Derived Macrophages. Journal of medicinal food. 2019 Jan; 22(1):62-73. doi: 10.1089/jmf.2018.4253. [PMID: 30383973]
  • Taek-In Oh, Hye-Jeong Jung, Yoon-Mi Lee, Sujin Lee, Geon-Hee Kim, Sang-Yeon Kan, Hyeji Kang, Taerim Oh, Hyun Myung Ko, Keun-Chang Kwak, Ji-Hong Lim. Zerumbone, a Tropical Ginger Sesquiterpene of Zingiber officinale Roscoe, Attenuates α-MSH-Induced Melanogenesis in B16F10 Cells. International journal of molecular sciences. 2018 Oct; 19(10):. doi: 10.3390/ijms19103149. [PMID: 30322121]
  • Chien-Ying Lee, Shih-Pin Chen, Chun-Hung Su, Yung-Chyuan Ho, Ming-Ling Yang, Shiuan-Shinn Lee, Rosa Huang-Liu, Ching-Ping Yang, Chun-Jung Chen, Yu-Hsiang Kuan. Zerumbone from Zingiber zerumbet Ameliorates Lipopolysaccharide-Induced ICAM-1 and Cytokines Expression via p38 MAPK/JNK-IκB/NF-κB Pathway in Mouse Model of Acute Lung Injury. The Chinese journal of physiology. 2018 Jun; 61(3):171-180. doi: 10.4077/cjp.2018.bag562. [PMID: 29962177]
  • Nissar Ahmad Wani, Bo Zhang, Kun-Yu Teng, Juan M Barajas, Tasneem Motiwala, Peng Hu, Lianbo Yu, Rafael Brüschweiler, Kalpana Ghoshal, Samson T Jacob. Reprograming of Glucose Metabolism by Zerumbone Suppresses Hepatocarcinogenesis. Molecular cancer research : MCR. 2018 02; 16(2):256-268. doi: 10.1158/1541-7786.mcr-17-0304. [PMID: 29187559]
  • Giovanni Benelli, Marimuthu Govindarajan, Mohan Rajeswary, Baskaralingam Vaseeharan, Sami A Alyahya, Naiyf S Alharbi, Shine Kadaikunnan, Jamal M Khaled, Filippo Maggi. Insecticidal activity of camphene, zerumbone and α-humulene from Cheilocostus speciosus rhizome essential oil against the Old-World bollworm, Helicoverpa armigera. Ecotoxicology and environmental safety. 2018 Feb; 148(?):781-786. doi: 10.1016/j.ecoenv.2017.11.044. [PMID: 29190597]
  • Le T Huong, Nguyen V Hung, Mai V Chung, Do N Dai, Isiaka A Ogunwande. Essential oils Constituents of the leaves of Amomum gagnepainii and Amomum repoense. Natural product research. 2018 Feb; 32(3):316-321. doi: 10.1080/14786419.2017.1346643. [PMID: 28670920]
  • Thomas Sithara, B P Dhanya, K B Arun, Suresh Sini, Mathew Dan, Radhakrishnan Kokkuvayil Vasu, P Nisha. Zerumbone, a Cyclic Sesquiterpene from Zingiber zerumbet Induces Apoptosis, Cell Cycle Arrest, and Antimigratory Effects in SW480 Colorectal Cancer Cells. Journal of agricultural and food chemistry. 2018 Jan; 66(3):602-612. doi: 10.1021/acs.jafc.7b04472. [PMID: 29276946]
  • Krishnadas Nandagopal, Mihir Halder, Biswabhusan Dash, Sanghamitra Nayak, Sumita Jha. Biotechnological Approaches for Production of Anti-Cancerous Compounds Resveratrol, Podophyllotoxin and Zerumbone. Current medicinal chemistry. 2018; 25(36):4693-4717. doi: 10.2174/0929867324666170404145656. [PMID: 28393691]
  • Albaayit Sf, Rukesh Maharjan. Immunomodulation of Zerumbone via Decreasing the Production of Reactive Oxygen Species from Immune Cells. Pakistan journal of biological sciences : PJBS. 2018 Jan; 21(9):475-479. doi: 10.3923/pjbs.2018.475.479. [PMID: 30724050]
  • Jia Ning Foong, Gayathri Thevi Selvarajah, Abdullah Rasedee, Heshu Sulaiman Rahman, Chee Wun How, Chaw Yee Beh, Guan Young Teo, Chi Ling Ku. Zerumbone-Loaded Nanostructured Lipid Carrier Induces Apoptosis of Canine Mammary Adenocarcinoma Cells. BioMed research international. 2018; 2018(?):8691569. doi: 10.1155/2018/8691569. [PMID: 30410940]
  • Kyu-Sik Chang, Jin-Hwan Jeon, Gi-Hun Kim, Chang-Won Jang, Se-Jin Jeong, Young-Ran Ju, Young-Joon Ahn. Repellency of zerumbone identified in Cyperus rotundus rhizome and other constituents to Blattella germanica. Scientific reports. 2017 11; 7(1):16643. doi: 10.1038/s41598-017-16099-6. [PMID: 29192195]
  • Chomanahalli B Shrikanth, Nandini D Chilkunda. Zerumbone Ameliorates High Glucose-Induced Reduction in AMP-Activated Protein Kinase Phosphorylation in Tubular Kidney Cells. Journal of agricultural and food chemistry. 2017 Oct; 65(42):9208-9216. doi: 10.1021/acs.jafc.7b02379. [PMID: 28971677]
  • Md Areeful Haque, Ibrahim Jantan, Laiba Arshad, Syed Nasir Abbas Bukhari. Exploring the immunomodulatory and anticancer properties of zerumbone. Food & function. 2017 Oct; 8(10):3410-3431. doi: 10.1039/c7fo00595d. [PMID: 28714500]
  • Ritis K Shyanti, Anuradha Sehrawat, Shivendra V Singh, J P N Mishra, Rana P Singh. Zerumbone modulates CD1d expression and lipid antigen presentation pathway in breast cancer cells. Toxicology in vitro : an international journal published in association with BIBRA. 2017 Oct; 44(?):74-84. doi: 10.1016/j.tiv.2017.06.016. [PMID: 28633979]
  • Katayoon Kalantari, Mona Moniri, Amin Boroumand Moghaddam, Raha Abdul Rahim, Arbakariya Bin Ariff, Zahra Izadiyan, Rosfarizan Mohamad. A Review of the Biomedical Applications of Zerumbone and the Techniques for Its Extraction from Ginger Rhizomes. Molecules (Basel, Switzerland). 2017 Sep; 22(10):. doi: 10.3390/molecules22101645. [PMID: 28974019]
  • Wayne Young Liu, Thing-Fong Tzeng, I-Min Liu. Healing potential of zerumbone ointment on experimental full-thickness excision cutaneous wounds in rat. Journal of tissue viability. 2017 Aug; 26(3):202-207. doi: 10.1016/j.jtv.2017.04.002. [PMID: 28454680]
  • Jiyun Ahn, Hyunjung Lee, Chang Hwa Jung, Won Hee Choi, Tae Youl Ha. Zerumbone ameliorates high-fat diet-induced adiposity by restoring AMPK-regulated lipogenesis and microRNA-146b/SIRT1-mediated adipogenesis. Oncotarget. 2017 Jun; 8(23):36984-36995. doi: 10.18632/oncotarget.16974. [PMID: 28445161]
  • Wai-Shing Leung, Ming-Ling Yang, Shiuan-Shinn Lee, Chi-Wen Kuo, Yung-Chyuan Ho, Rosa Huang-Liu, Hui-Wen Lin, Yu-Hsiang Kuan. Protective effect of zerumbone reduces lipopolysaccharide-induced acute lung injury via antioxidative enzymes and Nrf2/HO-1 pathway. International immunopharmacology. 2017 May; 46(?):194-200. doi: 10.1016/j.intimp.2017.03.008. [PMID: 28315822]
  • Yan Wu, Shan-Shan Guo, Dong-Ye Huang, Cheng-Fang Wang, Jian-Yu Wei, Zhi-Hua Li, Jian-Sheng Sun, Jia-Feng Bai, Zhao-Fu Tian, Ping-Juan Wang, Shu-Shan Du. Contact and Repellant Activities of Zerumbone and Its Analogues from the Essential Oil of Zingiber zerumbet (L.) Smith against Lasioderma serricorne. Journal of oleo science. 2017 Apr; 66(4):399-405. doi: 10.5650/jos.ess16166. [PMID: 28239059]
  • Jasmine Siew Min Chia, Ahmad Akira Omar Farouk, Azam Shah Mohamad, Mohd Roslan Sulaiman, Enoch Kumar Perimal. Zerumbone alleviates chronic constriction injury-induced allodynia and hyperalgesia through serotonin 5-HT receptors. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2016 Oct; 83(?):1303-1310. doi: 10.1016/j.biopha.2016.08.052. [PMID: 27570173]
  • Thing-Fong Tzeng, Shorong-Shii Liou, Yu-Cheng Tzeng, I-Min Liu. Zerumbone, a Phytochemical of Subtropical Ginger, Protects against Hyperglycemia-Induced Retinal Damage in Experimental Diabetic Rats. Nutrients. 2016 Jul; 8(8):. doi: 10.3390/nu8080449. [PMID: 27463726]
  • Alexander Schifrin, Martin Litzenburger, Michael Ringle, Thuy T B Ly, Rita Bernhardt. New Sesquiterpene Oxidations with CYP260A1 and CYP264B1 from Sorangium cellulosum So ce56. Chembiochem : a European journal of chemical biology. 2015 Dec; 16(18):2624-32. doi: 10.1002/cbic.201500417. [PMID: 26449371]
  • Mei-Ling Chan, Jui-Wei Liang, Lih-Ching Hsu, Wei-Ling Chang, Shoei-Sheng Lee, Jih-Hwa Guh. Zerumbone, a ginger sesquiterpene, induces apoptosis and autophagy in human hormone-refractory prostate cancers through tubulin binding and crosstalk between endoplasmic reticulum stress and mitochondrial insult. Naunyn-Schmiedeberg's archives of pharmacology. 2015 Nov; 388(11):1223-36. doi: 10.1007/s00210-015-1152-z. [PMID: 26246051]
  • Muthu K Shanmugam, Peramaiyan Rajendran, Feng Li, Chulwon Kim, Sakshi Sikka, Kodappully Sivaraman Siveen, Alan Prem Kumar, Kwang Seok Ahn, Gautam Sethi. Abrogation of STAT3 signaling cascade by zerumbone inhibits proliferation and induces apoptosis in renal cell carcinoma xenograft mouse model. Molecular carcinogenesis. 2015 Oct; 54(10):971-85. doi: 10.1002/mc.22166. [PMID: 24797723]
  • Arabinda Das, Rickey Miller, Philip Lee, Chrysanthe Alyssa Holden, Scott M Lindhorst, Jerry Jaboin, William A Vandergrift, Naren L Banik, Pierre Giglio, Abhay K Varma, Jeffery J Raizer, Sunil J Patel. A novel component from citrus, ginger, and mushroom family exhibits antitumor activity on human meningioma cells through suppressing the Wnt/β-catenin signaling pathway. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 2015 Sep; 36(9):7027-34. doi: 10.1007/s13277-015-3388-0. [PMID: 25864108]
  • Fabio Fusi, Miriam Durante, Giampietro Sgaragli, Pham Ngoc Khanh, Ninh The Son, Tran Thu Huong, Van Ngoc Huong, Nguyen Manh Cuong. In vitro vasoactivity of zerumbone from Zingiber zerumbet. Planta medica. 2015 Mar; 81(4):298-304. doi: 10.1055/s-0034-1396307. [PMID: 25714723]
  • Ying-Hua Shieh, Huei-Mei Huang, Ching-Chiung Wang, Chen-Chen Lee, Chia-Kwung Fan, Yueh-Lun Lee. Zerumbone enhances the Th1 response and ameliorates ovalbumin-induced Th2 responses and airway inflammation in mice. International immunopharmacology. 2015 Feb; 24(2):383-391. doi: 10.1016/j.intimp.2014.12.027. [PMID: 25573403]
  • Heshu Sulaiman Rahman, Abdullah Rasedee, Chee Wun How, Nazariah Allaudin Zeenathul, Max Stanley Chartrand, Swee Keong Yeap, Ahmad Bustamam Abdul, Sheau Wei Tan, Hemn Hassan Othman, Zahra Ajdari, Farideh Namvar, Palanisamy Arulselvan, Sharida Fakurazi, Parvaneh Mehrbod, Nasibeh Daneshvar, Hasina Begum. Antileukemic effect of zerumbone-loaded nanostructured lipid carrier in WEHI-3B cell-induced murine leukemia model. International journal of nanomedicine. 2015; 10(?):1649-66. doi: 10.2147/ijn.s67113. [PMID: 25767386]
  • Hassan Othman Hemn, Muhammad Mustapha Noordin, Heshu Sulaiman Rahman, Hamza Hazilawati, Abubakr Zuki, Max Stanley Chartrand. Antihypercholesterolemic and antioxidant efficacies of zerumbone on the formation, development, and establishment of atherosclerosis in cholesterol-fed rabbits. Drug design, development and therapy. 2015; 9(?):4173-208. doi: 10.2147/dddt.s76225. [PMID: 26347047]
  • Heyam Mohamed Ali Sidahmed, Najihah Mohd Hashim, Mahmood Ameen Abdulla, Hapipah Mohd Ali, Syam Mohan, Siddig Ibrahim Abdelwahab, Manal Mohamed Elhassan Taha, Loke Mun Fai, Jamuna Vadivelu. Antisecretory, gastroprotective, antioxidant and anti-Helicobcter pylori activity of zerumbone from Zingiber zerumbet (L.) Smith. PloS one. 2015; 10(3):e0121060. doi: 10.1371/journal.pone.0121060. [PMID: 25798602]
  • Heshu Sulaiman Rahman, Abdullah Rasedee, Max Stanley Chartrand, Hemn Hassan Othman, Swee Keong Yeap, Farideh Namvar. Zerumbone induces G2/M cell cycle arrest and apoptosis via mitochondrial pathway in Jurkat cell line. Natural product communications. 2014 Sep; 9(9):1237-42. doi: . [PMID: 25918781]
  • Thing-Fong Tzeng, Hung-Jen Lu, Shorong-Shii Liou, Chia Ju Chang, I-Min Liu. Lipid-lowering effects of zerumbone, a natural cyclic sesquiterpene of Zingiber zerumbet Smith, in high-fat diet-induced hyperlipidemic hamsters. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2014 Jul; 69(?):132-9. doi: 10.1016/j.fct.2014.03.036. [PMID: 24709573]
  • D Keerthi, C Geethu, R Aswati Nair, Padmesh Pillai. Metabolic profiling of Zingiber zerumbet following Pythium myriotylum infection: investigations on the defensive role of the principal secondary metabolite, zerumbone. Applied biochemistry and biotechnology. 2014 Mar; 172(5):2593-603. doi: 10.1007/s12010-013-0707-z. [PMID: 24414941]
  • Heshu Sulaiman Rahman, Abdullah Rasedee, Ahmad Bustamam Abdul, Nazariah Allaudin Zeenathul, Hemn Hassan Othman, Swee Keong Yeap, Chee Wun How, Wan Abd Ghani Wan Nor Hafiza. Zerumbone-loaded nanostructured lipid carrier induces G2/M cell cycle arrest and apoptosis via mitochondrial pathway in a human lymphoblastic leukemia cell line. International journal of nanomedicine. 2014; 9(?):527-38. doi: 10.2147/ijn.s54346. [PMID: 24549090]
  • Heshu Sulaiman Rahman, Abdullah Rasedee, Swee Keong Yeap, Hemn Hassan Othman, Max Stanley Chartrand, Farideh Namvar, Ahmad Bustamam Abdul, Chee Wun How. Biomedical properties of a natural dietary plant metabolite, zerumbone, in cancer therapy and chemoprevention trials. BioMed research international. 2014; 2014(?):920742. doi: 10.1155/2014/920742. [PMID: 25025076]
  • Heshu Sulaiman Rahman, Abdullah Rasedee, Hemn Hassan Othman, Max Stanley Chartrand, Farideh Namvar, Swee Keong Yeap, Nozlena Abdul Samad, Reena Joys Andas, Nabilah Muhammad Nadzri, Theebaa Anasamy, Kuan Beng Ng, Chee Wun How. Acute toxicity study of zerumbone-loaded nanostructured lipid carrier on BALB/c mice model. BioMed research international. 2014; 2014(?):563930. doi: 10.1155/2014/563930. [PMID: 25276798]
  • S C Santosh Kumar, P Srinivas, P S Negi, B K Bettadaiah. Antibacterial and antimutagenic activities of novel zerumbone analogues. Food chemistry. 2013 Nov; 141(2):1097-103. doi: 10.1016/j.foodchem.2013.04.021. [PMID: 23790891]
  • I Batubara, I H Suparto, S Sadiah, R Matsuoka, T Mitsunaga. Effect of Zingiber zerumbet essential oils and zerumbone inhalation on body weight of Sprague Dawley rat. Pakistan journal of biological sciences : PJBS. 2013 Oct; 16(19):1028-33. doi: 10.3923/pjbs.2013.1028.1033. [PMID: 24502166]
  • Kohta Ohnishi, Erina Nakahata, Kazuhiro Irie, Akira Murakami. Zerumbone, an electrophilic sesquiterpene, induces cellular proteo-stress leading to activation of ubiquitin-proteasome system and autophagy. Biochemical and biophysical research communications. 2013 Jan; 430(2):616-22. doi: 10.1016/j.bbrc.2012.11.104. [PMID: 23219816]
  • Heshu Sulaiman Rahman, Abdullah Rasedee, Chee Wun How, Ahmad Bustamam Abdul, Nazariah Allaudin Zeenathul, Hemn Hassan Othman, Mohamed Ibrahim Saeed, Swee Keong Yeap. Zerumbone-loaded nanostructured lipid carriers: preparation, characterization, and antileukemic effect. International journal of nanomedicine. 2013; 8(?):2769-81. doi: 10.2147/ijn.s45313. [PMID: 23946649]
  • Remya Prasannan, Karunakaran A Kalesh, Muthu K Shanmugam, Alamelu Nachiyappan, Lalitha Ramachandran, An H Nguyen, Alan Prem Kumar, Manikandan Lakshmanan, Kwang Seok Ahn, Gautam Sethi. Key cell signaling pathways modulated by zerumbone: role in the prevention and treatment of cancer. Biochemical pharmacology. 2012 Nov; 84(10):1268-76. doi: 10.1016/j.bcp.2012.07.015. [PMID: 22842489]
  • Tg Siti Amirah Tg Kamazeri, Othman Abd Samah, Muhammad Taher, Deny Susanti, Haitham Qaralleh. Antimicrobial activity and essential oils of Curcuma aeruginosa, Curcuma mangga, and Zingiber cassumunar from Malaysia. Asian Pacific journal of tropical medicine. 2012 Mar; 5(3):202-9. doi: 10.1016/s1995-7645(12)60025-x. [PMID: 22305785]
  • Behnam Kamalidehghan, Fatemeh Ahmadipour, Mohamed Ibrahim Noordin. DNA fragmentation is not associated with apoptosis in zerumbone-induced HepG2 cells. Iranian biomedical journal. 2012; 16(4):226. doi: ". [PMID: 23183623]
  • John H Beattie, Fergus Nicol, Margaret-Jane Gordon, Martin D Reid, Louise Cantlay, Graham W Horgan, In-Sook Kwun, Ji-Yun Ahn, Tae-Youl Ha. Ginger phytochemicals mitigate the obesogenic effects of a high-fat diet in mice: a proteomic and biomarker network analysis. Molecular nutrition & food research. 2011 Sep; 55 Suppl 2(?):S203-13. doi: 10.1002/mnfr.201100193. [PMID: 21954187]
  • Sho Okamoto, Fengnian Yu, Hisashi Harada, Toshihide Okajima, Jun-ichiro Hattan, Norihiko Misawa, Ryutaro Utsumi. A short-chain dehydrogenase involved in terpene metabolism from Zingiber zerumbet. The FEBS journal. 2011 Aug; 278(16):2892-900. doi: 10.1111/j.1742-4658.2011.08211.x. [PMID: 21668645]
  • Eltayeb E M Eid, Ahmad Bustamam Abdul, A Rasedee, Fakhr Eldin O Suliman, Mohd A Sukari, Safa A Fatah. Liquid chromatography-tandem mass spectroscopic method for the determination of zerumbone in human plasma and its application to pharmacokinetics. Journal of mass spectrometry : JMS. 2011 Aug; 46(8):772-81. doi: 10.1002/jms.1942. [PMID: 21834015]
  • Bo-Yie Chen, David Pei-Cheng Lin, Kuo-Chen Su, Yi-Ling Chen, Chia-Yung Wu, Mei-Ching Teng, Yuan-Ting Tsai, Chi-Yun Sun, Soo-Ray Wang, Han-Hsin Chang. Dietary zerumbone prevents against ultraviolet B-induced cataractogenesis in the mouse. Molecular vision. 2011 Mar; 17(?):723-30. doi: . [PMID: 21423870]
  • Fengnian Yu, Sho Okamoto, Hisashi Harada, Kazuhisa Yamasaki, Norihiko Misawa, Ryutaro Utsumi. Zingiber zerumbet CYP71BA1 catalyzes the conversion of α-humulene to 8-hydroxy-α-humulene in zerumbone biosynthesis. Cellular and molecular life sciences : CMLS. 2011 Mar; 68(6):1033-40. doi: 10.1007/s00018-010-0506-4. [PMID: 20730551]
  • Eric M Sciullo, Christoph F Vogel, Dalei Wu, Akira Murakami, Hajime Ohigashi, Fumio Matsumura. Effects of selected food phytochemicals in reducing the toxic actions of TCDD and p,p'-DDT in U937 macrophages. Archives of toxicology. 2010 Dec; 84(12):957-66. doi: 10.1007/s00204-010-0592-y. [PMID: 20865247]
  • M R Sulaiman, E K Perimal, M N Akhtar, A S Mohamad, M H Khalid, N A Tasrip, F Mokhtar, Z A Zakaria, N H Lajis, D A Israf. Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice. Fitoterapia. 2010 Oct; 81(7):855-8. doi: 10.1016/j.fitote.2010.05.009. [PMID: 20546845]
  • Siddig Ibrahim Abdelwahab, Ahmad Bustamam Abdul, Nirmala Devi, Manal Mohamed Ehassan Taha, Adel Sharaf Al-zubairi, Syam Mohan, Abdelbasit Adam Mariod. Regression of cervical intraepithelial neoplasia by zerumbone in female Balb/c mice prenatally exposed to diethylstilboestrol: involvement of mitochondria-regulated apoptosis. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. 2010 Sep; 62(5):461-9. doi: 10.1016/j.etp.2009.06.005. [PMID: 19581075]
  • Manal Mohamed Elhassan Taha, Ahmad Bustamam Abdul, Rasedee Abdullah, Tengku Azmi Tengku Ibrahim, Siddig Ibrahim Abdelwahab, Syam Mohan. Potential chemoprevention of diethylnitrosamine-initiated and 2-acetylaminofluorene-promoted hepatocarcinogenesis by zerumbone from the rhizomes of the subtropical ginger (Zingiber zerumbet). Chemico-biological interactions. 2010 Aug; 186(3):295-305. doi: 10.1016/j.cbi.2010.04.029. [PMID: 20452335]
  • Adel S Al-Zubairi, Ahmad Bustamam Abdul, M M Syam. Evaluation of the genotoxicity of zerumbone in cultured human peripheral blood lymphocytes. Toxicology in vitro : an international journal published in association with BIBRA. 2010 Apr; 24(3):707-12. doi: 10.1016/j.tiv.2010.01.011. [PMID: 20123012]
  • Yeap Swee Keong, Noorjahan Banu Alitheen, Shuhaimi Mustafa, Suraini Abdul Aziz, Mashitoh Abdul Rahman, Abdul Manaf Ali. Immunomodulatory effects of zerumbone isolated from roots of Zingiber zerumbet. Pakistan journal of pharmaceutical sciences. 2010 Jan; 23(1):75-82. doi: ". [PMID: 20067871]
  • Supachai Yodkeeree, Bokyung Sung, Pornngarm Limtrakul, Bharat B Aggarwal. Zerumbone enhances TRAIL-induced apoptosis through the induction of death receptors in human colon cancer cells: Evidence for an essential role of reactive oxygen species. Cancer research. 2009 Aug; 69(16):6581-9. doi: 10.1158/0008-5472.can-09-1161. [PMID: 19654295]
  • Ahmad Bustamam Abdul, Siddig Ibrahim Abdelwahab, Johari Bin Jalinas, Adel Sharaf Al-Zubairi, Manal Mohamed Elhassan Taha. Combination of zerumbone and cisplatin to treat cervical intraepithelial neoplasia in female BALB/c mice. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. 2009 Aug; 19(6):1004-10. doi: 10.1111/igc.0b013e3181a83b51. [PMID: 19820360]
  • M R Sulaiman, E K Perimal, Z A Zakaria, F Mokhtar, M N Akhtar, N H Lajis, D A Israf. Preliminary analysis of the antinociceptive activity of zerumbone. Fitoterapia. 2009 Jun; 80(4):230-2. doi: 10.1016/j.fitote.2009.02.002. [PMID: 19535012]
  • Bokyung Sung, Sonia Jhurani, Kwang Seok Ahn, Yoichi Mastuo, Tingfang Yi, Sushovan Guha, Mingyao Liu, Bharat B Aggarwal. Zerumbone down-regulates chemokine receptor CXCR4 expression leading to inhibition of CXCL12-induced invasion of breast and pancreatic tumor cells. Cancer research. 2008 Nov; 68(21):8938-44. doi: 10.1158/0008-5472.can-08-2155. [PMID: 18974138]
  • Samir Kumar Sadhu, Amina Khatun, Takashi Ohtsuki, Masami Ishibashi. First isolation of sesquiterpenes and flavonoids from Zingiber spectabile and identification of zerumbone as the major cell growth inhibitory component. Natural product research. 2007 Dec; 21(14):1242-7. doi: 10.1080/14786410701371421. [PMID: 18075886]
  • Akira Murakami, Hajime Ohigashi. Targeting NOX, INOS and COX-2 in inflammatory cells: chemoprevention using food phytochemicals. International journal of cancer. 2007 Dec; 121(11):2357-63. doi: 10.1002/ijc.23161. [PMID: 17893865]
  • Yoshimasa Nakamura, Chiho Yoshida, Akira Murakami, Hajime Ohigashi, Toshihiko Osawa, Koji Uchida. Zerumbone, a tropical ginger sesquiterpene, activates phase II drug metabolizing enzymes. FEBS letters. 2004 Aug; 572(1-3):245-50. doi: 10.1016/j.febslet.2004.07.042. [PMID: 15304356]
  • Akira Murakami, Masaaki Miyamoto, Hajime Ohigashi. Zerumbone, an anti-inflammatory phytochemical, induces expression of proinflammatory cytokine genes in human colon adenocarcinoma cell lines. BioFactors (Oxford, England). 2004; 21(1-4):95-101. doi: 10.1002/biof.552210118. [PMID: 15630177]
  • Chandra Kirana, Graeme H McIntosh, Ian R Record, Graham P Jones. Antitumor activity of extract of Zingiber aromaticum and its bioactive sesquiterpenoid zerumbone. Nutrition and cancer. 2003; 45(2):218-25. doi: 10.1207/s15327914nc4502_12. [PMID: 12881017]
  • Akira Murakami, Daisuke Takahashi, Takashi Kinoshita, Koichi Koshimizu, Ha Won Kim, Akira Yoshihiro, Yoshimasa Nakamura, Suratwadee Jiwajinda, Junji Terao, Hajime Ohigashi. Zerumbone, a Southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: the alpha,beta-unsaturated carbonyl group is a prerequisite. Carcinogenesis. 2002 May; 23(5):795-802. doi: 10.1093/carcin/23.5.795. [PMID: 12016152]
  • A Murakami, M Takahashi, S Jiwajinda, K Koshimizu, H Ohigashi. Identification of zerumbone in Zingiber zerumbet Smith as a potent inhibitor of 12-O-tetradecanoylphorbol-13-acetate-induced Epstein-Barr virus activation. Bioscience, biotechnology, and biochemistry. 1999 Oct; 63(10):1811-2. doi: 10.1271/bbb.63.1811. [PMID: 10586508]
  • . . . . doi: . [PMID: 18273640]