Azosemide (BioDeep_00000036529)

 

Secondary id: BioDeep_00000015138, BioDeep_00000624660

human metabolite


代谢物信息卡片


2-chloro-5-(2H-1,2,3,4-tetrazol-5-yl)-4-[(thiophen-2-ylmethyl)amino]benzene-1-sulfonamide

化学式: C12H11ClN6O2S2 (370.0073)
中文名称: 阿佐酰胺
谱图信息: 最多检出来源 Mus musculus(not specific) 1.49%

分子结构信息

SMILES: C1=CSC(=C1)CNC2=CC(=C(C=C2C3=NNN=N3)S(=O)(=O)N)Cl
InChI: InChI=1S/C12H11ClN6O2S2/c13-9-5-10(15-6-7-2-1-3-22-7)8(12-16-18-19-17-12)4-11(9)23(14,20)21/h1-5,15H,6H2,(H2,14,20,21)(H,16,17,18,19)

描述信息

C78275 - Agent Affecting Blood or Body Fluid > C448 - Diuretic > C49184 - Loop Diuretic
D002317 - Cardiovascular Agents > D045283 - Natriuretic Agents
D000890 - Anti-Infective Agents > D013424 - Sulfanilamides
D045283 - Natriuretic Agents > D004232 - Diuretics
Azosemide is a high-ceiling diuretic agent.

同义名列表

13 个代谢物同义名

2-chloro-5-(2H-1,2,3,4-tetrazol-5-yl)-4-[(thiophen-2-ylmethyl)amino]benzene-1-sulfonamide; 2-Chloro-5-(1H-tetrazol-5-yl)-4-[(thiophen-2-ylmethyl)amino]benzenesulfonamide; 2-Chloro-5-(1H-tetrazol-5-yl)-N(4)-2-thenylsulphanilamide; 2-Chloro-5-(1H-tetrazol-5-yl)-N(4)-2-thenylsulfanilamide; 5-(4-Chloro-5-sulphamoyl-2-thenylaminophenyl)tetrazole; 2-Chloro-5-(1H-tetrazol-5-yl)-N4-2-thenylsulfanilamide; 5-(4-Chloro-5-sulfamyl-2-thienylaminophenyl)tetrazole; 5-(4-Chloro-5-sulfamoyl-2-thenylaminophenyl)tetrazole; Azosemidum; Azosemida; Azosemide; Azosemid; Diart



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Philip Hampel, Kerstin Römermann, Björn Gailus, Marie Johne, Birthe Gericke, Edith Kaczmarek, Wolfgang Löscher. Effects of the NKCC1 inhibitors bumetanide, azosemide, and torasemide alone or in combination with phenobarbital on seizure threshold in epileptic and nonepileptic mice. Neuropharmacology. 2021 03; 185(?):108449. doi: 10.1016/j.neuropharm.2021.108449. [PMID: 33450274]
  • Philip Hampel, Kerstin Römermann, Martina Gramer, Wolfgang Löscher. The search for brain-permeant NKCC1 inhibitors for the treatment of seizures: Pharmacokinetic-pharmacodynamic modelling of NKCC1 inhibition by azosemide, torasemide, and bumetanide in mouse brain. Epilepsy & behavior : E&B. 2021 01; 114(Pt A):107616. doi: 10.1016/j.yebeh.2020.107616. [PMID: 33279441]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Shigeru Toyoda, Takuo Arikawa, Shu Inami, Riichi Nishikawa, Fumiya Saito, Ryo Watanabe, Masashi Sakuma, Tomoaki Kanaya, Shichiro Abe, Teruo Inoue. Patients With CONgestive Heart Failure Benefit From Long-Term Treatment Effects With Novel Treatment Using Azosemide Compared With Furosemide Derived From Existing Retrospective Study Data: CONTENTED. Journal of cardiovascular pharmacology. 2019 06; 73(6):365-372. doi: 10.1097/fjc.0000000000000669. [PMID: 31162245]
  • Miho Fukui, Takeshi Tsujino, Shinichi Hirotani, Hiroshi Ito, Kazuhiro Yamamoto, Takashi Akasaka, Yutaka Hirano, Nobuyuki Ohte, Takashi Daimon, Satoshi Nakatani, Masaaki Kawabata, Tohru Masuyama. Changes in brain natriuretic peptide in chronic heart failure patients treated with long-acting versus short-acting loop diuretics: J-MELODIC subanalysis. Heart and vessels. 2017 Jul; 32(7):865-871. doi: 10.1007/s00380-017-0945-z. [PMID: 28105515]
  • Taro Hoshino, Susumu Ookawara, Haruhisa Miyazawa, Kiyonori Ito, Yuichiro Ueda, Yoshio Kaku, Keiji Hirai, Honami Mori, Izumi Yoshida, Kaoru Tabei. Renoprotective effects of thiazides combined with loop diuretics in patients with type 2 diabetic kidney disease. Clinical and experimental nephrology. 2015 Apr; 19(2):247-53. doi: 10.1007/s10157-014-0981-2. [PMID: 24821289]
  • Masaaki Miyata, Takeshi Sasaki, Yoshiyuki Ikeda, Takuro Shinsato, Takuro Kubozono, Yuko Furusho, Atsushi Kusumoto, Shuichi Hamasaki, Chuwa Tei. Comparative study of therapeutic effects of short- and long-acting loop diuretics in outpatients with chronic heart failure (COLD-CHF). Journal of cardiology. 2012 May; 59(3):352-8. doi: 10.1016/j.jjcc.2011.12.007. [PMID: 22365947]
  • Ken Harada, Hideo Izawa, Takao Nishizawa, Akihiro Hirashiki, Yosuke Murase, Masakazu Kobayashi, Satoshi Isobe, Xian Wu Cheng, Akiko Noda, Kohzo Nagata, Mitsuhiro Yokota, Toyoaki Murohara. Beneficial effects of torasemide on systolic wall stress and sympathetic nervous activity in asymptomatic or mildly symptomatic patients with heart failure: comparison with azosemide. Journal of cardiovascular pharmacology. 2009 Jun; 53(6):468-73. doi: 10.1097/fjc.0b013e3181a717f7. [PMID: 19430310]
  • Yasutomo Hori, Akiko Katou, Mizuho Tsubaki, Kazutaka Kanai, Ruriko Nakao, Fumio Hoshi, Naoyuki Itoh, Sei-ichi Higuchi. Assessment of diuretic effects and changes in plasma aldosterone concentration following oral administration of a single dose of furosemide or azosemide in healthy dogs. American journal of veterinary research. 2008 Dec; 69(12):1664-9. doi: 10.2460/ajvr.69.12.1664. [PMID: 19046016]
  • Ka Y Choi, Yu C Kim, Myung G Lee. Mechanism of enhanced bioavailability and diuretic effect of azosemide by ascorbic acid in rats. Life sciences. 2006 Feb; 78(10):1057-62. doi: 10.1016/j.lfs.2005.06.013. [PMID: 16153662]
  • Junichi Yoshida, Kazuhiro Yamamoto, Toshiaki Mano, Yasushi Sakata, Mayu Nishio, Tomohito Ohtani, Masatsugu Hori, Takeshi Miwa, Tohru Masuyama. Different effects of long- and short-acting loop diuretics on survival rate in Dahl high-salt heart failure model rats. Cardiovascular research. 2005 Oct; 68(1):118-27. doi: 10.1016/j.cardiores.2005.05.023. [PMID: 16002057]
  • Yun Zhang, Xiao-sheng Hu, Jun-zhu Chen, Zong-Gui Wu, Gao-zhong Huang, Yong-lin Hu, Xiao-sheng Huang, Wei-qin Lin, Jing-chuan Zheng. [Efficacy and safety of azosemide in patients with edema and ascites]. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences. 2005 09; 34(5):459-64. doi: 10.3785/j.issn.1008-9292.2005.05.016. [PMID: 16216060]
  • Gabriele Adam, Jiraporn Ousingsawat, Rainer Schreiber, Karl Kunzelmann. Increase in intracellular Cl- concentration by cAMP- and Ca2+-dependent stimulation of M1 collecting duct cells. Pflugers Archiv : European journal of physiology. 2005 Feb; 449(5):470-8. doi: 10.1007/s00424-004-1356-4. [PMID: 15517342]
  • Ok K Suh, So H Kim, Myung G Lee. Pharmacokinetics and pharmacodynamics of azosemide. Biopharmaceutics & drug disposition. 2003 Oct; 24(7):275-97. doi: 10.1002/bdd.365. [PMID: 14520682]
  • Eun J Kim, Ae K Lee, So H Kim, Sang G Kim, Myung G Lee. Pharmacokinetics and pharmacodynamics of intravenous azosemide in mutant Nagase analbuminemic rats. Drug metabolism and disposition: the biological fate of chemicals. 2003 Feb; 31(2):194-201. doi: 10.1124/dmd.31.2.194. [PMID: 12527700]
  • Hee J Kim, Ae K Lee, Yoon G Kim, Seong C Bu, So H Kim, Chae H Yang, Ok Kyung Suh, Sang G Kim, Myung G Lee. Influence of 4-week and 8-week exercise training on the pharmacokinetics and pharmacodynamics of intravenous and oral azosemide in rats. Life sciences. 2002 Mar; 70(19):2299-319. doi: 10.1016/s0024-3205(02)01516-3. [PMID: 12005188]
  • T Tsutsui, T Tsutamoto, K Maeda, M Kinoshita. Comparison of neurohumoral effects of short-acting and long-acting loop diuretics in patients with chronic congestive heart failure. Journal of cardiovascular pharmacology. 2001 Oct; 38 Suppl 1(?):S81-5. doi: 10.1097/00005344-200110001-00017. [PMID: 11811366]
  • K Fujikawa, M Kasahara, Y Matsui, H Takeuchi. Human atrial natriuretic peptide is a useful criterion in treatment of nocturia. Scandinavian journal of urology and nephrology. 2001 Sep; 35(4):310-3. doi: 10.1080/003655901750425909. [PMID: 11676358]
  • Y G Kim, M K Cho, J W Kwon, S G Kim, S H Kim, M G Lee. Effects of cysteine on the pharmacokinetics and pharmacodynamics of intravenous and oral azosemide in rats with protein-calorie malnutrition. Life sciences. 2001 Apr; 68(21):2329-45. doi: 10.1016/s0024-3205(01)01025-6. [PMID: 11350005]
  • Y G Kim, M K Cho, J W Kwon, S H Kim, S G Kim, M G Lee. No effect of cysteine on the pharmacokinetics of intravenous azosemide in rats with protein-calorie malnutrition by pretreatment with 3-methylcholanthrene. Research communications in molecular pathology and pharmacology. 2001; 110(5-6):347-60. doi: NULL. [PMID: 12889526]
  • M K Cho, Y G Kim, M G Lee, S G Kim. Suppression of rat hepatic cytochrome P450s by protein-calorie malnutrition: complete or partial restoration by cysteine or methionine supplementation. Archives of biochemistry and biophysics. 1999 Dec; 372(1):150-8. doi: 10.1006/abbi.1999.1482. [PMID: 10562428]
  • Y S Lee, K S Han, M G Lee. Gender differences in pharmacokinetics and pharmacodynamics of azosemide in rats. Biopharmaceutics & drug disposition. 1999 May; 20(4):225-9. doi: 10.1002/(sici)1099-081x(199905)20:4<225::aid-bdd176>3.0.co;2-e. [PMID: 10440798]
  • H Tomiyama, T Nakayama, G Watanabe, K Shiojima, Y Sakuma, A Yamamoto, Y Imai, H Yoshida, N Doba. Effects of short-acting and long-acting loop diuretics on heart rate variability in patients with chronic compensated congestive heart failure. American heart journal. 1999 Mar; 137(3):543-8. doi: 10.1016/s0002-8703(99)70504-1. [PMID: 10047639]
  • K S Han, M G Lee. Circadian changes in the pharmacokinetics and pharmacodynamics of azosemide in rats. The Journal of pharmacy and pharmacology. 1998 Jul; 50(7):767-74. doi: 10.1111/j.2042-7158.1998.tb07138.x. [PMID: 9720626]
  • K J Park, W H Yoon, S H Kim, W G Shin, M G Lee. Pharmacokinetic and pharmacodynamic changes of azosemide after intravenous and oral administration of azosemide to uranyl nitrate-induced acute renal failure rats. Biopharmaceutics & drug disposition. 1998 Apr; 19(3):141-6. doi: 10.1002/(sici)1099-081x(199804)19:3<141::aid-bdd119>3.0.co;2-3. [PMID: 9569995]
  • K J Park, W H Yoon, W G Shin, M G Lee. Effects of the rate and composition of fluid replacement on the pharmacokinetics and pharmacodynamics of intravenous azosemide. Biopharmaceutics & drug disposition. 1997 Oct; 18(7):595-610. doi: 10.1002/(sici)1099-081x(199710)18:7<595::aid-bdd44>3.0.co;2-f. [PMID: 9330780]
  • J Kim, S H Kim, M G Lee. Liver and gastrointestinal first-pass effects of azosemide in rats. The Journal of pharmacy and pharmacology. 1997 Sep; 49(9):878-83. doi: 10.1111/j.2042-7158.1997.tb06129.x. [PMID: 9306255]
  • S H Lee, M G Lee. Effect of phenobarbital, 3-methylcholanthrene, and chloramphenicol pretreatment on the pharmacokinetics and pharmacodynamics of azosemide in rats. Biopharmaceutics & drug disposition. 1997 Jul; 18(5):371-86. doi: 10.1002/(sici)1099-081x(199707)18:5<371::aid-bdd40>3.0.co;2-l. [PMID: 9210976]
  • K J Park, W H Yoon, W G Shin, M G Lee. The effect of intravenous infusion time on the pharmacokinetics and pharmacodynamics of the same total dose of azosemide in rabbits. Biopharmaceutics & drug disposition. 1997 Jan; 18(1):41-52. doi: 10.1002/(sici)1099-081x(199701)18:1<41::aid-bdd1>3.0.co;2-m. [PMID: 9008268]
  • S H Lee, M G Lee. Pharmacokinetics and pharmacodynamics of azosemide after intravenous and oral administration to rats: absorption from various GI segments. Journal of pharmacokinetics and biopharmaceutics. 1996 Dec; 24(6):551-68. doi: 10.1007/bf02353480. [PMID: 9300350]
  • K J Park, W H Yoon, W G Shin, M G Lee. Pharmacokinetics and pharmacodynamics of azosemide after intravenous and oral administration to rats with alloxan-induced diabetes mellitus. The Journal of pharmacy and pharmacology. 1996 Oct; 48(10):1093-7. doi: 10.1111/j.2042-7158.1996.tb05906.x. [PMID: 8953515]
  • H A Ha, S H Lee, S H Kim, O N Kim, M G Lee. Effect of water deprivation for 48 hours on the pharmacokinetics and pharmacodynamics of azosemide in rats. Research communications in molecular pathology and pharmacology. 1996 Jul; 93(1):109-28. doi: NULL. [PMID: 8865375]
  • S H Lee, M G Lee. Stability, tissue metabolism, tissue distribution and blood partition of azosemide. Biopharmaceutics & drug disposition. 1995 Oct; 16(7):547-61. doi: 10.1002/bdd.2510160704. [PMID: 8785379]
  • S H Lee, M G Lee. Factors influencing the protein binding of azosemide using an equilibrium dialysis technique. Biopharmaceutics & drug disposition. 1995 Oct; 16(7):615-26. doi: 10.1002/bdd.2510160709. [PMID: 8785384]
  • S H Lee, M G Lee. Determination of azosemide and its metabolite in plasma, blood, urine and tissue homogenates by high-performance liquid chromatography. Journal of chromatography. B, Biomedical applications. 1994 Jun; 656(2):367-72. doi: 10.1016/0378-4347(94)00130-8. [PMID: 7987489]
  • S H Lee, W G Shin, M G Lee, N D Kim. Arterial and venous blood sampling in pharmacokinetic studies: azosemide in rabbits. Biopharmaceutics & drug disposition. 1994 May; 15(4):305-16. doi: 10.1002/bdd.2510150405. [PMID: 8068868]
  • A Osajima, H Anai, K Segawa, T Muta, M Takasugi, A Kuroiwa. Comparative effects of loop diuretics on AVP-receptor binding and AVP-sensitive adenylate cyclase activity. Nihon Jinzo Gakkai shi. 1992 Sep; 34(9):965-72. doi: NULL. [PMID: 1479733]
  • H W Schuchmann, W Rösch, U Koch, H H Maurer, U Stengl, E Mutschler. Pharmacokinetics of azosemide in patients with T-drain after cholecystectomy. Arzneimittel-Forschung. 1992 Jun; 42(6):812-4. doi: NULL. [PMID: 1418035]
  • J Greven. Attenuation of azosemide's action in the loop of Henle of rat kidney by nonsteroidal anti-inflammatory drugs. Arzneimittel-Forschung. 1991 Aug; 41(8):805-8. doi: NULL. [PMID: 1781802]
  • Y Takamitsu, S Yuasa, S Miki, T Yura, N Takahashi, K Uchida, H Tanaka, T Yamamoto, H Kiyomoto, H Matsuo. [Effect of azosemide and furosemide on body fluid distribution and vasoactive hormones]. Nihon Jinzo Gakkai shi. 1991 Mar; 33(3):295-303. doi: NULL. [PMID: 2062015]
  • K Tsuchiya, S Sasaki, F Marumo. Effect of azosemide on the in vitro perfused thick ascending limb of Henle's loop from the mouse. Pharmacology. 1990; 41(4):195-9. doi: 10.1159/000138718. [PMID: 2080229]
  • K H Göttl, A Roesch, R Klinke. Quantitative evaluation of ototoxic side effects of furosemide, piretanide, bumetanide, azosemide and ozolinone in the cat--a new approach to the problem of ototoxicity. Naunyn-Schmiedeberg's archives of pharmacology. 1985 Nov; 331(2-3):275-82. doi: 10.1007/bf00634249. [PMID: 4088324]
  • A Satta, R Faedda, G F Branca, E Bartoli. [Diuretic and antihypertensive activity of azosemide]. Minerva medica. 1985 Jun; 76(24):1149-54. doi: NULL. [PMID: 4011012]
  • K Ogawa, T Hatano, M Yamamoto, N Matsui. Influence of acute diuresis on calcium balance--a comparative study of furosemide and azosemide. International journal of clinical pharmacology, therapy, and toxicology. 1984 Aug; 22(8):401-5. doi: NULL. [PMID: 6490222]
  • F Kuzuya, N Sugino, K Yoshizumi, U Goto, K Oshima. Clinical investigations on the pharmacology of azosemide (SK-110) in comparison with furosemide in healthy volunteers. International journal of clinical pharmacology, therapy, and toxicology. 1984 Jun; 22(6):291-9. doi: NULL. [PMID: 6746152]
  • K Ogawa, T Hatano, M Yamamoto, N Matsui. Hormonal response to acute diuresis--a comparative study of furosemide and azosemide. International journal of clinical pharmacology, therapy, and toxicology. 1984 Jun; 22(6):284-90. doi: NULL. [PMID: 6378806]
  • N Asaeda, M Shinoda, S Tamano, E Ikawa, T Yoshiyasu, H Iwai, N Nagai, Y Tagawa, M Koide. [Effect of diuretic, azosemide (SK-110), in combination with antibiotic, cephaloridine, on kidney]. The Journal of toxicological sciences. 1984 Jun; 9 Suppl 1(?):73-88. doi: 10.2131/jts.9.supplementi_73. [PMID: 6492216]
  • D C Brater, B Day, S Anderson, R Seiwell. Azosemide kinetics and dynamics. Clinical pharmacology and therapeutics. 1983 Oct; 34(4):454-8. doi: 10.1038/clpt.1983.197. [PMID: 6617067]
  • J Osten, M Vrzánová, M Horácková. [A contribution to the problem of the clinical use of the diuretic Azosemid]. Vnitrni lekarstvi. 1983 Aug; 29(8):808-13. doi: NULL. [PMID: 6636562]
  • H Nádvorníková, O Schück, V Teplan, D Tomková. [The effect of azosemide and furosemide on the renal excretion of amino acids]. Casopis lekaru ceskych. 1983 Apr; 122(13):401-4. doi: NULL. [PMID: 6861178]
  • F Kuzuya. Phase 1 study of azosemide (SK-110): single- and multiple-dose study. International journal of clinical pharmacology, therapy, and toxicology. 1983 Jan; 21(1):10-23. doi: NULL. [PMID: 6832863]
  • Y Suzuki, M Ito, T Komura. [Pharmacological studies on the diuretic action of azosemide [5-(4'-chloro-5'-sulfamoyl-2'-thenylamino)-phenyltetrazole], a new diuretic (3). Effect of azosemide following pretreatment with SA-446, an angiotensin I converting enzyme inhibitor, or propranolol, a beta-adrenergic blocker, in HgCl2-induced acute renal failure in rats]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 1982 Nov; 80(5):395-404. doi: NULL. [PMID: 6187650]
  • J P Radó, Z Molnár, A Hartai, G Gercsák. Comparison of azosemide and furosemide in ascitic patients without and during administration of spironolactone. International journal of clinical pharmacology, therapy, and toxicology. 1982 Nov; 20(11):532-7. doi: NULL. [PMID: 7174156]
  • Y Suzuki, M Ito, T Komura. [Pharmacological studies on diuretic action of azosemide [5-(4'-chloro-5'-sulfamoyl-2'-thenylamino)-phenyltetrazole], a new diuretic (2). Diuretic action of azosemide in HgCl2-induced acute renal failure in rats]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 1982 Oct; 80(4):289-98. doi: NULL. [PMID: 6218035]
  • Y Suzuki, M Ito, T Komura. [Pharmacological studies on azosemide [5-(4'-chloro-5'-sulfamoyl-2'-thenylamino)-phenyltetrazole], a new diuretic (1) Effects on diuresis, plasma renin activity and urinary prostaglandin E excretion in normal rats (author's transl)]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 1982 Apr; 79(4):317-25. doi: 10.1254/fpj.79.317. [PMID: 7047325]
  • Z Gerová, M Nándoryová, R Dzúrik. [Determination and interpretation of the diuretic equivalence of azosemid and furosemide]. Vnitrni lekarstvi. 1982 Mar; 28(3):266-73. doi: NULL. [PMID: 6896778]
  • K Horký, I Gregorová, J Dvoráková. The effect of renin and aldosterone inhibition by beta-adrenergic blockade on the response to the new diuretic azosemide. European journal of pharmacology. 1981 Feb; 69(4):439-46. doi: 10.1016/0014-2999(81)90447-7. [PMID: 6113965]
  • J Greven, O Heidenreich. Renal actions of azosemide. 2. Micropuncture investigations in rats. Arzneimittel-Forschung. 1981; 31(2):350-3. doi: NULL. [PMID: 7194652]
  • J Greven, O Heidenreich. Renal actions of azosemide. 1. Clearance investigations in dogs. Arzneimittel-Forschung. 1981; 31(2):346-50. doi: NULL. [PMID: 7194651]
  • R Seiwell, C Brater. Separation and analysis of azosemide in urine and in serum by high-performance liquid chromatography. Journal of chromatography. 1980 May; 182(2):257-61. doi: 10.1016/s0378-4347(00)81633-3. [PMID: 7380919]
  • K Horký, I Gregorová, J Dvoráková. [Effect of beta-adrenergic block with trimepranol on the diuretic and renin-aldosterone stimulating action of the new diuretic azosemide (author's transl)]. Sbornik lekarsky. 1980; 82(4):111-23. doi: . [PMID: 6104352]
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  • D C Brater. Renal sites of action of azosemide. Clinical pharmacology and therapeutics. 1979 Apr; 25(4):428-34. doi: 10.1002/cpt1979254428. [PMID: 428187]
  • F Krück, W Bablok, E Besenfelder, G Betzien, B Kaufmann. Clinical and pharmacological investigations of the new saluretic azosemid. European journal of clinical pharmacology. 1978 Nov; 14(3):153-61. doi: 10.1007/bf02089953. [PMID: 729610]