Terlipressin (BioDeep_00000033344)
Secondary id: BioDeep_00000015142
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
化学式: C52H74N16O15S2 (1226.4960734000001)
中文名称: 醋酸特利加压素
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CC(N(C1)C(=O)C2CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=C(C=C4)O)NC(=O)CNC(=O)CNC(=O)CN)C(=O)NC(CCCCN)C(=O)NCC(=O)N
InChI: InChI=1S/C52H74N16O15S2/c53-17-5-4-9-31(45(76)60-23-41(57)72)63-51(82)38-10-6-18-68(38)52(83)37-27-85-84-26-36(61-44(75)25-59-43(74)24-58-42(73)22-54)50(81)65-34(20-29-11-13-30(69)14-12-29)48(79)64-33(19-28-7-2-1-3-8-28)47(78)62-32(15-16-39(55)70)46(77)66-35(21-40(56)71)49(80)67-37/h1-3,7-8,11-14,31-38,69H,4-6,9-10,15-27,53-54H2,(H2,55,70)(H2,56,71)(H2,57,72)(H,58,73)(H,59,74)(H,60,76)(H,61,75)(H,62,78)(H,63,82)(H,64,79)(H,65,81)(H,66,77)(H,67,80)/t31-,32-,33-,34-,35-,36-,37-,38-/m0/s1
描述信息
Terlipressin is only found in individuals that have used or taken this drug. It is an analogue of vasopressin used as a vasoactive drug in the management of hypotension. It has been found to be effective when norepinephrine does not help. [Wikipedia]Terlipressin acts on three different receptors, vasopressin receptor V1a (which initiates vasoconstriction, liver gluconeogenesis, platelet aggregation and release of factor VIII), vasopressin receptor V1b (which mediates corticotrophin secretion from the pituitary) and vasopressin receptor V2 which controls free water reabsorption in the renal medullar. The binding of terlipressin to the V2 receptor activates adenylate cyclase which causes the release of aquaporin 2 channels into the cells lining the renal medullar duct. This allows water to be reabsorbed down an osmotic gradient so the urine is more concentrated.
H - Systemic hormonal preparations, excl. sex hormones and insulins > H01 - Pituitary and hypothalamic hormones and analogues > H01B - Posterior pituitary lobe hormones > H01BA - Vasopressin and analogues
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C80212 - Antidiuretic Hormone Analogue
D002317 - Cardiovascular Agents > D014662 - Vasoconstrictor Agents > D014667 - Vasopressins
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
同义名列表
18 个代谢物同义名
(2S)-6-Amino-2-({[(2S)-1-[(4R,7S,10S,13S,16S,19R)-19-{[2-({2-[(2-amino-1-hydroxyethylidene)amino]-1-hydroxyethylidene}amino)-1-hydroxyethylidene]amino}-13-benzyl-6,9,12,15,18-pentahydroxy-10-[2-(C-hydroxycarbonimidoyl)ethyl]-7-[(C-hydroxycarbonimidoyl)methyl]-16-[(4-hydroxyphenyl)methyl]-1,2-dithia-5,8,11,14,17-pentaazacycloicosa-5,8,11,14,17-pentaene-4-carbonyl]pyrrolidin-2-yl](hydroxy)methylidene}amino)-N-[(C-hydroxycarbonimidoyl)methyl]hexanimidate; (2S)-6-amino-2-{[(2S)-1-[(4R,7S,10S,13S,16S,19R)-19-{2-[2-(2-aminoacetamido)acetamido]acetamido}-13-benzyl-10-(2-carbamoylethyl)-7-(carbamoylmethyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carbonyl]pyrrolidin-2-yl]formamido}-N-(carbamoylmethyl)hexanamide; N-(alpha)-Glycyl-glycyl-glycyl-8-lysine vasopressin; N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin; Triglycyl-(8-lysine)vasopressin; Gly gly gly 8 lys vasopressin; Gly-gly-gly-8-lys-vasopressin; Triglycyl lysine vasopressin; Tri-gly-8-lys- vasopressin; Terlipressin acetate salt; Triglycylvasopressin; Glycylpressin; Terlipressin; Terlypressin; Glypressin; Glipressin; Remestyp; TGLVP
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:135905
- KEGG: C72780
- PubChem: 72081
- HMDB: HMDB0015569
- DrugBank: DB02638
- ChEMBL: CHEMBL2135460
- Wikipedia: Terlipressin
- MeSH: Terlipressin
- chemspider: 65067
- CAS: 14636-12-5
- RefMet: Terlipressin
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
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Clinics in liver disease.
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American journal of kidney diseases : the official journal of the National Kidney Foundation.
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Scientific reports.
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. [PMID: 35365736] - Luciana Marcondes Ferreira, Débora Raquel Terrabuio, Caroline Marcondes Ferreira, Daniel Ferraz de Campos Mazo, Luciana Bertocco de Paiva Haddad. COST EFFECTIVENESS OF USING TERLIPRESSIN TO TREAT HEPATORENAL SYNDROME.
Arquivos de gastroenterologia.
2022 Apr; 59(2):268-274. doi:
10.1590/s0004-2803.202202000-48
. [PMID: 35830040] - Mladena Glavaš, Agata Gitlin-Domagalska, Dawid Dębowski, Natalia Ptaszyńska, Anna Łęgowska, Krzysztof Rolka. Vasopressin and Its Analogues: From Natural Hormones to Multitasking Peptides.
International journal of molecular sciences.
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Kidney360.
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European journal of gastroenterology & hepatology.
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The New England journal of medicine.
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Advances in therapy.
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Alimentary pharmacology & therapeutics.
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BMC nephrology.
2020 08; 21(1):360. doi:
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Alimentary pharmacology & therapeutics.
2020 07; 52(2):351-358. doi:
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Scandinavian journal of gastroenterology.
2020 Jul; 55(7):860-864. doi:
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Surgery.
2020 06; 167(6):926-932. doi:
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. [PMID: 32113581] - Andreas Kohler, Stéphanie Perrodin, Andrea De Gottardi, Daniel Candinas, Guido Beldi. Effectiveness of terlipressin for prevention of complications after major liver resection - A randomized placebo-controlled trial.
HPB : the official journal of the International Hepato Pancreato Biliary Association.
2020 06; 22(6):884-891. doi:
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Digestive diseases and sciences.
2020 05; 65(5):1539-1548. doi:
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Expert opinion on drug safety.
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American journal of physiology. Gastrointestinal and liver physiology.
2020 02; 318(2):G313-G321. doi:
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. [PMID: 31841026] - Xiaofeng Pan, Ziye Zhou, Xiangxiang Jin, Dawei Shi. Clinical characteristics and risk factors of severe hyponatremia in cirrhotic patients treated with terlipressin.
Journal of clinical pharmacy and therapeutics.
2020 Feb; 45(1):191-198. doi:
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Hepatology (Baltimore, Md.).
2020 02; 71(2):600-610. doi:
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Zhonghua wei zhong bing ji jiu yi xue.
2020 Feb; 32(2):134-139. doi:
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BMJ case reports.
2020 Jan; 13(1):. doi:
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International journal of medical sciences.
2020; 17(17):2751-2762. doi:
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Canadian journal of gastroenterology & hepatology.
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PloS one.
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Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology.
2019 Dec; 27(12):982-988. doi:
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Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology.
2019 Dec; 27(12):929-932. doi:
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Journal of clinical pharmacy and therapeutics.
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European journal of gastroenterology & hepatology.
2019 Oct; 31(10):1292-1294. doi:
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Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology.
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Liver international : official journal of the International Association for the Study of the Liver.
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BMC anesthesiology.
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Journal of the College of Physicians and Surgeons--Pakistan : JCPSP.
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Hepatology (Baltimore, Md.).
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Hepatology (Baltimore, Md.).
2019 04; 69(4):1845. doi:
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Nigerian journal of clinical practice.
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Therapeutics and clinical risk management.
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Hepatology (Baltimore, Md.).
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Critical care medicine.
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Hepatology (Baltimore, Md.).
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Hepatology (Baltimore, Md.).
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