Dextrothyroxine (BioDeep_00000033240)
Main id: BioDeep_00000001625
human metabolite PANOMIX_OTCML-2023 blood metabolite
代谢物信息卡片
(2R)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid
化学式: C15H11I4NO4 (776.6867126)
中文名称: D-甲状腺素
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=C(C=C(C(=C1I)OC2=CC(=C(C(=C2)I)O)I)I)CC(C(=O)O)N
InChI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m1/s1
描述信息
The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (monoiodotyrosine) and the coupling of iodotyrosines (diiodotyrosine) in the thyroglobulin. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form triiodothyronine which exerts a broad spectrum of stimulatory effects on cell metabolism. [PubChem]
C - Cardiovascular system > C10 - Lipid modifying agents > C10A - Lipid modifying agents, plain
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1553 - Thyroid Agent
D-Thyroxine (D-T4) is a thyroid hormone that can inhibit TSH secretion. D-Thyroxine can be used for the research of hypercholesterolemia[1][2].
同义名列表
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:30659
- PubChem: 8730
- HMDB: HMDB0014651
- DrugBank: DB00509
- ChEMBL: CHEMBL559
- Wikipedia: Dextrothyroxine
- MeSH: Dextrothyroxine
- chemspider: 8402
- CAS: 51-49-0
- medchemexpress: HY-A0152
分类词条
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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Boletin del Instituto de Estudios Medicos y Biologicos, Universidad Nacional Autonoma de Mexico.
1964 Aug; 22(?):323-30. doi:
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Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.).
1964 Feb; 115(?):517-21. doi:
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Metabolism: clinical and experimental.
1964 Jan; 13(?):1-7. doi:
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Bibliotheca nutritio et dieta.
1964; 6(?):106-38. doi:
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Metabolism: clinical and experimental.
1963 Dec; 12(?):1132-40. doi:
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Endocrinology.
1963 Dec; 73(?):764-74. doi:
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Prensa medica argentina.
1963 Feb; 50(?):550-1. doi:
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Current therapeutic research, clinical and experimental.
1962 Jun; 4(?):297-300. doi:
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Medecine et hygiene.
1962 Apr; 20(?):307-11. doi:
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Annals of internal medicine.
1962 Feb; 56(?):265-75. doi:
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Angiology.
1962 Feb; 13(?):88-93. doi:
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JAMA.
1961 Dec; 178(?):1036-8. doi:
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Lancet (London, England).
1961 Aug; 2(7200):492-3. doi:
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British medical journal.
1961 Jun; 1(5239):1572-4. doi:
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Endocrinology.
1959 Aug; 65(2):336-9. doi:
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