Acitretin (BioDeep_00000033237)

 

Secondary id: BioDeep_00000014954, BioDeep_00000603954

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


(2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid

化学式: C21H26O3 (326.1881846)
中文名称: 阿曲汀
谱图信息: 最多检出来源 Escherichia coli(natural_products) 37.5%

分子结构信息

SMILES: CC1=CC(=C(C(=C1C=CC(=CC=CC(=CC(=O)O)C)C)C)C)OC
InChI: InChI=1S/C21H26O3/c1-14(8-7-9-15(2)12-21(22)23)10-11-19-16(3)13-20(24-6)18(5)17(19)4/h7-13H,1-6H3,(H,22,23)/b9-7+,11-10+,14-8+,15-12+

描述信息

Acitretin is only found in individuals that have used or taken this drug. It is an oral retinoid effective in the treatment of psoriasis. It is the major metabolite of etretinate with the advantage of a much shorter half-life when compared with etretinate (PubChem). The mechanism of action of acitretin is unknown, however it is believed to work by targeting specific receptors (retinoid receptors such as RXR and RAR) in the skin which help normalize the growth cycle of skin cells.
An oral retinoid effective in the treatment of psoriasis. It is the major metabolite of etretinate with the advantage of a much shorter half-life when compared with etretinate. -- Pubchem [HMDB]
D - Dermatologicals > D05 - Antipsoriatics > D05B - Antipsoriatics for systemic use > D05BB - Retinoids for treatment of psoriasis
C274 - Antineoplastic Agent > C2122 - Cell Differentiating Agent > C1934 - Differentiation Inducer
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C804 - Retinoic Acid Agent
C308 - Immunotherapeutic Agent > C129820 - Antineoplastic Immunomodulating Agent
D020011 - Protective Agents > D000975 - Antioxidants > D002338 - Carotenoids
D003879 - Dermatologic Agents > D007641 - Keratolytic Agents

同义名列表

26 个代谢物同义名

(2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid; (2E,4E,6E,8E)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid; all-trans-3,7-Dimethyl-9-(4-methoxy-2,3,6-trimethylphenyl)-2,4,6,8-nonatetraenoic acid; (all-e)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid; all-trans-3,7-Dimethyl-9-(4-methoxy-2,3,6-trimethylphenyl)-2,4,6,8-nonatetraenoate; (all-e)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoate; Hoffmann-la roche brand OF acitretin; Hoffmann la roche brand OF acitretin; Acitretin, (Z,e,e,e)-isomer; Andreu brand OF acitretin; Roche brand OF acitretin; Acitretin andreu brand; Acitretin roche brand; all-trans-Acitretin; 13-cis-Acitretin; Isoacitretin; Acitretinoin; Acitretinum; Neotigason; Isoetretin; Acitretine; Acitretina; Soriatane; acetretin; Acitretin; Etretin



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(3)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Anna A Lauer, Vu Thu Thuy Nguyen, Daniel Janitschke, Malena Dos Santos Guilherme, Cornel M Bachmann, Heike S Grimm, Tobias Hartmann, Kristina Endres, Marcus O W Grimm. The Influence of Acitretin on Brain Lipidomics in Adolescent Mice-Implications for Pediatric and Adolescent Dermatological Therapy. International journal of molecular sciences. 2022 Dec; 23(24):. doi: 10.3390/ijms232415535. [PMID: 36555176]
  • Gabriele Roccuzzo, Tommaso Tibaldi, Francesco Cavallo, Carola Aquino, Teresa Rolle, Pietro Quaglino, Simone Ribero. Retinoid-associated myopia in dermatologic patients: a systematic review. Cutaneous and ocular toxicology. 2022 Dec; 41(4):318-322. doi: 10.1080/15569527.2022.2137177. [PMID: 36260481]
  • Lin Yi, L I Xun, Wang Zi, Zheng Xiaoran, Hang Haiyan, L I Lingling. Efficacy and safety of external application of Chinese herbal medicine for psoriasis vulgaris: a systematic review of randomized controlled trials. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2022 08; 42(4):493-504. doi: 10.19852/j.cnki.jtcm.20220617.001. [PMID: 35848965]
  • Aiai Geng, Tianli Pei, Xueyi Zhao, Bo Jia. A Meta-analysis of Xiaoyin Granules Combined with Acitretin Capsule in the Treatment of Psoriasis Vulgaris. Computational and mathematical methods in medicine. 2022; 2022(?):7360975. doi: 10.1155/2022/7360975. [PMID: 35936361]
  • Lin Chen, Jie Li, Ying Yao, Shanlong Wang, Shuangjin Zheng, Xinggang Ju, Bin Zhang. Circulating microRNA profile unveils mechanisms of action of acitretin for psoriasis vulgaris. Bioengineered. 2021 12; 12(1):1838-1850. doi: 10.1080/21655979.2021.1925205. [PMID: 33975513]
  • Pelin Esme, Sema Nur Coban, Bilge Ugur, Meltem Aylı, Ercan Caliskan. A case of psoriasis successfully treated by extracorporeal photopheresis during COVID-19 pandemic. Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis. 2021 Oct; 60(5):103200. doi: 10.1016/j.transci.2021.103200. [PMID: 34215520]
  • Anna A Lauer, Daniel Janitschke, Malena Dos Santos Guilherme, Vu Thu Thuy Nguyen, Cornel M Bachmann, Sen Qiao, Bianca Schrul, Ulrich Boehm, Heike S Grimm, Tobias Hartmann, Kristina Endres, Marcus O W Grimm. Shotgun lipidomics of liver and brain tissue of Alzheimer's disease model mice treated with acitretin. Scientific reports. 2021 07; 11(1):15301. doi: 10.1038/s41598-021-94706-3. [PMID: 34315969]
  • Zongsong Wu, Fabrice E Graf, Hans H Hirsch. Acitretin and Retinoic Acid Derivatives Inhibit BK Polyomavirus Replication in Primary Human Proximal Renal Tubular Epithelial and Urothelial Cells. Journal of virology. 2021 07; 95(15):e0012721. doi: 10.1128/jvi.00127-21. [PMID: 34011542]
  • Omar Badri, Chrysalyne D Schmults, Pritesh S Karia, Emily S Ruiz. Efficacy and Cost Analysis for Acitretin for Basal and Squamous Cell Carcinoma Prophylaxis in Renal Transplant Recipients. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. 2021 01; 47(1):125-126. doi: 10.1097/dss.0000000000002423. [PMID: 32371782]
  • Ania Henning, Joshua Weaver, Matthew Reedy. Acquired Epidermodysplasia Verruciformis in the Setting of Renal Transplant. The American Journal of dermatopathology. 2021 Jan; 43(1):71-74. doi: 10.1097/dad.0000000000001696. [PMID: 32568838]
  • Denny L Cottle, Gloria M A Ursino, Lynelle K Jones, Ming Shen Tham, Allara K Zylberberg, Ian M Smyth. Topical Aminosalicylic Acid Improves Keratinocyte Differentiation in an Inducible Mouse Model of Harlequin Ichthyosis. Cell reports. Medicine. 2020 11; 1(8):100129. doi: 10.1016/j.xcrm.2020.100129. [PMID: 33294854]
  • W Bahtaoui, F-Z El Fetoiki, F Hali, S Chiheb. [Acute pancreatitis under acitretin]. Annales de dermatologie et de venereologie. 2020 Sep; 147(8-9):530-534. doi: 10.1016/j.annder.2020.01.015. [PMID: 32057450]
  • Paulina Kiluk, Anna Baran, Magdalena Świderska, Magdalena Maciaszek, Iwona Flisiak. Lp-PLA2 as a promising predictor of comorbidities in patients with severe psoriasis. The Journal of dermatological treatment. 2020 Aug; 31(5):524-530. doi: 10.1080/09546634.2019.1606887. [PMID: 30998429]
  • H Yang, Q Tan, G H Chen, J S Chen, Z Fu, F L Ren, X Y Luo, H Wang. Plasma retinol as a predictive biomarker of disease activity and response to acitretin monotherapy in children with generalized pustular psoriasis. Journal of the European Academy of Dermatology and Venereology : JEADV. 2020 Jun; 34(6):e270-e272. doi: 10.1111/jdv.16244. [PMID: 31991497]
  • Mao Li, Xia Hu, Ping-Sheng Hao. Research 'recover from illness defense complex' helper T cell immune mechanisms based on the 'Fuxie' theory clearing away heat evil thoroughly nourishing kidney treatment of recurrent blood-heat syndrome Psoriasis. Medicine. 2020 May; 99(20):e20161. doi: 10.1097/md.0000000000020161. [PMID: 32443332]
  • Pedro Miguel Garrido, Catarina Queirós, João Borges-Costa, Luís Soares-Almeida, Paulo Filipe. Acquired perforating dermatosis: clinicopathologic study of a 10-year period at a tertiary teaching hospital. International journal of dermatology. 2020 Apr; 59(4):445-450. doi: 10.1111/ijd.14760. [PMID: 31876297]
  • Burhan Engin, Ali Tanakol, Huri Bulut, Abdullah Songür, Hayriye E Vehid, Eral Gökalp, Zekayi Kutlubay, Defne Özkoca, Yalçın Tüzün, Server Serdaroğlu. Changes in serum TNF-like weak inducer of apoptosis (TWEAK) levels and Psoriasis Area Severity Index (PASI) scores in plaque psoriasis patients treated with conventional versus anti-TNF treatments. International journal of dermatology. 2020 Feb; 59(2):207-215. doi: 10.1111/ijd.14646. [PMID: 31531981]
  • Xiao Wang, Chunwei Cao, Yongshun Li, Tang Hai, Qitao Jia, Ying Zhang, Qiantao Zheng, Jing Yao, Guosong Qin, Hongyong Zhang, Ruigao Song, Yanfang Wang, Guanghou Shui, Sin Man Lam, Zhonghua Liu, Hong Wei, Anming Meng, Qi Zhou, Jianguo Zhao. A harlequin ichthyosis pig model with a novel ABCA12 mutation can be rescued by acitretin treatment. Journal of molecular cell biology. 2019 12; 11(12):1029-1041. doi: 10.1093/jmcb/mjz021. [PMID: 30925591]
  • Yu Chen, Liang Xue, Dong-Jie Guo, Jing-Yi Mao, Min-Feng Wu, Rong Xu, Xin Li, Bin Li, Fu-Lun Li. Combination Therapy of Acitretin Capsule and Chinese Herbs for Patients with Lichen Planus Pigmentosus-Inversus. Chinese journal of integrative medicine. 2019 Dec; 25(12):922-925. doi: 10.1007/s11655-019-3033-7. [PMID: 31444667]
  • H-J Shi, H Zhou, A-L Ma, L Wang, Q Gao, N Zhang, H-B Song, K-P Bo, W Ma. Oxymatrine therapy inhibited epidermal cell proliferation and apoptosis in severe plaque psoriasis. The British journal of dermatology. 2019 11; 181(5):1028-1037. doi: 10.1111/bjd.17852. [PMID: 30822359]
  • Anna Baran, Paulina Kiluk, Magdalena Świderska, Magdalena Maciaszek, Hanna Myśliwiec, Iwona Flisiak. Adipocyte Fatty Acid-Binding Protein as a Novel Marker of Psoriasis and Clinical Response to Acitretin. Lipids. 2019 08; 54(8):445-452. doi: 10.1002/lipd.12173. [PMID: 31281982]
  • Yanjuan Duan, Jialing Zou, Jingyi Mao, Dongjie Guo, Minfeng Wu, Ning Xu, Jie Zhou, Yanbin Zhang, Wanjun Guo, Waishu Jin. Plasma miR-126 expression correlates with risk and severity of psoriasis and its high level at baseline predicts worse response to Tripterygium wilfordii Hook F in combination with acitretin. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2019 Jul; 115(?):108761. doi: 10.1016/j.biopha.2019.108761. [PMID: 31100542]
  • Leena Chularojanamontri, Narumol Silpa-Archa, Chanisada Wongpraparut, Pichaya Limphoka. Long-term safety and drug survival of acitretin in psoriasis: a retrospective observational study. International journal of dermatology. 2019 May; 58(5):593-599. doi: 10.1111/ijd.14349. [PMID: 30548592]
  • Anna Rita Bilia, Maria Camilla Bergonzi, Benedetta Isacchi, Emiliano Antiga, Marzia Caproni. Curcumin nanoparticles potentiate therapeutic effectiveness of acitrein in moderate-to-severe psoriasis patients and control serum cholesterol levels. The Journal of pharmacy and pharmacology. 2018 Jul; 70(7):919-928. doi: 10.1111/jphp.12910. [PMID: 29600580]
  • Danit Maor, Sarah Brennand, Michelle Sy Goh, Vanessa Fahey, Sepehr N Tabrizi, Alvin H Chong. A case of acquired epidermodysplasia verruciformis in a renal transplant recipient clearing with multimodal treatment including HPV (Gardasil) vaccination. The Australasian journal of dermatology. 2018 May; 59(2):147-148. doi: 10.1111/ajd.12684. [PMID: 28718200]
  • Jonathan C Lin, Daniele Massera, Mohammad Ghalib, Robert Marion, Lauren Graf, Steven R Cohen, Robert J Ostfeld. Hyperlipidemia secondary to acitretin therapy for lamellar ichthyosis associated with a NIPAL4 mutation improves on a plant-based diet and relapses on a standard Western diet. Clinical nutrition ESPEN. 2018 04; 24(?):54-57. doi: 10.1016/j.clnesp.2018.01.070. [PMID: 29576363]
  • Juan-Hua Liu, Hui-Hui Wu, Yu-Kun Zhao, Fang Wang, Qian Gao, Di-Qing Luo. Thalidomide Improves Psoriasis-like Lesions and Inhibits Cutaneous VEGF Expression without Alteration of Microvessel Density in Imiquimod- induced Psoriatic Mouse Model. Current vascular pharmacology. 2018; 16(5):510-521. doi: 10.2174/1570161115666171004123428. [PMID: 28982338]
  • Qian Wang, Wei Liu, Lixia Zhang. Clinical features of von Zumbusch type of generalized pustular psoriasis in children: a retrospective study of 26 patients in southwestern China. Anais brasileiros de dermatologia. 2017 May; 92(3):319-322. doi: 10.1590/abd1806-4841.20175536. [PMID: 29186241]
  • Chen Yu, Xueli Fan, Zhenlu Li, Xiaoming Liu, Gang Wang. Efficacy and safety of total glucosides of paeony combined with acitretin in the treatment of moderate-to-severe plaque psoriasis: a double-blind, randomised, placebo-controlled trial. European journal of dermatology : EJD. 2017 Apr; 27(2):150-154. doi: 10.1684/ejd.2016.2946. [PMID: 28400341]
  • Jaclyn Smith, Abigail Cline, Steven R Feldman. Advances in Psoriasis. Southern medical journal. 2017 01; 110(1):65-75. doi: 10.14423/smj.0000000000000596. [PMID: 28052180]
  • Anthony M Rossi, Brian P Hibler, Hillary Johnson-Jahangir. Serum Sirolimus Level Elevation Induced by Acitretin: Report of a Novel Drug-Drug Interaction. Journal of drugs in dermatology : JDD. 2015 Jul; 14(7):747-9. doi: NULL. [PMID: 26151793]
  • Fanny Raguideau, Myriam Mezzarobba, Mahmoud Zureik, Alain Weill, Philippe Ricordeau, François Alla. Compliance with pregnancy prevention plan recommendations in 8672 French women of childbearing potential exposed to acitretin. Pharmacoepidemiology and drug safety. 2015 May; 24(5):526-33. doi: 10.1002/pds.3763. [PMID: 25753265]
  • Chao Wu, Hong-Zhong Jin, Dan Shu, Feng Li, Chun-Xia He, Ju Qiao, Xiao-Ling Yu, Ying Zhang, Yi-Bo He, Tie-Jun Liu. Efficacy and safety of Tripterygium wilfordii hook F versus acitretin in moderate to severe psoriasis vulgaris: a randomized clinical trial. Chinese medical journal. 2015 Feb; 128(4):443-9. doi: 10.4103/0366-6999.151069. [PMID: 25673443]
  • Jordane Saunier, Sébastien Debarbieux, Denis Jullien, Lorna Garnier, Stéphane Dalle, Luc Thomas. Acrodermatitis continua of Hallopeau treated successfully with ustekinumab and acitretin after failure of tumour necrosis factor blockade and anakinra. Dermatology (Basel, Switzerland). 2015; 230(2):97-100. doi: 10.1159/000367690. [PMID: 25471551]
  • S-G Consoli, P Assouly, L Martin, E Mahé, D Penso-Assathiany. [Saying no]. Annales de dermatologie et de venereologie. 2014 Dec; 141(12):790-8. doi: 10.1016/j.annder.2014.09.022. [PMID: 25433935]
  • Claire Shuiqing Zhang, Jason Jingjie Yu, Shefton Parker, Anthony Lin Zhang, Brian May, Chuanjian Lu, Charlie Changli Xue. Oral Chinese herbal medicine combined with pharmacotherapy for psoriasis vulgaris: a systematic review. International journal of dermatology. 2014 Nov; 53(11):1305-18. doi: 10.1111/ijd.12607. [PMID: 25208594]
  • Cenk Akçali, Ebru Homurlu Guven, Necmettin Kirtak, H Serhat Inaloz, Orhan Ozgoztasi, Ulas Guvenc. Serum concentrations of interleukin-2 and tumour necrosis factor-α under cyclosporine versus acitretin treatment in plaque-type psoriasis. The Journal of international medical research. 2014 Oct; 42(5):1118-22. doi: 10.1177/0300060514539280. [PMID: 25143337]
  • Rangan Srinivasaraghavan, Sriram Krishnamurthy, Rumesh Chandar, Denise Cassandrini, Subramanian Mahadevan, Claudio Bruno, Filippo M Santorelli. Acitretin-responsive ichthyosis in Chanarin-Dorfman syndrome with a novel mutation in the ABHD5/CGI-58 gene. Pediatric dermatology. 2014 Sep; 31(5):612-4. doi: 10.1111/pde.12170. [PMID: 23756328]
  • Jonathan C Ng, Simon Cumming, Vivian Leung, Alvin H Chong. Accrual of non-melanoma skin cancer in renal-transplant recipients: experience of a Victorian tertiary referral institution. The Australasian journal of dermatology. 2014 Feb; 55(1):43-8. doi: 10.1111/ajd.12072. [PMID: 23808627]
  • Frida Gustafsson, Alison J Foster, Sunil Sarda, Matthew H Bridgland-Taylor, J Gerry Kenna. A correlation between the in vitro drug toxicity of drugs to cell lines that express human P450s and their propensity to cause liver injury in humans. Toxicological sciences : an official journal of the Society of Toxicology. 2014 Jan; 137(1):189-211. doi: 10.1093/toxsci/kft223. [PMID: 24085192]
  • Jeremy Hugh, Abby S Van Voorhees, Rajiv I Nijhawan, Jerry Bagel, Mark Lebwohl, Andrew Blauvelt, Sylvia Hsu, Jeffrey M Weinberg. From the Medical Board of the National Psoriasis Foundation: The risk of cardiovascular disease in individuals with psoriasis and the potential impact of current therapies. Journal of the American Academy of Dermatology. 2014 Jan; 70(1):168-77. doi: 10.1016/j.jaad.2013.09.020. [PMID: 24184141]
  • Ming-Lian Yu, Yue Yang, Cong-Min Wang, Meng-Meng Zhang, Miao-Chun Bai, Yue-Ling Guo. Acitretin exhibits inhibitory effects towards UDP-glucuronosyltransferase (UGT)1A9-mediated 4-methylumbelliferone (4-MU) and propofol glucuronidation reaction. Die Pharmazie. 2013 Jun; 68(6):449-52. doi: . [PMID: 23875253]
  • Ayse Serap Karadag, Derun Taner Ertugrul, Goknur Kalkan, Serap Gunes Bilgili, Huseyin Tugrul Celik, Zennure Takci, Ragıp Balahoroglu, Omer Calka. The effect of acitretin treatment on insulin resistance, retinol-binding protein-4, leptin, and adiponectin in psoriasis vulgaris: a noncontrolled study. Dermatology (Basel, Switzerland). 2013; 227(2):103-8. doi: 10.1159/000351769. [PMID: 24021889]
  • Xinwu Niu, Wei Cao, Huiqun Ma, Jie Feng, Ximei Li, Xinhua Zhang. Acitretin exerted a greater influence on T-helper (Th)1 and Th17 than on Th2 cells in treatment of psoriasis vulgaris. The Journal of dermatology. 2012 Nov; 39(11):916-21. doi: 10.1111/j.1346-8138.2012.01637.x. [PMID: 22913391]
  • S Y Shin, Y H Shin, S W Lee, J Y Shin, C H Kim. Blood donors on teratogenic drugs and donor deferral periods in a clinical situation. Vox sanguinis. 2012 May; 102(4):362-4. doi: 10.1111/j.1423-0410.2011.01566.x. [PMID: 22211799]
  • Sarah Dawson, Simone Stahl, Nikki Paul, Jane Barber, J Gerald Kenna. In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans. Drug metabolism and disposition: the biological fate of chemicals. 2012 Jan; 40(1):130-8. doi: 10.1124/dmd.111.040758. [PMID: 21965623]
  • S Israeli, Y Pessach, O Sarig, I Goldberg, E Sprecher. Beneficial effect of acitretin in Chanarin-Dorfman syndrome. Clinical and experimental dermatology. 2012 Jan; 37(1):31-3. doi: 10.1111/j.1365-2230.2011.04164.x. [PMID: 21981352]
  • Lili Wu, Jingjing Wu, Ke Zhou, Fang Cheng, Yun Chen. Determination of isotretinoin in human plasma by high performance liquid chromatography-electrospray ionization mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2011 Sep; 56(2):324-9. doi: 10.1016/j.jpba.2011.05.012. [PMID: 21664787]
  • Ajay Kumar, Tausif Monif, Arshad Khuroo, Dinakar Sasmal, Dipanjan Goswami, Vijay Kumar Lahkar. Stability-indicating validation of acitretin and isoacitretin in human plasma by LC-ESI-MS/MS bioanalytical method and its application to pharmacokinetic analysis. Biomedical chromatography : BMC. 2011 Jun; 25(6):680-8. doi: 10.1002/bmc.1503. [PMID: 20845366]
  • Bogusław Czerny, Maria Teister, Zygmunt Juzyszyn, Łukasz Teister, Andrzej Pawlik, Piotr Gazda, Adam Kaminski, Aleksandra Chałas. The effect of retinoic acid receptor agonist acitretin on the production of bile and concentrations of some serum components in ovariectomized rats. Menopause (New York, N.Y.). 2011 Feb; 18(2):213-8. doi: 10.1097/gme.0b013e3181ef22b8. [PMID: 20861754]
  • Dimitra Hadjipavlou-Litina, George E Magoulas, Stavros E Bariamis, Denis Drainas, Konstantinos Avgoustakis, Dionissios Papaioannou. Does conjugation of antioxidants improve their antioxidative/anti-inflammatory potential?. Bioorganic & medicinal chemistry. 2010 Dec; 18(23):8204-17. doi: 10.1016/j.bmc.2010.10.012. [PMID: 21041094]
  • Yogeeta Agrawal, Kailash C Petkar, Krutika K Sawant. Development, evaluation and clinical studies of Acitretin loaded nanostructured lipid carriers for topical treatment of psoriasis. International journal of pharmaceutics. 2010 Nov; 401(1-2):93-102. doi: 10.1016/j.ijpharm.2010.09.007. [PMID: 20858539]
  • E Eilers, K Stieler, C Thies, U Blume-Peytavi, M Obladen, D Hüseman. [Harlequin ichthyosis--medical and psychosocial challenges]. Klinische Padiatrie. 2010 Mar; 222(2):86-69. doi: 10.1055/s-0029-1220943. [PMID: 20166009]
  • Dimitra Hadjipavlou-Litina, George E Magoulas, Marios Krokidis, Dionissios Papaioannou. Syntheses and evaluation of the antioxidant activity of acitretin analogs with amide bond(s) in the polyene spacer. European journal of medicinal chemistry. 2010 Jan; 45(1):298-310. doi: 10.1016/j.ejmech.2009.10.012. [PMID: 19939514]
  • H B Harvey, M G Shaw, D S Morrell. Perinatal management of harlequin ichthyosis: a case report and literature review. Journal of perinatology : official journal of the California Perinatal Association. 2010 Jan; 30(1):66-72. doi: 10.1038/jp.2009.100. [PMID: 20038941]
  • ". Childhood psoriasis: often favorable outcome. Prescrire international. 2009 Dec; 18(104):275. doi: ". [PMID: 20027717]
  • Pan Deng, Xiaoyan Chen, Yunbiao Tang, Yongqing Wang, Hongwen Zhang, Dafang Zhong. Determination of arotinoid acid in human plasma by liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2009 Oct; 877(27):2983-8. doi: 10.1016/j.jchromb.2009.07.017. [PMID: 19632163]
  • Anil Kurien, Christopher Henderson, Simon Lee. Recurrent keratoacanthoma with vascular invasion: a diagnostic and management dilemma. The Australasian journal of dermatology. 2009 Aug; 50(3):194-7. doi: 10.1111/j.1440-0960.2009.00537.x. [PMID: 19659982]
  • Giuseppe Monfrecola, Antonello Baldo. Retinoids and phototherapy for psoriasis. The Journal of rheumatology. Supplement. 2009 Aug; 83(?):71-2. doi: 10.3899/jrheum.090231. [PMID: 19661548]
  • H-D Park, H-K Kim, M-R Chun, J-W Kim, D-W Kim, J-H Lee, W S Huh, J-I Youn, H-G Kim, Y G Kim, M-H Kim, S-Y Lee. A fully validated HPLC method for the simultaneous determination of acitretin and etretinate in plasma and its application to a pharmacokinetic study in healthy Korean subjects. International journal of clinical pharmacology and therapeutics. 2009 Jul; 47(7):476-82. doi: 10.5414/cpp47476. [PMID: 19640355]
  • A Nofal, I Al-Makhzangy, E Attwa, A Nassar, A Abdalmoati. Vascular endothelial growth factor in psoriasis: an indicator of disease severity and control. Journal of the European Academy of Dermatology and Venereology : JEADV. 2009 Jul; 23(7):803-6. doi: 10.1111/j.1468-3083.2009.03181.x. [PMID: 19309427]
  • Li-xin Zhang, Yan-ping Bai, Pei-hua Song, Li-ping You, Ding-quan Yang. Effect of Chinese herbal medicine combined with acitretin capsule in treating psoriasis of blood-heat syndrome type. Chinese journal of integrative medicine. 2009 Apr; 15(2):141-4. doi: 10.1007/s11655-009-0145-5. [PMID: 19407953]
  • M Caproni, E Antiga, L Melani, W Volpi, E Del Bianco, P Fabbri. Serum levels of IL-17 and IL-22 are reduced by etanercept, but not by acitretin, in patients with psoriasis: a randomized-controlled trial. Journal of clinical immunology. 2009 Mar; 29(2):210-4. doi: 10.1007/s10875-008-9233-0. [PMID: 18763027]
  • Hyung-Doo Park, Hye-Kyung Kim, Jong-Won Kim, Dae-Won Kim, Joo-Heung Lee, Wooseong Huh, Jai-Il Youn, Hyung-Gun Kim, Yoon-Gyoon Kim, Myung-Hwa Kim, Soo-Youn Lee. Evaluation of the transfusion safety of blood products and determination of plasma concentrations of acitretin and etretinate in patients receiving transfusions. Transfusion. 2008 Nov; 48(11):2395-400. doi: 10.1111/j.1537-2995.2008.01850.x. [PMID: 18657077]
  • Alessandro Borghi, Emanuela Fogli, Marina Stignani, Loredana Melchiorri, Ermete Altieri, Olavio Baricordi, Roberta Rizzo, Annarosa Virgili. Soluble human leukocyte antigen-G and interleukin-10 levels in plasma of psoriatic patients: preliminary study on a possible correlation between generalized immune status, treatments and disease. Archives of dermatological research. 2008 Nov; 300(10):551-9. doi: 10.1007/s00403-008-0886-6. [PMID: 18797896]
  • S A Walsh, S A Holme. Acne successfully treated with acitretin in a patient with peanut allergy. Reply. The British journal of dermatology. 2008 Nov; 159(5):1208-9. doi: 10.1111/j.1365-2133.2008.08824.x. [PMID: 18795928]
  • Keith L Duffy, Layne Green, Ronald Harris, Douglas Powell. Treatment of nephrogenic systemic fibrosis with Re-PUVA. Journal of the American Academy of Dermatology. 2008 Aug; 59(2 Suppl 1):S39-40. doi: 10.1016/j.jaad.2007.08.035. [PMID: 18625379]
  • Christopher M Hunzeker, William Fangman, Jo-Ann M Latkowski. Folliculotropic mycosis fungoides. Dermatology online journal. 2007 Jan; 13(1):5. doi: NULL. [PMID: 17511938]
  • A Damasiewicz-Bodzek, B Kos-Kudła, B Suwała-Jurczyk. The effect of various methods of psoriasis treatment on somatotrophin axis hormones in serum. Journal of clinical pharmacy and therapeutics. 2006 Aug; 31(4):343-9. doi: 10.1111/j.1365-2710.2006.00747.x. [PMID: 16882103]
  • E Campalani, M H Allen, D Fairhurst, H S Young, C O Mendonca, A D Burden, C E M Griffiths, M A Crook, J N W N Barker, C H Smith. Apolipoprotein E gene polymorphisms are associated with psoriasis but do not determine disease response to acitretin. The British journal of dermatology. 2006 Feb; 154(2):345-52. doi: 10.1111/j.1365-2133.2005.06950.x. [PMID: 16433808]
  • R P Katugampola, A Y Finlay. Oral retinoid therapy for disorders of keratinization: single-centre retrospective 25 years' experience on 23 patients. The British journal of dermatology. 2006 Feb; 154(2):267-76. doi: 10.1111/j.1365-2133.2005.06906.x. [PMID: 16433796]
  • Helen S Young, Angela M Summers, Ian R Read, David A Fairhurst, Darren J Plant, Emanuela Campalani, Catherine H Smith, Jonathan N W N Barker, Michael J Detmar, Paul E C Brenchley, Christopher E M Griffiths. Interaction between genetic control of vascular endothelial growth factor production and retinoid responsiveness in psoriasis. The Journal of investigative dermatology. 2006 Feb; 126(2):453-9. doi: 10.1038/sj.jid.5700096. [PMID: 16385345]
  • S Corbetta, R Angioni, A Cattaneo, P Beck-Peccoz, A Spada. Effects of retinoid therapy on insulin sensitivity, lipid profile and circulating adipocytokines. European journal of endocrinology. 2006 Jan; 154(1):83-6. doi: 10.1530/eje.1.02057. [PMID: 16381995]
  • A R Angioni, A Lania, A Cattaneo, P Beck-Peccoz, A Spada. Effects of chronic retinoid administration on pituitary function. Journal of endocrinological investigation. 2005 Dec; 28(11):961-4. doi: 10.1007/bf03345332. [PMID: 16483172]
  • Victoria L Brown, Catherine L Atkins, Lucy Ghali, Rino Cerio, Catherine A Harwood, Charlotte M Proby. Safety and efficacy of 5\% imiquimod cream for the treatment of skin dysplasia in high-risk renal transplant recipients: randomized, double-blind, placebo-controlled trial. Archives of dermatology. 2005 Aug; 141(8):985-93. doi: 10.1001/archderm.141.8.985. [PMID: 16103328]
  • Renata V Carneiro, Mírian N Sotto, Luiz S Azevedo, Luiz E Ianhez, Evandro A Rivitti. Acitretin and skin cancer in kidney transplanted patients. Clinical and histological evaluation and immunohistochemical analysis of lymphocytes, natural killer cells and Langerhans' cells in sun exposed and sun protected skin. Clinical transplantation. 2005 Feb; 19(1):115-21. doi: 10.1111/j.1399-0012.2004.00311.x. [PMID: 15659144]
  • Uwe-Frithjof Haustein, Uwe Paasch. Aggressive undifferentiated squamous cell carcinoma in an immunosuppressed patient after kidney transplantation. Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG. 2005 Jan; 3(1):44-6. doi: 10.1046/j.1439-0353.2005.04740.x. [PMID: 16353749]
  • Xin Liu, Hai-Shu Lin, Sui Yung Chan, Paul C Ho. Biopharmaceutics of beta-cyclodextrin derivative-based formulations of acitretin in Sprague-Dawley rats. Journal of pharmaceutical sciences. 2004 Apr; 93(4):805-15. doi: 10.1002/jps.10578. [PMID: 14999719]
  • Jürgen V Smit, Ruud G L de Sévaux, Willeke A M Blokx, Peter C M van de Kerkhof, Andries J Hoitsma, Elke M G J de Jong. Acitretin treatment in (pre)malignant skin disorders of renal transplant recipients: Histologic and immunohistochemical effects. Journal of the American Academy of Dermatology. 2004 Feb; 50(2):189-96. doi: 10.1016/s0190-9622(03)01837-1. [PMID: 14726871]
  • E Lee, J Koo. Single-center retrospective study of long-term use of low-dose acitretin (Soriatane) for psoriasis. The Journal of dermatological treatment. 2004 Jan; 15(1):8-13. doi: 10.1080/095466303100184473. [PMID: 14754643]
  • R G L de Sévaux, J V Smit, E M G J de Jong, P C M van de Kerkhof, A J Hoitsma. Acitretin treatment of premalignant and malignant skin disorders in renal transplant recipients: clinical effects of a randomized trial comparing two doses of acitretin. Journal of the American Academy of Dermatology. 2003 Sep; 49(3):407-12. doi: 10.1067/s0190-9622(03)01831-0. [PMID: 12963902]
  • Willeke A M Blokx, Jurgen V Smit, Peter C M de Wilde, Peter C M van de Kerkhof, Dirk J Ruiter, Elke M G J de Jong. Immunohistochemical effects of temporary cessation of long-term acitretin treatment in keratinocytic intraepidermal neoplasia of renal transplant recipients. Archives of dermatology. 2003 May; 139(5):671-3. doi: 10.1001/archderm.139.5.671. [PMID: 12756113]
  • P I Spuls, M Rozenblit, M Lebwohl. Retrospective study of the efficacy of narrowband UVB and acitretin. The Journal of dermatological treatment. 2003; 14 Suppl 2(?):17-20. doi: 10.1080/jdt.14.s2.17.20. [PMID: 14578094]
  • Iain Robert McNamara, James Muir, Andrew John Galbraith. Acitretin for prophylaxis of cutaneous malignancies after cardiac transplantation. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 2002 Nov; 21(11):1201-5. doi: 10.1016/s1053-2498(02)00456-4. [PMID: 12431493]
  • Renu George, Warren Weightman, Graeme R Russ, Kym M Bannister, Timothy H Mathew. Acitretin for chemoprevention of non-melanoma skin cancers in renal transplant recipients. The Australasian journal of dermatology. 2002 Nov; 43(4):269-73. doi: 10.1046/j.1440-0960.2002.00613.x. [PMID: 12423433]
  • Ozlem Yerebakan, Oya Ermis, Ertan Yilmaz, Erdal Basaran. Treatment of arsenical keratosis and Bowen's disease with acitretin. International journal of dermatology. 2002 Feb; 41(2):84-7. doi: 10.1046/j.1365-4362.2002.01372.x. [PMID: 11982642]
  • Stacy L McClure, Jayme Valentine, Kenneth B Gordon. Comparative tolerability of systemic treatments for plaque-type psoriasis. Drug safety. 2002; 25(13):913-27. doi: 10.2165/00002018-200225130-00003. [PMID: 12381213]
  • Willeke A M Blokx, Jurgen V Smit, Elke M G J de Jong, Monique M G M Link, Peter C M van de Kerkhof, Dirk J Ruiter. Retinoids strongly and selectively correlate with keratin 13 and not keratin 19 expression in cutaneous warts of renal transplant recipients. Archives of dermatology. 2002 Jan; 138(1):61-5. doi: 10.1001/archderm.138.1.61. [PMID: 11790168]
  • K Thestrup-Pedersen, K E Andersen, T Menné, N K Veien. Treatment of hyperkeratotic dermatitis of the palms (eczema keratoticum) with oral acitretin. A single-blind placebo-controlled study. Acta dermato-venereologica. 2001 Oct; 81(5):353-5. doi: 10.1080/000155501317140089. [PMID: 11800144]
  • F Grønhøj Larsen, B Steinkjer, P Jakobsen, A Hjorter, P B Brockhoff, F Nielsen-Kudsk. Acitretin is converted to etretinate only during concomitant alcohol intake. The British journal of dermatology. 2000 Dec; 143(6):1164-9. doi: 10.1046/j.1365-2133.2000.03883.x. [PMID: 11122016]
  • G M Gaeta, F Gombos, F Femiano, C Battista, P Minghetti, L Montanari, R A Satriano, G Argenziano. Acitretin and treatment of the oral leucoplakias. A model to have an active molecules release. Journal of the European Academy of Dermatology and Venereology : JEADV. 2000 Nov; 14(6):473-8. doi: 10.1046/j.1468-3083.2000.00155.x. [PMID: 11444269]
  • H I Katz, J Waalen, E E Leach. Acitretin in psoriasis: an overview of adverse effects. Journal of the American Academy of Dermatology. 1999 Sep; 41(3 Pt 2):S7-S12. doi: 10.1016/s0190-9622(99)70359-2. [PMID: 10459140]
  • D B McKenna, G M Murphy. Skin cancer chemoprophylaxis in renal transplant recipients: 5 years of experience using low-dose acitretin. The British journal of dermatology. 1999 Apr; 140(4):656-60. doi: 10.1046/j.1365-2133.1999.02765.x. [PMID: 10233316]
  • O Vanhooteghem, J Andre, J M Pochet, J Demaubeuge, M Song. Occurrence of gouty tophi following acitretin therapy. Clinical and experimental dermatology. 1998 Nov; 23(6):274-6. doi: 10.1046/j.1365-2230.1998.00362.x. [PMID: 10233625]
  • A L Kuijpers, J P Van Pelt, M Bergers, P J Boegheim, J E Den Bakker, G Siegenthaler, P C Van de Kerkhof, J Schalkwijk. The effects of oral liarozole on epidermal proliferation and differentiation in severe plaque psoriasis are comparable with those of acitretin. The British journal of dermatology. 1998 Sep; 139(3):380-9. doi: 10.1046/j.1365-2133.1998.02399.x. [PMID: 9988537]
  • NULL. Two new retinoids for psoriasis. The Medical letter on drugs and therapeutics. 1997 Nov; 39(1013):105-6. doi: NULL. [PMID: 9391501]
  • H Zachariae, L Heickendorff, P Bjerring. Plasma endothelin in psoriasis: possible relations to therapy and toxicity. Acta dermato-venereologica. 1996 Nov; 76(6):442-3. doi: 10.2340/0001555576442443. [PMID: 8982406]
  • H Maier, H Hönigsmann. Concentration of etretinate in plasma and subcutaneous fat after long-term acitretin. Lancet (London, England). 1996 Oct; 348(9034):1107. doi: 10.1016/s0140-6736(05)64457-1. [PMID: 8874484]
  • G P Rajan, B Seifert, O Prümmer, H I Joller-Jemelka, G Burg, R Dummer. Incidence and in-vivo relevance of anti-interferon antibodies during treatment of low-grade cutaneous T-cell lymphomas with interferon alpha-2a combined with acitretin or PUVA. Archives of dermatological research. 1996 Aug; 288(9):543-8. doi: 10.1007/bf02505252. [PMID: 8874750]