Thyroxine sulfate (BioDeep_00000027845)

 

Secondary id: BioDeep_00000627433

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite


代谢物信息卡片


(2S)-2-Amino-3-{4-[3,5-diiodo-4-(sulphooxy)phenoxy]-3,5-diiodophenyl}propanoic acid

化学式: C15H11I4NO7S (856.6435)
中文名称:
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 86.89%

分子结构信息

SMILES: C1=C(C=C(C(=C1I)OC2=CC(=C(C(=C2)I)OS(=O)(=O)O)I)I)CC(C(=O)O)N
InChI: InChI=1S/C15H11I4NO7S/c16-8-1-6(3-12(20)15(21)22)2-9(17)13(8)26-7-4-10(18)14(11(19)5-7)27-28(23,24)25/h1-2,4-5,12H,3,20H2,(H,21,22)(H,23,24,25)/t12-/m0/s1

描述信息

Thyroxine Sulfate (abbreviated T4) is a major Thyroid hormone metabolite secreted by follicular cells of the Thyroid gland. T4 is transported in blood, with 99.95\\\% of the secreted T4 being protein bound, principally to thyroxine binding globulin (TBG) and to a lesser extent to thyroxine binding pre-albumin (TBPA) and serum albumin. T4 is involved in controlling the rate of metabolic processes in the body and influencing physical development. T4 is considered a prohormone and a reservoir for the active thyroid hormone triiodothyronine (T3), T4 being converted as required in the tissues by deiodinases.
Thyroxine Sulfate (abbreviated T4) is a major Thyroid hormone metabolite secreted by follicular cells of the Thyroid gland. T4 is transported in blood, with 99.95\\\% of the secreted T4 being protein bound, principally to thyroxine binding globulin (TBG) and to a lesser extent to thyroxine binding pre-albumin (TBPA) and serum albumin.
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
Thyroxine sulfate is a thyroid hormone metabolite.

同义名列表

21 个代谢物同义名

(2S)-2-Amino-3-{4-[3,5-diiodo-4-(sulphooxy)phenoxy]-3,5-diiodophenyl}propanoic acid; (2S)-2-amino-3-{4-[3,5-diiodo-4-(sulfooxy)phenoxy]-3,5-diiodophenyl}propanoic acid; (2S)-2-Amino-3-{4-[3,5-diiodo-4-(sulphooxy)phenoxy]-3,5-diiodophenyl}propanoate; (2S)-2-Amino-3-{4-[3,5-diiodo-4-(sulfooxy)phenoxy]-3,5-diiodophenyl}propanoate; 3-[4-(4-Hydroxy-3,5-diiodophenoxy-4-O-sulphate)-3,5-diiodophenyl]-L-alanine; 3-[4-(4-Hydroxy-3,5-diiodophenoxy-4-O-sulfate)-3,5-diiodophenyl]-L-alanine; O-(4-Hydroxy-3,5-diiodophenyl-4-O-sulphate)-3,5-diiodo-L-tyrosine; O-(4-Hydroxy-3,5-diiodophenyl-4-O-sulfate)-3,5-diiodo-L-tyrosine; 3,5,3,5-Tetraiodo-L-thyronine 4-O-sulphate; 3,5,3,5-Tetraiodo-L-thyronine 4-O-sulfate; Thyroxine sulphuric acid; L-Thyroxine 4-O-sulphate; Thyroxine sulfuric acid; L-Thyroxine 4-O-sulfate; thyroxine sulfic acid; Thyroxine-4-sulfate; Thyroxine sulphate; Thyroxine sulfate; T4 Sulfate; T4S; T4?Sulfate



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Debasish Manna, Santanu Mondal, Govindasamy Mugesh. Halogen bonding controls the regioselectivity of the deiodination of thyroid hormones and their sulfate analogues. Chemistry (Weinheim an der Bergstrasse, Germany). 2015 Feb; 21(6):2409-16. doi: 10.1002/chem.201405442. [PMID: 25487845]
  • Robin P Peeters, Monique H A Kester, Pieter J Wouters, Ellen Kaptein, Hans van Toor, Theo J Visser, Greet Van den Berghe. Increased thyroxine sulfate levels in critically ill patients as a result of a decreased hepatic type I deiodinase activity. The Journal of clinical endocrinology and metabolism. 2005 Dec; 90(12):6460-5. doi: 10.1210/jc.2005-0866. [PMID: 16189257]
  • Edith C H Friesema, Sumita Ganguly, Amal Abdalla, Jocelyn E Manning Fox, Andrew P Halestrap, Theo J Visser. Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter. The Journal of biological chemistry. 2003 Oct; 278(41):40128-35. doi: 10.1074/jbc.m300909200. [PMID: 12871948]
  • W S Huang, S C Cherng, C H Wang, B F Shih, S W Kuo, S Y Wu. Increased urinary thyroxine sulfate excretion in thyroxine therapy. Endocrine journal. 1997 Aug; 44(4):467-72. doi: 10.1507/endocrj.44.467. [PMID: 9447277]
  • D H Polk, A Reviczky, S Y Wu, W S Huang, D A Fisher. Metabolism of sulfoconjugated thyroid hormone derivatives in developing sheep. The American journal of physiology. 1994 Jun; 266(6 Pt 1):E892-6. doi: 10.1152/ajpendo.1994.266.6.e892. [PMID: 8023919]
  • S Y Wu, D H Polk, W S Huang, A Reviczky, K Wang, D A Fisher. Sulfate conjugates of iodothyronines in developing sheep: effect of fetal hypothyroidism. The American journal of physiology. 1993 Jul; 265(1 Pt 1):E115-20. doi: 10.1152/ajpendo.1993.265.1.e115. [PMID: 8338144]
  • I J Chopra, F Santini, R E Hurd, G N Chua Teco. A radioimmunoassay for measurement of thyroxine sulfate. The Journal of clinical endocrinology and metabolism. 1993 Jan; 76(1):145-50. doi: 10.1210/jcem.76.1.8421080. [PMID: 8421080]
  • S Wu, D Polk, S Wong, A Reviczky, R Vu, D A Fisher. Thyroxine sulfate is a major thyroid hormone metabolite and a potential intermediate in the monodeiodination pathways in fetal sheep. Endocrinology. 1992 Oct; 131(4):1751-6. doi: 10.1210/endo.131.4.1396320. [PMID: 1396320]
  • S Y Wu, W S Huang, D Polk, W H Florsheim, W L Green, D A Fisher. Identification of thyroxine-sulfate (T4S) in human serum and amniotic fluid by a novel T4S radioimmunoassay. Thyroid : official journal of the American Thyroid Association. 1992; 2(2):101-5. doi: 10.1089/thy.1992.2.101. [PMID: 1525576]
  • M Rutgers, I G Pigmans, F Bonthuis, R Docter, T J Visser. Effects of propylthiouracil on the biliary clearance of thyroxine (T4) in rats: decreased excretion of 3,5,3'-triiodothyronine glucuronide and increased excretion of 3,3',5'-triiodothyronine glucuronide and T4 sulfate. Endocrinology. 1989 Oct; 125(4):2175-86. doi: 10.1210/endo-125-4-2175. [PMID: 2791984]
  • M P Kung, S W Spaulding, J A Roth. Desulfation of 3,5,3'-triiodothyronine sulfate by microsomes from human and rat tissues. Endocrinology. 1988 Apr; 122(4):1195-200. doi: 10.1210/endo-122-4-1195. [PMID: 2964360]