Ethopropazine (BioDeep_00000027079)

   

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


N,N-Diethyl-alpha-methyl-10H-phenothiazine-10-ethanamine

  化学式: C19H24N2S (312.166)
中文名称: 乙丙嗪
  谱图信息: 最多检出来源 Homo sapiens(blood) 64.63%

分子结构信息

SMILES: CCN(CC)C(C)CN1C2=CC=CC=C2SC2=CC=CC=C12
InChI: InChI=1S/C19H24N2S/c1-4-20(5-2)15(3)14-21-16-10-6-8-12-18(16)22-19-13-9-7-11-17(19)21/h6-13,15H,4-5,14H2,1-3H3

描述信息

Ethopropazine is only found in individuals that have used or taken this drug.Ethopropazine (also known as profenamine hydrochloride) is a medication derived from phenothiazine. It is primarily used as an antidyskinetic to treat parkinsonism. It is sold under the trade names Parsidol in the United States and Parsidan in Canada.Ethopropazines antiparkinson action can be attributed to its anticholinergic properties. Ethopropazine partially blocks central (striatal) cholinergic receptors, thereby helping to balance cholinergic and dopaminergic activity in the basal ganglia; salivation may be decreased, and smooth muscle may be relaxed. Drug-induced extrapyramidal symptoms and those due to parkinsonism may be relieved, but tardive dyskinesia is not alleviated and may be aggravated by anticholinergic effects. Ethopropazines local anesthetic effect is due to its antagonism of the NMDA glutamate receptor. Glutamate is recognized as an important transmitter in nociceptive pathways, and the N-methyl-D-aspartate (NMDA) subtype of the glutamate receptor, in particular, has been implicated in the mediation of neuropathic pain. Excessive release of glutamate at NMDA receptors on dorsal horn neurons of the spinal cord results in hyperactivation and hypersensitivity of these receptors (perceived as hyperalgesia), thought to be an integral feature of neuropathic pain.
N - Nervous system > N04 - Anti-parkinson drugs > N04A - Anticholinergic agents > N04AA - Tertiary amines
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018680 - Cholinergic Antagonists
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
C78272 - Agent Affecting Nervous System > C38149 - Antiparkinsonian Agent

同义名列表

36 个代谢物同义名

N,N-Diethyl-alpha-methyl-10H-phenothiazine-10-ethanamine; N,N-Diethyl-a-methyl-10H-phenothiazine-10-ethanamine; N,N-Diethyl-α-methyl-10H-phenothiazine-10-ethanamine; N,N-Diethyl-1-(10H-phenothiazin-10-yl)-2-propanamine; 10-[2-(Diethylamino)-2-methylethyl]phenothiazine; 2-Diethylamino-1-propyl-N-dibenzoparathiazine; 10-[2-(Diethylamino)-1-propyl]phenothiazine; 10-[2-(Diethylamino)propyl]phenothiazine; 10-(2-Diethylaminopropyl)phenothiazine; Profenamine monohydrochloride; Ethopropazine hydrochloride; Profenamine hydrochloride; Aethopropropazin; Phenopropazine; Prophenaminum; Athapropazine; ethopropazine; Ethopromazine; Ethapropazine; Fenpropazina; Profenaminum; Etopropezina; Prophenamine; Prodierazine; Fempropazine; Athopropazin; Phenoprozine; Profenamine; Isopthazine; Isothiazine; Profenamina; Isothazine; Lysivane; Parsidol; Isotazin; Parsitan



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome()

BioCyc()

PlantCyc()

代谢反应

个相关的代谢反应过程信息。

Reactome()

BioCyc()

WikiPathways()

Plant Reactome()

INOH()

PlantCyc()

COVID-19 Disease Map()

PathBank()

PharmGKB()

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Ramachandra S Naik, Tatyana Belinskaya, C R Vinayaka, Ashima Saxena. Monoclonal antibodies to fetal bovine serum acetylcholinesterase distinguish between acetylcholinesterases from ruminant and non-ruminant species. Chemico-biological interactions. 2020 Oct; 330(?):109225. doi: 10.1016/j.cbi.2020.109225. [PMID: 32795450]
  • Fatma Goksin Bahar, Teruko Imai. Aspirin hydrolysis in human and experimental animal plasma and the effect of metal cations on hydrolase activities. Drug metabolism and disposition: the biological fate of chemicals. 2013 Jul; 41(7):1450-6. doi: 10.1124/dmd.113.051805. [PMID: 23649702]
  • Asta Tvarijonaviciute, Jose J Ceron, Fernando Tecles. Acetylcholinesterase and butyrylcholinesterase activities in obese Beagle dogs before and after weight loss. Veterinary clinical pathology. 2013 Jun; 42(2):207-11. doi: 10.1111/vcp.12032. [PMID: 23550593]
  • Ramachandra S Naik, Weiyi Liu, Ashima Saxena. Development and validation of a simple assay for the determination of cholinesterase activity in whole blood of laboratory animals. Journal of applied toxicology : JAT. 2013 Apr; 33(4):290-300. doi: 10.1002/jat.2730. [PMID: 22407886]
  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • Haobo Jiang, Siwei Liu, Picheng Zhao, Carey Pope. Recombinant expression and biochemical characterization of the catalytic domain of acetylcholinesterase-1 from the African malaria mosquito, Anopheles gambiae. Insect biochemistry and molecular biology. 2009 Sep; 39(9):646-53. doi: 10.1016/j.ibmb.2009.07.002. [PMID: 19607916]
  • Yasemin Yücel Yücel, Ozden Tacal, Inci Ozer. Comparative effects of cationic triarylmethane, phenoxazine and phenothiazine dyes on horse serum butyrylcholinesterase. Archives of biochemistry and biophysics. 2008 Oct; 478(2):201-5. doi: 10.1016/j.abb.2008.07.006. [PMID: 18656440]
  • Anooshirvan Shayeganpour, Vishwa Somayaji, Dion R Brocks. A liquid chromatography-mass spectrometry assay method for simultaneous determination of amiodarone and desethylamiodarone in rat specimens. Biomedical chromatography : BMC. 2007 Mar; 21(3):284-90. doi: 10.1002/bmc.754. [PMID: 17221913]
  • Elsa Reiner, Anita Bosak, Vera Simeon-Rudolf. Activity of cholinesterases in human whole blood measured with acetylthiocholine as substrate and ethopropazine as selective inhibitor of plasma butyrylcholinesterase. Arhiv za higijenu rada i toksikologiju. 2004 Apr; 55(1):1-4. doi: NULL. [PMID: 15137175]
  • Marko Golicnik, Goran Sinko, Vera Simeon-Rudolf, Zoran Grubic, Jure Stojan. Kinetic model of ethopropazine interaction with horse serum butyrylcholinesterase and its docking into the active site. Archives of biochemistry and biophysics. 2002 Feb; 398(1):23-31. doi: 10.1006/abbi.2001.2697. [PMID: 11811945]
  • M Maboudian-Esfahani, D R Brocks. Pharmacokinetics of ethopropazine in the rat after oral and intravenous administration. Biopharmaceutics & drug disposition. 1999 Apr; 20(3):159-63. doi: 10.1002/(sici)1099-081x(199904)20:3<159::aid-bdd164>3.0.co;2-d. [PMID: 10211869]
  • D R Brocks, M Maboudian-Esfahani. Disposition of ethopropazine enantiomers in the rat: tissue distribution and plasma protein binding. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques. 1999 Jan; 2(1):23-9. doi: NULL. [PMID: 10951659]
  • F Eyer, P Eyer. Enzyme-based assay for quantification of paraoxon in blood of parathion poisoned patients. Human & experimental toxicology. 1998 Dec; 17(12):645-51. doi: 10.1177/096032719801701201. [PMID: 9988368]
  • M Maboudian-Esfahani, D R Brocks. High-performance liquid chromatographic assay of (+/-)-ethopropazine and its enantiomers in rat plasma. Journal of chromatography. B, Biomedical sciences and applications. 1998 Sep; 715(2):417-23. doi: 10.1016/s0378-4347(98)00245-x. [PMID: 9792528]


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