Tuftsin (BioDeep_00000026815)
human metabolite Endogenous blood metabolite
代谢物信息卡片
化学式: C21H40N8O6 (500.3071)
中文名称:
谱图信息:
最多检出来源 Mus musculus(blood) 21.46%
分子结构信息
SMILES: CC(C(C(=O)NC(CCCCN)C(=O)N1CCCC1C(=O)NC(CCCN=C(N)N)C(=O)O)N)O
InChI: InChI=1S/C21H40N8O6/c1-12(30)16(23)18(32)27-13(6-2-3-9-22)19(33)29-11-5-8-15(29)17(31)28-14(20(34)35)7-4-10-26-21(24)25/h12-16,30H,2-11,22-23H2,1H3,(H,27,32)(H,28,31)(H,34,35)(H4,24,25,26)/t12-,13?,14+,15+,16+/m1/s1
描述信息
Tuftsin (L-threonyl-L-lysyl-L-prolyl-L-arginine) is a peptide related primarily to the immune system function. Tuftsin is a tetrapeptide (Thr-Lys-Pro-Arg) produced by enzymatic cleavage of the Fc-domain of the heavy chain of immunoglobulin G. It is produced primarily in the spleen. Its biological activity is related primarily to the immune system function. Tuftsin binds to specific receptors on the surface of macrophages and polymorphonuclear leukocytes, stimulating their migration, phagocytic, bactericidal, and tumoricidal activity. It also influences antibody formation. Tuftsin deficiency, either hereditary or following splenectomy, results in increased susceptibility to certain infections. Tuftsin has been chemically synthesized and it is considered for use in immunotherapy. [HMDB]
Tuftsin (L-threonyl-L-lysyl-L-prolyl-L-arginine) is a peptide related primarily to the immune system function. Tuftsin is a tetrapeptide (Thr-Lys-Pro-Arg) produced by enzymatic cleavage of the Fc-domain of the heavy chain of immunoglobulin G. It is produced primarily in the spleen. Its biological activity is related primarily to the immune system function. Tuftsin binds to specific receptors on the surface of macrophages and polymorphonuclear leukocytes, stimulating their migration, phagocytic, bactericidal, and tumoricidal activity. It also influences antibody formation. Tuftsin deficiency, either hereditary or following splenectomy, results in increased susceptibility to certain infections. Tuftsin has been chemically synthesized and it is considered for use in immunotherapy.
同义名列表
6 个代谢物同义名
(2S)-2-({[(2S)-1-(6-amino-2-{[(2S,3R)-2-amino-1,3-dihydroxybutylidene]amino}hexanoyl)pyrrolidin-2-yl](hydroxy)methylidene}amino)-5-carbamimidamidopentanoate; (2S)-2-{[(2S)-1-{6-amino-2-[(2S,3R)-2-amino-3-hydroxybutanamido]hexanoyl}pyrrolidin-2-yl]formamido}-5-carbamimidamidopentanoic acid; L-Threonyl-L-lysyl-L-prolyl-L-arginine; L-THR-L-Lys-L-pro-L-arg; Taftsin; TUFTSIN
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:88947
- PubChem: 53477795
- PubChem: 24780
- HMDB: HMDB0005770
- Wikipedia: Tuftsin
- MeSH: Tuftsin
- foodb: FDB023760
- chemspider: 35015985
- CAS: 112592-90-2
- PMhub: MS000236895
- RefMet: Tuftsin
分类词条
相关代谢途径
Reactome()
BioCyc()
PlantCyc()
代谢反应
个相关的代谢反应过程信息。
Reactome()
BioCyc()
WikiPathways()
Plant Reactome()
INOH()
PlantCyc()
COVID-19 Disease Map()
PathBank()
PharmGKB()
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
亚细胞结构定位 | 关联基因列表 |
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文献列表
- Zsuzsa Baranyai, Beáta Biri-Kovács, Martin Krátký, Bálint Szeder, Márta L Debreczeni, Johanna Budai, Bence Kovács, Lilla Horváth, Edit Pári, Zsuzsanna Németh, László Cervenak, Ferenc Zsila, Előd Méhes, Éva Kiss, Jarmila Vinšová, Szilvia Bősze. Cellular Internalization and Inhibition Capacity of New Anti-Glioma Peptide Conjugates: Physicochemical Characterization and Evaluation on Various Monolayer- and 3D-Spheroid-Based in Vitro Platforms.
Journal of medicinal chemistry.
2021 03; 64(6):2982-3005. doi:
10.1021/acs.jmedchem.0c01399
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Current drug targets.
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Clinical and experimental immunology.
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Scientific reports.
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Biomaterials.
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"
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Fish & shellfish immunology.
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FEMS immunology and medical microbiology.
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Gut.
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Journal of drug targeting.
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Gut.
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Eksperimental'naia i klinicheskaia farmakologiia.
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FEBS letters.
1997 Jul; 412(1):227-32. doi:
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Physiological research.
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1996 Nov; 39(24):4833-43. doi:
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Zhonghua wai ke za zhi [Chinese journal of surgery].
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Hepatology (Baltimore, Md.).
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The Journal of surgical research.
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Leprosy review.
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Archivum immunologiae et therapiae experimentalis.
1992; 40(3-4):207-12. doi:
NULL
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Journal of medicinal chemistry.
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International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association.
1991 Dec; 59(4):576-81. doi:
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Immunological investigations.
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Izvestiia Akademii nauk SSSR. Seriia biologicheskaia.
1991 Mar; ?(2):302-6. doi:
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Tsitologiia.
1991; 33(7):69-78. doi:
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Archivum immunologiae et therapiae experimentalis.
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Archivum immunologiae et therapiae experimentalis.
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International journal of immunopharmacology.
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The International journal of biochemistry.
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Tsitologiia.
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Immunological investigations.
1989 Jul; 18(6):817-24. doi:
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Journal of biological response modifiers.
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Biulleten' eksperimental'noi biologii i meditsiny.
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Analytical biochemistry.
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Molecular and cellular biochemistry.
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