L-3-Amino-2-(oxalylamino)propanoic acid (BioDeep_00000024498)

Main id: BioDeep_00000000206

 

human metabolite


代谢物信息卡片


oxalyldiaminopropionic acid, (L-Ala)-isomer

化学式: C5H8N2O5 (176.0433)
中文名称:
谱图信息: 最多检出来源 not specific(not specific) 0%

分子结构信息

SMILES: C(C(C(=O)O)NC(=O)C(=O)O)N
InChI: InChI=1S/C5H8N2O5/c6-1-2(4(9)10)7-3(8)5(11)12/h2H,1,6H2,(H,7,8)(H,9,10)(H,11,12)

描述信息

L-3-Amino-2-(oxalylamino)propanoic acid is found in pulses. L-3-Amino-2-(oxalylamino)propanoic acid is present in seeds of Lathyrus sativus (chickling pea).
Present in seeds of Lathyrus sativus (chickling pea). L-3-Amino-2-(oxalylamino)propanoic acid is found in pulses.

同义名列表

23 个代谢物同义名

oxalyldiaminopropionic acid, (L-Ala)-isomer; 3-amino-2-(carboxyformamido)propanoic acid; L-3-Amino-2-(oxalylamino)propanoic acid; (2-amino-2-carboxymethyl)-L-oxamic acid; 3-Amino-2-(carboxyformamido)propanoate; 3-amino-N-(carboxycarbonyl)-DL-alanine; 3-amino-N-(Carboxycarbonyl)-L-alanine; beta-N-oxalylaminoalanine, (L)-isomer; 3-oxalylamino-2-aminopropionic acid; L-3-Amino-2-(oxalylamino)propanoate; 2-oxalylamino-3-aminopropionic acid; 3-amino-N-(carboxycarbonyl)alanine; carboxycarbonyl-aminoalanine; beta-N-oxalylamino-L-alanine; oxalyldiaminopropionic acid; beta-N-oxalylaminoalanine; lathyrus neurotoxin; oxalylaminoalanine; dencichine; Dencichin; L-BOAA; ODAP; BOAA



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Dan Huang, Xin Wang, Wei-Bing Liu, Bang-Ce Ye. Remodeling metabolism of Corynebacterium glutamicum for high-level dencichine production. Bioresource technology. 2023 Nov; 388(?):129800. doi: 10.1016/j.biortech.2023.129800. [PMID: 37748563]
  • Yu Sui, Xiaojiang Duan, Jingming Zhang, Yingming Chu, Xing Yang. Synthesis and characterization of a novel 68Ga-labeled p-bromobenzyl lysine-urea-ODAP PSMA inhibitor. Bioorganic & medicinal chemistry letters. 2023 07; 91(?):129382. doi: 10.1016/j.bmcl.2023.129382. [PMID: 37348571]
  • Rym Boulfekhar, Leanne Ohlund, Kathrina Mae Kumaresan, Meriem Megoura, Thomas D Warkentin, Pompilia Ispas-Szabo, Lekha Sleno, Mircea Alexandru Mateescu. Diamine Oxidase as a Therapeutic Enzyme: Study of Germination from Vegetal Sources and Investigation of the Presence of β-N-Oxalyl-L-α,β-diaminopropionic Acid (β-ODAP) Using LC-MS/MS. International journal of molecular sciences. 2023 Feb; 24(5):. doi: 10.3390/ijms24054625. [PMID: 36902055]
  • Anne Edwards, Isaac Njaci, Abhimanyu Sarkar, Zhouqian Jiang, Gemy George Kaithakottil, Christopher Moore, Jitender Cheema, Clare E M Stevenson, Martin Rejzek, Petr Novák, Marielle Vigouroux, Martin Vickers, Roland H M Wouters, Pirita Paajanen, Burkhard Steuernagel, Jonathan D Moore, Janet Higgins, David Swarbreck, Stefan Martens, Colin Y Kim, Jing-Ke Weng, Sagadevan Mundree, Benjamin Kilian, Shiv Kumar, Matt Loose, Levi Yant, Jiří Macas, Trevor L Wang, Cathie Martin, Peter M F Emmrich. Genomics and biochemical analyses reveal a metabolon key to β-L-ODAP biosynthesis in Lathyrus sativus. Nature communications. 2023 Feb; 14(1):876. doi: 10.1038/s41467-023-36503-2. [PMID: 36797319]
  • Wenna Li, Zhao Zhou, Xianglai Li, Lin Ma, Qingyuan Guan, Guojun Zheng, Hao Liang, Yajun Yan, Xiaolin Shen, Jia Wang, Xinxiao Sun, Qipeng Yuan. Biosynthesis of plant hemostatic dencichine in Escherichia coli. Nature communications. 2022 09; 13(1):5492. doi: 10.1038/s41467-022-33255-3. [PMID: 36123371]
  • Moshe Goldsmith, Shiri Barad, Maor Knafo, Alon Savidor, Shifra Ben-Dor, Alexander Brandis, Tevie Mehlman, Yoav Peleg, Shira Albeck, Orly Dym, Efrat Ben-Zeev, Ranjit S Barbole, Asaph Aharoni, Ziv Reich. Identification and characterization of the key enzyme in the biosynthesis of the neurotoxin β-ODAP in grass pea. The Journal of biological chemistry. 2022 05; 298(5):101806. doi: 10.1016/j.jbc.2022.101806. [PMID: 35271851]
  • Zijiang Yang, Guanze Liu, Guanghui Zhang, Jing Yan, Yang Dong, Yingchun Lu, Wei Fan, Bing Hao, Yuan Lin, Ying Li, Xuejiao Li, Qingyan Tang, Guisheng Xiang, Simei He, Junwen Chen, Wei Chen, Zhongping Xu, Zichao Mao, Shengchang Duan, Shuangxia Jin, Shengchao Yang. The chromosome-scale high-quality genome assembly of Panax notoginseng provides insight into dencichine biosynthesis. Plant biotechnology journal. 2021 05; 19(5):869-871. doi: 10.1111/pbi.13558. [PMID: 33529371]
  • Chao Huang, Lijing Cheng, Xinyan Feng, Xiaojun Li, Lihua Wang. Dencichine ameliorates renal injury by improving oxidative stress, apoptosis and fibrosis in diabetic rats. Life sciences. 2020 Oct; 258(?):118146. doi: 10.1016/j.lfs.2020.118146. [PMID: 32721462]
  • Yan-Hai Zhang, Yuan-Gui Yang, Lei Shi, Yan Jin, Zheng-Tao Wang. [Fingerprinting analysis of non-saponins from water-soluble part and determination of dencichine from Panax notoginseng, P. ginseng and P. quinquefolium based on liquid chromatography coupled with charged aerosol detection]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2020 Jul; 45(14):3475-3480. doi: 10.19540/j.cnki.cjcmm.20200403.202. [PMID: 32726064]
  • Suman, Yasmin Ahmad, Vikrant Nain. A convenient and robust protocol for preparation of ODAP-free Lathyrus sativus protein. Analytical biochemistry. 2020 02; 591(?):113544. doi: 10.1016/j.ab.2019.113544. [PMID: 31866288]
  • Peter M F Emmrich, Martin Rejzek, Lionel Hill, Paul Brett, Anne Edwards, Abhimanyu Sarkar, Rob A Field, Cathie Martin, Trevor L Wang. Linking a rapid throughput plate-assay with high-sensitivity stable-isotope label LCMS quantification permits the identification and characterisation of low β-L-ODAP grass pea lines. BMC plant biology. 2019 Nov; 19(1):489. doi: 10.1186/s12870-019-2091-5. [PMID: 31718544]
  • Kimino Minagawa, Shin-Ichi Yamada, Ayano Suzuki, Saeko Ta, Toshio Kumai, Fernand Lambein, Kuniko Kusama-Eguchi. Stress-related over-enhancement of the hypothalamic-pituitary-adrenal axis causes experimental neurolathyrism in rats. Environmental toxicology and pharmacology. 2019 Nov; 72(?):103245. doi: 10.1016/j.etap.2019.103245. [PMID: 31499324]
  • Veerababu Nagati, Monika Kallubai, Dinesh Kumar Chinthapalli, Rajagopal Subramanyam. Exploration of binding studies of β-oxalyldiamino propionic acid (β-ODAP), a non-protein amino acid with human serum albumin-biophysical and computational approach. Journal of biomolecular structure & dynamics. 2019 09; 37(15):3914-3922. doi: 10.1080/07391102.2018.1528181. [PMID: 30257618]
  • Jie Li, Pengcheng Qiu, Siwang Wang, Junsheng Wu, Qiaoyan He, Kaifeng Li, Lu Xu. β-N-Oxalyl-L-α,β-diaminopropionic acid from Panax notoginseng plays a major role in the treatment of type 2 diabetic nephropathy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2019 Jun; 114(?):108801. doi: 10.1016/j.biopha.2019.108801. [PMID: 30928803]
  • Fengjuan Liu, Chengjin Jiao, Chunxiao Bi, Quanle Xu, Peng Chen, Adam L Heuberger, Hari B Krishnan. Metabolomics Approach To Understand Mechanisms of β-N-Oxalyl-l-α,β-diaminopropionic Acid (β-ODAP) Biosynthesis in Grass Pea (Lathyrus sativus L.). Journal of agricultural and food chemistry. 2017 Nov; 65(47):10206-10213. doi: 10.1021/acs.jafc.7b04037. [PMID: 29112818]
  • Li Jie, Qiu Pengcheng, He Qiaoyan, Bi Linlin, Zhang Meng, Wang Fang, Jia Min, Yan Li, Zhang Ya, Yang Qian, Wang Siwang. Dencichine ameliorates kidney injury in induced type II diabetic nephropathy via the TGF-β/Smad signalling pathway. European journal of pharmacology. 2017 Oct; 812(?):196-205. doi: 10.1016/j.ejphar.2017.06.024. [PMID: 28633927]
  • Quanle Xu, Fengjuan Liu, Peng Chen, Joseph M Jez, Hari B Krishnan. β-N-Oxalyl-l-α,β-diaminopropionic Acid (β-ODAP) Content in Lathyrus sativus: The Integration of Nitrogen and Sulfur Metabolism through β-Cyanoalanine Synthase. International journal of molecular sciences. 2017 Feb; 18(3):. doi: 10.3390/ijms18030526. [PMID: 28264526]
  • Rui-Yue Tan, Geng-Yan Xing, Guang-Ming Zhou, Feng-Min Li, Wen-Tao Hu, Fernand Lambein, Jun-Lan Xiong, Sheng-Xiang Zhang, Hai-Yan Kong, Hao Zhu, Zhi-Xiao Li, You-Cai Xiong. Plant toxin β-ODAP activates integrin β1 and focal adhesion: A critical pathway to cause neurolathyrism. Scientific reports. 2017 01; 7(?):40677. doi: 10.1038/srep40677. [PMID: 28094806]
  • Lin Li, Cheng-xiao Wang, Yuan Qu, Xiu-ming Cui. [Content determination of dencichine in Panax Notoginseng by a reversed phase ion-pair chromatography]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2015 Oct; 40(20):4026-30. doi: ". [PMID: 27062822]
  • Jun-Lan Xiong, You-Cai Xiong, Xue Bai, Hai-Yan Kong, Rui-Yue Tan, Hao Zhu, Kadambot H M Siddique, Jian-Yong Wang, Neil C Turner. Genotypic Variation in the Concentration of β-N-Oxalyl-L-α,β-diaminopropionic Acid (β-ODAP) in Grass Pea (Lathyrus sativus L.) Seeds Is Associated with an Accumulation of Leaf and Pod β-ODAP during Vegetative and Reproductive Stages at Three Levels of Water Stress. Journal of agricultural and food chemistry. 2015 Jul; 63(27):6133-41. doi: 10.1021/acs.jafc.5b01729. [PMID: 26027639]
  • Ling-juan Yang, Cheng-jin Jiao, Er-quan Gao. [Determination of Dencichine and Its Isomer in Panax notoginseng by Pre-column Derivatization HPLC]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2015 Feb; 38(2):311-4. doi: ". [PMID: 26415407]
  • Bidisha Ghosh, Joy Mitra, Saikat Chakraborty, Jagannath Bhattacharyya, Anirban Chakraborty, Soumitra Kumar Sen, Muniasamy Neerathilingam. Simple Detection Methods for Antinutritive Factor β-ODAP Present in Lathyrus sativus L. by High Pressure Liquid Chromatography and Thin Layer Chromatography. PloS one. 2015; 10(11):e0140649. doi: 10.1371/journal.pone.0140649. [PMID: 26524073]
  • E Rivadeneyra-Domínguez, J F Rodríguez-Landa. Cycads and their association with certain neurodegenerative diseases. Neurologia (Barcelona, Spain). 2014 Nov; 29(9):517-22. doi: 10.1016/j.nrl.2013.03.005. [PMID: 23725821]
  • Ling-Fang Huang, Hai-Lian Shi, Bo Gao, Hui Wu, Li Yang, Xiao-Jun Wu, Zheng-Tao Wang. Decichine enhances hemostasis of activated platelets via AMPA receptors. Thrombosis research. 2014 May; 133(5):848-54. doi: 10.1016/j.thromres.2014.02.009. [PMID: 24630643]
  • Jun-Lan Xiong, Xue Bai, Asfa Batool, Hai-Yan Kong, Rui-Yue Tan, Ya-Fu Wang, Zhi-Xiao Li, You-Cai Xiong. [Ecological function and application of toxin beta-ODAP in grass pea (Lathyrus sativus)]. Ying yong sheng tai xue bao = The journal of applied ecology. 2014 Apr; 25(4):1197-205. doi: . [PMID: 25011318]
  • A Nur Onar, Behice Yavuz Erdoğan, Ilknur Ayan, Zeki Acar. Homoarginine, β-ODAP, and asparagine contents of grass pea landraces cultivated in Turkey. Food chemistry. 2014 Jan; 143(?):277-81. doi: 10.1016/j.foodchem.2013.07.051. [PMID: 24054240]
  • Maria Hoernke, Christian Schwieger, Andreas Kerth, Alfred Blume. Binding of cationic pentapeptides with modified side chain lengths to negatively charged lipid membranes: Complex interplay of electrostatic and hydrophobic interactions. Biochimica et biophysica acta. 2012 Jul; 1818(7):1663-72. doi: 10.1016/j.bbamem.2012.03.001. [PMID: 22433675]
  • Dirk Enneking. The nutritive value of grasspea (Lathyrus sativus) and allied species, their toxicity to animals and the role of malnutrition in neurolathyrism. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2011 Mar; 49(3):694-709. doi: 10.1016/j.fct.2010.11.029. [PMID: 21112364]
  • Peter B Nunn, James R A Lyddiard, K P W Christopher Perera. Brain glutathione as a target for aetiological factors in neurolathyrism and konzo. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2011 Mar; 49(3):662-7. doi: 10.1016/j.fct.2010.08.037. [PMID: 20816718]
  • C-J Jiao, J-L Jiang, C Li, L-M Ke, W Cheng, F-M Li, Z-X Li, C-Y Wang. β-ODAP accumulation could be related to low levels of superoxide anion and hydrogen peroxide in Lathyrus sativus L. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2011 Mar; 49(3):556-62. doi: 10.1016/j.fct.2010.05.054. [PMID: 20510333]
  • C-J Jiao, J-L Jiang, L-M Ke, W Cheng, F-M Li, Z-X Li, C-Y Wang. Factors affecting β-ODAP content in Lathyrus sativus and their possible physiological mechanisms. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2011 Mar; 49(3):543-9. doi: 10.1016/j.fct.2010.04.050. [PMID: 20510335]
  • M Van Moorhem, F Lambein, L Leybaert. Unraveling the mechanism of β-N-oxalyl-α,β-diaminopropionic acid (β-ODAP) induced excitotoxicity and oxidative stress, relevance for neurolathyrism prevention. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2011 Mar; 49(3):550-5. doi: 10.1016/j.fct.2010.03.054. [PMID: 20510327]
  • Kuniko Kusama-Eguchi, Yoshiko Yamazaki, Tadashi Ueda, Atsuhiro Suda, Yukari Hirayama, Fumio Ikegami, Kazuko Watanabe, Mike May, Fernand Lambein, Tadashi Kusama. Hind-limb paraparesis in a rat model for neurolathyrism associated with apoptosis and an impaired vascular endothelial growth factor system in the spinal cord. The Journal of comparative neurology. 2010 Mar; 518(6):928-42. doi: 10.1002/cne.22257. [PMID: 20058324]
  • Geeta Mishra, Rakesh Shukla, Mahdi Hasan, Subhash K Khanna, Mukul Das. Potentiation of neurotoxicity of Lathyrus sativus by manganese: alterations in blood-brain barrier permeability. Toxicology mechanisms and methods. 2009 May; 19(4):318-26. doi: 10.1080/15376510902758947. [PMID: 19778223]
  • Patricia Puig, F W Alexander Tempels, Francesc Borrull, Marta Calull, Carme Aguilar, Govert W Somsen, Gerhardus J de Jong. On-line coupling of solid-phase extraction and capillary electrophoresis for the determination of cefoperazone and ceftiofur in plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2007 Sep; 856(1-2):365-70. doi: 10.1016/j.jchromb.2007.05.030. [PMID: 17572160]
  • George K Shinomol, Muralidhara. Differential induction of oxidative impairments in brain regions of male mice following subchronic consumption of Khesari dhal (Lathyrus sativus) and detoxified Khesari dhal. Neurotoxicology. 2007 Jul; 28(4):798-806. doi: 10.1016/j.neuro.2007.03.002. [PMID: 17451808]
  • Guo-Xiang Xie, Yun-Ping Qiu, Ming-Feng Qiu, Xian-Fu Gao, Yu-Min Liu, Wei Jia. Analysis of dencichine in Panax notoginseng by gas chromatography-mass spectrometry with ethyl chloroformate derivatization. Journal of pharmaceutical and biomedical analysis. 2007 Feb; 43(3):920-5. doi: 10.1016/j.jpba.2006.09.009. [PMID: 17029672]
  • Jing Zhu, San-kang Liu, Chun-mei Fu, Zhang-wan Li. [Analysis of dencichine by HPLC with pre-column derivatization]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2006 Nov; 31(22):1865-8. doi: ". [PMID: 17285985]
  • Jing Zhu, Xin Zhou, Hu Zheng, Zhangwan Li. Enantioselective determination of dencichine in rabbit plasma by high-performance liquid chromatography-electrospray mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2006 Aug; 840(2):124-31. doi: 10.1016/j.jchromb.2006.04.041. [PMID: 16730243]
  • You-Cai Xiong, Geng-Mei Xing, Feng-Min Li, Shao-Ming Wang, Xian-Wei Fan, Zhi-Xiao Li, Ya-Fu Wang. Abscisic acid promotes accumulation of toxin ODAP in relation to free spermine level in grass pea seedlings (Lathyrus sativus L.). Plant physiology and biochemistry : PPB. 2006 Feb; 44(2-3):161-9. doi: 10.1016/j.plaphy.2006.03.002. [PMID: 16650769]
  • Asnake Fikre, Fernand Lambein, Godelieve Gheysen. A life-saving food plant producing more neurotoxin under environmental stress. Communications in agricultural and applied biological sciences. 2006; 71(1):79-82. doi: ". [PMID: 17191478]
  • Hwee-Ling Koh, Aik-Jiang Lau, Eric Chun-Yong Chan. Hydrophilic interaction liquid chromatography with tandem mass spectrometry for the determination of underivatized dencichine (beta-N-oxalyl-L-alpha,beta-diaminopropionic acid) in Panax medicinal plant species. Rapid communications in mass spectrometry : RCM. 2005; 19(10):1237-44. doi: 10.1002/rcm.1928. [PMID: 15838924]
  • M P Pratap Rudra, M Raghuveer Singh, M A Junaid, P Jyothi, S L N Rao. Metabolism of dietary ODAP in humans may be responsible for the low incidence of neurolathyrism. Clinical biochemistry. 2004 Apr; 37(4):318-22. doi: 10.1016/j.clinbiochem.2003.11.014. [PMID: 15003735]
  • Tina T X Dong, Xiu M Cui, Zong H Song, Kui J Zhao, Zhao N Ji, Chun K Lo, Karl W K Tsim. Chemical assessment of roots of Panax notoginseng in China: regional and seasonal variations in its active constituents. Journal of agricultural and food chemistry. 2003 Jul; 51(16):4617-23. doi: 10.1021/jf034229k. [PMID: 14705886]
  • Yu-Haey Kuo, Fumio Ikegami, Fernand Lambein. Neuroactive and other free amino acids in seed and young plants of Panax ginseng. Phytochemistry. 2003 Apr; 62(7):1087-91. doi: 10.1016/s0031-9422(02)00658-1. [PMID: 12591261]
  • Vijayalakshmi Ravindranath. Neurolathyrism: mitochondrial dysfunction in excitotoxicity mediated by L-beta-oxalyl aminoalanine. Neurochemistry international. 2002 May; 40(6):505-9. doi: 10.1016/s0197-0186(01)00121-8. [PMID: 11850107]
  • Z Gongke, K Yingzhen, C Kairong, L Zhixiao, W Yafu. Hydroxyl radical scavenging activity of beta-N-oxalyl-L-alpha, beta-diaminopropionic acid. Phytochemistry. 2001 Nov; 58(5):759-62. doi: 10.1016/s0031-9422(01)00250-3. [PMID: 11672741]
  • G Xing, K Cui, L Ji, Y Wang, Z Li. Water stress and accumulation of beta-N-oxalyl-L-alpha,beta-diaminopropionic acid in grass pea (Lathyrus sativus). Journal of agricultural and food chemistry. 2001 Jan; 49(1):216-20. doi: 10.1021/jf000912k. [PMID: 11170580]
  • G Xing, G Zhou, Z Li, K Cui. [Accumulation of ABA and ODAP in Lathyrus sativus under water stress]. Ying yong sheng tai xue bao = The journal of applied ecology. 2000 Oct; 11(5):693-8. doi: . [PMID: 11767523]
  • X Chen, F Wang, Q Chen, X C Qin, Z Li. Analysis of neurotoxin 3-N-oxalyl-L-2,3-diaminopropionic acid and its alpha-isomer in Lathyrus sativus by high-performance liquid chromatography with 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate (AQC) derivatization. Journal of agricultural and food chemistry. 2000 Aug; 48(8):3383-6. doi: 10.1021/jf000033y. [PMID: 10956120]
  • L Zhao, X Chen, Z Hu, Q Li, Q Chen, Z Li. Analysis of beta-N-oxalyl-L-alpha,beta-diaminopropionic acid and homoarginine in Lathyrus sativus by capillary zone electrophoresis. Journal of chromatography. A. 1999 Oct; 857(1-2):295-302. doi: 10.1016/s0021-9673(99)00788-8. [PMID: 10536848]
  • K Sriram, S K Shankar, M R Boyd, V Ravindranath. Thiol oxidation and loss of mitochondrial complex I precede excitatory amino acid-mediated neurodegeneration. The Journal of neuroscience : the official journal of the Society for Neuroscience. 1998 Dec; 18(24):10287-96. doi: . [PMID: 9852566]
  • P Jyothi, M P Rudra, S L Rao. In vivo metabolism of beta-N-oxalyl-L-alpha,beta-diaminopropionic acid: the Lathyrus sativus neurotoxin in experimental animals. Natural toxins. 1998; 6(5):189-95. doi: 10.1002/(sici)1522-7189(199809/10)6:5<189::aid-nt22>3.0.co;2-f. [PMID: 10398516]
  • H Andersson, E Lindqvist, L Olson. Plant-derived amino acids increase hippocampal BDNF, NGF, c-fos and hsp70 mRNAs. Neuroreport. 1997 May; 8(8):1813-7. doi: 10.1097/00001756-199705260-00005. [PMID: 9223057]
  • Y C Long, Y H Ye, Q Y Xing. Studies on the neuroexcitotoxin beta-N-oxalo-L-alpha,beta-diaminopropionic acid and its isomer alpha-N-oxalo-L-alpha,beta-diaminopropionic acid from the root of Panax species. International journal of peptide and protein research. 1996 Jan; 47(1-2):42-6. doi: 10.1111/j.1399-3011.1996.tb00808.x. [PMID: 8907498]
  • K S Pai, V Ravindranath. L-BOAA induces selective inhibition of brain mitochondrial enzyme, NADH-dehydrogenase. Brain research. 1993 Sep; 621(2):215-21. doi: 10.1016/0006-8993(93)90109-z. [PMID: 8242335]
  • K S Pai, S K Shankar, V Ravindranath. Billion-fold difference in the toxic potencies of two excitatory plant amino acids, L-BOAA and L-BMAA: biochemical and morphological studies using mouse brain slices. Neuroscience research. 1993 Aug; 17(3):241-8. doi: 10.1016/0168-0102(93)90051-q. [PMID: 7901822]
  • Y C Chang, S J Chiu, K P Kao. beta-N-methylamino-L-alanine (L-BMAA) decreases brain glutamate receptor number and induces behavioral changes in rats. The Chinese journal of physiology. 1993; 36(2):79-84. doi: ". [PMID: 7904554]
  • G R Stewart, J W Olney, M Pathikonda, W D Snider. Excitotoxicity in the embryonic chick spinal cord. Annals of neurology. 1991 Dec; 30(6):758-66. doi: 10.1002/ana.410300604. [PMID: 1686386]
  • H Lindström, J Luthman, P Mouton, P Spencer, L Olson. Plant-derived neurotoxic amino acids (beta-N-oxalylamino-L-alanine and beta-N-methylamino-L-alanine): effects on central monoamine neurons. Journal of neurochemistry. 1990 Sep; 55(3):941-9. doi: 10.1111/j.1471-4159.1990.tb04582.x. [PMID: 1974606]
  • J H Weiss, J Y Koh, D W Choi. Neurotoxicity of beta-N-methylamino-L-alanine (BMAA) and beta-N-oxalylamino-L-alanine (BOAA) on cultured cortical neurons. Brain research. 1989 Sep; 497(1):64-71. doi: 10.1016/0006-8993(89)90970-0. [PMID: 2551452]
  • R J Bridges, D R Stevens, J S Kahle, P B Nunn, M Kadri, C W Cotman. Structure-function studies on N-oxalyl-diamino-dicarboxylic acids and excitatory amino acid receptors: evidence that beta-L-ODAP is a selective non-NMDA agonist. The Journal of neuroscience : the official journal of the Society for Neuroscience. 1989 Jun; 9(6):2073-9. doi: . [PMID: 2542485]
  • ". A poison tree. Lancet (London, England). 1987 Oct; 2(8565):947-8. doi: ". [PMID: 2889865]
  • P B Nunn, M Seelig, J C Zagoren, P S Spencer. Stereospecific acute neuronotoxicity of 'uncommon' plant amino acids linked to human motor-system diseases. Brain research. 1987 May; 410(2):375-9. doi: 10.1016/0006-8993(87)90342-8. [PMID: 3109690]
  • K Jha. Effect of the boiling and decanting method of Khesari (Lathyrus sativus) detoxification, on changes in selected nutrients. Archivos latinoamericanos de nutricion. 1987 Mar; 37(1):101-7. doi: . [PMID: 3454610]
  • P S Spencer, S M Ross, P B Nunn, D N Roy, M Seelig. Detection and characterization of plant-derived amino acid motorsystem toxins in mouse CNS cultures. Progress in clinical and biological research. 1987; 253(?):349-61. doi: ". [PMID: 3124127]
  • R D Holbert, J E Pearson, F M Gonzalez. Effect of sodium acetate infusion on renal function in the dog. Archives internationales de pharmacodynamie et de therapie. 1976 Feb; 219(2):211-22. doi: NULL. [PMID: 5975]