Urolithin A (BioDeep_00000020887)

 

Secondary id: BioDeep_00000412821

human metabolite Endogenous blood metabolite PANOMIX_OTCML-2023 natural product


代谢物信息卡片


3,8-Dihydroxy-6H-dibenzo(b,D)pyran-6-one

化学式: C13H8O4 (228.0422568)
中文名称: 尿石素A
谱图信息: 最多检出来源 Homo sapiens(blood) 0.05%

分子结构信息

SMILES: C1=CC2=C(C=C1O)C(=O)OC3=C2C=CC(=C3)O
InChI: InChI=1S/C13H8O4/c14-7-1-3-9-10-4-2-8(15)6-12(10)17-13(16)11(9)5-7/h1-6,14-15H

描述信息

Urolithin A is a secondary metabolite of ellagic acid which may be glucuronidated by liver enzymes during phase II metabolism.
A polyphenol metabolite detected in biological fluids [PhenolExplorer]
Urolithin A, a gut-microbial metabolite of ellagic acid, exerts anti-inflammatory, antiproliferative, and antioxidant properties. Urolithin A induces autophagy and apoptosis, suppresses cell cycle progression, and inhibits DNA synthesis[1][2].
Urolithin A, a gut-microbial metabolite of ellagic acid, exerts anti-inflammatory, antiproliferative, and antioxidant properties. Urolithin A induces autophagy and apoptosis, suppresses cell cycle progression, and inhibits DNA synthesis[1][2].

同义名列表

5 个代谢物同义名

3,8-Dihydroxy-6H-dibenzo(b,D)pyran-6-one; 3,8-dihydroxy-6H-benzo[c]chromen-6-one; 3,8-dihydroxybenzo[c]chromen-6-one; 3,8-dihydroxy-urolithin; urolithin A



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(0)

代谢反应

1 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(1)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

18 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Hongxin Kang, Qian Hu, Yue Yang, Gaigai Huang, Juan Li, Xianlin Zhao, Lv Zhu, Hang Su, Wenfu Tang, Meihua Wan. Urolithin A's Role in Alleviating Severe Acute Pancreatitis via Endoplasmic Reticulum-Mitochondrial Calcium Channel Modulation. ACS nano. 2024 May; 18(21):13885-13898. doi: 10.1021/acsnano.4c03044. [PMID: 38757565]
  • Ilham Naeem Abd Ali Al-Fatlawi, Vahid Pouresmaeil, Fatemeh Davoodi-Dehaghani, Aida Pouresmaeil, Ali Akhtari, Masoud Homayouni Tabrizi. Effects of solid lipid nanocarrier containing methyl urolithin A by coating folate-bound chitosan and evaluation of its anti-cancer activity. BMC biotechnology. 2024 Apr; 24(1):18. doi: 10.1186/s12896-024-00845-6. [PMID: 38600497]
  • Adrián Cortés-Martín, Carlos E Iglesias-Aguirre, Alicia Marín, María Romo-Vaquero, Fernando Vallejo, Juan Carlos Espín, María Victoria Selma. Urolithin A production drives the effects of pomegranate on the gut microbial metabolism of bile acids and cholesterol in mild dyslipidaemic overweight and obese individuals. Food & function. 2024 Mar; 15(5):2422-2432. doi: 10.1039/d3fo05014a. [PMID: 38329279]
  • Jiahao Li, Xinxin Huang, Linjiao He, Chao Li, Hongxin Jing, Jianwei Lin, Chaoyu Ma, Xiaobin Li. Effect of ellagic acid on body weight, nutrient digestibility, fecal microbiota, and urolithin A metabolism in Thoroughbred horses. Journal of animal science. 2023 Jul; ?(?):. doi: 10.1093/jas/skad232. [PMID: 37422771]
  • M Tolmie, M J Bester, J C Serem, M Nell, Z Apostolides. The potential antidiabetic properties of green and purple tea [Camellia sinensis (L.) O Kuntze], purple tea ellagitannins, and urolithins. Journal of ethnopharmacology. 2023 Jun; 309(?):116377. doi: 10.1016/j.jep.2023.116377. [PMID: 36907477]
  • Cong Zhang, Yingying Song, Ming Yuan, Liang Chen, Qianyu Zhang, Junjie Hu, Yan Meng, Shan Li, Guohua Zheng, Zhenpeng Qiu. Ellagitannins-Derived Intestinal Microbial Metabolite Urolithin A Ameliorates Fructose-Driven Hepatosteatosis by Suppressing Hepatic Lipid Metabolic Reprogramming and Inducing Lipophagy. Journal of agricultural and food chemistry. 2023 Mar; 71(9):3967-3980. doi: 10.1021/acs.jafc.2c05776. [PMID: 36825491]
  • Jian-Rong Huang, Ming-Hua Zhang, Ying-Jie Chen, Yu-Ling Sun, Zhi-Min Gao, Zhuo-Jia Li, Gui-Ping Zhang, Yuan Qin, Xiao-Yan Dai, Xi-Yong Yu, Xiao-Qian Wu. Urolithin A ameliorates obesity-induced metabolic cardiomyopathy in mice via mitophagy activation. Acta pharmacologica Sinica. 2023 Feb; 44(2):321-331. doi: 10.1038/s41401-022-00919-1. [PMID: 35655094]
  • Zepeng Xu, Songtao Li, Kunmeng Li, Xiaoyu Wang, Xiaojie Li, Meixia An, Xiaoyi Yu, Xinguang Long, Ruiying Zhong, Qiuhong Liu, Xiaochuan Wang, Yan Yang, Ni Tian. Urolithin A ameliorates diabetic retinopathy via activation of the Nrf2/HO-1 pathway. Endocrine journal. 2022 Aug; 69(8):971-982. doi: 10.1507/endocrj.ej21-0490. [PMID: 35321989]
  • Maciej Korczak, Piotr Roszkowski, Sebastian Granica, Jakub P Piwowarski. Conjugates of urolithin A with NSAIDs, their stability, cytotoxicity, and anti-inflammatory potential. Scientific reports. 2022 07; 12(1):11676. doi: 10.1038/s41598-022-15870-8. [PMID: 35804000]
  • Kailin Li, Yao Xiao, Ji Bian, Lin Han, Caian He, Emad El-Omar, Lan Gong, Min Wang. Ameliorative Effects of Gut Microbial Metabolite Urolithin A on Pancreatic Diseases. Nutrients. 2022 Jun; 14(12):. doi: 10.3390/nu14122549. [PMID: 35745279]
  • Anurag Singh, Davide D'Amico, Pénélope A Andreux, Andréane M Fouassier, William Blanco-Bose, Mal Evans, Patrick Aebischer, Johan Auwerx, Chris Rinsch. Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults. Cell reports. Medicine. 2022 05; 3(5):100633. doi: 10.1016/j.xcrm.2022.100633. [PMID: 35584623]
  • Yi Zhang, Mengmeng Liu, Yaoyuan Zhang, Mi Tian, Peng Chen, Yu Lan, Benhong Zhou. Urolithin A alleviates acute kidney injury induced by renal ischemia reperfusion through the p62-Keap1-Nrf2 signaling pathway. Phytotherapy research : PTR. 2022 Feb; 36(2):984-995. doi: 10.1002/ptr.7370. [PMID: 35040204]
  • Anurag Singh, Davide D'Amico, Pénélope A Andreux, Gillian Dunngalvin, Timo Kern, William Blanco-Bose, Johan Auwerx, Patrick Aebischer, Chris Rinsch. Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population. European journal of clinical nutrition. 2022 02; 76(2):297-308. doi: 10.1038/s41430-021-00950-1. [PMID: 34117375]
  • Sophia Liu, Davide D'Amico, Eric Shankland, Saakshi Bhayana, Jose M Garcia, Patrick Aebischer, Chris Rinsch, Anurag Singh, David J Marcinek. Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults: A Randomized Clinical Trial. JAMA network open. 2022 01; 5(1):e2144279. doi: 10.1001/jamanetworkopen.2021.44279. [PMID: 35050355]
  • YanZhi Zhang, Gulimila Aisker, Huaiyang Dong, Gulihaixia Halemahebai, Yan Zhang, Linai Tian. Urolithin A suppresses glucolipotoxicity-induced ER stress and TXNIP/NLRP3/IL-1β inflammation signal in pancreatic β cells by regulating AMPK and autophagy. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2021 Dec; 93(?):153741. doi: 10.1016/j.phymed.2021.153741. [PMID: 34656886]
  • Chun-Yan Peng, Hua-Dong Zhu, Lu Zhang, Xiao-Feng Li, Wen-Na Zhou, Zong-Cai Tu. Urolithin A alleviates advanced glycation end-product formation by altering protein structures, trapping methylglyoxal and forming complexes. Food & function. 2021 Nov; 12(23):11849-11861. doi: 10.1039/d1fo02631c. [PMID: 34734623]
  • Abdulrasheed O Abdulrahman, Mohammed Yahya Alzubaidi, Muhammad Shahid Nadeem, Jalaluddin Awlia Khan, Irfan A Rather, Mohammad Imran Khan. Effects of urolithins on obesity-associated gut dysbiosis in rats fed on a high-fat diet. International journal of food sciences and nutrition. 2021 Nov; 72(7):923-934. doi: 10.1080/09637486.2021.1886255. [PMID: 33618593]
  • Caocao Yin, Yue Wang, Yue Peng, Rongqiang Zhang, Na Sun, Chuandao Shi, Qiling Liu. [Urolithin A inhibits inflammation and oxidative stress induced by high lipid in hepatocytes via activating Nrf2 pathway and autophagy]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. 2021 Nov; 37(11):973-980. doi: ". [PMID: 34809736]
  • Ali Khalaf Al Khalaf, Abdulrasheed O Abdulrahman, Mohammed Kaleem, Suza Mohammad Nur, Amer H Asseri, Hani Choudhry, Mohammad Imran Khan. Comparative Analysis of the Impact of Urolithins on the Composition of the Gut Microbiota in Normal-Diet Fed Rats. Nutrients. 2021 Oct; 13(11):. doi: 10.3390/nu13113885. [PMID: 34836145]
  • YanZhi Zhang, Yan Zhang, Gulihaixia Halemahebai, Linai Tian, Huaiyang Dong, Gulimila Aisker. Urolithin A, a pomegranate metabolite, protects pancreatic β cells from apoptosis by activating autophagy. Journal of ethnopharmacology. 2021 May; 272(?):113628. doi: 10.1016/j.jep.2020.113628. [PMID: 33246115]
  • Abdulaziz Musa Alzahrani, Mohammed Razeeth Shait Mohammed, Raed Ahmed Alghamdi, Abrar Ahmad, Mazin A Zamzami, Hani Choudhry, Mohammad Imran Khan. Urolithin A and B Alter Cellular Metabolism and Induce Metabolites Associated with Apoptosis in Leukemic Cells. International journal of molecular sciences. 2021 May; 22(11):. doi: 10.3390/ijms22115465. [PMID: 34067305]
  • Barbara Mc Cormack, N Maenhoudt, V Fincke, A Stejskalova, B Greve, L Kiesel, G F Meresman, H Vankelecom, M Götte, R I Barañao. The ellagic acid metabolites urolithin A and B differentially affect growth, adhesion, motility, and invasion of endometriotic cells in vitro. Human reproduction (Oxford, England). 2021 05; 36(6):1501-1519. doi: 10.1093/humrep/deab053. [PMID: 33748857]
  • Ewa Żary-Sikorska, Bartosz Fotschki, Adam Jurgoński, Monika Kosmala, Joanna Milala, Krzysztof Kołodziejczyk, Michał Majewski, Katarzyna Ognik, Jerzy Juśkiewicz. Protective Effects of a Strawberry Ellagitannin-Rich Extract against Pro-Oxidative and Pro-Inflammatory Dysfunctions Induced by a High-Fat Diet in a Rat Model. Molecules (Basel, Switzerland). 2020 Dec; 25(24):. doi: 10.3390/molecules25245874. [PMID: 33322602]
  • Shin-Ichi Adachi, Kazunori Sasaki, Shinji Kondo, Wataru Komatsu, Fumiaki Yoshizawa, Hiroko Isoda, Kazumi Yagasaki. Antihyperuricemic Effect of Urolithin A in Cultured Hepatocytes and Model Mice. Molecules (Basel, Switzerland). 2020 Nov; 25(21):. doi: 10.3390/molecules25215136. [PMID: 33158257]
  • Jieping Yang, Yuanqiang Guo, Susanne M Henning, Brenda Chan, Jianfeng Long, Jin Zhong, Rebeca Acin-Perez, Anton Petcherski, Orian Shirihai, David Heber, Zhaoping Li. Ellagic Acid and Its Microbial Metabolite Urolithin A Alleviate Diet-Induced Insulin Resistance in Mice. Molecular nutrition & food research. 2020 10; 64(19):e2000091. doi: 10.1002/mnfr.202000091. [PMID: 32783299]
  • Małgorzata Kujawska, Jadwiga Jodynis-Liebert. Potential of the ellagic acid-derived gut microbiota metabolite - Urolithin A in gastrointestinal protection. World journal of gastroenterology. 2020 Jun; 26(23):3170-3181. doi: 10.3748/wjg.v26.i23.3170. [PMID: 32684733]
  • Juan Antonio Giménez-Bastida, Antonio González-Sarrías, Juan Carlos Espín, Claus Schneider. Inhibition of 5-Lipoxygenase-Derived Leukotrienes and Hemiketals as a Novel Anti-Inflammatory Mechanism of Urolithins. Molecular nutrition & food research. 2020 06; 64(11):e2000129. doi: 10.1002/mnfr.202000129. [PMID: 32306507]
  • Juan Antonio Giménez-Bastida, María Ángeles Ávila-Gálvez, Juan Carlos Espín, Antonio González-Sarrías. The gut microbiota metabolite urolithin A, but not other relevant urolithins, induces p53-dependent cellular senescence in human colon cancer cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2020 May; 139(?):111260. doi: 10.1016/j.fct.2020.111260. [PMID: 32179165]
  • Bahetibieke Tuohetaerbaike, Yan Zhang, Yali Tian, Nan Nan Zhang, Jinsen Kang, Xinmin Mao, Yanzhi Zhang, Xuejun Li. Pancreas protective effects of Urolithin A on type 2 diabetic mice induced by high fat and streptozotocin via regulating autophagy and AKT/mTOR signaling pathway. Journal of ethnopharmacology. 2020 Mar; 250(?):112479. doi: 10.1016/j.jep.2019.112479. [PMID: 31846746]
  • Luis Cisneros-Zevallos, Woo Young Bang, Claudia Delgadillo-Puga. Ellagic Acid and Urolithins A and B Differentially Regulate Fat Accumulation and Inflammation in 3T3-L1 Adipocytes While Not Affecting Adipogenesis and Insulin Sensitivity. International journal of molecular sciences. 2020 Mar; 21(6):. doi: 10.3390/ijms21062086. [PMID: 32197417]
  • Małgorzata Kujawska, Michael Jourdes, Monika Kurpik, Michał Szulc, Hanna Szaefer, Piotr Chmielarz, Grzegorz Kreiner, Violetta Krajka-Kuźniak, Przemyslaw Łukasz Mikołajczak, Pierre-Louis Teissedre, Jadwiga Jodynis-Liebert. Neuroprotective Effects of Pomegranate Juice against Parkinson's Disease and Presence of Ellagitannins-Derived Metabolite-Urolithin A-In the Brain. International journal of molecular sciences. 2019 Dec; 21(1):. doi: 10.3390/ijms21010202. [PMID: 31892167]
  • Ruiqi Zhao, Xingyu Long, Junqi Yang, Lin Du, Xitong Zhang, Jianke Li, Chen Hou. Pomegranate peel polyphenols reduce chronic low-grade inflammatory responses by modulating gut microbiota and decreasing colonic tissue damage in rats fed a high-fat diet. Food & function. 2019 Dec; 10(12):8273-8285. doi: 10.1039/c9fo02077b. [PMID: 31720661]
  • Dianxiong Zou, Raghu Ganugula, Meenakshi Arora, Mary B Nabity, David Sheikh-Hamad, M N V Ravi Kumar. Oral delivery of nanoparticle urolithin A normalizes cellular stress and improves survival in mouse model of cisplatin-induced AKI. American journal of physiology. Renal physiology. 2019 11; 317(5):F1255-F1264. doi: 10.1152/ajprenal.00346.2019. [PMID: 31532243]
  • Izaskun García-Mantrana, Marta Calatayud, María Romo-Vaquero, Juan Carlos Espín, María V Selma, María Carmen Collado. Urolithin Metabotypes Can Determine the Modulation of Gut Microbiota in Healthy Individuals by Tracking Walnuts Consumption over Three Days. Nutrients. 2019 Oct; 11(10):. doi: 10.3390/nu11102483. [PMID: 31623169]
  • Adrián Cortés-Martín, María Romo-Vaquero, Izaskun García-Mantrana, Ana Rodríguez-Varela, María Carmen Collado, Juan Carlos Espín, María Victoria Selma. Urolithin Metabotypes can Anticipate the Different Restoration of the Gut Microbiota and Anthropometric Profiles during the First Year Postpartum. Nutrients. 2019 Sep; 11(9):. doi: 10.3390/nu11092079. [PMID: 31484413]
  • Ying Wang, Haipeng Huang, Yuewei Jin, Kezhen Shen, Xiaoyi Chen, Zhijie Xu, Baiye Jin, Hao Pan. Role of TFEB in autophagic modulation of ischemia reperfusion injury in mice kidney and protection by urolithin A. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2019 Sep; 131(?):110591. doi: 10.1016/j.fct.2019.110591. [PMID: 31212009]
  • Taile Jing, Jiezhi Liao, Kezhen Shen, Xiaoyi Chen, Zhijie Xu, Wenjun Tian, Yimin Wang, Baiye Jin, Hao Pan. Protective effect of urolithin a on cisplatin-induced nephrotoxicity in mice via modulation of inflammation and oxidative stress. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2019 Jul; 129(?):108-114. doi: 10.1016/j.fct.2019.04.031. [PMID: 31014901]
  • M A Ávila-Gálvez, J A Giménez-Bastida, A González-Sarrías, J C Espín. Tissue deconjugation of urolithin A glucuronide to free urolithin A in systemic inflammation. Food & function. 2019 Jun; 10(6):3135-3141. doi: 10.1039/c9fo00298g. [PMID: 31041969]
  • Pénélope A Andreux, William Blanco-Bose, Dongryeol Ryu, Frédéric Burdet, Mark Ibberson, Patrick Aebischer, Johan Auwerx, Anurag Singh, Chris Rinsch. The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans. Nature metabolism. 2019 06; 1(6):595-603. doi: 10.1038/s42255-019-0073-4. [PMID: 32694802]
  • Chun-Feng Liu, Xiao-Lin Li, Zi-Long Zhang, Lu Qiu, Shi-Xuan Ding, Jun-Xin Xue, Guo-Ping Zhao, Jian Li. Antiaging Effects of Urolithin A on Replicative Senescent Human Skin Fibroblasts. Rejuvenation research. 2019 Jun; 22(3):191-200. doi: 10.1089/rej.2018.2066. [PMID: 30215291]
  • Nicholas A DaSilva, Pragati P Nahar, Hang Ma, Aseel Eid, Zhengxi Wei, Susan Meschwitz, Nasser H Zawia, Angela L Slitt, Navindra P Seeram. Pomegranate ellagitannin-gut microbial-derived metabolites, urolithins, inhibit neuroinflammation in vitro. Nutritional neuroscience. 2019 Mar; 22(3):185-195. doi: 10.1080/1028415x.2017.1360558. [PMID: 28784051]
  • María Romo-Vaquero, Adrián Cortés-Martín, Viviana Loria-Kohen, Ana Ramírez-de-Molina, Izaskun García-Mantrana, María Carmen Collado, Juan Carlos Espín, María Victoria Selma. Deciphering the Human Gut Microbiome of Urolithin Metabotypes: Association with Enterotypes and Potential Cardiometabolic Health Implications. Molecular nutrition & food research. 2019 02; 63(4):e1800958. doi: 10.1002/mnfr.201800958. [PMID: 30471188]
  • Shaqiu Zhang, Tamer Al-Maghout, Hang Cao, Lisann Pelzl, Madhuri S Salker, Marc Veldhoen, Anchun Cheng, Florian Lang, Yogesh Singh. Gut Bacterial Metabolite Urolithin A (UA) Mitigates Ca2+ Entry in T Cells by Regulating miR-10a-5p. Frontiers in immunology. 2019; 10(?):1737. doi: 10.3389/fimmu.2019.01737. [PMID: 31417547]
  • Rebeca Busto, Jorge Serna, Aránzazu Perianes-Cachero, Rocío Quintana-Portillo, David García-Seisdedos, Alberto Canfrán-Duque, Carlos L Paino, Milagros Lerma, María E Casado, Antonia Martín-Hidalgo, Eduardo Arilla-Ferreiro, Miguel A Lasunción, Óscar Pastor. Ellagic acid protects from myelin-associated sphingolipid loss in experimental autoimmune encephalomyelitis. Biochimica et biophysica acta. Molecular and cell biology of lipids. 2018 09; 1863(9):958-967. doi: 10.1016/j.bbalip.2018.05.009. [PMID: 29793057]
  • María Ángeles Ávila-Gálvez, Juan Carlos Espín, Antonio González-Sarrías. Physiological Relevance of the Antiproliferative and Estrogenic Effects of Dietary Polyphenol Aglycones versus Their Phase-II Metabolites on Breast Cancer Cells: A Call of Caution. Journal of agricultural and food chemistry. 2018 Aug; 66(32):8547-8555. doi: 10.1021/acs.jafc.8b03100. [PMID: 30025453]
  • Geoffrey Istas, Rodrigo P Feliciano, Timon Weber, Rocio Garcia-Villalba, Francisco Tomas-Barberan, Christian Heiss, Ana Rodriguez-Mateos. Plasma urolithin metabolites correlate with improvements in endothelial function after red raspberry consumption: A double-blind randomized controlled trial. Archives of biochemistry and biophysics. 2018 08; 651(?):43-51. doi: 10.1016/j.abb.2018.05.016. [PMID: 29802820]
  • Guang-Hao Cui, Wei-Qian Chen, Zhen-Ya Shen. Urolithin A shows anti-atherosclerotic activity via activation of class B scavenger receptor and activation of Nef2 signaling pathway. Pharmacological reports : PR. 2018 Jun; 70(3):519-524. doi: 10.1016/j.pharep.2017.04.020. [PMID: 29660655]
  • María V Selma, Antonio González-Sarrías, Jordi Salas-Salvadó, Cristina Andrés-Lacueva, Cesarettin Alasalvar, Asım Örem, Francisco A Tomás-Barberán, Juan C Espín. The gut microbiota metabolism of pomegranate or walnut ellagitannins yields two urolithin-metabotypes that correlate with cardiometabolic risk biomarkers: Comparison between normoweight, overweight-obesity and metabolic syndrome. Clinical nutrition (Edinburgh, Scotland). 2018 06; 37(3):897-905. doi: 10.1016/j.clnu.2017.03.012. [PMID: 28347564]
  • Joanna Milala, Monika Kosmala, Elżbieta Karlińska, Jerzy Juśkiewicz, Zenon Zduńczyk, Bartosz Fotschki. Ellagitannins from Strawberries with Different Degrees of Polymerization Showed Different Metabolism through Gastrointestinal Tract of Rats. Journal of agricultural and food chemistry. 2017 Dec; 65(49):10738-10748. doi: 10.1021/acs.jafc.7b04120. [PMID: 29143528]
  • Melissa Guada, Raghu Ganugula, Manicka Vadhanam, Majeti N V Ravi Kumar. Urolithin A Mitigates Cisplatin-Induced Nephrotoxicity by Inhibiting Renal Inflammation and Apoptosis in an Experimental Rat Model. The Journal of pharmacology and experimental therapeutics. 2017 10; 363(1):58-65. doi: 10.1124/jpet.117.242420. [PMID: 28784820]
  • Jacqueline Heilman, Pénélope Andreux, Nga Tran, Chris Rinsch, William Blanco-Bose. Safety assessment of Urolithin A, a metabolite produced by the human gut microbiota upon dietary intake of plant derived ellagitannins and ellagic acid. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2017 Oct; 108(Pt A):289-297. doi: 10.1016/j.fct.2017.07.050. [PMID: 28757461]
  • Rocío García-Villalba, Hanne Vissenaekens, Judit Pitart, María Romo-Vaquero, Juan C Espín, Charlotte Grootaert, María V Selma, Katleen Raes, Guy Smagghe, Sam Possemiers, John Van Camp, Francisco A Tomas-Barberan. Gastrointestinal Simulation Model TWIN-SHIME Shows Differences between Human Urolithin-Metabotypes in Gut Microbiota Composition, Pomegranate Polyphenol Metabolism, and Transport along the Intestinal Tract. Journal of agricultural and food chemistry. 2017 Jul; 65(27):5480-5493. doi: 10.1021/acs.jafc.7b02049. [PMID: 28616977]
  • Monia Savi, Leonardo Bocchi, Pedro Mena, Margherita Dall'Asta, Alan Crozier, Furio Brighenti, Donatella Stilli, Daniele Del Rio. In vivo administration of urolithin A and B prevents the occurrence of cardiac dysfunction in streptozotocin-induced diabetic rats. Cardiovascular diabetology. 2017 07; 16(1):80. doi: 10.1186/s12933-017-0561-3. [PMID: 28683791]
  • Jakub P Piwowarski, Iwona Stanisławska, Sebastian Granica, Joanna Stefańska, Anna K Kiss. Phase II Conjugates of Urolithins Isolated from Human Urine and Potential Role of β-Glucuronidases in Their Disposition. Drug metabolism and disposition: the biological fate of chemicals. 2017 06; 45(6):657-665. doi: 10.1124/dmd.117.075200. [PMID: 28283501]
  • Julie Rodriguez, Olivier Caille, Daneel Ferreira, Marc Francaux. Pomegranate extract prevents skeletal muscle of mice against wasting induced by acute TNF-α injection. Molecular nutrition & food research. 2017 04; 61(4):. doi: 10.1002/mnfr.201600169. [PMID: 27804206]
  • Antonio González-Sarrías, María Ángeles Núñez-Sánchez, Rocío García-Villalba, Francisco A Tomás-Barberán, Juan Carlos Espín. Antiproliferative activity of the ellagic acid-derived gut microbiota isourolithin A and comparison with its urolithin A isomer: the role of cell metabolism. European journal of nutrition. 2017 Mar; 56(2):831-841. doi: 10.1007/s00394-015-1131-7. [PMID: 26680596]
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