8-Hydroxyguanine (BioDeep_00000019622)

 

Secondary id: BioDeep_00000013259

human metabolite Endogenous blood metabolite


代谢物信息卡片


1H-Purine-6,8-dione, 2-amino-7,9-dihydro-1H-purine-6,8-dione

化学式: C5H5N5O2 (167.04432300000002)
中文名称: 2-氨基-6,8-二羟基嘌呤
谱图信息: 最多检出来源 Homo sapiens(blood) 0.84%

分子结构信息

SMILES: C12=C(NC(=O)N1)N=C(NC2=O)N
InChI: InChI=1S/C5H5N5O2/c6-4-8-2-1(3(11)10-4)7-5(12)9-2/h(H5,6,7,8,9,10,11,12)

描述信息

Formation of 8-hydroxyguanine (8-OHG), a mutagenic base which is a marker for OH-mediated DNA damage, requires peroxidase and halides and occurs in the presence of transition metal chelators (DTPA +/- desferrioxamine), and is inhibited by catalase, superoxide dismutase (SOD), and scavengers of hypohalous acids. (PMID 10820020). 8-Hydroxyguanine is an oxidative stress marker for diagnosis of Alzheimers disease (AD). (PMID 15977989).
Formation of 8-hydroxyguanine (8-OHG), a mutagenic base which is a marker for OH-mediated DNA damage, requires peroxidase and halides and occurs in the presence of transition metal chelators (DTPA +/- desferrioxamine), and is inhibited by catalase, superoxide dismutase (SOD), and scavengers of hypohalous acids. (PMID 10820020)

同义名列表

11 个代谢物同义名

1H-Purine-6,8-dione, 2-amino-7,9-dihydro-1H-purine-6,8-dione; 2-amino-6,7,8,9-tetrahydro-1H-purine-6,8-dione; 2-amino-7,9-dihydro-1H-Purine-6,8-dione; 2-amino-6,8-Dihydroxypurine; 7,8-dihydro-8-Oxoguanine; 8-oxo-7,8-Dihydroguanine; 2-amino-Purine-6,8-diol; 2-Aminopurine-6,8-diol; 8-Hydroxyguanine; 8-Oxoguanine; oxo-8-Gua



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yiping Li, Xiaolong Wang. The role of DNA and RNA guanosine oxidation in cardiovascular diseases. Pharmacological research. 2024 Jun; 204(?):107187. doi: 10.1016/j.phrs.2024.107187. [PMID: 38657843]
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  • George Pappas-Gogos, Constantinos C Tellis, Kostas Tepelenis, Konstantinos Vlachos, Emmanuel Chrysos, Alexandros D Tselepis, Georgios K Glantzounis. Urine 8-Hydroxyguanine (8-OHG) in Patients Undergoing Surgery for Colorectal Cancer. Journal of investigative surgery : the official journal of the Academy of Surgical Research. 2022 Mar; 35(3):591-597. doi: 10.1080/08941939.2021.1904466. [PMID: 33769178]
  • Daniela Martini, Raúl Domínguez-Perles, Alice Rosi, Michele Tassotti, Donato Angelino, Sonia Medina, Cristian Ricci, Alexandre Guy, Camille Oger, Letizia Gigliotti, Thierry Durand, Mirko Marino, Hans Gottfried-Genieser, Marisa Porrini, Monica Antonini, Alessandra Dei Cas, Riccardo C Bonadonna, Federico Ferreres, Francesca Scazzina, Furio Brighenti, Patrizia Riso, Cristian Del Bo', Pedro Mena, Angel Gil-Izquierdo, Daniele Del Rio. Effect of Coffee and Cocoa-Based Confectionery Containing Coffee on Markers of DNA Damage and Lipid Peroxidation Products: Results from a Human Intervention Study. Nutrients. 2021 Jul; 13(7):. doi: 10.3390/nu13072399. [PMID: 34371907]
  • Ana-Maria Chiorcea-Paquim, Ana Maria Oliveira-Brett. Nanostructured material-based electrochemical sensing of oxidative DNA damage biomarkers 8-oxoguanine and 8-oxodeoxyguanosine: a comprehensive review. Mikrochimica acta. 2021 01; 188(2):58. doi: 10.1007/s00604-020-04689-7. [PMID: 33507409]
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  • Xi-Luan Yan, Meng-Meng Jiang, Ying Hu, Le Wu, Kun Zhao, Xin-Xin Xue, Xiang-Juan Zheng. A new chemiluminescence method for the determination of 8-hydroxyguanine based on l-histidine bound nickel nanoparticles. Chemical communications (Cambridge, England). 2020 Jun; 56(48):6535-6538. doi: 10.1039/d0cc01746a. [PMID: 32395729]
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  • Emil List Larsen, Lucia Padella, Helle Kirstine Mørup Bergholdt, Trine Henriksen, Lucia Santoro, Orazio Gabrielli, Henrik Enghusen Poulsen, Gian Paolo Littarru, Patrick Orlando, Luca Tiano. The effect of long-term treatment with coenzyme Q10 on nucleic acid modifications by oxidation in children with Down syndrome. Neurobiology of aging. 2018 07; 67(?):159-161. doi: 10.1016/j.neurobiolaging.2018.03.001. [PMID: 29665577]
  • Katja Scheffler, Lyudmila Rachek, Panpan You, Alexander D Rowe, Wei Wang, Anna Kuśnierczyk, Lene Kittelsen, Magnar Bjørås, Lars Eide. 8-oxoguanine DNA glycosylase (Ogg1) controls hepatic gluconeogenesis. DNA repair. 2018 01; 61(?):56-62. doi: 10.1016/j.dnarep.2017.11.008. [PMID: 29207315]
  • Ki Cheon Kim, Madduma Hewage Susara Ruwan Kumara, Kyoung Ah Kang, Mei Jing Piao, Min Chang Oh, Yea Seong Ryu, Jin Oh Jo, Young Sun Mok, Jennifer H Shin, Yeunsoo Park, Seong Bong Kim, Suk Jae Yoo, Jin Won Hyun. Exposure of keratinocytes to non‑thermal dielectric barrier discharge plasma increases the level of 8‑oxoguanine via inhibition of its repair enzyme. Molecular medicine reports. 2017 Nov; 16(5):6870-6875. doi: 10.3892/mmr.2017.7454. [PMID: 28901448]
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