PC(16:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)) (BioDeep_00000018529)

   

human metabolite Endogenous blood metabolite LipidSearch


代谢物信息卡片


(2-{[(2R)-2-[(4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoyloxy]-3-(hexadecanoyloxy)propyl phosphono]oxy}ethyl)trimethylazanium

  化学式: C46H80NO8P (805.5621)
中文名称: 1-棕榈酰-2-二十二碳六烯酰-磷脂酰胆碱
  谱图信息: 最多检出来源 Homo sapiens(lipidomics) 93.06%

Reviewed

Last reviewed on 2024-09-25.

Cite this Page

PC(16:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)). BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/pc(16:0_22:6(4z,7z,10z,13z,16z,19z)) (retrieved 2025-06-06) (BioDeep RN: BioDeep_00000018529). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CCC=CCC=CCC=CCC=CCC=CCC=CCCC(=O)OC(COC(=O)CCCCCCCCCCCCCCC)COP(=O)([O-])OCC[N+](C)(C)C
InChI: InChI=1S/C46H80NO8P/c1-6-8-10-12-14-16-18-20-21-22-23-24-25-27-29-31-33-35-37-39-46(49)55-44(43-54-56(50,51)53-41-40-47(3,4)5)42-52-45(48)38-36-34-32-30-28-26-19-17-15-13-11-9-7-2/h8,10,14,16,20-21,23-24,27,29,33,35,44H,6-7,9,11-13,15,17-19,22,25-26,28,30-32,34,36-43H2,1-5H3/b10-8-,16-14-,21-20-,24-23-,29-27-,35-33-/t44-/m1/s1

描述信息

PC(16:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)) is a phosphatidylcholine (PC or GPCho). It is a glycerophospholipid in which a phosphorylcholine moiety occupies a glycerol substitution site. As is the case with diacylglycerols, glycerophosphocholines can have many different combinations of fatty acids of varying lengths and saturation attached at the C-1 and C-2 positions. Fatty acids containing 16, 18 and 20 carbons are the most common. PC(16:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)), in particular, consists of one chain of palmitic acid at the C-1 position and one chain of docosahexaenoic acid at the C-2 position. The palmitic acid moiety is derived from fish oils, milk fats, vegetable oils and animal fats, while the docosahexaenoic acid moiety is derived from fish oils. Phospholipids, are ubiquitous in nature and are key components of the lipid bilayer of cells, as well as being involved in metabolism and signaling.While most phospholipids have a saturated fatty acid on C-1 and an unsaturated fatty acid on C-2 of the glycerol backbone, the fatty acid distribution at the C-1 and C-2 positions of glycerol within phospholipids is continually in flux, owing to phospholipid degradation and the continuous phospholipid remodeling that occurs while these molecules are in membranes. PCs can be synthesized via three different routes. In one route, choline is activated first by phosphorylation and then by coupling to CDP prior to attachment to phosphatidic acid. PCs can also synthesized by the addition of choline to CDP-activated 1,2-diacylglycerol. A third route to PC synthesis involves the conversion of either PS or PE to PC.
PC(16:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)) is a phosphatidylcholine (PC or GPCho). It is a glycerophospholipid in which a phosphorylcholine moiety occupies a glycerol substitution site. As is the case with diacylglycerols, glycerophosphocholines can have many different combinations of fatty acids of varying lengths and saturation attached at the C-1 and C-2 positions. Fatty acids containing 16, 18 and 20 carbons are the most common. PC(16:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)), in particular, consists of one chain of palmitic acid at the C-1 position and one chain of docosahexaenoic acid at the C-2 position. The palmitic acid moiety is derived from fish oils, milk fats, vegetable oils and animal fats, while the docosahexaenoic acid moiety is derived from fish oils. Phospholipids, are ubiquitous in nature and are key components of the lipid bilayer of cells, as well as being involved in metabolism and signaling.

同义名列表

25 个代谢物同义名

(2-{[(2R)-2-[(4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoyloxy]-3-(hexadecanoyloxy)propyl phosphono]oxy}ethyl)trimethylazanium; 1-Hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-sn-glycero-3-phosphocholine; 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine; 1-Palmitoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-sn-glycero-3-phosphocholine; 1-(16,16,16-Trideuteriopalmitoyl)-2-docosahexaenoyl-sn-glycero-3-phosphocholine; 1-Palmitoyl-2-docosahexaenoyl-sn-glycero-3-phosphocholine; 1-Palmitoyl-2-docosahexaenoylphosphatidylcholine; 1-Palmitoyl-2-docosahexaenoyl-GPC (16:0/22:6); 1-C16:0-2-C22:6(Omega-3)-phosphatidylcholine; PC(16:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)); Phosphatidylcholine(16:0/22:6omega3); 1-Palmitoyl-2-docosahexaenoyl-GPC; Phosphatidylcholine(16:0/22:6); Phosphatidylcholine(38:6); PC(16:0/22:6omega3); (CD3-16.0)(22.6)PC; GPCho(16:0/22:6); GPC(16:0/22:6); PC(16:0/22:6); GPCho(38:6); FT-0627687; PDCH-GPC; PC(38:6); Lecithin; PDPC



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

8 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(8)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Stephen R Wassall, Xiaoling Leng, Samuel W Canner, Edward Ross Pennington, Jacob J Kinnun, Andres T Cavazos, Sahil Dadoo, Dylan Johnson, Frederick A Heberle, John Katsaras, Saame Raza Shaikh. Docosahexaenoic acid regulates the formation of lipid rafts: A unified view from experiment and simulation. Biochimica et biophysica acta. Biomembranes. 2018 10; 1860(10):1985-1993. doi: 10.1016/j.bbamem.2018.04.016. [PMID: 29730243]
  • J Le Guillou, M-H Ropers, C Gaillard, E David-Briand, S Desherces, E Schmitt, D Bencharif, L Amirat-Briand, D Tainturier, M Anton. Organization of lipids in the artificial outer membrane of bull spermatozoa reconstructed at the air-water interface. Colloids and surfaces. B, Biointerfaces. 2013 Aug; 108(?):246-54. doi: 10.1016/j.colsurfb.2013.02.040. [PMID: 23563290]
  • Michael J Bruno, Radda Rusinova, Nicholas J Gleason, Roger E Koeppe, Olaf S Andersen. Interactions of drugs and amphiphiles with membranes: modulation of lipid bilayer elastic properties by changes in acyl chain unsaturation and protonation. Faraday discussions. 2013; 161(?):461-80; discussion 563. doi: 10.1039/c2fd20092a. [PMID: 23805753]
  • Justin A Williams, Shawn E Batten, Mitchel Harris, Benjamin Drew Rockett, Saame Raza Shaikh, William Stillwell, Stephen R Wassall. Docosahexaenoic and eicosapentaenoic acids segregate differently between raft and nonraft domains. Biophysical journal. 2012 Jul; 103(2):228-37. doi: 10.1016/j.bpj.2012.06.016. [PMID: 22853900]
  • Justine Taylor, Nava E Whiteford, Geoff Bradley, Graeme W Watson. Validation of all-atom phosphatidylcholine lipid force fields in the tensionless NPT ensemble. Biochimica et biophysica acta. 2009 Mar; 1788(3):638-49. doi: 10.1016/j.bbamem.2008.10.013. [PMID: 19014902]
  • Kerry-Anne Rye, MyNgan Duong, Maria K Psaltis, Linda K Curtiss, David J Bonnet, Roland Stocker, Philip J Barter. Evidence that phospholipids play a key role in pre-beta apoA-I formation and high-density lipoprotein remodeling. Biochemistry. 2002 Oct; 41(41):12538-45. doi: 10.1021/bi025998k. [PMID: 12369845]
  • Thomas Huber, Kannan Rajamoorthi, Volker F Kurze, Klaus Beyer, Michael F Brown. Structure of docosahexaenoic acid-containing phospholipid bilayers as studied by (2)H NMR and molecular dynamics simulations. Journal of the American Chemical Society. 2002 Jan; 124(2):298-309. doi: 10.1021/ja011383j. [PMID: 11782182]
  • S Everts, J H Davis. 1H and (13)C NMR of multilamellar dispersions of polyunsaturated (22:6) phospholipids. Biophysical journal. 2000 Aug; 79(2):885-97. doi: 10.1016/s0006-3495(00)76344-2. [PMID: 10920020]
  • D C Mitchell, B J Litman. Effect of ethanol on metarhodopsin II formation is potentiated by phospholipid polyunsaturation. Biochemistry. 1994 Nov; 33(43):12752-6. doi: 10.1021/bi00209a004. [PMID: 7947679]