Oxfendazole (BioDeep_00000017922)

 

Secondary id: BioDeep_00000014952

human metabolite Endogenous


代谢物信息卡片


(5-(Phenylsulphinyl)-1H-benzimidazol-2-yl)carbamic acid methyl ester

化学式: C15H13N3O3S (315.06775880000004)
中文名称: 奥芬达唑
谱图信息: 最多检出来源 Homo sapiens(blood) 1.97%

分子结构信息

SMILES: COC(=O)NC1=NC2=C(N1)C=C(C=C2)S(=O)C3=CC=CC=C3
InChI: InChI=1S/C15H13N3O3S/c1-21-15(19)18-14-16-12-8-7-11(9-13(12)17-14)22(20)10-5-3-2-4-6-10/h2-9H,1H3,(H2,16,17,18,19)

描述信息

D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000871 - Anthelmintics
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C250 - Antihelminthic Agent
Anthelmintic, used in cattle, sheep and horse

同义名列表

34 个代谢物同义名

(5-(Phenylsulphinyl)-1H-benzimidazol-2-yl)carbamic acid methyl ester; (5-(Phenylsulfinyl)-1H-benzimidazol-2-yl)carbamic acid methyl ester; (5-(Phenylsulphinyl)-1H-benzimidazol-2-yl)carbamate methyl ester; (5-(Phenylsulfinyl)-1H-benzimidazol-2-yl)carbamate methyl ester; methyl N-[5-(benzenesulfinyl)-1H-1,3-benzodiazol-2-yl]carbamate; Methyl [5-(phenylsulfinyl)-1H-benzimidazol-2-yl]carbamate, 9ci; 5-(Phenylsulphinyl)-2-benzimidazolecarbamic acid methyl ester; 5-(Phenylsulfinyl)-2-benzimidazolecarbamic acid methyl ester; 5-(Phenylsulphinyl)-2-benzimidazolecarbamate methyl ester; Methyl [5-(phenylsulfinyl)-1H-benzimidazol-2-yl]carbamate; 5-(Phenylsulfinyl)-2-benzimidazolecarbamate methyl ester; Methyl (5-phenylsulfinyl)-1H-benzimidazol-2-yl carbamate; Methyl 5(6)-phenylsulfinyl-2-benzimidazolecarbamate; 5-Phenylsulphinyl-2-carbomethoxyaminobenzimidazole; Methyl 5-(phenylsulfinyl)-benzimidazol-2-carbamate; Methyl 5-(phenylsulfinyl)-2-benzimidazolecarbamate; 5-Phenylsulfinyl-2-carbomethoxyaminobenzimidazole; Oxfendazole monohydrochloride; Fenbendazole sulphoxide; Synanthic (veterinary); Fenbendazole sulfoxide; Fenbendazole S-oxide; Oxfendazolum; Oxfendazole; Oxfendazol; Synanthic; Benzelmin; Systemax; Systamex; Repidose; Nanthic; RS 8858; FBZ-SO; OFDZ



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Abdul Jabbar, Muhammad Zahid Iqbal, Muhammad Ashraf, Aneela Zameer Durrani, Hira Sajjad, Mohammed Nasiru Wana, Asad Ullah, Muhammad Imran, Muhammad Shair Zaman Ghauri, Hafiz Ishfaq Ahmad. Effects of Ferula asafetida, closantel, albendazole, oxfendazole, and ivermectin against Haemonchus contortus in goats and sheep. Tropical animal health and production. 2022 Feb; 54(2):107. doi: 10.1007/s11250-022-03111-z. [PMID: 35187616]
  • Shabnam Jawahar, Nancy Tricoche, Christina A Bulman, Judy Sakanari, Sara Lustigman. Drugs that target early stages of Onchocerca volvulus: A revisited means to facilitate the elimination goals for onchocerciasis. PLoS neglected tropical diseases. 2021 02; 15(2):e0009064. doi: 10.1371/journal.pntd.0009064. [PMID: 33600426]
  • Thanh Bach, Shirley Galbiati, Jessie K Kennedy, Gregory Deye, Effie Y H Nomicos, Ellen E Codd, Hector H Garcia, John Horton, Robert H Gilman, Armando E Gonzalez, Patricia Winokur, Guohua An. Pharmacokinetics, Safety, and Tolerability of Oxfendazole in Healthy Adults in an Open-Label Phase 1 Multiple Ascending Dose and Food Effect Study. Antimicrobial agents and chemotherapy. 2020 10; 64(11):. doi: 10.1128/aac.01018-20. [PMID: 32816721]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Thanh Bach, SoHyun Bae, Ronilda D'Cunha, Patricia Winokur, Guohua An. Development and validation of a simple, fast, and sensitive LC/MS/MS method for the quantification of oxfendazole in human plasma and its application to clinical pharmacokinetic study. Journal of pharmaceutical and biomedical analysis. 2019 Jul; 171(?):111-117. doi: 10.1016/j.jpba.2019.03.048. [PMID: 30981954]
  • Guohua An, Daryl J Murry, Kiran Gajurel, Thanh Bach, Greg Deye, Larissa V Stebounova, Ellen E Codd, John Horton, Armando E Gonzalez, Hector H Garcia, Dilek Ince, Denice Hodgson-Zingman, Effie Y H Nomicos, Thomas Conrad, Jessie Kennedy, Walt Jones, Robert H Gilman, Patricia Winokur. Pharmacokinetics, Safety, and Tolerability of Oxfendazole in Healthy Volunteers: a Randomized, Placebo-Controlled First-in-Human Single-Dose Escalation Study. Antimicrobial agents and chemotherapy. 2019 04; 63(4):. doi: 10.1128/aac.02255-18. [PMID: 30745383]
  • Laura Ceballos, Candela Canton, Gabriela Cadenazzi, Guillermo Virkel, Paula Dominguez, Laura Moreno, Carlos Lanusse, Luis Alvarez. Oxfendazole kinetics in pigs: In vivo assessment of its pattern of accumulation in Ascaris suum. Experimental parasitology. 2019 Apr; 199(?):52-58. doi: 10.1016/j.exppara.2019.02.017. [PMID: 30831078]
  • H W Ploeger, R R Everts. Alarming levels of anthelmintic resistance against gastrointestinal nematodes in sheep in the Netherlands. Veterinary parasitology. 2018 Oct; 262(?):11-15. doi: 10.1016/j.vetpar.2018.09.007. [PMID: 30389005]
  • M Ballent, P Viviani, F Imperiale, P Dominguez, S Halwachs, H Mahnke, W Honscha, C Lanusse, G Virkel, A Lifschitz. Pharmacokinetic assessment of the monepantel plus oxfendazole combined administration in dairy cows. Journal of veterinary pharmacology and therapeutics. 2018 Apr; 41(2):292-300. doi: 10.1111/jvp.12466. [PMID: 29139145]
  • Tina V A Hansen, Andrew R Williams, Matthew Denwood, Peter Nejsum, Stig M Thamsborg, Christian Friis. Pathway of oxfendazole from the host into the worm: Trichuris suis in pigs. International journal for parasitology. Drugs and drug resistance. 2017 12; 7(3):416-424. doi: 10.1016/j.ijpddr.2017.11.002. [PMID: 29156431]
  • Anna L Okello, Lian Thomas, Phouth Inthavong, Amanda Ash, Boualam Khamlome, Chattouphone Keokamphet, Kim Newberry, Charles G Gauci, Sarah Gabriël, Pierre Dorny, Rc Andrew Thompson, Marshall W Lightowlers, John Allen. Assessing the impact of a joint human-porcine intervention package for Taenia solium control: Results of a pilot study from northern Lao PDR. Acta tropica. 2016 Jul; 159(?):185-91. doi: 10.1016/j.actatropica.2016.03.012. [PMID: 26992295]
  • Gabriella Klausz, Éva Keller, Zoltán Sára, Péter Székely-Körmöczy, Péter Laczay, Kornélia Ary, Péter Sótonyi, Kálmán Róna. Simultaneous determination of praziquantel, pyrantel embonate, febantel and its active metabolites, oxfendazole and fenbendazole, in dog plasma by liquid chromatography/mass spectrometry. Biomedical chromatography : BMC. 2015 Dec; 29(12):1859-65. doi: 10.1002/bmc.3507. [PMID: 26104502]
  • J T Howard, R E Baynes, J D Brooks, J L Yeatts, B Bellis, M S Ashwell, P Routh, A T O'Nan, C Maltecca. The effect of breed and sex on sulfamethazine, enrofloxacin, fenbendazole and flunixin meglumine pharmacokinetic parameters in swine. Journal of veterinary pharmacology and therapeutics. 2014 Dec; 37(6):531-41. doi: 10.1111/jvp.12128. [PMID: 24731191]
  • Chia-Wen Hsu, Jinghua Zhao, Ruili Huang, Jui-Hua Hsieh, Jon Hamm, Xiaoqing Chang, Keith Houck, Menghang Xia. Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor. Scientific reports. 2014 Sep; 4(?):6437. doi: 10.1038/srep06437. [PMID: 25257666]
  • W De Jaeghere, B G De Geest, J Van Bocxlaer, J P Remon, C Vervaet, A Antunes da Fonseca. Formulation of poorly water-soluble drugs via coacervation--a pilot study using febantel. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2013 Nov; 85(3 Pt B):930-5. doi: 10.1016/j.ejpb.2013.07.006. [PMID: 23872178]
  • Ernatus Martin Mkupasi, Helena Aminiel Ngowi, Chummy Sikalizyo Sikasunge, Pall S Leifsson, Maria Vang Johansen. Efficacy of ivermectin and oxfendazole against Taenia solium cysticercosis and other parasitoses in naturally infected pigs. Acta tropica. 2013 Oct; 128(1):48-53. doi: 10.1016/j.actatropica.2013.06.010. [PMID: 23806569]
  • Luis Alvarez, Carlos Saumell, Luis Fusé, Laura Moreno, Laura Ceballos, Gilbert Domingue, Meritxell Donadeu, Baptiste Dungu, Carlos Lanusse. Efficacy of a single high oxfendazole dose against gastrointestinal nematodes in naturally infected pigs. Veterinary parasitology. 2013 May; 194(1):70-4. doi: 10.1016/j.vetpar.2013.01.003. [PMID: 23357598]
  • L Moreno, M T Lopez-Urbina, C Farias, G Domingue, M Donadeu, B Dungu, H H García, L A Gomez-Puerta, C Lanusse, A E González. A high oxfendazole dose to control porcine cysticercosis: pharmacokinetics and tissue residue profiles. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2012 Oct; 50(10):3819-25. doi: 10.1016/j.fct.2012.07.023. [PMID: 22841955]
  • Laura Ceballos, Laura Moreno, Juan J Torrado, Carlos Lanusse, Luis Alvarez. Exploring flubendazole formulations for use in sheep. Pharmacokinetic evaluation of a cyclodextrin-based solution. BMC veterinary research. 2012 May; 8(?):71. doi: 10.1186/1746-6148-8-71. [PMID: 22640491]
  • Luis A Gomez-Puerta, Cesar Gavidia, Maria T Lopez-Urbina, Hector H Garcia, Armando E Gonzalez. Efficacy of a single oral dose of oxfendazole against Fasciola hepatica in naturally infected sheep. The American journal of tropical medicine and hygiene. 2012 Mar; 86(3):486-8. doi: 10.4269/ajtmh.2012.11-0476. [PMID: 22403323]
  • Emmanuel Varesio, J C Yves Le Blanc, Gérard Hopfgartner. Real-time 2D separation by LC × differential ion mobility hyphenated to mass spectrometry. Analytical and bioanalytical chemistry. 2012 Mar; 402(8):2555-64. doi: 10.1007/s00216-011-5444-y. [PMID: 22006241]
  • Xinle Zhu, Shuhuai Wang, Qi Liu, Qian Xu, Congmin Zhang, Shixin Xu, Xia Wang, Dan Li, Haiyan Hu. Simultaneous determination of benzimidazoles and their metabolites in plasma using high-performance liquid chromatography/tandem mass spectrometry: application to pharmacokinetic studies in rabbits. Journal of AOAC International. 2011 May; 94(3):839-46. doi: . [PMID: 21797012]
  • M D Edmonds, E G Johnson, J D Edmonds. Anthelmintic resistance of Ostertagia ostertagi and Cooperia oncophora to macrocyclic lactones in cattle from the western United States. Veterinary parasitology. 2010 Jun; 170(3-4):224-9. doi: 10.1016/j.vetpar.2010.02.036. [PMID: 20347229]
  • Muhammad Saeed, Zafar Iqbal, Abdul Jabbar, Sabiqaa Masood, Wasim Babar, Hafiz A Saddiqi, Muhammad Yaseen, Muhammad Sarwar, Muhammad Arshad. Multiple anthelmintic resistance and the possible contributory factors in Beetal goats in an irrigated area (Pakistan). Research in veterinary science. 2010 Apr; 88(2):267-72. doi: 10.1016/j.rvsc.2009.08.004. [PMID: 19733870]
  • Laura Ceballos, Laura Moreno, Luis Alvarez, Laura Shaw, Ian Fairweather, Carlos Lanusse. Unchanged triclabendazole kinetics after co-administration with ivermectin and methimazole: failure of its therapeutic activity against triclabendazole-resistant liver flukes. BMC veterinary research. 2010 Feb; 6(?):8. doi: 10.1186/1746-6148-6-8. [PMID: 20128898]
  • Bettencourt P S Capece, Guillermo L Virkel, Carlos E Lanusse. Enantiomeric behaviour of albendazole and fenbendazole sulfoxides in domestic animals: pharmacological implications. Veterinary journal (London, England : 1997). 2009 Sep; 181(3):241-50. doi: 10.1016/j.tvjl.2008.11.010. [PMID: 19124257]
  • A F Vatta, P J Waller, J B Githiori, G F Medley. The potential to control Haemonchus contortus in indigenous South African goats with copper oxide wire particles. Veterinary parasitology. 2009 Jun; 162(3-4):306-13. doi: 10.1016/j.vetpar.2009.03.005. [PMID: 19346076]
  • Yasuaki Dewa, Jihei Nishimura, Masako Muguruma, Meilan Jin, Masaomi Kawai, Yukie Saegusa, Toshiya Okamura, Takashi Umemura, Kunitoshi Mitsumori. Involvement of oxidative stress in hepatocellular tumor-promoting activity of oxfendazole in rats. Archives of toxicology. 2009 May; 83(5):503-11. doi: 10.1007/s00204-008-0349-z. [PMID: 18754104]
  • Pj Martin, M Chambers, Dr Hennessy. Efficacy against Fasciola hepatica and the pharmacokinetics of triclabendazole administered by oral and topical routes. Australian veterinary journal. 2009 May; 87(5):200-3. doi: 10.1111/j.1751-0813.2009.00425.x. [PMID: 19382929]
  • A A M Stolker, P Rutgers, E Oosterink, J J P Lasaroms, R J B Peters, J A van Rhijn, M W F Nielen. Comprehensive screening and quantification of veterinary drugs in milk using UPLC-ToF-MS. Analytical and bioanalytical chemistry. 2008 Jul; 391(6):2309-22. doi: 10.1007/s00216-008-2168-8. [PMID: 18491081]
  • Abdul Jabbar, Zafar Iqbal, Hafiz Abubaker Saddiqi, Wasim Babar, Muhammad Saeed. Prevalence of multiple anthelmintic resistant gastrointestinal nematodes in dairy goats in a desolated tract (Pakistan). Parasitology research. 2008 Jun; 103(1):29-35. doi: 10.1007/s00436-008-0923-6. [PMID: 18301923]
  • Alparslan Yildirim, Vehbi Güneş, Anil Iça, Savaş Sariözkan, Onder Düzlü, Abdullah Inci, Hasan Albasan. [The investigation of short term efficiency of oxfendazole + oxyclozanide paste and tablet formulations against gastrointestinal nematodes in sheep]. Turkiye parazitolojii dergisi. 2008; 32(2):134-8. doi: NULL. [PMID: 18645944]
  • C Gokbulut, A Bilgili, B Hanedan, Q A McKellar. Comparative plasma disposition of fenbendazole, oxfendazole and albendazole in dogs. Veterinary parasitology. 2007 Sep; 148(3-4):279-87. doi: 10.1016/j.vetpar.2007.06.028. [PMID: 17673370]
  • Yasuaki Dewa, Jihei Nishimura, Masako Muguruma, Sayaka Matsumoto, Miwa Takahashi, Meilan Jin, Kunitoshi Mitsumori. Gene expression analyses of the liver in rats treated with oxfendazole. Archives of toxicology. 2007 Sep; 81(9):647-54. doi: 10.1007/s00204-007-0190-9. [PMID: 17340121]
  • S Giannetto, E Brianti, G Poglayen, C Sorgi, G Capelli, M G Pennisi, G Coci. Efficacy of oxfendazole and fenbendazole against tortoise (Testudo hermanni) oxyurids. Parasitology research. 2007 Apr; 100(5):1069-73. doi: 10.1007/s00436-006-0361-2. [PMID: 17120044]
  • S E Ives, T A Yazwinski, C A Tucker. Fecal egg count reductions and performance effect of Dectomax, Cydectin, and Cydectin plus Synanthic as used in feedlot steers. Veterinary therapeutics : research in applied veterinary medicine. 2007; 8(4):311-7. doi: NULL. [PMID: 18183550]
  • D M Leathwick, T S Waghorn, C M Miller, D S Atkinson, N A Haack, A-M Oliver. Selective and on-demand drenching of lambs: impact on parasite populations and performance of lambs. New Zealand veterinary journal. 2006 Dec; 54(6):305-12. doi: 10.1080/00480169.2006.36715. [PMID: 17151729]
  • Cengiz Gokbulut, Ferda Akar, Quintin A McKellar. Plasma disposition and faecal excretion of oxfendazole, fenbendazole and albendazole following oral administration to donkeys. Veterinary journal (London, England : 1997). 2006 Jul; 172(1):166-72. doi: 10.1016/j.tvjl.2005.02.022. [PMID: 16772142]
  • C J Ward. Mathematical models to assess strategies for the control of gastrointestinal roundworms in cattle 2. Validation. Veterinary parasitology. 2006 Jun; 138(3-4):268-79. doi: 10.1016/j.vetpar.2006.01.053. [PMID: 16517081]
  • M Eysker, A E van Graafeiland, H W Ploeger. [Resistance of Teladorsagia circumcincta in goats to ivermectin in the Netherlands]. Tijdschrift voor diergeneeskunde. 2006 May; 131(10):358-61. doi: NULL. [PMID: 16736643]
  • S F Sánchez Bruni, D G Jones, J Small, Q A McKellar. Effects of formulation concentration on intravenous pharmacokinetics, chirality and in vitro solubility of oxfendazole and its metabolites in sheep. Journal of veterinary pharmacology and therapeutics. 2005 Oct; 28(5):467-73. doi: 10.1111/j.1365-2885.2005.00678.x. [PMID: 16207310]
  • S F Sánchez Bruni, L A Fusé, L Moreno, C A Saumell, L I Alvarez, C Fiel, Q A McKellar, C E Lanusse. Changes to oxfendazole chiral kinetics and anthelmintic efficacy induced by piperonyl butoxide in horses. Equine veterinary journal. 2005 May; 37(3):257-62. doi: 10.2746/0425164054530669. [PMID: 15892236]
  • P L Hughes, P B McKenna, A F Dowling. A survey of the prevalence of emerging macrocyclic lactone resistance and of benzimidazole resistance in sheep nematodes in the lower North Island of New Zealand. New Zealand veterinary journal. 2005 Feb; 53(1):87-90. doi: 10.1080/00480169.2005.36475. [PMID: 15731841]
  • Miwa Okamura, Takao Watanabe, Yoko Kashida, Noboru Machida, Kunitoshi Mitsumori. Possible mechanisms underlying the testicular toxicity of oxfendazole in rats. Toxicologic pathology. 2004 Jan; 32(1):1-8. doi: 10.1080/01926230490260655. [PMID: 14713541]
  • S Sánchez, J Small, D G Jones, Q A McKellar. Dexamethasone decreases plasma levels of the prochiral fenbendazole and its chiral and achiral metabolites in sheep. Xenobiotica; the fate of foreign compounds in biological systems. 2003 Jul; 33(7):731-42. doi: 10.1080/0049825031000089119. [PMID: 12893522]
  • M L Mottier, L I Alvarez, M A Pis, C E Lanusse. Transtegumental diffusion of benzimidazole anthelmintics into Moniezia benedeni: correlation with their octanol-water partition coefficients. Experimental parasitology. 2003 Jan; 103(1-2):1-7. doi: 10.1016/s0014-4894(03)00060-2. [PMID: 12810040]
  • Q A McKellar, C Gokbulut, K Muzandu, H Benchaoui. Fenbendazole pharmacokinetics, metabolism, and potentiation in horses. Drug metabolism and disposition: the biological fate of chemicals. 2002 Nov; 30(11):1230-9. doi: 10.1124/dmd.30.11.1230. [PMID: 12386129]
  • I A Sutherland, I C Moen, D M Leathwick. Increased burdens of drug-resistant nematodes due to anthelmintic treatment. Parasitology. 2002 Oct; 125(Pt 4):375-81. doi: 10.1017/s0031182002002184. [PMID: 12403326]
  • H Hoste, Y Le Frileux, A Pommaret. Comparison of selective and systematic treatments to control nematode infection of the digestive tract in dairy goats. Veterinary parasitology. 2002 Jul; 106(4):345-55. doi: 10.1016/s0304-4017(02)00084-5. [PMID: 12079740]
  • S Sánchez, J Small, D G Jones, Q A McKellar. Plasma achiral and chiral pharmacokinetic behaviour of intravenous oxfendazole co-administered with piperonyl butoxide in sheep. Journal of veterinary pharmacology and therapeutics. 2002 Feb; 25(1):7-13. doi: 10.1046/j.1365-2885.2002.00365.x. [PMID: 11874521]
  • N Sargison, P Scott, F Jackson. Multiple anthelmintic resistance in sheep. The Veterinary record. 2001 Dec; 149(25):778-9. doi: NULL. [PMID: 11808671]
  • H Ziam, V S Pandey, E Elegbe, V Kumar, P Dorny, J F Huntley, L Maes. Drug-abbreviated infections of Trichostrongylus colubriformis and development of immunity in jirds (Meriones unguiculatus). Parasitology research. 2000 Aug; 86(8):647-54. doi: 10.1007/pl00008546. [PMID: 10952264]
  • M B Petersen, C Friis. Pharmacokinetics of fenbendazole following intravenous and oral administration to pigs. American journal of veterinary research. 2000 May; 61(5):573-6. doi: 10.2460/ajvr.2000.61.573. [PMID: 10803655]
  • H D Schallig, W M van der Aar, J H Boersema, A W Cornelissen. The effect of oxfendazole terminated infections with Haemonchus contortus on the development of immunity in sheep. Veterinary parasitology. 2000 Feb; 88(1-2):61-72. doi: 10.1016/s0304-4017(99)00193-4. [PMID: 10681023]
  • S J Andrews. The efficacy of levamisole, and a mixture of oxfendazole and levamisole, against the arrested stages of benzimidazole-resistant Haemonchus contortus and Ostertagia circumcincta in sheep. Veterinary parasitology. 2000 Feb; 88(1-2):139-46. doi: 10.1016/s0304-4017(99)00195-8. [PMID: 10681032]
  • A Vlassoff, S A Bisset, L W McMurtry. Faecal egg counts in Angora goats following natural or experimental challenge with nematode parasites: within-flock variability and repeatabilities. Veterinary parasitology. 1999 Jul; 84(1-2):113-23. doi: 10.1016/s0304-4017(99)00072-2. [PMID: 10435796]
  • M D Rose. A method for the separation of residues of nine compounds in cattle liver related to treatment with oxfendazole. The Analyst. 1999 Jul; 124(7):1023-6. doi: 10.1039/a809058k. [PMID: 10736859]
  • J W Steel, D R Hennessy. Influence of ruminal bypass on the pharmacokinetics and efficacy of benzimidazole anthelmintics in sheep. International journal for parasitology. 1999 Feb; 29(2):305-14. doi: 10.1016/s0020-7519(98)00156-8. [PMID: 10221631]
  • E Claerebout, J Vercruysse, P Dorny, D Demeulenaere, A Dereu. The effect of different infection levels on acquired resistance to gastrointestinal nematodes in artificially infected cattle. Veterinary parasitology. 1998 Feb; 75(2-3):153-67. doi: 10.1016/s0304-4017(97)00218-5. [PMID: 9637217]
  • J Vercruysse, P Dorny, E Claerebout, A Weatherley. Field evaluation of a topical doramectin formulation for the chemoprophylaxis of parasitic bronchitis in calves. Veterinary parasitology. 1998 Feb; 75(2-3):169-79. doi: 10.1016/s0304-4017(97)00210-0. [PMID: 9637218]
  • S K Katiyar, T D Edlind. In vitro susceptibilities of the AIDS-associated microsporidian Encephalitozoon intestinalis to albendazole, its sulfoxide metabolite, and 12 additional benzimidazole derivatives. Antimicrobial agents and chemotherapy. 1997 Dec; 41(12):2729-32. doi: 10.1128/aac.41.12.2729. [PMID: 9420047]
  • M Oukessou, S Chkounda. Effect of diet variations on the kinetic disposition of oxfendazole in sheep. International journal for parasitology. 1997 Nov; 27(11):1347-51. doi: 10.1016/s0020-7519(97)00107-0. [PMID: 9421722]
  • F H Borgsteede, J J Pekelder, D P Dercksen, J Sol, P Vellema, C P Gaasenbeek, J N van der Linden. A survey of anthelmintic resistance in nematodes of sheep in The Netherlands. The veterinary quarterly. 1997 Nov; 19(4):167-72. doi: 10.1080/01652176.1997.9694765. [PMID: 9413114]
  • E Hadas, M Stankiewicz. The results of anthelmintic-abbreviated infections of Trichostrongylus colubriformis and Teladorsagia circumcincta on fecal egg counts in goats on pasture. The Journal of parasitology. 1997 Jun; 83(3):532-3. doi: 10.2307/3284425. [PMID: 9194842]
  • D M Leathwick, C M Miller, A Vlassoff, I A Sutherland. The death rate of Ostertagia circumcincta and Trichostrongylus colubriformis in lactating ewes: implications for anthelmintic resistance. International journal for parasitology. 1997 Apr; 27(4):411-6. doi: 10.1016/s0020-7519(96)00193-2. [PMID: 9184933]
  • S A Spence, G C Fraser, S Chang. Responses in milk production to control of gastrointestinal nematode and paramphistome parasites in dairy cattle. Australian veterinary journal. 1996 Dec; 74(6):456-9. doi: 10.1111/j.1751-0813.1996.tb07569.x. [PMID: 9006864]
  • H Hertzberg, B Durgiai, T Schnieder, L Kohler, J Eckert. Prophylaxis of bovine trichostrongylidosis and dictyocaulosis in the alpine region: comparison of an early and late administration of the oxfendazole pulse release bolus to first year grazing calves. Veterinary parasitology. 1996 Nov; 66(3-4):181-92. doi: 10.1016/s0304-4017(96)01020-5. [PMID: 9017881]
  • I Kyriazakis, D H Anderson, R L Coop, F Jackson. The pathophysiology and development of immunity during long-term subclinical infection with Trichostrongylus colubriformis of sheep receiving different nutritional treatments. Veterinary parasitology. 1996 Oct; 65(1-2):41-54. doi: 10.1016/0304-4017(96)00947-8. [PMID: 8916399]
  • F H Borgsteede, J J Pekelder, D P Dercksen. Anthelmintic resistant nematodes in goats in The Netherlands. Veterinary parasitology. 1996 Oct; 65(1-2):83-7. doi: 10.1016/0304-4017(95)00931-0. [PMID: 8916403]
  • R M Waruiru, E H Weda, R O Otieno, J W Ngotho, H O Bøgh. Comparative efficacies of closantel, ivermectin, oxfendazole, thiophanate and levamisole against thiabendazole resistant Haemonchus contortus in sheep. Tropical animal health and production. 1996 Aug; 28(3):216-20. doi: 10.1007/bf02240938. [PMID: 8888527]
  • Z Ben-Zvi, E Gussarsky, C van Creveld, R Yagil. The bioavailability of febantel in dehydrated camels. Journal of veterinary pharmacology and therapeutics. 1996 Aug; 19(4):288-94. doi: 10.1111/j.1365-2885.1996.tb00051.x. [PMID: 8866457]
  • B C Hosking, T G Watson, D M Leathwick. Multigeneric resistance to oxfendazole by nematodes in cattle. The Veterinary record. 1996 Jan; 138(3):67-8. doi: 10.1136/vr.138.3.67. [PMID: 8629333]
  • M Stankiewicz, W Cabaj, A Pernthaner, W Jonas, B Rabel. Drug-abbreviated infections and development of immunity against Trichostrongylus colubriformis in sheep. International journal for parasitology. 1996 Jan; 26(1):97-103. doi: 10.1016/0020-7519(95)00088-7. [PMID: 9198604]
  • M A Fisher, D E Jacobs. Influence of chemoprophylaxis on protective immunity to nematodes in cattle: a two-year study comparing four control strategies. The Veterinary record. 1995 Dec; 137(23):581-5. doi: NULL. [PMID: 8748170]
  • J J Vermunt, D M West, W E Pomroy. Multiple resistance to ivermectin and oxfendazole in Cooperia species of cattle in New Zealand. The Veterinary record. 1995 Jul; 137(2):43-5. doi: 10.1136/vr.137.2.43. [PMID: 8525583]
  • C E Lanusse, L H Gascon, R K Prichard. Comparative plasma disposition kinetics of albendazole, fenbendazole, oxfendazole and their metabolites in adult sheep. Journal of veterinary pharmacology and therapeutics. 1995 Jun; 18(3):196-203. doi: 10.1111/j.1365-2885.1995.tb00578.x. [PMID: 7674455]
  • J Landuyt, M Debackere, J Vercruysse, Q McKellar. The influence of a heavy infection with sensitive and resistant strains of Ostertagia circumcincta and with Trichostrongylus colubriformis on the pharmacokinetics of febantel in lambs. Journal of veterinary pharmacology and therapeutics. 1995 Jun; 18(3):180-6. doi: 10.1111/j.1365-2885.1995.tb00576.x. [PMID: 7674453]
  • C E Lanusse, L H Gascon, R K Prichard. Influence on the antithyroid compound methimazole on the plasma disposition of fenbendazole and oxfendazole in sheep. Research in veterinary science. 1995 May; 58(3):222-6. doi: 10.1016/0034-5288(95)90106-x. [PMID: 7659845]
  • D N Ali, D R Hennessy. The effect of level of feed intake on the pharmacokinetic disposition of oxfendazole in sheep. International journal for parasitology. 1995 Jan; 25(1):63-70. doi: 10.1016/0020-7519(94)e0054-q. [PMID: 7797374]
  • N V Chebyshev, I A Berechikidze. [The pathomorphological changes in the kidneys of white mice with experimental trichocephaliasis and after the use of anthelmintic preparations]. Meditsinskaia parazitologiia i parazitarnye bolezni. 1994 Jul; ?(3):36-9. doi: NULL. [PMID: 7799855]
  • H T Purvis, J C Whittier, S L Boyles, L J Johnson, H D Ritchie, S R Rust, D B Faulkner, R P Lemenager, K S Hendrix. Weight gain and reproductive performance of spring-born beef heifer calves intraruminally administered oxfendazole. Journal of animal science. 1994 Apr; 72(4):817-23. doi: 10.2527/1994.724817x. [PMID: 8014145]
  • P K Sanyal. Pharmacokinetic behaviour of fenbendazole in buffalo and cattle. Journal of veterinary pharmacology and therapeutics. 1994 Feb; 17(1):1-4. doi: 10.1111/j.1365-2885.1994.tb00513.x. [PMID: 8196087]
  • M Stankiewicz, W Cabaj, W E Jonas, L G Moore, W N Chie. Oxfendazole treatment of non-parasitized lambs and its effect on the immune system. Veterinary research communications. 1994; 18(1):7-18. doi: 10.1007/bf01839256. [PMID: 8091642]
  • P K Sanyal. Plasma levels of fenbendazole metabolites in buffalo and cattle after long-term intraruminal administration. The veterinary quarterly. 1993 Dec; 15(4):157-9. doi: 10.1080/01652176.1993.9694396. [PMID: 8122352]
  • D R Hennessy, N C Sangster, J W Steel, G H Collins. Comparative kinetic disposition of oxfendazole in sheep and goats before and during infection with Haemonchus contortus and Trichostrongylus colubriformis. Journal of veterinary pharmacology and therapeutics. 1993 Sep; 16(3):245-53. doi: 10.1111/j.1365-2885.1993.tb00171.x. [PMID: 8230395]
  • M Debackere, J Landuyt, J Vercruysse, Q McKellar. The influence of Ostertagia circumcincta and Trichostrongylus colubriformis infections on the pharmacokinetics of febantel in lambs. Journal of veterinary pharmacology and therapeutics. 1993 Sep; 16(3):261-74. doi: 10.1111/j.1365-2885.1993.tb00173.x. [PMID: 8230397]
  • D Gray, G B Mitchell, R E Purnell. Efficacy of morantel citrate against benzimidazole resistant field strains of Ostertagia circumcincta. The Veterinary record. 1993 Jun; 132(26):657-8. doi: 10.1136/vr.132.26.657. [PMID: 8362473]
  • K G Wardhaugh, R J Mahon, A Axelsen, M W Rowland, W Wanjura. Effects of ivermectin residues in sheep dung on the development and survival of the bushfly, Musca vetustissima Walker and a scarabaeine dung beetle, Euoniticellus fulvus Goeze. Veterinary parasitology. 1993 Jun; 48(1-4):139-57. doi: 10.1016/0304-4017(93)90151-c. [PMID: 8346628]
  • H Hilderson, J Vercruysse, D C de Graaf, P Bastiaensen, J Fransen, P Berghen. The presence of an early L4 larvae population in relation to the immune response of calves against Ostertagia ostertagi. Veterinary parasitology. 1993 May; 47(3-4):255-66. doi: 10.1016/0304-4017(93)90027-k. [PMID: 8333131]
  • J Landuyt, M Debackere, F Delbeke, Q McKellar. A high performance liquid chromatographic method for the determination of febantel and its major metabolites in lamb plasma. Biomedical chromatography : BMC. 1993 Mar; 7(2):78-81. doi: 10.1002/bmc.1130070206. [PMID: 8485378]
  • I A Barger, J W Steel, B R Rodden. Effects of a controlled-release albendazole capsule on parasitism and production from grazing Merino ewes and lambs. Australian veterinary journal. 1993 Feb; 70(2):41-8. doi: 10.1111/j.1751-0813.1993.tb15136.x. [PMID: 8457171]
  • P K Sanyal. The uptake of fenbendazole by cattle and buffalo following long-term low-level administration in urea-molasses blocks: further studies on block formulations. Veterinary research communications. 1993; 17(4):325-31. doi: 10.1007/bf01839223. [PMID: 8146957]
  • D N Ali, B F Chick. The effect of an oil formulation on the systemic availability of oxfendazole. International journal for parasitology. 1992 Jul; 22(4):541-3. doi: 10.1016/0020-7519(92)90158-h. [PMID: 1644532]
  • D N Ali, B F Chick. Effect of feed type on the pharmacokinetic disposition of oxfendazole in sheep. Research in veterinary science. 1992 May; 52(3):382-3. doi: 10.1016/0034-5288(92)90042-z. [PMID: 1620973]
  • W Hollanders, P Berghen, P Dorny, H Hilderson, J Vercruysse, W G Ryan. Prevention of parasitic gastroenteritis and parasitic bronchitis in first and second season grazing cattle. The Veterinary record. 1992 Apr; 130(16):355-6. doi: 10.1136/vr.130.16.355. [PMID: 1534429]
  • V H Suarez, M R Busetti, M C Fort. Epidemiology and effects of nematode infections on beef cow-calf systems of Argentina's western pampas. Veterinary parasitology. 1992 Apr; 42(1-2):73-81. doi: 10.1016/0304-4017(92)90104-h. [PMID: 1615632]
  • D R Hennessy, J W Steel, R K Prichard, E Lacey. The effect of co-administration of parbendazole on the disposition of oxfendazole in sheep. Journal of veterinary pharmacology and therapeutics. 1992 Mar; 15(1):10-8. doi: 10.1111/j.1365-2885.1992.tb00981.x. [PMID: 1573698]
  • E T Lyons, J H Drudge, S C Tolliver, D E Granstrom, S Stamper. Evaluation of exclusive use of ivermectin vs alternation of antiparasitic compounds for control of internal parasites of horses. American journal of veterinary research. 1992 Jan; 53(1):97-104. doi: NULL. [PMID: 1539922]
  • E T Lyons, J H Drudge, S C Tolliver, S Stamper. Controlled tests on activity of contemporary parasiticides on natural infections of helminths in lambs, with emphasis on strains of Haemonchus contortus isolated in 1955. American journal of veterinary research. 1992 Jan; 53(1):91-6. doi: NULL. [PMID: 1539921]