2-Hydroxyvaleric acid (BioDeep_00000017753)

 

Secondary id: BioDeep_00000265238, BioDeep_00000398352, BioDeep_00000400463, BioDeep_00000595726

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite


代谢物信息卡片


alpha-Hydroxy-N-valeric acid

化学式: C5H10O3 (118.06299100000001)
中文名称: 2-羟基戊酸
谱图信息: 最多检出来源 Viridiplantae(plant) 0.88%

分子结构信息

SMILES: CCCC(C(=O)O)O
InChI: InChI=1S/C5H10O3/c1-2-3-4(6)5(7)8/h4,6H,2-3H2,1H3,(H,7,8)

描述信息

2-Hydroxyvaleric acid is an organic acid present in human biofluids. Its presence in urine has been associated with lactic acidosis, which occurs in Succinic Acidemia (OMIM 600335), a syndrome of organic acidemia associated with congenital lactic acidosis and decreased NADH-cytochrome c reductase activity. 2-Hydroxyvaleric acid presence associated with lactic acidosis has also been found in Propionyl-CoA carboxylase deficiency (OMIM 253260), or Multiple carboxylase deficiency (MCD), an autosomal recessive metabolic disorder characterized primarily by cutaneous and neurologic abnormalities. (PMID: 9389332, 1790187, 3378323, 3383430, 7313494) [HMDB]
2-Hydroxyvaleric acid is an organic acid present in human biofluids. Its presence in urine has been associated with lactic acidosis, which occurs in Succinic Acidemia (OMIM 600335), a syndrome of organic acidemia associated with congenital lactic acidosis and decreased NADH-cytochrome c reductase activity. 2-Hydroxyvaleric acid presence associated with lactic acidosis has also been found in Propionyl-CoA carboxylase deficiency (OMIM 253260), or Multiple carboxylase deficiency (MCD), an autosomal recessive metabolic disorder characterized primarily by cutaneous and neurologic abnormalities. (PMID: 9389332, 1790187, 3378323, 3383430, 7313494).

同义名列表

24 个代谢物同义名

alpha-Hydroxy-N-valeric acid; (+-)-2-Hydroxypentanoic acid; pentanoic acid, 2-hydroxy-; alpha-Hydroxyvaleric acid; DL-2-hydroxy valeric acid; (S)-2-Hydroxyvaleric Acid; a-Hydroxy-N-valeric acid; alpha-Hydroxy-N-valerate; 2-hydroxy-pentanoic acid; (+-)-2-Hydroxypentanoate; Α-hydroxy-N-valeric acid; 2-Hydroxypentanoic acid; Α-hydroxyvaleric acid; 2-Hydroxyvaleric acid; DL-2-Hydroxy valerate; alpha-Hydroxyvalerate; a-Hydroxyvaleric acid; 2-Hydroxy-pentanoate; a-Hydroxy-N-valerate; Α-hydroxy-N-valerate; 2-Hydroxypentanoate; 2-Hydroxyvalerate; a-Hydroxyvalerate; Α-hydroxyvalerate



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Oliver Fiehn, W Timothy Garvey, John W Newman, Kerry H Lok, Charles L Hoppel, Sean H Adams. Plasma metabolomic profiles reflective of glucose homeostasis in non-diabetic and type 2 diabetic obese African-American women. PloS one. 2010 Dec; 5(12):e15234. doi: 10.1371/journal.pone.0015234. [PMID: 21170321]
  • Jianghua Feng, Huili Liu, Limin Zhang, Kishore Bhakoo, Lehui Lu. An insight into the metabolic responses of ultra-small superparamagnetic particles of iron oxide using metabonomic analysis of biofluids. Nanotechnology. 2010 Oct; 21(39):395101. doi: 10.1088/0957-4484/21/39/395101. [PMID: 20820093]
  • Claire L Gavaghan McKee, Ian D Wilson, Jeremy K Nicholson. Metabolic phenotyping of nude and normal (Alpk:ApfCD, C57BL10J) mice. Journal of proteome research. 2006 Feb; 5(2):378-84. doi: 10.1021/pr050255h. [PMID: 16457604]
  • Yu Momose, Tsuyoshi Maekawa, Tohru Yamano, Mitsuru Kawada, Hiroyuki Odaka, Hitoshi Ikeda, Takashi Sohda. Novel 5-substituted 2,4-thiazolidinedione and 2,4-oxazolidinedione derivatives as insulin sensitizers with antidiabetic activities. Journal of medicinal chemistry. 2002 Mar; 45(7):1518-34. doi: 10.1021/jm010490l. [PMID: 11906293]