isoborneol (BioDeep_00000015046)
Main id: BioDeep_00000619422
PANOMIX_OTCML-2023
描述信息
(-)-isoborneol, also known as isoborneol, (1r-endo)-isomer, is a member of the class of compounds known as bicyclic monoterpenoids. Bicyclic monoterpenoids are monoterpenoids containing exactly 2 rings, which are fused to each other (-)-isoborneol is practically insoluble (in water) and an extremely weak acidic compound (based on its pKa). Within the cell, (-)-isoborneol is primarily located in the membrane (predicted from logP). It can also be found in the extracellular space.
Isoborneol ((±)-Isoborneol) is a monoterpenoid alcohol present in the essential oils of numerous medicinal plants and has antioxidant and antiviral properties. Isoborneol is a potent inhibitor of herpes simplex virus type 1 (HSV-1)[1][2].
Isoborneol ((±)-Isoborneol) is a monoterpenoid alcohol present in the essential oils of numerous medicinal plants and has antioxidant and antiviral properties. Isoborneol is a potent inhibitor of herpes simplex virus type 1 (HSV-1)[1][2].
同义名列表
数据库引用编号
16 个数据库交叉引用编号
- KEGG: C01766
- PubChem: 6850744
- PubChem: 439569
- Metlin: METLIN41071
- foodb: FDB009636
- CAS: 124-76-5
- CAS: 464-45-9
- ChEBI: CHEBI:15394
- PubChem: 4899
- LipidMAPS: LMPR0102120004
- KNApSAcK: C00011024
- 3DMET: B04812
- NIKKAJI: J9.306H
- RefMet: Isoborneol
- medchemexpress: HY-N2004
- KNApSAcK: 15394
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
2 个相关的代谢反应过程信息。
Reactome(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
8 个相关的物种来源信息
- 35608 - Artemisia Annua L.: -
- 265785 - Atractylodes Macrocephala Koidz.: -
- 313920 - Blumea balsamifera DC.: -
- 714477 - Homalomena Occulta (Lour.) Schott: -
- 124772 - Illicium Difengpi K. L. B. Et K. I. M.: -
- 85864 - Magnolia Officinalis Rehd Et Wils\uff0e: -
- 33090 - Plants: -
- 94328 - Zingiber Officinale Roscoe: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Yuqi Mei, Yan Chen, Haoyue Zhang, Wenxiang Fan, Longchan Liu, Ziying Wang, Jinyuan Wang, Linhong Fan, Aizhen Xiong, Li Yang, Zhengtao Wang. Borneol acts as an adjuvant agent to enhance the oral absorption of Panax notoginseng saponins in rats: Effect of optical configuration and compatibility ratios.
Journal of ethnopharmacology.
2024 Sep; 331(?):118331. doi:
10.1016/j.jep.2024.118331. [PMID: 38734392] - Minyi Tian, Dan Xie, Yi Hong, Furong Ding, Xia Wu, Dongxin Tang. Anti-inflammatory effects and related mechanisms in vitro and in vivo of Hedychium coccineum rhizome essential oil.
Journal of ethnopharmacology.
2024 Jun; 328(?):118103. doi:
10.1016/j.jep.2024.118103. [PMID: 38527573] - Xiaofeng Zhang, Fengjiao Deng, Xueqing Wang, Fanghan Liu, Yue Zhu, Bin Yu, Ming Ruan. Synergistic amelioration between Ligusticum striatum DC and borneol against cerebral ischemia by promoting astrocytes-mediated neurogenesis.
Journal of ethnopharmacology.
2024 Jun; 327(?):118062. doi:
10.1016/j.jep.2024.118062. [PMID: 38492790] - Miao Luo, Jinfeng He, Liang Yin, Ping Zhan, Zhongqiu Zhao, Hui Xiong, Zhinan Mei. Borneol exerts its antipruritic effects by inhibiting TRPA1 and activating TRPM8.
Journal of ethnopharmacology.
2024 Mar; 322(?):117581. doi:
10.1016/j.jep.2023.117581. [PMID: 38103845] - Peiwu Xie, Qiyi Yang, Jielian Chen, Tieyao Tu, Huiming Lian, Boxiang He, Yanling Cai. Unpredictable Chemical Diversity of Essential Oils in Cinnamomum burmanni (Lauraceae) Living Collections: Beyond Maternally Inherited Phylogenetic Relationships.
Molecules (Basel, Switzerland).
2024 Mar; 29(6):. doi:
10.3390/molecules29061206. [PMID: 38542843] - Guodong Chen, Jialong Yang, An Wang, Jiapeng Deng, Kaitao Wang, Minle Ye, Qingyu Chen, Xinye Wang, Xinyu Wu, Dingsheng Lin. L-Borneol promotes skin flap survival by regulating HIF-1α/NF-κB pathway.
Journal of ethnopharmacology.
2024 Mar; 321(?):117543. doi:
10.1016/j.jep.2023.117543. [PMID: 38056540] - Liang Fang, Junying Li, Hongyan Cheng, Huanhuan Liu, Caiyun Zhang. Dual fluorescence images, transport pathway, and blood-brain barrier penetration of B-Met-W/O/W SE.
International journal of pharmaceutics.
2024 Jan; 652(?):123854. doi:
10.1016/j.ijpharm.2024.123854. [PMID: 38280499] - Dongyuan Wang, Dan Wang, Qipeng Jin, Xiaolong Wang. Suxiao Jiuxin Pill alleviates myocardial ischemia/reperfusion-induced autophagy via miR-193a-3p/ALKBH5 pathway.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Jan; 125(?):155359. doi:
10.1016/j.phymed.2024.155359. [PMID: 38301300] - Yang Liu, Jia-Yu Cai, Yang Liu, Lu Zhang, Rui-Bo Guo, Xue-Tao Li, Ling-Yue Ma, Liang Kong. Borneol-modified docetaxel plus tetrandrine micelles for treatment of drug-resistant brain glioma.
Drug development and industrial pharmacy.
2024 Jan; ?(?):1-15. doi:
10.1080/03639045.2024.2302886. [PMID: 38235554] - Tianyu Huang, Meng Lai, Zhenwei Lin, Ruiqi Luo, Xuezheng Xiang, Haozhe Xu, Ning Pan, Zhaojiang Zuo. Identification of algicidal monoterpenoids from four chemotypes of Cinnamomum camphora and their algicidal mechanisms on Microcystis aeruginosa.
Environmental research.
2024 Jan; 241(?):117714. doi:
10.1016/j.envres.2023.117714. [PMID: 37989462] - Feng-Rui Li, Yang Yu, Yu-Meng Du, Liang Kong, Yang Liu, Jia-Hua Wang, Mu-Han Chen, Mo Liu, Zi-Xu Zhang, Xue-Tao Li, Rui-Jun Ju. Borneol-Modified Schisandrin B Micelles Cross the Blood-Brain Barrier To Treat Alzheimer's Disease in Aged Mice.
ACS chemical neuroscience.
2024 Jan; ?(?):. doi:
10.1021/acschemneuro.3c00625. [PMID: 38214579] - Zhijie Zhao, Xiao Fan, Xinyu Li, Yuwei Qiu, Yunfeng Yi, Yuping Wei, Yong Wang. All-Natural Injectable Antibacterial Hydrogel Enabled by Chitosan and Borneol.
Biomacromolecules.
2024 Jan; 25(1):134-142. doi:
10.1021/acs.biomac.3c00874. [PMID: 38145887] - Luting Lin, Jingming Luo, Zeng Wang, Xinjun Cai. Borneol promotes autophagic degradation of HIF-1α and enhances chemotherapy sensitivity in malignant glioma.
PeerJ.
2024; 12(?):e16691. doi:
10.7717/peerj.16691. [PMID: 38188151] - Qian Xie, Danni Lu, Jianmei Yuan, Mihong Ren, Yong Li, Jiajun Wang, Rong Ma, Jian Wang. l-borneol promotes neurovascular unit protection in the subacute phase of transient middle cerebral artery occlusion rats: p38-MAPK pathway activation, anti-inflammatory, and anti-apoptotic effect.
Phytotherapy research : PTR.
2023 Sep; 37(9):4166-4184. doi:
10.1002/ptr.7878. [PMID: 37310024] - Xiaojing Lin, Linxuan Huang, Huilin Liang, Chen Hou, Xuli Ling, Yuanxia Chen, Peng Yang, Qingwen Wu, Haiying Zhao, Sirong Wu, Ruoting Zhan, Dongming Ma, Jinfen Yang. Genome-wide identification and functional characterization of borneol dehydrogenases in Wurfbainia villosa.
Planta.
2023 Aug; 258(4):69. doi:
10.1007/s00425-023-04221-0. [PMID: 37608037] - Rong Ma, Danni Lu, Jian Wang, Qian Xie, Jialiang Guo. Comparison of pharmacological activity and safety of different stereochemical configurations of borneol: L-borneol, D-borneol, and synthetic borneol.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Jun; 164(?):114668. doi:
10.1016/j.biopha.2023.114668. [PMID: 37321057] - Weifeng Tian, Dongmei He, Jingjing Liu, Feiyu Chen, Wenjie Zhang, Jinsheng Hu, Shu Wang. Topical borneol relieves nonhistaminergic pruritus via targeting TRPA1 and TRPM8 channels in peripheral nerve terminals of mice.
European journal of pharmacology.
2023 Jun; 953(?):175833. doi:
10.1016/j.ejphar.2023.175833. [PMID: 37290679] - Zhiyong Xu, Junhui Chen, Ruifeng Shang, Fan Yang, Chuanqi Xie, Yunfei Liu, Xuefang Wen, Jianping Fu, Wei Xiong, Lei Wu. The Mosquito Larvicidal Activity of Lignans from Branches of Cinnamomum camphora chvar. Borneol.
Molecules (Basel, Switzerland).
2023 Apr; 28(9):. doi:
10.3390/molecules28093769. [PMID: 37175177] - Huang Ding, Xiao-Ping Huang, Xiao-Dan Liu, Yan-Ling Li, San Tang, Hai-Long Xiong, Mei-Ting Huang, Ying Li, Cai-Xia Liu, Wei Zhang, Chang-Qing Deng. Effects of borneol combined with astragaloside IV and Panax notoginseng saponins regulation of microglia polarization to promote neurogenesis after cerebral ischaemia.
The Journal of pharmacy and pharmacology.
2023 Apr; ?(?):. doi:
10.1093/jpp/rgad033. [PMID: 37185938] - Dongli Qi, Huihui Li, Chunxia Liang, Peijin Peng, Zhen Yang, Yanquan Gao, Ziwei Li, Qingqing Zhang, Zhidong Liu. Herb-drug interaction of Xingnaojing injection and Edaravone via pharmacokinetics, mixed inhibition of UGTs, and molecular docking.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2023 Apr; 112(?):154696. doi:
10.1016/j.phymed.2023.154696. [PMID: 36764095] - Yu Wang, Xiao-Yun Qiu, Jia-Ying Liu, Bei Tan, Fei Wang, Min-Juan Sun, Xu-Hong Jiang, Xu-Ming Ji, Ceng-Lin Xu, Yi Wang, Zhong Chen. (+)-Borneol enantiomer ameliorates epileptic seizure via decreasing the excitability of glutamatergic transmission.
Acta pharmacologica Sinica.
2023 Mar; ?(?):. doi:
10.1038/s41401-023-01075-w. [PMID: 36973542] - Wenting Su, Congyan Liu, Xi Jiang, Yanli Lv, Qin Chen, Jiachen Shi, Huangqin Zhang, Qiuling Ma, Chang Ge, Fei Kong, Xiaoqi Li, Yuping Liu, Yan Chen, Ding Qu. An intravitreal-injectable hydrogel depot doped borneol-decorated dual-drug-coloaded microemulsions for long-lasting retina delivery and synergistic therapy of wAMD.
Journal of nanobiotechnology.
2023 Mar; 21(1):71. doi:
10.1186/s12951-023-01829-y. [PMID: 36859261] - Xuan Ni, Xiaoyu Yin, Chelimuge Qi, Chunyu Liu, Hao Chen, Yini Zhou, Wuliji Ao, Shuyin Bao, Jiangdong Xue, Jingfeng Yang, Wu Dong. Cardiotoxicity of (-)-borneol, (+)-borneol, and isoborneol in zebrafish embryos is associated with Na+ /K+ -ATPase and Ca2+ -ATPase inhibition.
Journal of applied toxicology : JAT.
2023 Mar; 43(3):373-386. doi:
10.1002/jat.4388. [PMID: 36062847] - Dan-Ni Lu, Qian Xie, Zhuo Xu, Jian-Mei Yuan, Rong Ma, Jian Wang. [Protective effects of three kinds of borneol on different brain regions in acute cerebral ischemia/reperfusion model rats].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2023 Mar; 48(5):1289-1299. doi:
10.19540/j.cnki.cjcmm.20221025.406. [PMID: 37005813] - Yu Long, Songyu Liu, Jinyan Wan, Yulu Zhang, Dan Li, Shuang Yu, Ai Shi, Nan Li, Fei He. Brain targeted borneol-baicalin liposome improves blood-brain barrier integrity after cerebral ischemia-reperfusion injury via inhibiting HIF-1α/VEGF/eNOS/NO signal pathway.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Feb; 160(?):114240. doi:
10.1016/j.biopha.2023.114240. [PMID: 36731339] - Marwa Chraibi, Mouhcine Fadil, Abdellah Farah, Nesrine Benkhaira, Sara Lebrazi, Kawtar Fikri-Benbrahim. Simplex-centroid design as innovative approach in the optimization of antimicrobial effect of Thymus satureioides, Myrtus communis and Artemisia herba alba essential oils against Escherichia coli, Staphylococcus aureus and Candidatropicalis.
Experimental parasitology.
2023 Jan; 247(?):108472. doi:
10.1016/j.exppara.2023.108472. [PMID: 36693583] - Zerui Yang, Ting Zhan, Chunzhu Xie, Song Huang, Xiasheng Zheng. Genome-wide analyzation and functional characterization on the TPS family provide insight into the biosynthesis of mono-terpenes in the camphor tree.
Plant physiology and biochemistry : PPB.
2023 Jan; 196(?):55-64. doi:
10.1016/j.plaphy.2023.01.039. [PMID: 36696798] - Ting Zhang, Yongjie Zheng, Chao Fu, Haikuan Yang, Xinliang Liu, Fengying Qiu, Xindong Wang, Zongde Wang. Chemical Variation and Environmental Influence on Essential Oil of Cinnamomum camphora.
Molecules (Basel, Switzerland).
2023 Jan; 28(3):. doi:
10.3390/molecules28030973. [PMID: 36770639] - Yuqi Mei, Linnan Li, Linghong Fan, Wenxiang Fan, Longchan Liu, Fangli Zhang, Zhizhi Hu, Kang Wang, Li Yang, Zhengtao Wang. The history, stereochemistry, ethnopharmacology and quality assessment of borneol.
Journal of ethnopharmacology.
2023 Jan; 300(?):115697. doi:
10.1016/j.jep.2022.115697. [PMID: 36087846] - Ayelign M Adal, Elaheh Najafianashrafi, Lukman S Sarker, Soheil S Mahmoud. Cloning, functional characterization and evaluating potential in metabolic engineering for lavender ( +)-bornyl diphosphate synthase.
Plant molecular biology.
2023 Jan; 111(1-2):117-130. doi:
10.1007/s11103-022-01315-3. [PMID: 36271988] - L Liu, Y Yang, F Yang, Y Lin, K Liu, X Wang, Y Zhang. A mechanistic investigation about hepatoxic effects of borneol using zebrafish.
Human & experimental toxicology.
2023 Jan; 42(?):9603271221149011. doi:
10.1177/09603271221149011. [PMID: 36594174] - Wenzhe Yang, Xue Pan, Peng Zhang, Xue Yang, Huashi Guan, Huan Dou, Qian Lu. Defeating Melanoma Through a Nano-Enabled Revision of Hypoxic and Immunosuppressive Tumor Microenvironment.
International journal of nanomedicine.
2023; 18(?):3711-3725. doi:
10.2147/ijn.s414882. [PMID: 37435153] - Abdellatif Alami, Abdelhakim El Ouali Lalami, Saoussan Annemer, Fouad El-Akhal, Yassine Ez Zoubi, Abdellah Farah. Chemical Composition and Larvicidal Properties of Essential Oils from Wild and Cultivated Artemisia campestris L., an Endemic Plant in Morocco.
TheScientificWorldJournal.
2023; 2023(?):5748133. doi:
10.1155/2023/5748133. [PMID: 37849964] - Rong Ma, Danni Lu, Qian Xie, Jianmei Yuan, Mihong Ren, Yong Li, Jiajun Wang, Jinxiu Li, Zhuo Xu, Jian Wang. l-Borneol and d-Borneol promote transdifferentiation of astrocytes into neurons in rats by regulating Wnt/Notch pathway to exert neuroprotective effect during recovery from cerebral ischaemia.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2023 Jan; 109(?):154583. doi:
10.1016/j.phymed.2022.154583. [PMID: 36610167] - Xin Guan, Jianbing Wu, Jiahui Geng, Duorui Ji, Dasha Wei, Yong Ling, Yihua Zhang, Guojun Jiang, Tao Pang, Zhangjian Huang. A Novel Hybrid of Telmisartan and Borneol Ameliorates Neuroinflammation and White Matter Injury in Ischemic Stroke Through ATF3/CH25H Axis.
Translational stroke research.
2022 Dec; ?(?):. doi:
10.1007/s12975-022-01121-5. [PMID: 36577854] - Yu Wen, Zuxian Zhang, Zhongmou Cai, Baoning Liu, Zhehao Wu, Yude Liu. Ligustrazine-Loaded Borneol Liposome Alleviates Cerebral Ischemia-Reperfusion Injury in Rats.
ACS biomaterials science & engineering.
2022 11; 8(11):4930-4941. doi:
10.1021/acsbiomaterials.2c00847. [PMID: 36227861] - Zunzhe Tian, Peng Zeng, Xiaoyun Lu, Tinggan Zhou, Yuwei Han, Yingmei Peng, Yunxue Xiao, Botong Zhou, Xue Liu, Yongting Zhang, Yang Yu, Qiong Li, Hang Zong, Feining Zhang, Huifeng Jiang, Juan He, Jing Cai. Thirteen Dipterocarpoideae genomes provide insights into their evolution and borneol biosynthesis.
Plant communications.
2022 11; 3(6):100464. doi:
10.1016/j.xplc.2022.100464. [PMID: 36303430] - Jia-Yu Li, Jin-Xin Wang, Qiu-Hao Li, Xiao-Feng Li, Jun-Ping Xiao, Shan-Shan Li, Xiu-Ping Shen, Wei-Dong Zhang, Yun-Heng Shen. Natural borneol enhances the anti-cerebral ischaemia efficacy of formononetin in MCAO/R rats by promoting its delivery in the brain.
The Journal of pharmacy and pharmacology.
2022 Nov; 74(11):1598-1608. doi:
10.1093/jpp/rgac070. [PMID: 36106815] - Jinxiu Li, Jianmei Yuan, Yong Li, Jian Wang, Qian Xie, Rong Ma, Jiajun Wang, Mihong Ren, Danni Lu, Zhuo Xu. d-Borneol enhances cisplatin sensitivity via autophagy dependent EMT signaling and NCOA4-mediated ferritinophagy.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Nov; 106(?):154411. doi:
10.1016/j.phymed.2022.154411. [PMID: 36030746] - Sharareh Najafian, Mahmoud Afshar, Mohsen Radi. Annual Phytochemical Variations and Antioxidant Activity within the Aerial Parts of Lavandula angustifolia, an Evergreen Medicinal Plant.
Chemistry & biodiversity.
2022 Oct; 19(10):e202200536. doi:
10.1002/cbdv.202200536. [PMID: 36099157] - Igor A Schepetkin, Gulmira Özek, Temel Özek, Liliya N Kirpotina, Andrei I Khlebnikov, Mark T Quinn. Neutrophil Immunomodulatory Activity of (-)-Borneol, a Major Component of Essential Oils Extracted from Grindelia squarrosa.
Molecules (Basel, Switzerland).
2022 Jul; 27(15):. doi:
10.3390/molecules27154897. [PMID: 35956847] - Jinxiu Li, Jianmei Yuan, Yong Li, Jian Wang, Daoyin Gong, Qian Xie, Rong Ma, Jiajun Wang, Mihong Ren, Danni Lu, Zhuo Xu. d-Borneol enhances cisplatin sensitivity via p21/p27-mediated S-phase arrest and cell apoptosis in non-small cell lung cancer cells and a murine xenograft model.
Cellular & molecular biology letters.
2022 Jul; 27(1):61. doi:
10.1186/s11658-022-00362-4. [PMID: 35883026] - Olga I Yarovaya, Dmitriy N Shcherbakov, Sophia S Borisevich, Anastasiya S Sokolova, Maxim A Gureev, Edward M Khamitov, Nadezda B Rudometova, Anastasiya V Zybkina, Ekaterina D Mordvinova, Anna V Zaykovskaya, Artem D Rogachev, Oleg V Pyankov, Rinat A Maksyutov, Nariman F Salakhutdinov. Borneol Ester Derivatives as Entry Inhibitors of a Wide Spectrum of SARS-CoV-2 Viruses.
Viruses.
2022 06; 14(6):. doi:
10.3390/v14061295. [PMID: 35746766] - Kyohei Fukuda, Masayoshi Uefune, Hidehiro Fukaki, Yasuo Yamauchi, Ikuko Hara-Nishimura, Rika Ozawa, Kenji Matsui, Koichi Sugimoto, Kazunori Okada, Ryozo Imai, Kenshi Takahashi, Shinichi Enami, René Wurst, Junji Takabayashi. Aerial (+)-borneol modulates root morphology, auxin signalling and meristematic activity in Arabidopsis roots.
Biology letters.
2022 05; 18(5):20210629. doi:
10.1098/rsbl.2021.0629. [PMID: 35506238] - Mickael S Luz, Danilo D A Gadelha, Kaio J S Andrade, Renata A Travassos, Juliene D Ribeiro, Alynne Carvalho-Galvão, Josiane C Cruz, Camille M Balarini, Valdir A Braga, Maria S França-Falcão. Borneol reduces sympathetic vasomotor hyperactivity and restores depressed baroreflex sensitivity in rats with renovascular hypertension.
Hypertension research : official journal of the Japanese Society of Hypertension.
2022 05; 45(5):802-813. doi:
10.1038/s41440-022-00868-6. [PMID: 35194168] - Dayong Zheng, Yang Chu, Shuming Li, Shuiping Zhou, Wei Li, Yuesheng Xie, He Sun. Enhancing effect of borneol on pharmacokinetics of ginsenoside Rb1 , ginsenoside Rg1 , and notoginsenoside R1 in healthy volunteers after oral administration of compound Danshen dropping pills.
Biomedical chromatography : BMC.
2022 May; 36(5):e5311. doi:
10.1002/bmc.5311. [PMID: 34981536] - Qian Xie, Jinxiu Li, Taiwei Dong, Jianmei Yuan, Danni Lu, Rong Ma, Hongyan Li, Yong Li, Mihong Ren, Hai Chen, Jian Wang. Neuroprotective effects of synthetic borneol and natural borneol based on the neurovascular unit against cerebral ischaemic injury.
The Journal of pharmacy and pharmacology.
2022 Feb; 74(2):236-249. doi:
10.1093/jpp/rgab167. [PMID: 34888686] - H Yu, X Ren, F Yang, Y Xie, Y Guo, Y Cheng, W Yao. Antimicrobial and anti-dust mite efficacy of Cinnamomum camphora chvar. Borneol essential oil using pilot-plant neutral cellulase-assisted steam distillation.
Letters in applied microbiology.
2022 Feb; 74(2):258-267. doi:
10.1111/lam.13610. [PMID: 34822727] - Qiu-Yan Zhu, San Tang, Xiao-Qian Yang, Huang Ding, Xiao-Dan Liu, Xin-Bing Zeng, Xiao-Ping Huang, Chang-Qing Deng. Borneol enhances the protective effect against cerebral ischemia/reperfusion injury by promoting the access of astragaloside IV and the components of Panax notoginseng saponins into the brain.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Jan; 94(?):153822. doi:
10.1016/j.phymed.2021.153822. [PMID: 34763313] - Nian Chen, Jing Wen, Zhilei Wang, Jian Wang. Multiple regulation and targeting effects of borneol in the neurovascular unit in neurodegenerative diseases.
Basic & clinical pharmacology & toxicology.
2022 Jan; 130(1):5-19. doi:
10.1111/bcpt.13656. [PMID: 34491621] - Jui-Feng Lin, Yen-Shuo Liu, Yu-Chuen Huang, Chih-Wen Chi, Cheng-Chia Tsai, Tung-Hu Tsai, Yu-Jen Chen. Borneol and Tetrandrine Modulate the Blood-Brain Barrier and Blood-Tumor Barrier to Improve the Therapeutic Efficacy of 5-Fluorouracil in Brain Metastasis.
Integrative cancer therapies.
2022 Jan; 21(?):15347354221077682. doi:
10.1177/15347354221077682. [PMID: 35168384] - Luting Wang, Lin Xu, Junfeng Du, Xiao Zhao, Mei Liu, Jianfang Feng, Kaili Hu. Nose-to-brain delivery of borneol modified tanshinone IIA nanoparticles in prevention of cerebral ischemia/reperfusion injury.
Drug delivery.
2021 Dec; 28(1):1363-1375. doi:
10.1080/10717544.2021.1943058. [PMID: 34180761] - Xuting Li, Sicong Li, Bin Wang, Min Zhang, Dingsheng Yuan, Jinliang Li, Ge Liang. Borneol influences the pharmacokinetics of florfenicol through regulation of cytochrome P450 1A2 (CYP1A2), CYP2C11, CYP3A1, and multidrug resistance 1 (MDR1) mRNA expression levels in rats.
The Journal of veterinary medical science.
2021 Aug; 83(8):1338-1344. doi:
10.1292/jvms.20-0641. [PMID: 34176823] - Anastasiya S Sokolova, Olga I Yarovaya, Darya V Baranova, Anastasia V Galochkina, Anna A Shtro, Marina V Kireeva, Sophia S Borisevich, Yuriy V Gatilov, Vladimir V Zarubaev, Nariman F Salakhutdinov. Quaternary ammonium salts based on (-)-borneol as effective inhibitors of influenza virus.
Archives of virology.
2021 Jul; 166(7):1965-1976. doi:
10.1007/s00705-021-05102-1. [PMID: 33983502] - Songyu Liu, Yu Long, Shuang Yu, Dingkun Zhang, Qiyue Yang, Zhimin Ci, Mingquan Cui, Yulu Zhang, Jinyan Wan, Dan Li, Ai Shi, Nan Li, Ming Yang, Junzhi Lin. Borneol in cardio-cerebrovascular diseases: Pharmacological actions, mechanisms, and therapeutics.
Pharmacological research.
2021 07; 169(?):105627. doi:
10.1016/j.phrs.2021.105627. [PMID: 33892091] - Dengwei Lei, Zetian Qiu, Jihua Wu, Bin Qiao, Jianjun Qiao, Guang-Rong Zhao. Combining Metabolic and Monoterpene Synthase Engineering for de Novo Production of Monoterpene Alcohols in Escherichia coli.
ACS synthetic biology.
2021 06; 10(6):1531-1544. doi:
10.1021/acssynbio.1c00081. [PMID: 34100588] - Artem D Rogachev, Valentina P Putilova, Anna V Zaykovskaya, Olga I Yarovaya, Anastasiya S Sokolova, Vladislav V Fomenko, Oleg V Pyankov, Rinat A Maksyutov, Andrey G Pokrovsky, Nariman F Salakhutdinov. Biostability study, quantitation method and preliminary pharmacokinetics of a new antifilovirus agent based on borneol and 3-(piperidin-1-yl)propanoic acid.
Journal of pharmaceutical and biomedical analysis.
2021 May; 199(?):114062. doi:
10.1016/j.jpba.2021.114062. [PMID: 33862506] - Madhur Kulkarni, Niserga Sawant, Anjali Kolapkar, Aishwarya Huprikar, Namita Desai. Borneol: a Promising Monoterpenoid in Enhancing Drug Delivery Across Various Physiological Barriers.
AAPS PharmSciTech.
2021 Apr; 22(4):145. doi:
10.1208/s12249-021-01999-8. [PMID: 33913042] - Sapana Bansod, Shrilekha Chilvery, Mohd Aslam Saifi, Tridip Jyoti Das, Hui Tag, Chandraiah Godugu. Borneol protects against cerulein-induced oxidative stress and inflammation in acute pancreatitis mice model.
Environmental toxicology.
2021 Apr; 36(4):530-539. doi:
10.1002/tox.23058. [PMID: 33166053] - Xiaoli Ye, Xueying Peng, Qing Song, Taohui Zeng, Xuefeng Xiong, Yuye Huang, Xinjun Cai, Chao Zhang, Congyao Wang, Binhui Wang. Borneol-modified tanshinone IIA liposome improves cerebral ischemia reperfusion injury by suppressing NF-κB and ICAM-1 expression.
Drug development and industrial pharmacy.
2021 Apr; 47(4):609-617. doi:
10.1080/03639045.2021.1908331. [PMID: 33834937] - Wenwen Zhang, Jianxia Wen, Yinxiao Jiang, Qichao Hu, Jian Wang, Shizhang Wei, Haotian Li, Xiao Ma. l-Borneol ameliorates cerebral ischaemia by downregulating the mitochondrial calcium uniporter-induced apoptosis cascade in pMCAO rats.
The Journal of pharmacy and pharmacology.
2021 Mar; 73(2):272-280. doi:
10.1093/jpp/rgaa028. [PMID: 33793797] - Shanshan Xiao, Hang Yu, Yunfei Xie, Yahui Guo, Jiajia Fan, Weirong Yao. The anti-inflammatory potential of Cinnamomum camphora (L.) J.Presl essential oil in vitro and in vivo.
Journal of ethnopharmacology.
2021 Mar; 267(?):113516. doi:
10.1016/j.jep.2020.113516. [PMID: 33141054] - Qiuli Cheng, Anika Benozir Asha, Yang Liu, Yi-Yang Peng, Diana Diaz-Dussan, Zuosen Shi, Zhanchen Cui, Ravin Narain. Antifouling and Antibacterial Polymer-Coated Surfaces Based on the Combined Effect of Zwitterions and the Natural Borneol.
ACS applied materials & interfaces.
2021 Feb; 13(7):9006-9014. doi:
10.1021/acsami.0c22658. [PMID: 33576614] - Jie Zhang, Sheng-Lan Liu, Hui Wang, Li-Ying Shi, Jin-Ping Li, Lu-Juan Jia, Bao-Ping Xie. The effects of borneol on the pharmacokinetics and brain distribution of tanshinone IIA, salvianolic acid B and ginsenoside Rg1 in Fufang Danshen preparation in rats.
Chinese journal of natural medicines.
2021 Feb; 19(2):153-160. doi:
10.1016/s1875-5364(21)60016-x. [PMID: 33641786] - Rong Yang, Zhenxing Chen, Fuda Xie, Mingxiang Xie, Na Liu, Ziren Su, Jiangyong Gu, Ruizhi Zhao. (+/-)-Borneol Reverses Mitoxantrone Resistance against P-Glycoprotein.
Journal of chemical information and modeling.
2021 01; 61(1):252-262. doi:
10.1021/acs.jcim.0c00892. [PMID: 33378196] - Qing Ma, Rui Ma, Bao-Long Jin, Guang-Hong Cui. [Research progress of natural borneol resources].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2021 Jan; 46(1):57-61. doi:
10.19540/j.cnki.cjcmm.20200915.609. [PMID: 33645052] - Rui Ma, Ping Su, Baolong Jin, Juan Guo, Mei Tian, Liuying Mao, Jinfu Tang, Tong Chen, Changjiangsheng Lai, Wen Zeng, Guanghong Cui, Luqi Huang. Molecular cloning and functional identification of a high-efficiency (+)-borneol dehydrogenase from Cinnamomum camphora (L.) Presl.
Plant physiology and biochemistry : PPB.
2021 Jan; 158(?):363-371. doi:
10.1016/j.plaphy.2020.11.023. [PMID: 33243711] - X L Xiong, G Song. [A study on the knowledge construction of the transformation of Borneol into traditional Chinese medicine].
Zhonghua yi shi za zhi (Beijing, China : 1980).
2020 Nov; 50(6):341-345. doi:
10.3760/cma.j.cn112155-20200624-00096. [PMID: 33596610] - Liangyu Shao, Chaojie Sun, Wenjie Lu, Jiayi Chen, Dan Su, Song Gao, Shengqi Chen, Wenyou Fang, Yu Liu, Bin Wang, Rongfeng Hu. Effects of Borneol on the Release of Compound Danshen Colon-Specific Osmotic Pump Capsule In Vitro and Pharmacokinetics Study in Beagle Dogs.
AAPS PharmSciTech.
2020 Nov; 21(8):316. doi:
10.1208/s12249-020-01840-8. [PMID: 33174133] - Aye Aye Khine, Ming-Yeh Yang, Anren Hu, Guang-Huey Lin, Yee-Huan Toh, Hao-Ping Chen. Production of optically pure (-)-borneol by Pseudomonas monteilii TCU-CK1 and characterization of borneol dehydrogenase involved.
Enzyme and microbial technology.
2020 Sep; 139(?):109586. doi:
10.1016/j.enzmictec.2020.109586. [PMID: 32732035] - Bin Zhang, Ying Jiang, Chun-Song Cheng, Hong Lin, You-Ping Guo. External application of two unrestricted herbal medicines to treat costochondritis in a young collegiate athlete: A case report.
Journal of integrative medicine.
2020 Sep; 18(5):450-454. doi:
10.1016/j.joim.2020.07.001. [PMID: 32712025] - Aye Aye Khine, Hao Ping Chen, Kai Fa Huang, Tzu Ping Ko. Structural characterization of borneol dehydrogenase from Pseudomonas sp. TCU-HL1.
Acta crystallographica. Section F, Structural biology communications.
2020 Jul; 76(Pt 7):309-313. doi:
10.1107/s2053230x20008584. [PMID: 32627746] - Seyedeh Maedeh Majidi, Mohammad Reza Hadjmohammadi. Hydrophobic borneol-based natural deep eutectic solvents as a green extraction media for air-assisted liquid-liquid micro-extraction of warfarin in biological samples.
Journal of chromatography. A.
2020 Jun; 1621(?):461030. doi:
10.1016/j.chroma.2020.461030. [PMID: 32192705] - Weicong Wang, Yan Wang, Weiwei Zhao, Jingbo Zhong, Yongjun Wang, Xia Chen. Pharmacokinetics, pharmacodynamics, safety, tolerability, and mass balance of single and continuous intravenous infusion of SPT-07A in healthy volunteers.
European journal of clinical pharmacology.
2020 Jun; 76(6):785-793. doi:
10.1007/s00228-020-02851-x. [PMID: 32147750] - Qun Ma, Manman Dai, Huimin Zhang, Luyu Bai, Ning He. Effect of different doses of borneol on the pharmacokinetics of vinpocetine in rat plasma and brain after intraocular administration.
Xenobiotica; the fate of foreign compounds in biological systems.
2020 May; 50(5):580-587. doi:
10.1080/00498254.2019.1658139. [PMID: 31424307] - Jin Ji, Ruohua Zhang, Hongmin Li, Jie Zhu, Yongzheng Pan, Qin Guo. Analgesic and anti-inflammatory effects and mechanism of action of borneol on photodynamic therapy of acne.
Environmental toxicology and pharmacology.
2020 Apr; 75(?):103329. doi:
10.1016/j.etap.2020.103329. [PMID: 31978868] - Sirui Xiao, Yulu Yan, Jihui Zhao, Yongtai Zhang, Nianping Feng. Increased microneedle-mediated transdermal delivery of tetramethylpyrazine to the brain, combined with borneol and iontophoresis, for MCAO prevention.
International journal of pharmaceutics.
2020 Feb; 575(?):118962. doi:
10.1016/j.ijpharm.2019.118962. [PMID: 31857187] - Shanshan Zhang, Sajid Asghar, Liu Yang, Ziyi Hu, Zhipeng Chen, Feng Shao, Yanyu Xiao. Borneol and poly (ethylene glycol) dual modified BSA nanoparticles as an itraconazole vehicle for brain targeting.
International journal of pharmaceutics.
2020 Feb; 575(?):119002. doi:
10.1016/j.ijpharm.2019.119002. [PMID: 31893546] - Xiangjiang Nie, Bin Wang, Rongfeng Hu, Wenjie Lu, Jiayi Chen, Songlin Liu, Dong Jin, Chaojie Sun, Song Gao, Yuxing Guo, Wenyou Fang, Haiping Hao. Development and Evaluation of Controlled and Simultaneous Release of Compound Danshen Based on a Novel Colon-Specific Osmotic Pump Capsule.
AAPS PharmSciTech.
2020 Jan; 21(2):38. doi:
10.1208/s12249-019-1603-9. [PMID: 31897797] - Yulu Zhang, Songyu Liu, Jinyan Wan, Qiyue Yang, Yan Xiang, Li Ni, Yu Long, Mingquan Cui, Zhimin Ci, Donglei Tang, Nan Li. Preparation, Characterization and in vivo Study of Borneol-Baicalin-Liposomes for Treatment of Cerebral Ischemia-Reperfusion Injury.
International journal of nanomedicine.
2020; 15(?):5977-5989. doi:
10.2147/ijn.s259938. [PMID: 32904394] - Yujia Zhang, Nan Zhang, Hui Song, He Li, Jin Wen, Xiaochuan Tan, Wensheng Zheng. Design, characterization and comparison of transdermal delivery of colchicine via borneol-chemically-modified and borneol-physically-modified ethosome.
Drug delivery.
2019 Dec; 26(1):70-77. doi:
10.1080/10717544.2018.1559258. [PMID: 30744424] - Mariia Nesterkina, Sergii Smola, Iryna Kravchenko. Effect of esters based on terpenoids and GABA on fluidity of phospholipid membranes.
Journal of liposome research.
2019 Sep; 29(3):239-246. doi:
10.1080/08982104.2018.1538238. [PMID: 30350740] - Liping Wang, Xiao Zhao, Junfeng Du, Mei Liu, Jianfang Feng, Kaili Hu. Improved brain delivery of pueraria flavones via intranasal administration of borneol-modified solid lipid nanoparticles.
Nanomedicine (London, England).
2019 08; 14(16):2105-2119. doi:
10.2217/nnm-2018-0417. [PMID: 31397219] - Mehran Mojarrad, Siavash Hosseini Sarghein, Ali Sonboli. Chemical diversity of the essential oils of twenty populations of Tanacetum polycephalum Sch. Bip. from Iran.
Natural product research.
2019 May; 33(9):1379-1382. doi:
10.1080/14786419.2018.1474468. [PMID: 29768020] - Jian Ren, Chang-Liang Hu, Zheng-Ping Zhang, Rong Chen, Shi-Bao Yang, Zhen-Yu Miao, Lu-Ning Sun, Yong-Qing Wang. Development and validation an LC-MS/MS method to quantify (+)-borneol in rat plasma: Application to a pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2019 Mar; 1109(?):121-127. doi:
10.1016/j.jchromb.2019.01.023. [PMID: 30743141] - Lin Chen, Lu Liao, Ting Zhai, Xiangtao Huang, Yong Chen. Influence of Orally Administered Borneol on the Expression of Hepatic Transporters in Rats.
European journal of drug metabolism and pharmacokinetics.
2019 Feb; 44(1):103-109. doi:
10.1007/s13318-018-0499-1. [PMID: 30105488] - Xingxing Dai, Ran Wang, Zhimin Wu, Shujuan Guo, Chang Yang, Lina Ma, Liping Chen, Xinyuan Shi, Yanjiang Qiao. Permeation-enhancing effects and mechanisms of borneol and menthol on ligustrazine: A multiscale study using in vitro and coarse-grained molecular dynamics simulation methods.
Chemical biology & drug design.
2018 11; 92(5):1830-1837. doi:
10.1111/cbdd.13350. [PMID: 29923687] - Yude Liu, Lian Rao, Hongguan Zhang, Yanyou Cen, Kaili Cheng. Conjugation of vitamin E-TPGS and guar gum to carry borneol for enhancing blood-brain barrier permeability.
Journal of biomaterials applications.
2018 10; 33(4):590-598. doi:
10.1177/0885328218799551. [PMID: 30208770] - Krystyna Skalicka-Woźniak, Magdalena Walasek, Tariq M Aljarba, Paul Stapleton, Simon Gibbons, Jianbo Xiao, Jarogniew J Łuszczki. The anticonvulsant and anti-plasmid conjugation potential of Thymus vulgaris chemistry: An in vivo murine and in vitro study.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2018 Oct; 120(?):472-478. doi:
10.1016/j.fct.2018.07.045. [PMID: 30055314] - Taiwei Dong, Nian Chen, Xiao Ma, Jian Wang, Jing Wen, Qian Xie, Rong Ma. The protective roles of L-borneolum, D-borneolum and synthetic borneol in cerebral ischaemia via modulation of the neurovascular unit.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Jun; 102(?):874-883. doi:
10.1016/j.biopha.2018.03.087. [PMID: 29728011] - Feng Liu, Xia DU, Pei-Rong Liu, Yu-Hong Sun, Yan-Min Zhang. Screening and analysis of key active constituents in Guanxinshutong capsule using mass spectrum and integrative network pharmacology.
Chinese journal of natural medicines.
2018 Apr; 16(4):302-312. doi:
10.1016/s1875-5364(18)30060-8. [PMID: 29703330] - Xiao-Fen Ruan, Yong-Jun Li, Cheng-Wei Ju, Yan Shen, Wei Lei, Can Chen, Yang Li, Hong Yu, Yu-Tao Liu, Il-Man Kim, Xiao-Long Wang, Neal L Weintraub, Yaoliang Tang. Exosomes from Suxiao Jiuxin pill-treated cardiac mesenchymal stem cells decrease H3K27 demethylase UTX expression in mouse cardiomyocytes in vitro.
Acta pharmacologica Sinica.
2018 Apr; 39(4):579-586. doi:
10.1038/aps.2018.18. [PMID: 29542684] - Efat Jafari, Gholamabbas Ghanbarian, Atefeh Bahmanzadegan. Essential oil composition of aerial parts of Micromeria persica Boiss. from Western of Shiraz, Iran.
Natural product research.
2018 Apr; 32(8):991-996. doi:
10.1080/14786419.2017.1374270. [PMID: 28893105] - Xiao-Fen Ruan, Cheng-Wei Ju, Yan Shen, Yu-Tao Liu, Il-Man Kim, Hong Yu, Neal Weintraub, Xiao-Long Wang, Yaoliang Tang. Suxiao Jiuxin pill promotes exosome secretion from mouse cardiac mesenchymal stem cells in vitro.
Acta pharmacologica Sinica.
2018 Apr; 39(4):569-578. doi:
10.1038/aps.2018.19. [PMID: 29542682] - Zhiyang Lv, Yuwei Yang, Jie Wang, Jing Chen, Junsong Li, Liuqing Di. Optimization of the Preparation Conditions of Borneol-Modified Ginkgolide Liposomes by Response Surface Methodology and Study of Their Blood Brain Barrier Permeability.
Molecules (Basel, Switzerland).
2018 Jan; 23(2):. doi:
10.3390/molecules23020303. [PMID: 29385087] - Shunping Han, Hongyue Zheng, Yanping Lu, Yue Sun, Anhao Huang, Weidong Fei, Xiaowei Shi, Xiuling Xu, Jingjing Li, Fanzhu Li. A novel synergetic targeting strategy for glioma therapy employing borneol combination with angiopep-2-modified, DOX-loaded PAMAM dendrimer.
Journal of drug targeting.
2018 01; 26(1):86-94. doi:
10.1080/1061186x.2017.1344849. [PMID: 28635335] - Hui Song, Man Wei, Nan Zhang, He Li, Xiaochuan Tan, Yujia Zhang, Wensheng Zheng. Enhanced permeability of blood-brain barrier and targeting function of brain via borneol-modified chemically solid lipid nanoparticle.
International journal of nanomedicine.
2018; 13(?):1869-1879. doi:
10.2147/ijn.s161237. [PMID: 29636606] - Tsung-Jung Ho, Chien-Che Hung, Tzenge-Lien Shih, Lih-Ming Yiin, Hao-Ping Chen. Investigation of borneols sold in Taiwan by chiral gas chromatography.
Journal of food and drug analysis.
2018 01; 26(1):348-352. doi:
10.1016/j.jfda.2016.10.012. [PMID: 29389573] - Xinyi Yuan, Fuhuan Fei, Huanmei Sun, Chaoni Xiao, Xinfeng Zhao, Yajun Zhang, Xiaohui Zheng. Tanshinol borneol ester on nanostructured lipid carriers has longer brain and systemic effector retention and better antioxidant activity in vivo.
International journal of nanomedicine.
2018; 13(?):2265-2274. doi:
10.2147/ijn.s159789. [PMID: 29695905]
