Pancrelipase (BioDeep_00000014930)
Secondary id: BioDeep_00001868503
human metabolite
代谢物信息卡片
disodium 7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylate
化学式: C8H8Na2O5 (230.0167118)
中文名称: 内氧草索钠盐
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CC2C(C(C1O2)C(=O)[O-])C(=O)[O-].[Na+].[Na+]
InChI: /q
描述信息
Food additive and processing agent. Production by controlled fermentation of Aspergillus niger. Found in milk and milk products. It is used in food processing for flavour improvement, e.g. in cheese. Pancrelipase is a form of enzyme therapy for the treatment of various digestive disorders, primarily exocrine pancreatic insufficiency. It is a mixture of three digestive enzymes, amylase, trypsin, and lipase, which are normally produced by the pancreas. Pancrelipase is a form of pancreatin having a elevated content of lipase.
Food additive and processing agent. Production by controlled fermentation of Aspergillus niger. Found in milk and milk products. It is used in food processing for flavour improvement, e.g. in cheese
D005765 - Gastrointestinal Agents
同义名列表
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:81916
- KEGG: C18724
- PubChem: 8519
- HMDB: HMDB0304827
- Metlin: METLIN72500
- MeSH: Pancrelipase
- foodb: FDB001106
- chemspider: 8205
- CAS: 53608-75-6
- CAS: 13114-29-9
- CAS: 129-67-9
- PubChem: 124489398
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Vincenzo Musolino, Mariangela Marrelli, Maria Rosaria Perri, Martina Palermo, Micaela Gliozzi, Vincenzo Mollace, Filomena Conforti. Centranthus ruber (L.) DC. and Tropaeolum majus L.: Phytochemical Profile, In Vitro Anti-Denaturation Effects and Lipase Inhibitory Activity of Two Ornamental Plants Traditionally Used as Herbal Remedies.
Molecules (Basel, Switzerland).
2022 Dec; 28(1):. doi:
10.3390/molecules28010032. [PMID: 36615228] - Saeed Niazmand, Arezoo Gowhari Shabgah, Sara Hosseinian, Jamshid Gholizadeh Navashenaq, Ali Kamali, Mohammad Reza Khazdair, Yousef Baghcheghi, Mahdiyeh Hedayati-Moghadam. The effect of HTLV1 infection on inflammatory and oxidative parameters in the liver, kidney, and pancreases of BALB/c mice.
Physiological reports.
2022 04; 10(7):e15243. doi:
10.14814/phy2.15243. [PMID: 35373925] - Ruilin Li, Zihan Xue, Yanan Jia, Yajie Wang, Shuqin Li, Jingna Zhou, Junyu Liu, Min Zhang, Chengwei He, Haixia Chen. Polysaccharides from mulberry (Morus alba L.) leaf prevents obesity by inhibiting pancreatic lipase in high-fat diet induced mice.
International journal of biological macromolecules.
2021 Dec; 192(?):452-460. doi:
10.1016/j.ijbiomac.2021.10.010. [PMID: 34634334] - Ann Etohan Ogbemudia, Gabriella Hakim, Fungai Dengu, Faysal El-Gilani, Richard Dumbill, John Mulvey, Karen Sayal, Thomas Prudhomme, Benoit Mesnard, Kaithlyn Rozenberg, Letizia Lo Faro, Timothy James, Joshua Oliver, Edward Sharples, Shruti Mittal, Paul Johnson, Peter J Friend, Rutger Ploeg, James Hunter, Julien Branchereau. Development of ex situ normothermic reperfusion as an innovative method to assess pancreases after preservation.
Transplant international : official journal of the European Society for Organ Transplantation.
2021 Sep; 34(9):1630-1642. doi:
10.1111/tri.13990. [PMID: 34448276] - Jodie A Barkin, Jamie S Barkin. Effect of Pancrelipase Therapy on Exocrine Pancreatic Insufficiency Symptoms and Coefficient of Fat Absorption Associated With Chronic Pancreatitis.
Pancreas.
2021 02; 50(2):176-182. doi:
10.1097/mpa.0000000000001733. [PMID: 33560089] - Xu-Dong Hou, Li-Lin Song, Yun-Feng Cao, Yi-Nan Wang, Qi Zhou, Sheng-Quan Fang, Da-Chang Wu, Shi-Zhu Zang, Lu Chen, Yue Bai, Guang-Bo Ge, Jie Hou. Pancreatic lipase inhibitory constituents from Fructus Psoraleae.
Chinese journal of natural medicines.
2020 May; 18(5):369-378. doi:
10.1016/s1875-5364(20)30043-1. [PMID: 32451094] - Hang Su, Yi-Ting Ruan, Ying Li, Ji-Guang Chen, Zhong-Ping Yin, Qing-Feng Zhang. In vitro and in vivo inhibitory activity of taxifolin on three digestive enzymes.
International journal of biological macromolecules.
2020 May; 150(?):31-37. doi:
10.1016/j.ijbiomac.2020.02.027. [PMID: 32035149] - Yuri Yoshioka, Naori Yoshimura, Shinichi Matsumura, Hiroto Wada, Maya Hoshino, Shouhei Makino, Masanori Morimoto. α-Glucosidase and Pancreatic Lipase Inhibitory Activities of Diterpenes from Indian Mango Ginger (Curcuma amada Roxb.) and Its Derivatives.
Molecules (Basel, Switzerland).
2019 Nov; 24(22):. doi:
10.3390/molecules24224071. [PMID: 31717689] - Karin Purshouse, Sarah Chamberlain, Maria Soares, Mark Tuthill, Andrew Protheroe, David R Mole. Case report of oxalate nephropathy in a patient with pancreatic metastases from renal carcinoma.
BMC cancer.
2019 Oct; 19(1):967. doi:
10.1186/s12885-019-6215-y. [PMID: 31623580] - Ruilin Zhang, Jian Chen, Xinwu Mao, Ping Qi, Xuewu Zhang. Separation and Lipid Inhibition Effects of a Novel Decapeptide from Chlorella pyenoidose.
Molecules (Basel, Switzerland).
2019 Sep; 24(19):. doi:
10.3390/molecules24193527. [PMID: 31569521] - Annie Hasib, Ming T Ng, Dawood Khan, Victor A Gault, Peter R Flatt, Nigel Irwin. Characterisation and antidiabetic utility of a novel hybrid peptide, exendin-4/gastrin/xenin-8-Gln.
European journal of pharmacology.
2018 Sep; 834(?):126-135. doi:
10.1016/j.ejphar.2018.07.027. [PMID: 30025814] - Joseph Cyrus Parambeth, Geoffrey T Fosgate, Jan S Suchodolski, Jonathan A Lidbury, Jörg M Steiner. Randomized placebo controlled clinical trial of an enteric coated micro-pelleted formulation of a pancreatic enzyme supplement in dogs with exocrine pancreatic insufficiency.
Journal of veterinary internal medicine.
2018 Sep; 32(5):1591-1599. doi:
10.1111/jvim.15235. [PMID: 30221800] - Marco Catarci, Manuele Berlanda, Giovanni Battista Grassi, Francesco Masedu, Stefano Guadagni. Pancreatic enzyme supplementation after gastrectomy for gastric cancer: a randomized controlled trial.
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association.
2018 May; 21(3):542-551. doi:
10.1007/s10120-017-0757-y. [PMID: 28804801] - Thiru Prasanna, Catriona M McNeil, Theresa Nielsen, David Parkin. Isolated immune-related pancreatic exocrine insufficiency associated with pembrolizumab therapy.
Immunotherapy.
2018 03; 10(3):171-175. doi:
10.2217/imt-2017-0126. [PMID: 29370723] - Janneke Keemink, Christel A S Bergström. Caco-2 Cell Conditions Enabling Studies of Drug Absorption from Digestible Lipid-Based Formulations.
Pharmaceutical research.
2018 Feb; 35(4):74. doi:
10.1007/s11095-017-2327-8. [PMID: 29484506] - Florence Mary, Anne Moesseler, Nadezda Khodorova, Angélique Foucault-Simonin, Robert Benamouzig, Daniel Tomé, Peter Colin Gregory, Claire Gaudichon. Metabolic markers of protein maldigestion after a 15N test meal in minipigs with pancreatic exocrine insufficiency.
American journal of physiology. Gastrointestinal and liver physiology.
2018 02; 314(2):G223-G230. doi:
10.1152/ajpgi.00218.2017. [PMID: 29074486] - Darren M Moss, Paul Domanico, Melynda Watkins, Seonghee Park, Ryan Randolph, Steve Wring, Rajith Kumar Reddy Rajoli, James Hobson, Steve Rannard, Marco Siccardi, Andrew Owen. Simulating Intestinal Transporter and Enzyme Activity in a Physiologically Based Pharmacokinetic Model for Tenofovir Disoproxil Fumarate.
Antimicrobial agents and chemotherapy.
2017 07; 61(7):. doi:
10.1128/aac.00105-17. [PMID: 28416547] - Tomotaka Saito, Kenji Hirano, Hiroyuki Isayama, Yousuke Nakai, Kei Saito, Gyotane Umefune, Dai Akiyama, Takeo Watanabe, Kaoru Takagi, Tsuyoshi Hamada, Naminatsu Takahara, Rie Uchino, Suguru Mizuno, Hirofumi Kogure, Saburo Matsubara, Natsuyo Yamamoto, Minoru Tada, Kazuhiko Koike. The Role of Pancreatic Enzyme Replacement Therapy in Unresectable Pancreatic Cancer: A Prospective Cohort Study.
Pancreas.
2017 03; 46(3):341-346. doi:
10.1097/mpa.0000000000000767. [PMID: 28099252] - James C Needell, Charles A Dinarello, Diana Ir, Charles E Robertson, Sarah M Ryan, Miranda E Kroehl, Daniel N Frank, Danny Zipris. Implication of the intestinal microbiome as a potential surrogate marker of immune responsiveness to experimental therapies in autoimmune diabetes.
PloS one.
2017; 12(3):e0173968. doi:
10.1371/journal.pone.0173968. [PMID: 28301545] - Simona Fabroni, Gabriele Ballistreri, Margherita Amenta, Flora V Romeo, Paolo Rapisarda. Screening of the anthocyanin profile and in vitro pancreatic lipase inhibition by anthocyanin-containing extracts of fruits, vegetables, legumes and cereals.
Journal of the science of food and agriculture.
2016 Nov; 96(14):4713-4723. doi:
10.1002/jsfa.7708. [PMID: 26970531] - Dogan Kose, Nuriye Tarakci, Zeliha Esin Celik, Husamettin Vatansev, Emine Ayca Cimbek, Serdar Ugras, Yasar Sen, Umran Caliskan, Yavuz Koksal. Effects of Prednisolone, L-Asparaginase, Gemfibrozil, and Combinations of These Elements on Mice Lipid Profile, Liver, and Pancreas.
Journal of pediatric hematology/oncology.
2016 Jan; 38(1):e42-9. doi:
10.1097/mph.0000000000000484. [PMID: 26599986] - Srishti Shukla, Dommati Anand Kumar, Sanga Venkata Anusha, Ashok Kumar Tiwari. Antihyperglucolipidaemic and anticarbonyl stress properties in green, yellow and red sweet bell peppers (Capsicum annuum L.).
Natural product research.
2016; 30(5):583-9. doi:
10.1080/14786419.2015.1026343. [PMID: 25868614] - Björn Lindkvist, Mary E Phillips, J Enrique Domínguez-Muñoz. Clinical, anthropometric and laboratory nutritional markers of pancreatic exocrine insufficiency: Prevalence and diagnostic use.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.].
2015 Nov; 15(6):589-97. doi:
10.1016/j.pan.2015.07.001. [PMID: 26243045] - Raffaele Pezzilli, Nicole Brighi, Lucia Calculli. Quality of life in patients with long-standing chronic non-pathological pancreatic hyperenzymemia.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.].
2015 Mar; 15(2):131-5. doi:
10.1016/j.pan.2015.02.002. [PMID: 25708931] - Wen-Yi Gao, Andrew E Mulberg. Dependence of PERT endpoint on endogenous lipase activity.
Pancreas.
2014 Nov; 43(8):1232-8. doi:
10.1097/mpa.0000000000000214. [PMID: 25102439] - L S Babinets', Iu V Droniak, K O Pliashko, A I Babinets'. [Efficiency of etiologic correction of concomitant ascaridosis in the complex treatment of chronic pancreatitis].
Likars'ka sprava.
2014 Nov; ?(11):116-8. doi:
NULL. [PMID: 25528847] - Shiree J Perano, Jennifer J Couper, Michael Horowitz, A James Martin, Stamatiki Kritas, Thomas Sullivan, Chris K Rayner. Pancreatic enzyme supplementation improves the incretin hormone response and attenuates postprandial glycemia in adolescents with cystic fibrosis: a randomized crossover trial.
The Journal of clinical endocrinology and metabolism.
2014 Jul; 99(7):2486-93. doi:
10.1210/jc.2013-4417. [PMID: 24670086] - Stefan Kahl, Kerstin Schütte, Bernhard Glasbrenner, Julia Mayerle, Peter Simon, Friederike Henniges, Suntje Sander-Struckmeier, Marcus M Lerch, Peter Malfertheiner. The effect of oral pancreatic enzyme supplementation on the course and outcome of acute pancreatitis: a randomized, double-blind parallel-group study.
JOP : Journal of the pancreas.
2014 Mar; 15(2):165-74. doi:
10.6092/1590-8577/797. [PMID: 24618443] - Yu Nobuoka, Akihiro Tanemura, Yoshinori Azumi, Masashi Kishiwada, Ichiro Osawa, Shugo Mizuno, Masanobu Usui, Hiroyuki Sakurai, Masami Tabata, Shuji Isaji. [Studies on the distribution of doripenem in pancreatic tissues, especially on the importance of the ratio in pancreatic tissue concentration of doripenem/serum concentration of doripenem].
The Japanese journal of antibiotics.
2014 Feb; 67(1):15-21. doi:
NULL. [PMID: 24809205] - Francisc Vasile Dulf, Ioan Oroian, Dan Cristian Vodnar, Carmen Socaciu, Adela Pintea. Lipid classes and fatty acid regiodistribution in triacylglycerols of seed oils of two Sambucus species (S. nigra L. and S. ebulus L.).
Molecules (Basel, Switzerland).
2013 Sep; 18(10):11768-82. doi:
10.3390/molecules181011768. [PMID: 24071984] - O Jun Kwon, Jong-Sup Bae, Ha Yeong Lee, Ju-Young Hwang, Eun-Woo Lee, Hideyuki Ito, Tae Hoon Kim. Pancreatic lipase inhibitory gallotannins from Galla Rhois with inhibitory effects on adipocyte differentiation in 3T3-L1 cells.
Molecules (Basel, Switzerland).
2013 Sep; 18(9):10629-38. doi:
10.3390/molecules180910629. [PMID: 24002138] - J R Huddy, F M S Macharg, A M Lawn, S R Preston. Exocrine pancreatic insufficiency following esophagectomy.
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus.
2013 Aug; 26(6):594-7. doi:
10.1111/dote.12004. [PMID: 23199208] - Annita Kolnagou, Konstantinos Natsiopoulos, Marios Kleanthous, Alexia Ioannou, George J Kontoghiorghes. Liver iron and serum ferritin levels are misleading for estimating cardiac, pancreatic, splenic and total body iron load in thalassemia patients: factors influencing the heterogenic distribution of excess storage iron in organs as identified by MRI T2*.
Toxicology mechanisms and methods.
2013 Jan; 23(1):48-56. doi:
10.3109/15376516.2012.727198. [PMID: 22943064] - M Słupecka, J Woliński, O Prykhodko, P Ochniewicz, D Gruijc, O Fedkiv, B R Weström, S G Pierzynowski. Stimulating effect of pancreatic-like enzymes on the development of the gastrointestinal tract in piglets.
Journal of animal science.
2012 Dec; 90 Suppl 4(?):311-4. doi:
10.2527/jas.53921. [PMID: 23365364] - M Díaz-Flores, S Angeles-Mejia, L A Baiza-Gutman, R Medina-Navarro, D Hernández-Saavedra, C Ortega-Camarillo, R Roman-Ramos, M Cruz, F J Alarcon-Aguilar. Effect of an aqueous extract of Cucurbita ficifolia Bouché on the glutathione redox cycle in mice with STZ-induced diabetes.
Journal of ethnopharmacology.
2012 Oct; 144(1):101-8. doi:
10.1016/j.jep.2012.08.036. [PMID: 22960550] - Jamnian Chompoo, Atul Upadhyay, Shinichi Gima, Masakazu Fukuta, Shinkichi Tawata. Antiatherogenic properties of acetone extract of Alpinia zerumbet seeds.
Molecules (Basel, Switzerland).
2012 May; 17(6):6237-48. doi:
10.3390/molecules17066237. [PMID: 22634836] - Steve Caras, David Boyd, Lisa Zipfel, Suntje Sander-Struckmeier. Evaluation of stool collections to measure efficacy of PERT in subjects with exocrine pancreatic insufficiency.
Journal of pediatric gastroenterology and nutrition.
2011 Dec; 53(6):634-40. doi:
10.1097/mpg.0b013e3182281c38. [PMID: 21681115] - Hayder H Al-Azzawi, Terence E Wade, Deborah A Swartz-Basile, Sue Wang, Henry A Pitt, Nicholas J Zyromski. Acute pancreatitis in obesity: adipokines and dietary fish oil.
Digestive diseases and sciences.
2011 Aug; 56(8):2318-25. doi:
10.1007/s10620-011-1626-x. [PMID: 21347559] - Els Van de Vijver, Kristine Desager, Andrew E Mulberg, Sofie Staelens, Henkjan J Verkade, Frank A J A Bodewes, Anne Malfroot, Bruno Hauser, Maarten Sinaasappel, Stefanie Van Biervliet, Martin Behm, Paul Pelckmans, Dirk Callens, Gigi Veereman-Wauters. Treatment of infants and toddlers with cystic fibrosis-related pancreatic insufficiency and fat malabsorption with pancrelipase MT.
Journal of pediatric gastroenterology and nutrition.
2011 Jul; 53(1):61-4. doi:
10.1097/mpg.0b013e31820e208e. [PMID: 21694537] - Tsuyoshi Uchiyama, Shoichi Tomono, Toshihiro Utsugi, Yoshio Ohyama, Tetsuya Nakamura, Hideaki Tomura, Shoji Kawazu, Fumikazu Okajima, Masahiko Kurabayashi. Constitutively active heat shock factor 1 enhances glucose-driven insulin secretion.
Metabolism: clinical and experimental.
2011 Jun; 60(6):789-98. doi:
10.1016/j.metabol.2010.07.029. [PMID: 20817212] - Fusako Maehira, Nau Ishimine, Ikuko Miyagi, Yukinori Eguchi, Katsumasa Shimada, Daisuke Kawaguchi, Yoshihide Oshiro. Anti-diabetic effects including diabetic nephropathy of anti-osteoporotic trace minerals on diabetic mice.
Nutrition (Burbank, Los Angeles County, Calif.).
2011 Apr; 27(4):488-95. doi:
10.1016/j.nut.2010.04.007. [PMID: 20708379] - Phillip P Toskes, Angelo Secci, Ruth Thieroff-Ekerdt. Efficacy of a novel pancreatic enzyme product, EUR-1008 (Zenpep), in patients with exocrine pancreatic insufficiency due to chronic pancreatitis.
Pancreas.
2011 Apr; 40(3):376-82. doi:
10.1097/mpa.0b013e31820b971c. [PMID: 21343835] - Alexander Link, Debbie L Hardie, Stéphanie Favre, Mirjam R Britschgi, David H Adams, Michael Sixt, Jason G Cyster, Christopher D Buckley, Sanjiv A Luther. Association of T-zone reticular networks and conduits with ectopic lymphoid tissues in mice and humans.
The American journal of pathology.
2011 Apr; 178(4):1662-75. doi:
10.1016/j.ajpath.2010.12.039. [PMID: 21435450] - Sergey A Ivanov, Kenzo Nomura, Ilya L Malfanov, Ilya V Sklyar, Leonid R Ptitsyn. Isolation of a novel catechin from Bergenia rhizomes that has pronounced lipase-inhibiting and antioxidative properties.
Fitoterapia.
2011 Mar; 82(2):212-8. doi:
10.1016/j.fitote.2010.09.013. [PMID: 20923698] - Ia M Vakhrushev, A A Volkova. [Differentiated approaches to the treatment of chronic pancreatitis patients with metabolic syndrome].
Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology.
2011; ?(11):33-6. doi:
". [PMID: 22629716] - J Enrique Domínguez-Muñoz, Julio Iglesias-García. Oral pancreatic enzyme substitution therapy in chronic pancreatitis: is clinical response an appropriate marker for evaluation of therapeutic efficacy?.
JOP : Journal of the pancreas.
2010 Mar; 11(2):158-62. doi:
NULL. [PMID: 20208327] - Young-Min Ye, Hyun-Young Lee, Sang-Hoon Kim, Sang-Ha Kim, Seung-Hyun Kim, Hae-Sim Park. Genetic polymorphisms of ADRB2 and IL10 may be associated with the risk of IgE sensitization to digestive powders in exposed medical personnel.
International archives of allergy and immunology.
2010; 153(2):193-200. doi:
10.1159/000312637. [PMID: 20413987] - Gavin R Graff, Karen Maguiness, John McNamara, Ronald Morton, David Boyd, Katrin Beckmann, Djenane Bennett. Efficacy and tolerability of a new formulation of pancrelipase delayed-release capsules in children aged 7 to 11 years with exocrine pancreatic insufficiency and cystic fibrosis: a multicenter, randomized, double-blind, placebo-controlled, two-period crossover, superiority study.
Clinical therapeutics.
2010 Jan; 32(1):89-103. doi:
10.1016/j.clinthera.2010.01.012. [PMID: 20171415] - Carla Colombo, Clara Fredella, Maria Chiara Russo, Nadia Faelli, Valentina Motta, Lauretta Valmarana, Luigina Longo, Ciro D'Orazio. Efficacy and tolerability of Creon for Children in infants and toddlers with pancreatic exocrine insufficiency caused by cystic fibrosis: an open-label, single-arm, multicenter study.
Pancreas.
2009 Aug; 38(6):693-9. doi:
10.1097/mpa.0b013e3181a85eaf. [PMID: 19531972] - Shannon R Christiansen, Alberto Broniscer, J Carl Panetta, Clinton F Stewart. Pharmacokinetics of erlotinib for the treatment of high-grade glioma in a pediatric patient with cystic fibrosis: case report and review of the literature.
Pharmacotherapy.
2009 Jul; 29(7):858-66. doi:
10.1592/phco.29.7.858. [PMID: 19558260] - Hisashi Matsuda, Yasunobu Asao, Seikou Nakamura, Makoto Hamao, Sachiko Sugimoto, Masako Hongo, Yutana Pongpiriyadacha, Masayuki Yoshikawa. Antidiabetogenic constituents from the Thai traditional medicine Cotylelobium melanoxylon.
Chemical & pharmaceutical bulletin.
2009 May; 57(5):487-94. doi:
10.1248/cpb.57.487. [PMID: 19420780] - Anne Munck, Jean-Francois Duhamel, Thierry Lamireau, Bernard Le Luyer, Claire Le Tallec, Gabriel Bellon, Michel Roussey, Pierre Foucaud, Jean Louis Giniès, Anne Houzel, Christophe Marguet, Marcel Guillot, Valerie David, Nathalie Kapel, François Dyard, Friederike Henniges. Pancreatic enzyme replacement therapy for young cystic fibrosis patients.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.
2009 Jan; 8(1):14-8. doi:
10.1016/j.jcf.2008.07.003. [PMID: 18718819] - Young-Jin Kang, Un Ju Jung, Mi-Kyung Lee, Hye-Jin Kim, Seon-Min Jeon, Yong Bok Park, Hae-Gon Chung, Nam-In Baek, Kyung Tae Lee, Tae-Sook Jeong, Myung-Sook Choi. Eupatilin, isolated from Artemisia princeps Pampanini, enhances hepatic glucose metabolism and pancreatic beta-cell function in type 2 diabetic mice.
Diabetes research and clinical practice.
2008 Oct; 82(1):25-32. doi:
10.1016/j.diabres.2008.06.012. [PMID: 18703253] - Y Yamada, T Kato, H Ogino, S Ashina, K Kato. Cetilistat (ATL-962), a novel pancreatic lipase inhibitor, ameliorates body weight gain and improves lipid profiles in rats.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
2008 Aug; 40(8):539-43. doi:
10.1055/s-2008-1076699. [PMID: 18500680] - Yuhao Li, Tom Hsun-Wei Huang, Johji Yamahara. Salacia root, a unique Ayurvedic medicine, meets multiple targets in diabetes and obesity.
Life sciences.
2008 May; 82(21-22):1045-9. doi:
10.1016/j.lfs.2008.03.005. [PMID: 18433791] - Isabel Lastres-Becker, Susanne Brodesser, Dieter Lütjohann, Mekhman Azizov, Jana Buchmann, Edith Hintermann, Konrad Sandhoff, Annette Schürmann, Joachim Nowock, Georg Auburger. Insulin receptor and lipid metabolism pathology in ataxin-2 knock-out mice.
Human molecular genetics.
2008 May; 17(10):1465-81. doi:
10.1093/hmg/ddn035. [PMID: 18250099] - Ayten Sagiroglu. Conversion of sunflower oil to biodiesel by alcoholysis using immobilized lipase.
Artificial cells, blood substitutes, and immobilization biotechnology.
2008; 36(2):138-49. doi:
10.1080/10731190801932124. [PMID: 18437590] - Juda Vecht, Tomas Symersky, Cornelis B H W Lamers, Ad A M Masclee. Efficacy of lower than standard doses of pancreatic enzyme supplementation therapy during acid inhibition in patients with pancreatic exocrine insufficiency.
Journal of clinical gastroenterology.
2006 Sep; 40(8):721-5. doi:
10.1097/00004836-200609000-00012. [PMID: 16940886] - Mary Sue Brady, Jennifer L Garson, Susan K Krug, Ajay Kaul, Karyl A Rickard, Helena Hoen Caffrey, Naomi Fineberg, William F Balistreri, John C Stevens. An enteric-coated high-buffered pancrelipase reduces steatorrhea in patients with cystic fibrosis: a prospective, randomized study.
Journal of the American Dietetic Association.
2006 Aug; 106(8):1181-6. doi:
10.1016/j.jada.2006.05.011. [PMID: 16863712] - Michael Safdi, Pradeep K Bekal, Stephen Martin, Zahid A Saeed, Frank Burton, Phillip P Toskes. The effects of oral pancreatic enzymes (Creon 10 capsule) on steatorrhea: a multicenter, placebo-controlled, parallel group trial in subjects with chronic pancreatitis.
Pancreas.
2006 Aug; 33(2):156-62. doi:
10.1097/01.mpa.0000226884.32957.5e. [PMID: 16868481] - Daina Kalnins, Lynda Ellis, Mary Corey, Paul B Pencharz, Cynthia Stewart, Elizabeth Tullis, Peter R Durie. Enteric-coated pancreatic enzyme with bicarbonate is equal to standard enteric-coated enzyme in treating malabsorption in cystic fibrosis.
Journal of pediatric gastroenterology and nutrition.
2006 Mar; 42(3):256-61. doi:
10.1097/01.mpg.0000189356.93784.01. [PMID: 16540792] - Li-Kun Han, Dong-Xia Li, Lan Xiang, Xiao-Jie Gong, Yasumasa Kondo, Isao Suzuki, Hiromichi Okuda. [Isolation of pancreatic lipase activity-inhibitory component of spirulina platensis and it reduce postprandial triacylglycerolemia].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
2006 Jan; 126(1):43-9. doi:
10.1248/yakushi.126.43. [PMID: 16394649] - Matthias Griese, Kathi Dokupil, Philipp Latzin. Skin prick test reactivity to supplemental enzymes in cystic fibrosis and pancreatic insufficiency.
Journal of pediatric gastroenterology and nutrition.
2005 Feb; 40(2):194-8. doi:
10.1097/00005176-200502000-00021. [PMID: 15699696] - E Jiménez-Ferrer, I Reynosa-Zapata, Y Pérez-Torres, J Tortoriello. The secretagogue effect of the poison from Centruroides limpidus limpidus on the pancreas of mice and the antagonistic action of the Bouvardia ternifolia extract.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2005 Jan; 12(1-2):65-71. doi:
10.1016/j.phymed.2004.05.001. [PMID: 15693710] - Hai Lin Zhao, Yeong Shik Kim. Determination of the kinetic properties of platycodin D for the inhibition of pancreatic lipase using a 1,2-diglyceride-based colorimetric assay.
Archives of pharmacal research.
2004 Oct; 27(10):1048-52. doi:
10.1007/bf02975430. [PMID: 15554263] - Roos C Padmos, Lynn Bekris, Esther M Knijff, Henning Tiemeier, Ralph W Kupka, Dan Cohen, Willem A Nolen, Ake Lernmark, Hemmo A Drexhage. A high prevalence of organ-specific autoimmunity in patients with bipolar disorder.
Biological psychiatry.
2004 Oct; 56(7):476-82. doi:
10.1016/j.biopsych.2004.07.003. [PMID: 15450782] - L Evilevitch, B R Weström, S G Pierzynowski. CCK-B receptor antagonist YF476 inhibits pancreatic enzyme secretion at a duodenal level in pigs.
Scandinavian journal of gastroenterology.
2004 Sep; 39(9):886-90. doi:
10.1080/00365520410006242. [PMID: 15513388] - Edwin K Jackson, Dubey K Raghvendra. The extracellular cyclic AMP-adenosine pathway in renal physiology.
Annual review of physiology.
2004; 66(?):571-99. doi:
10.1146/annurev.physiol.66.032102.111604. [PMID: 14977414] - Karin Gewert, Scott A Holowachuk, Catarina Rippe, Peter C Gregory, Charlotte Erlanson-Albertsson, Gunilla Olivecrona, Danuta Kruszewska, Jose Valverde Piedra, Björn Weström, Stefan G Pierzynowski. The enzyme levels in blood are not affected by oral administration of a pancreatic enzyme preparation (Creon 10,000) in pancreas-insufficient pigs.
Pancreas.
2004 Jan; 28(1):80-8. doi:
10.1097/00006676-200401000-00013. [PMID: 14707735] - Ji-Eun Shin, Myung Joo Han, Myoung-Chong Song, Nam-In Baek, Dong-Hyun Kim. 5-Hydroxy-7-(4'-hydroxy-3'-methoxyphenyl)-1-phenyl-3-heptanone: a pancreatic lipase inhibitor isolated from Alpinia officinarum.
Biological & pharmaceutical bulletin.
2004 Jan; 27(1):138-40. doi:
10.1248/bpb.27.138. [PMID: 14709919] - P Walther. Recent progress in freeze-fracturing of high-pressure frozen samples.
Journal of microscopy.
2003 Oct; 212(Pt 1):34-43. doi:
10.1046/j.1365-2818.2003.01236.x. [PMID: 14516360] - Pamela M J O'Connor, Scot R Kimball, Agus Suryawan, Jill A Bush, Hanh V Nguyen, Leonard S Jefferson, Teresa A Davis. Regulation of translation initiation by insulin and amino acids in skeletal muscle of neonatal pigs.
American journal of physiology. Endocrinology and metabolism.
2003 Jul; 285(1):E40-53. doi:
10.1152/ajpendo.00563.2002. [PMID: 12637260] - M Yaqoob, A Nabi. Flow injection chemiluminescent assays for glycerol and triglycerides using a co-immobilized enzyme reactor.
Luminescence : the journal of biological and chemical luminescence.
2003 Mar; 18(2):67-71. doi:
10.1002/bio.704. [PMID: 12687625] - Bhanu P Jena, Sang-Joon Cho, Aleksandar Jeremic, Marvin H Stromer, Rania Abu-Hamdah. Structure and composition of the fusion pore.
Biophysical journal.
2003 Feb; 84(2 Pt 1):1337-43. doi:
10.1016/s0006-3495(03)74949-2. [PMID: 12547814] - Ruggero Galici, Aurelio Galli, David J Jones, Teresa A Sanchez, Christine Saunders, Alan Frazer, Georgianna G Gould, Richard Z Lin, Charles P France. Selective decreases in amphetamine self-administration and regulation of dopamine transporter function in diabetic rats.
Neuroendocrinology.
2003 Feb; 77(2):132-40. doi:
10.1159/000068650. [PMID: 12624535] - Satoru Shimizu, Masuo Nakano. Structural characterization of triacylglycerol in several oils containing gamma-linolenic acid.
Bioscience, biotechnology, and biochemistry.
2003 Jan; 67(1):60-7. doi:
10.1271/bbb.67.60. [PMID: 12619674] - Ludwig Jonas, Ulrike Mikkat, Renate Lehmann, Wolfgang Schareck, Hermann Walzel, Werner Schröder, Hilja Lopp, Tönu Püssa, Peeter Toomik. Inhibitory effects of human and porcine alpha-amylase on CCK-8-stimulated lipase secretion of isolated rat pancreatic acini.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.].
2003; 3(4):342-8. doi:
10.1159/000071774. [PMID: 12890998] - C J Patchell, M Desai, P H Weller, A Macdonald, R L Smyth, A Bush, J S Gilbody, S A Duff. Creon 10,000 Minimicrospheres vs. Creon 8,000 microspheres--an open randomised crossover preference study.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.
2002 Dec; 1(4):287-91. doi:
10.1016/s1569-1993(02)00103-0. [PMID: 15463829] - A Stuecklin-Utsch, C Hasan, U Bode, G Fleischhack. Pancreatic toxicity after liposomal amphotericin B.
Mycoses.
2002 Jun; 45(5-6):170-3. doi:
10.1046/j.1439-0507.2002.00744.x. [PMID: 12100534] - Omar M E Abdel Salam, Somaia A Nada, Mahmoud S Arbid. The effect of ginseng on bile-pancreatic secretion in the rat. Increase in proteins and inhibition of total lipids and cholesterol secretion.
Pharmacological research.
2002 Apr; 45(4):349-53. doi:
10.1006/phrs.2002.0961. [PMID: 12030800] - A Carroccio, A Guarino, G Zuin, F Verghi, R Berni Canani, M Fontana, E Bruzzese, G Montalto, A Notarbartolo. Efficacy of oral pancreatic enzyme therapy for the treatment of fat malabsorption in HIV-infected patients.
Alimentary pharmacology & therapeutics.
2001 Oct; 15(10):1619-25. doi:
10.1046/j.1365-2036.2001.01070.x. [PMID: 11564002] - K Hartvigsen, A Ravandi, K Bukhave, G Hølmer, A Kuksis. Regiospecific analysis of neutral ether lipids by liquid chromatography/electrospray ionization/single quadrupole mass spectrometry: validation with synthetic compounds.
Journal of mass spectrometry : JMS.
2001 Oct; 36(10):1116-24. doi:
10.1002/jms.214. [PMID: 11747105] - P Layer, J Keller, P G Lankisch. Pancreatic enzyme replacement therapy.
Current gastroenterology reports.
2001 Apr; 3(2):101-8. doi:
10.1007/s11894-001-0005-8. [PMID: 11276376] - T Ma, S Jayaraman, K S Wang, Y Song, B Yang, J Li, J A Bastidas, A S Verkman. Defective dietary fat processing in transgenic mice lacking aquaporin-1 water channels.
American journal of physiology. Cell physiology.
2001 Jan; 280(1):C126-34. doi:
10.1152/ajpcell.2001.280.1.c126. [PMID: 11121384] - U Schäfer, A Schneider, E Neugebauer. Identification of a nitric oxide-regulated zinc finger containing transcription factor using motif-directed differential display.
Biochimica et biophysica acta.
2000 Dec; 1494(3):269-76. doi:
10.1016/s0167-4781(00)00249-9. [PMID: 11121585] - K Yoshinaga, M Washizuka, Y Segawa. Diet stimulation as a synergistic factor of aggravation in a pancreatic bile duct ligation-induced rat pancreatitis model.
Biological & pharmaceutical bulletin.
2000 Nov; 23(11):1318-22. doi:
10.1248/bpb.23.1318. [PMID: 11085359] - W J Malaisse, P Damhaut, L Ladriere, S Goldman. Fate of 2-deoxy-2-[18F]fluoro-D-glucose in hyperglycemic rats.
International journal of molecular medicine.
2000 Nov; 6(5):549-52. doi:
10.3892/ijmm.6.5.549. [PMID: 11029522] - A Chiou, T Markidis, V Constantinou-Kokotou, R Verger, G Kokotos. Synthesis and study of a lipophilic alpha-keto amide inhibitor of pancreatic lipase.
Organic letters.
2000 Feb; 2(3):347-50. doi:
10.1021/ol991295s. [PMID: 10814319] - T A Winter, E R Lemmer, S J O'Keefe, J M Ogden. The effect of severe undernutrition, and subsequent refeeding on digestive function in human patients.
European journal of gastroenterology & hepatology.
2000 Feb; 12(2):191-6. doi:
10.1097/00042737-200012020-00010. [PMID: 10741934] - A Devoto, P Piffanelli, I Nilsson, E Wallin, R Panstruga, G von Heijne, P Schulze-Lefert. Topology, subcellular localization, and sequence diversity of the Mlo family in plants.
The Journal of biological chemistry.
1999 Dec; 274(49):34993-5004. doi:
10.1074/jbc.274.49.34993. [PMID: 10574976] - A P Feranchak, M K Sontag, J S Wagener, K B Hammond, F J Accurso, R J Sokol. Prospective, long-term study of fat-soluble vitamin status in children with cystic fibrosis identified by newborn screen.
The Journal of pediatrics.
1999 Nov; 135(5):601-10. doi:
10.1016/s0022-3476(99)70059-4. [PMID: 10547249] - J P Loria, M Rance, A G Palmer. A TROSY CPMG sequence for characterizing chemical exchange in large proteins.
Journal of biomolecular NMR.
1999 Oct; 15(2):151-5. doi:
10.1023/a:1008355631073. [PMID: 10605088] - M P Walters, J M Littlewood. Faecal bile acid and dietary residue excretion in cystic fibrosis: age group variations.
Journal of pediatric gastroenterology and nutrition.
1998 Sep; 27(3):296-300. doi:
10.1097/00005176-199809000-00005. [PMID: 9740200] - B M Winklhofer-Roob, B Tiran, P E Tuchschmid, M A van't Hof, D H Shmerling. Effects of pancreatic enzyme preparations on erythrocyte glutathione peroxidase activities and plasma selenium concentrations in cystic fibrosis.
Free radical biology & medicine.
1998 Jul; 25(2):242-9. doi:
10.1016/s0891-5849(98)00061-6. [PMID: 9667502] - J Lee, W Ip, P Durie. Is fibrosing colonopathy an immune mediated disease?.
Archives of disease in childhood.
1997 Jul; 77(1):66-70. doi:
10.1136/adc.77.1.66. [PMID: 9279159] - B M Winklhofer-Roob, P E Tuchschmid, L Molinari, D H Shmerling. Response to a single oral dose of all-rac-alpha-tocopheryl acetate in patients with cystic fibrosis and in healthy individuals.
The American journal of clinical nutrition.
1996 May; 63(5):717-21. doi:
10.1093/ajcn/63.5.717. [PMID: 8615354] - G L Briars, T P Dean, J L Murphy, C J Rolles, J O Warner. Faecal interleukin-8 and tumour necrosis factor-alpha concentrations in cystic fibrosis.
Archives of disease in childhood.
1995 Jul; 73(1):74-6. doi:
10.1136/adc.73.1.74. [PMID: 7639556] - M Thomson, A Clague, G J Cleghorn, R W Shepherd. Comparative in vitro and in vivo studies of enteric-coated pancrelipase preparations for pancreatic insufficiency.
Journal of pediatric gastroenterology and nutrition.
1993 Nov; 17(4):407-13. doi:
10.1097/00005176-199311000-00013. [PMID: 8145097] - R B Elliott, L C Escobar, H R Lees, R M Akroyd, H C Reilly. A comparison of two pancreatin microsphere preparations in cystic fibrosis.
The New Zealand medical journal.
1992 Mar; 105(930):107-8. doi:
NULL. [PMID: 1553114]