Bromelains (BioDeep_00000014929)
Secondary id: BioDeep_00001868485
human metabolite
代谢物信息卡片
Sodium 5-ethyl-6-hydroxy-2-oxo-5-(pentan-2-yl)-2,5-dihydropyrimidin-4-olic acid
化学式: C11H17N2NaO3 (248.1136812)
中文名称: 戊巴比妥钠
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCC(C)C1(C(=O)NC(=NC1=O)[O-])CC.[Na+]
InChI: /q
描述信息
Enzymes occurring in pineapple juice (Ananas sativus); used in tenderising meat and chill-proofing beer [DFC]. Along with papain, bromelain is one of the most popular substances to use for meat tenderizing.; Bromelain can refer to one of two protease enzymes extracted from the plant family Bromeliaceae, or it can refer to a combination of those enzymes along with other compounds produced in an extract. [BioSpider]. Bromelains is found in pineapple and fruits.
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives
Enzymes occurring in pineapple juice (Ananas sativus); used in tenderising meat and chill-proofing beer [DFC]
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic > C67084 - Barbiturate
D018377 - Neurotransmitter Agents > D018682 - GABA Agents > D018757 - GABA Modulators
同义名列表
17 个代谢物同义名
Sodium 5-ethyl-6-hydroxy-2-oxo-5-(pentan-2-yl)-2,5-dihydropyrimidin-4-olic acid; sodium 5-ethyl-6-hydroxy-2-oxo-5-(pentan-2-yl)-2,5-dihydropyrimidin-4-olate; sodium 5-ethyl-6-hydroxy-2-oxo-5-(pentan-2-yl)pyrimidin-4-olate; Pentobarbital, monosodium salt; Monosodium salt pentobarbital; Pentobarbital sodium; Nembutal sodium; Pentobarbitone; pentobarbital; Mebubarbital; Bromelains; Ethaminal; Etaminal; Diabutal; Nembutal; Mebumal; Sagatal
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:7984
- KEGG: C07423
- KEGGdrug: D00500
- PubChem: 23676152
- PubChem: 5982
- HMDB: HMDB0304826
- Metlin: METLIN66640
- DrugBank: DBSALT000442
- ChEMBL: CHEMBL971
- MeSH: Pentobarbital
- foodb: FDB001083
- chemspider: 5762
- CAS: 57-33-0
- ChEBI: CHEBI:189244
- PubChem: 9627
- NIKKAJI: J378.224G
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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Journal of animal science.
2023 Jun; ?(?):. doi:
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Journal of food and drug analysis.
2023 Jun; 31(2):278-288. doi:
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The Journal of pharmacy and pharmacology.
2023 Jan; 75(1):57-65. doi:
10.1093/jpp/rgac077. [PMID: 36385301] - Shana Wuken, Junjun Li, Xiaoli Gao, Shungang Jiao, Xiaojing Ma, Suyile Chen, Pengfei Tu, Luqi Huang, Xingyun Chai. Zerumbone, a major sesquiterpene from Syringa pinnatifolia Hemsl., exerts the sedative effect by regulating GABAergic nervous system.
Journal of ethnopharmacology.
2023 Jan; 301(?):115813. doi:
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Molecules (Basel, Switzerland).
2023 Jan; 28(2):. doi:
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Phytomedicine : international journal of phytotherapy and phytopharmacology.
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2022 Dec; 60(1):810-824. doi:
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2022 06; 145(?):105501. doi:
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Nutrients.
2022 May; 14(11):. doi:
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Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc.
2022 Mar; 34(2):226-230. doi:
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The International journal of neuroscience.
2022 Feb; ?(?):1-9. doi:
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Feb; 146(?):112301. doi:
10.1016/j.biopha.2021.112301. [PMID: 34915415] - Li Han, Aimei Chen, Ling Liu, Fang Wang. Leonurine Preconditioning Attenuates Ischemic Acute Kidney Injury in Rats by Promoting Nrf2 Nuclear Translocation and Suppressing TLR4/NF-κB Pathway.
Chemical & pharmaceutical bulletin.
2022; 70(1):66-73. doi:
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American journal of veterinary research.
2021 Nov; 83(1):95-99. doi:
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Nutrients.
2021 Aug; 13(8):. doi:
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Molecules (Basel, Switzerland).
2021 May; 26(11):. doi:
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Journal of controlled release : official journal of the Controlled Release Society.
2021 04; 332(?):30-39. doi:
10.1016/j.jconrel.2021.02.010. [PMID: 33600879] - A-Hyun Jeong, Jisu Hwang, Kyungae Jo, Singeun Kim, Yejin Ahn, Hyung Joo Suh, Hyeon-Son Choi. Fermented Gamma Aminobutyric Acid Improves Sleep Behaviors in Fruit Flies and Rodent Models.
International journal of molecular sciences.
2021 Mar; 22(7):. doi:
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Arquivos de neuro-psiquiatria.
2021 03; 79(3):216-221. doi:
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Journal of pharmacy practice.
2020 Dec; 33(6):895-898. doi:
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Molecules (Basel, Switzerland).
2020 Oct; 25(20):. doi:
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2020 09; 22(3):2032-2042. doi:
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Food & function.
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Scientific reports.
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Current drug discovery technologies.
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Journal of medical toxicology : official journal of the American College of Medical Toxicology.
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Current drug discovery technologies.
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Methods in cell biology.
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The Journal of pharmacology and experimental therapeutics.
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PloS one.
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The Journal of toxicological sciences.
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Journal of animal science.
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Journal of ethnopharmacology.
2016 Nov; 192(?):90-98. doi:
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Molecular pharmacology.
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Journal of food and drug analysis.
2016 10; 24(4):831-838. doi:
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Transplantation proceedings.
2016 Oct; 48(8):2815-2820. doi:
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Pakistan journal of pharmaceutical sciences.
2016 Sep; 29(5):1625-1632. doi:
NULL. [PMID: 27731822] - Yoshinori Kobayashi, Hiroaki Takemoto, Ziqi Fua, Emiko Shimizu, Yukitaka Kinjo. Enhancement of Pentobarbital-induced Sleep by the Vaporized Essential Oil of Citrus keraji var. kabuchii and its Characteristic Component, y-Terpinene.
Natural product communications.
2016 Aug; 11(8):1175-1178. doi:
. [PMID: 30725585] - Zhijuan Cao, Wenling Dai, Ran Zhang, Lu Chen, Xiangyu Yang, Liang Hu, Li-Yang Chiang, Wentao Liu. Opening of the Adenosine Triphosphate-sensitive Potassium Channel Attenuates Morphine Tolerance by Inhibiting JNK and Astrocyte Activation in the Spinal Cord.
The Clinical journal of pain.
2016 07; 32(7):617-23. doi:
10.1097/ajp.0000000000000299. [PMID: 26626290] - Johanne A Windeløv, Jens Pedersen, Jens J Holst. Use of anesthesia dramatically alters the oral glucose tolerance and insulin secretion in C57Bl/6 mice.
Physiological reports.
2016 Jun; 4(11):. doi:
10.14814/phy2.12824. [PMID: 27255361] - O A Adeoluwa, A O Aderibigbe, G O Agu. Pharmacological Evaluation of Central Nervous System Effects of Ethanol Leaf Extract of Olax Subscorpioidea in Experimental Animals.
Drug research.
2016 Apr; 66(4):203-10. doi:
10.1055/s-0035-1564137. [PMID: 26624003] - Fatemeh Abdollahnejad, Mahmoud Mosaddegh, Mohammad Kamalinejad, Javad Mirnajafi-Zadeh, Forough Najafi, Mehrdad Faizi. Investigation of sedative and hypnotic effects of Amygdalus communis L. extract: behavioral assessments and EEG studies on rat.
Journal of natural medicines.
2016 Apr; 70(2):190-7. doi:
10.1007/s11418-015-0958-9. [PMID: 26711831] - Yasuhiro Tsubokura, Toshio Kobayashi, Yutaka Oshima, Naoki Hashizume, Makoto Nakai, Shozo Ajimi, Nobuya Imatanaka. Effects of pentobarbital, isoflurane, or medetomidine-midazolam-butorphanol anesthesia on bronchoalveolar lavage fluid and blood chemistry in rats.
The Journal of toxicological sciences.
2016; 41(5):595-604. doi:
10.2131/jts.41.595. [PMID: 27665769] - Robert M Humble, Alexandra Ehlers, Brittany L Pakalniskis, Cory Morris, Denny Drees, Jeff Kulhavy, Matthew D Krasowski. Therapeutic Drug Monitoring of Pentobarbital: Experience at an Academic Medical Center.
Therapeutic drug monitoring.
2015 Dec; 37(6):783-91. doi:
10.1097/ftd.0000000000000217. [PMID: 26565790] - Wenfang Zhao, Yun Li, William Ma, Yazhong Ge, Yahui Huang. A study on quality components and sleep-promoting effects of GABA black tea.
Food & function.
2015 Oct; 6(10):3393-8. doi:
10.1039/c5fo00265f. [PMID: 26290415] - Hao Liu, Zhi Song, Da-Guang Liao, Tian-Yi Zhang, Feng Liu, Kai Zhuang, Kui Luo, Liang Yang, Jing He, Jian-Ping Lei. Anticonvulsant and Sedative Effects of Eudesmin isolated from Acorus tatarinowii on mice and rats.
Phytotherapy research : PTR.
2015 Jul; 29(7):996-1003. doi:
10.1002/ptr.5337. [PMID: 25851178] - Xue-Yan Wu, Yu-Ting Hu, Lei Guo, Jing Lu, Qiong-Bin Zhu, Er Yu, Juan-Li Wu, Li-Gen Shi, Man-Li Huang, Ai-Min Bao. Effect of pentobarbital and isoflurane on acute stress response in rat.
Physiology & behavior.
2015 Jun; 145(?):118-21. doi:
10.1016/j.physbeh.2015.04.003. [PMID: 25846436] - Yuki Ota, Yukio Ago, Tatsunori Tanaka, Shigeru Hasebe, Yui Toratani, Yusuke Onaka, Hitoshi Hashimoto, Kazuhiro Takuma, Toshio Matsuda. Anxiolytic-like effects of restraint during the dark cycle in adolescent mice.
Behavioural brain research.
2015 May; 284(?):103-11. doi:
10.1016/j.bbr.2015.02.010. [PMID: 25687845] - Kathryn A Morbitzer, J Dedrick Jordan, Denise H Rhoney. Vancomycin pharmacokinetic parameters in patients with acute brain injury undergoing controlled normothermia, therapeutic hypothermia, or pentobarbital infusion.
Neurocritical care.
2015 Apr; 22(2):258-64. doi:
10.1007/s12028-014-0079-4. [PMID: 25330755] - Yuefeng Li, Pingan Wu, Yanmei Ning, Xingke Yan, Tiantian Zhu, Chongbing Ma, Anguo Liu. Sedative and hypnotic effect of freeze-dried paeoniflorin and sini san freeze-dried powder in pentobarbital sodium-induced mice.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2014 Apr; 34(2):184-7. doi:
10.1016/s0254-6272(14)60076-5. [PMID: 24783931] - Aleksandar Rašković, Jelena Cvejić, Nebojša Stilinović, Svetlana Goločorbin-Kon, Saša Vukmirović, Neda Mimica-Dukić, Momir Mikov. Interaction between different extracts of Hypericum perforatum L. from Serbia and pentobarbital, diazepam and paracetamol.
Molecules (Basel, Switzerland).
2014 Mar; 19(4):3869-82. doi:
10.3390/molecules19043869. [PMID: 24686576] - Zhenhua Jin, Sojin Kim, Suengmok Cho, In-Ho Kim, Daeseok Han, Young-Ho Jin. Potentiating effect of glabridin on GABAA receptor-mediated responses in dorsal raphe neurons.
Planta medica.
2013 Oct; 79(15):1408-12. doi:
10.1055/s-0033-1350698. [PMID: 23975867] - Ping Li, Megan M Eaton, Joe Henry Steinbach, Gustav Akk. The benzodiazepine diazepam potentiates responses of α1β2γ2L γ-aminobutyric acid type A receptors activated by either γ-aminobutyric acid or allosteric agonists.
Anesthesiology.
2013 Jun; 118(6):1417-25. doi:
10.1097/aln.0b013e318289bcd3. [PMID: 23407108] - M Katayama, P Jiamsripong, A E Bukatina, T R Lombari, E M McMahon, N M Gades, M Belohlavek. Optimized administration regimen of lopinavir for a myocardial ischaemia reperfusion study in Sprague-Dawley rats.
Laboratory animals.
2013 Apr; 47(2):122-6. doi:
10.1177/0023677213476864. [PMID: 23563365] - Sheikh Rayees, Rohit Sharma, Gurdarshan Singh, Ishtiyaq Ahmad Najar, Amarinder Singh, Dastagir Basheer Ahamad, Subash Chander Sharma, Manoj Kumar Tikoo, Vijay Kumar Gupta, Payare Lal Sangwan, Surjeet Singh, Surinder Koul, Rakesh Kamal Johri. Acute, sub-acute and general pharmacological evaluation of 5-(3,4-methylenedioxyphenyl)-4-ethyl-2E,4E-pentadienoic acid piperidide (SK-20): a novel drug bioavailability enhancer.
Environmental toxicology and pharmacology.
2013 Mar; 35(2):347-59. doi:
10.1016/j.etap.2012.08.007. [PMID: 23182722] - Maria Pedro Guarino, Ana Isabel Santos, Miguel Mota-Carmo, Pedro Freire Costa. Effects of anaesthesia on insulin sensitivity and metabolic parameters in Wistar rats.
In vivo (Athens, Greece).
2013 Jan; 27(1):127-32. doi:
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Food chemistry.
2013 Jan; 136(1):160-3. doi:
10.1016/j.foodchem.2012.07.111. [PMID: 23017407] - Carla F Sabatini, M Lynne O'Sullivan, James E Valcour, William Sears, Ron J Johnson. Effects of injectable anesthetic combinations on left ventricular function and cardiac morphology in Sprague-Dawley rats.
Journal of the American Association for Laboratory Animal Science : JAALAS.
2013 Jan; 52(1):34-43. doi:
NULL. [PMID: 23562031] - Wanna Sirisangtragul, Bungorn Sripanidkulchai. Moduratory effect of Thai traditional medicine (Yahom Tultavai) on hepatic cytochrome P450 enzymes and pentobarbital-induced sleeping in mice.
African journal of traditional, complementary, and alternative medicines : AJTCAM.
2013; 10(4):128-36. doi:
10.4314/ajtcam.v10i4.21. [PMID: 24146513] - Fei Du, Yi Zhang, Xiao-Hong Zhu, Wei Chen. Simultaneous measurement of glucose blood-brain transport constants and metabolic rate in rat brain using in-vivo 1H MRS.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
2012 Sep; 32(9):1778-87. doi:
10.1038/jcbfm.2012.82. [PMID: 22714049] - Germain Sotoing Taïwe, Elisabeth Ngo Bum, Emmanuel Talla, Amadou Dawe, Fleur Clarisse Okomolo Moto, Gwladys Temkou Ngoupaye, Neteydji Sidiki, Bernard Dabole, Paul Désiré Djomeni Dzeufiet, Théophile Dimo, Michel De Waard. Antipsychotic and sedative effects of the leaf extract of Crassocephalum bauchiense (Hutch.) Milne-Redh (Asteraceae) in rodents.
Journal of ethnopharmacology.
2012 Aug; 143(1):213-20. doi:
10.1016/j.jep.2012.06.026. [PMID: 22750453] - Liang Xiong, Cheng Peng, Xiao-Fang Xie, Li Guo, Cheng-Jun He, Zhao Geng, Feng Wan, Ou Dai, Qin-Mei Zhou. Alkaloids isolated from the lateral root of Aconitum carmichaelii.
Molecules (Basel, Switzerland).
2012 Aug; 17(8):9939-46. doi:
10.3390/molecules17089939. [PMID: 22907155] - Pablinny Moreira Galdino, Marcus Vinícius Mariano Nascimento, Iziara Ferreira Florentino, Roberta Campos Lino, James Oluwagbamigbe Fajemiroye, Beatriz Abdallah Chaibub, José Realino de Paula, Thereza Christina Monteiro de Lima, Elson Alves Costa. The anxiolytic-like effect of an essential oil derived from Spiranthera odoratissima A. St. Hil. leaves and its major component, β-caryophyllene, in male mice.
Progress in neuro-psychopharmacology & biological psychiatry.
2012 Aug; 38(2):276-84. doi:
10.1016/j.pnpbp.2012.04.012. [PMID: 22542869] - Suengmok Cho, Ji-Hae Park, Ae Nim Pae, Daeseok Han, Dongsoo Kim, Nam-Chul Cho, Kyoung Tai No, Hyejin Yang, Minseok Yoon, Changho Lee, Makoto Shimizu, Nam-In Baek. Hypnotic effects and GABAergic mechanism of licorice (Glycyrrhiza glabra) ethanol extract and its major flavonoid constituent glabrol.
Bioorganic & medicinal chemistry.
2012 Jun; 20(11):3493-501. doi:
10.1016/j.bmc.2012.04.011. [PMID: 22543233] - Isidora Samojlik, Stojan Petković, Neda Mimica-Dukić, Biljana Božin. Acute and chronic pretreatment with essential oil of peppermint (Mentha × piperita L., Lamiaceae) influences drug effects.
Phytotherapy research : PTR.
2012 Jun; 26(6):820-5. doi:
10.1002/ptr.3638. [PMID: 22076909] - M Brückner, C S Schwedes. Successful treatment of permethrin toxicosis in two cats with an intravenous lipid administration.
Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere.
2012 Apr; 40(2):129-34. doi:
10.1055/s-0038-1623631. [PMID: 22526817] - Agung Nugroho, Myung-Hoe Kim, Jongwon Choi, Jae Sue Choi, Won Tae Jung, Kyung-Tae Lee, Hee-Juhn Park. Phytochemical studies of the phenolic substances in Aster glehni extract and its sedative and anticonvulsant activity.
Archives of pharmacal research.
2012 Mar; 35(3):423-30. doi:
10.1007/s12272-012-0304-7. [PMID: 22477188] - Hassan Rakhshandeh, Hamid Reza Sadeghnia, Ahmad Ghorbani. Sleep-prolonging effect of Coriandrum sativum hydro-alcoholic extract in mice.
Natural product research.
2012; 26(22):2095-8. doi:
10.1080/14786419.2011.613388. [PMID: 21988208] - Norbert Kummerfeld, Marko Legler, Peter Wohlsein, Maren Kummerfeld. [Morphological studies in different avian species on artefacts induced by euthanasia with T 61 " or Pentobarbital (Narcoren)].
Berliner und Munchener tierarztliche Wochenschrift.
2012 Jan; 125(1-2):27-31. doi:
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Phytomedicine : international journal of phytotherapy and phytopharmacology.
2011 Nov; 18(14):1255-61. doi:
10.1016/j.phymed.2011.06.018. [PMID: 21788126] - Karyn Bischoff, Robin Jaeger, Joseph G Ebel. An unusual case of relay pentobarbital toxicosis in a dog.
Journal of medical toxicology : official journal of the American College of Medical Toxicology.
2011 Sep; 7(3):236-9. doi:
10.1007/s13181-011-0160-8. [PMID: 21660622] - Kuichang Hua, Lei Zhang, Zhenhui Zhang, Yong Guo, Tianying Guo. Surface hydrophilic modification with a sugar moiety for a uniform-sized polymer molecularly imprinted for phenobarbital in serum.
Acta biomaterialia.
2011 Aug; 7(8):3086-93. doi:
10.1016/j.actbio.2011.05.006. [PMID: 21605708] - Mohan G Kalaskar, Sanjay J Surana. Free radical scavenging and hepatoprotective potential of Ficus microcarpa L. fil. bark extracts.
Journal of natural medicines.
2011 Jul; 65(3-4):633-40. doi:
10.1007/s11418-011-0532-z. [PMID: 21625948] - Yu-Feng Chen, Ming-Hong Zhao, Ming Yan, Guo-Bing Shi, Guan-Xin Hou, Ying Huang, Xin Wang, Qin-Chun Zhao. Analgesic activity of the aqueous fraction from the ethanolic extract of Chrysanthemum indicum in mice.
Die Pharmazie.
2011 Jul; 66(7):538-42. doi:
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Journal of medical toxicology : official journal of the American College of Medical Toxicology.
2011 Jun; 7(2):154-7. doi:
10.1007/s13181-011-0135-9. [PMID: 21387119] - Xiang-yang Wu, Jiang-li Zhao, Min Zhang, Fang Li, Ting Zhao, Liu-qing Yang. Sedative, hypnotic and anticonvulsant activities of the ethanol fraction from Rhizoma Pinelliae Praeparatum.
Journal of ethnopharmacology.
2011 May; 135(2):325-9. doi:
10.1016/j.jep.2011.03.016. [PMID: 21402138]