Epirubicin (BioDeep_00000014656)

human metabolite blood metabolite Chemicals and Drugs Antibiotics

代谢物信息卡片

(8S,10S)-10-{[(2R,4S,5R,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy}-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,7,8,9,10,12-hexahydrotetracene-5,12-dione

化学式: C27H29NO11 (543.1740524)
中文名称: 表柔比星
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)CO)O)N)O
InChI: InChI=1S/C27H29NO11/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3/t10-,13-,15-,17-,22-,27-/m0/s1

描述信息

Epirubicin is only found in individuals that have used or taken this drug. It is an anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. [PubChem]Epirubicin has antimitotic and cytotoxic activity. It inhibits nucleic acid (DNA and RNA) and protein synthesis through a number of proposed mechanisms of action: Epirubicin forms complexes with DNA by intercalation between base pairs, and it inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the ligation-religation reaction that topoisomerase II catalyzes. It also interferes with DNA replication and transcription by inhibiting DNA helicase activity.
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01D - Cytotoxic antibiotics and related substances > L01DB - Anthracyclines and related substances
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor
D000970 - Antineoplastic Agents > D059003 - Topoisomerase Inhibitors > D059005 - Topoisomerase II Inhibitors
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C259 - Antineoplastic Antibiotic
C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor > C1748 - Topoisomerase Inhibitor
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent
D004791 - Enzyme Inhibitors
Same as: D07901

同义名列表

37 个代谢物同义名

(8S,10S)-10-{[(2R,4S,5R,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy}-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,7,8,9,10,12-hexahydrotetracene-5,12-dione; Kenfarma brand OF epirubicin hydrochloride; Lemery brand OF epirubicin hydrochloride; Pfizer brand OF epirubicin hydrochloride; Cell pharm brand OF epirubicin; Hydrochloride, epirubicin; Epirubicin hydrochloride; 4-Epi-doxorubicin; 4 Epi doxorubicin; 4 Epidoxorubicin; 4-Epi-adriamycin; 4 Epi adriamycin; 4-Epidoxorubicin; 4 Epiadriamycin; 4-Epiadriamycin; Pidorubicinum; Farmorubicine; Epiadriamycin; Pharmorubicin; Farmorubicina; Epirubicinum; Pidorubicina; Farmorubicin; Pidorubicine; Epirubicina; Epirubicine; Epirubicin; 4 Epi DXR; 4-Epi-DXR; EPI cell; EPI-cell; Ellence; EPIcell; IMI-28; Epilem; IMI 28; IMI28

数据库引用编号

15 个数据库交叉引用编号

ChEBI: CHEBI:47898
KEGG: C11230
PubChem: 41867
HMDB: HMDB0014588
Metlin: METLIN548
DrugBank: DB00445
ChEMBL: CHEMBL417
Wikipedia: Epirubicin
MeSH: Epirubicin
chemspider: 38201
CAS: 56420-45-2
PubChem: 13409
PDB-CCD: DM6
NIKKAJI: J81.933F
RefMet: Epirubicin

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

9606 - Homo sapiens: -
1950 - Streptomyces peucetius: 10.1038/NBT0198-69

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Ji'an He, Mei Li, Yan Xu, Ning Fan, Chong Tian, Tianye Lv, Wenge Xing, Haipeng Yu. In vitro characteristics of Epirubicin-loaded thermosensitive liquid embolic agent. Journal of cancer research and therapeutics. 2023 Dec; 19(6):1597-1602. doi: 10.4103/jcrt.jcrt_334_23. [PMID: 38156927]
Solomon Owumi, Uche Arunsi, Moses Otunla, Grace Adebisi, Ahmad Altayyar, Chioma Irozuru. 3-Indolepropionic acid mitigates sub-acute toxicity in the cardiomyocytes of epirubicin-treated female rats. Naunyn-Schmiedeberg's archives of pharmacology. 2023 Jul; ?(?):. doi: 10.1007/s00210-023-02618-y. [PMID: 37477660]
Shilin Tian, Yue Lu, Haifeng Gao, Zitong Chen, Min Niu, Changjun Wang, Bin Liu. Epirubicin may enhance the inhibition of hepatocellular carcinoma induced by iodine-125 seeds through downregulating WNT pathway. Asia-Pacific journal of clinical oncology. 2023 Jun; 19(3):355-364. doi: 10.1111/ajco.13873. [PMID: 36464954]
Yu-Jia Wang, Ling Tang, Xu-Hong Lu, Ji-Tao Liu, Yuan-Yuan Wang, Hong-Xia Geng, Xue-Tao Li, Quan An. Efficacy of epi-1 modified epirubicin and curcumin encapsulated liposomes targeting-EpCAM in the inhibition of epithelial ovarian cancer cells. Journal of liposome research. 2023 Jun; 33(2):197-213. doi: 10.1080/08982104.2022.2153138. [PMID: 36440599]
Solomon E Owumi, Grace Adebisi. Epirubicin Treatment Induces Neurobehavioral, Oxido-Inflammatory and Neurohistology Alterations in Rats: Protective Effect of the Endogenous Metabolite of Tryptophan - 3-Indolepropionic Acid. Neurochemical research. 2023 Apr; ?(?):. doi: 10.1007/s11064-023-03941-9. [PMID: 37097396]
Gang Yuan, Yanneng Xu, Xiaopeng Bai, Weiming Wang, Xuan Wu, Jianli Chen, Jie Li, Xiaohui Jia, Zeyun Gu, Xun Zhang, Wei Hu, Jianfang Wang, Yong Liu, Xiao-Ming Zhu. Autophagy-Targeted Calcium Phosphate Nanoparticles Enable Transarterial Chemoembolization for Enhanced Cancer Therapy. ACS applied materials & interfaces. 2023 Feb; ?(?):. doi: 10.1021/acsami.2c18267. [PMID: 36848495]
Hongli Yu, Jianqin Yan, Zhipeng Li, Tingting Song, Fang Ning, Jinshan Tan, Yong Sun. Enhanced photothermal-ferroptosis effects based on RBCm-coated PDA nanoparticles for effective cancer therapy. Journal of materials chemistry. B. 2023 01; 11(2):415-429. doi: 10.1039/d2tb02329f. [PMID: 36512437]
Xiaofang Li, Xin Guo, Jun Li, Li Yuan, Haixiong Wang. Preventing effect of astragalus polysaccharide on cardiotoxicity induced by chemotherapy of epirubicin: A pilot study. Medicine. 2022 Aug; 101(32):e30000. doi: 10.1097/md.0000000000030000. [PMID: 35960075]
Wei Ha, Jun-Li Yang, Yan-Ping Shi. Antibacterial metal-phenolic nanosheets as smart carriers for the controlled release of epirubicin hydrochloride. Nanoscale. 2022 Jul; 14(27):9806-9817. doi: 10.1039/d2nr02066a. [PMID: 35770915]
P Rollin, E Xylinas, C Lanz, F Audenet, S Brunelle, E Compérat, N Houédé, S Larré, A Masson-Lecomte, G Pignot, M Roumiguié, A Méjean, M Rouprêt, Y Neuzillet. [Intravesical adjuvant regimen of epitubicin for intermediate risk NMIBC: Feasability study from CC-AFU vessie]. Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie. 2022 Apr; 32(5):326-331. doi: 10.1016/j.purol.2021.12.008. [PMID: 35151544]
P Leon, F Saint, F Audenet, M Roumiguié, Y Allory, Y Loriot, A Masson-Lecomte, B Pradère, T Seisen, O Traxer, E Xylinas, M Roupret, Y Neuzillet. [Guidelines from the cancer committee of the French Association of Urology (CC-AFU) for adequate intravesical instillations of Mitomycin C, Epirubicin, and BCG for non-muscle invasive bladder cancer]. Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie. 2022 Apr; 32(5):299-311. doi: 10.1016/j.purol.2022.01.004. [PMID: 35151545]
Huaran Zhang, Xuejia Zhang, Yun Huang, Jie Yuan, Xiaoyi Wei, Jianhua Ju. Discovery, Structure Correction, and Biosynthesis of Actinopyrones, Cytotoxic Polyketides from the Deep-Sea Hydrothermal-Vent-Derived Streptomyces sp. SCSIO ZS0520. Journal of natural products. 2022 03; 85(3):625-633. doi: 10.1021/acs.jnatprod.1c00901. [PMID: 34852194]
Dehua Kong, Wenyu Hong, Miao Yu, Yanxia Li, YaXin Zheng, Xue Ying. Multifunctional Targeting Liposomes of Epirubicin Plus Resveratrol Improved Therapeutic Effect on Brain Gliomas. International journal of nanomedicine. 2022; 17(?):1087-1110. doi: 10.2147/ijn.s346948. [PMID: 35313461]
Luo Qiong, Jun Yin. Orosomucoid 1 promotes epirubicin resistance in breast cancer by upregulating the expression of matrix metalloproteinases 2 and 9. Bioengineered. 2021 12; 12(1):8822-8832. doi: 10.1080/21655979.2021.1987067. [PMID: 34654351]
Elizabeth C Smyth, Georgios Vlachogiannis, Somaieh Hedayat, Alice Harbery, Sanna Hulkki-Wilson, Massimiliano Salati, Kyriakos Kouvelakis, Javier Fernandez-Mateos, George D Cresswell, Elisa Fontana, Therese Seidlitz, Clare Peckitt, Jens C Hahne, Andrea Lampis, Ruwaida Begum, David Watkins, Sheela Rao, Naureen Starling, Tom Waddell, Alicia Okines, Tom Crosby, Was Mansoor, Jonathan Wadsley, Gary Middleton, Matteo Fassan, Andrew Wotherspoon, Chiara Braconi, Ian Chau, Igor Vivanco, Andrea Sottoriva, Daniel E Stange, David Cunningham, Nicola Valeri. EGFR amplification and outcome in a randomised phase III trial of chemotherapy alone or chemotherapy plus panitumumab for advanced gastro-oesophageal cancers. Gut. 2021 09; 70(9):1632-1641. doi: 10.1136/gutjnl-2020-322658. [PMID: 33199443]
Margarita Y Zhelyazkova, Nadya G Hristova-Avakumova, Georgi Tsv Momekov. Antitumor activity of the combination of artemisinin and epirubicin in human leukemia cells. Folia medica. 2021 Aug; 63(4):488-495. doi: 10.3897/folmed.63.e55938. [PMID: 35851170]
Xue-Tao Li, Ming Jing, Fu-Yi Cai, Xue-Min Yao, Liang Kong, Xiao-Bo Wang. Enhanced antitumour efficiency of R8GD-modified epirubicin plus tetrandrine liposomes in treatment of gastric cancer via inhibiting tumour metastasis. Journal of liposome research. 2021 Jun; 31(2):145-157. doi: 10.1080/08982104.2020.1748647. [PMID: 32223361]
Julie M Janssen, Kristel Van Calsteren, Thomas P C Dorlo, Michael J Halaska, Robert Fruscio, Petronella Ottevanger, Carolien P Schröder, Ingrid Boere, Petronella O Witteveen, Rebecca C Painter, Ruud Bekkers, Vit Drochytek, Jos H Beijnen, Alwin D R Huitema, Frederic C H Amant. Population Pharmacokinetics of Docetaxel, Paclitaxel, Doxorubicin and Epirubicin in Pregnant Women with Cancer: A Study from the International Network of Cancer, Infertility and Pregnancy (INCIP). Clinical pharmacokinetics. 2021 06; 60(6):775-784. doi: 10.1007/s40262-020-00961-4. [PMID: 33506375]
Yi-Ting Lin, Xin-Yue Zheng, Yi-Fan Yao, Yu-Ying Zhang, Ting-Ting Huang, Yun-Lan Zhu, Jun Pei, Jin Wang, Ming Chu, Yue-Dan Wang. [Therapeutic Effect of Spleen Low Molecular Weight Extracts on Leukopenia Caused by Epirubicin in Mice and Its Mechanism]. Zhongguo shi yan xue ye xue za zhi. 2021 Jun; 29(3):969-974. doi: 10.19746/j.cnki.issn.1009-2137.2021.03.050. [PMID: 34105502]
Irisvan S Ribeiro, Francisco J G Pontes, Maria J M Carneiro, Nayara A Sousa, Vicente P T Pinto, Fábio O S Ribeiro, Durcilene A Silva, Gisele S Araújo, José D B Marinho Filho, Ana J Araújo, Haroldo C B Paula, Judith P A Feitosa, Regina C M de Paula. Poly(ε-caprolactone) grafted cashew gum nanoparticles as an epirubicin delivery system. International journal of biological macromolecules. 2021 May; 179(?):314-323. doi: 10.1016/j.ijbiomac.2021.03.011. [PMID: 33675833]
Alessandro De Vita, Chiara Liverani, Roberto Molinaro, Jonathan O Martinez, Kelly A Hartman, Chiara Spadazzi, Giacomo Miserocchi, Francesca Taraballi, Michael Evangelopoulos, Federica Pieri, Alberto Bongiovanni, Laura Mercatali, Ennio Tasciotti, Toni Ibrahim. Lysyl oxidase engineered lipid nanovesicles for the treatment of triple negative breast cancer. Scientific reports. 2021 03; 11(1):5107. doi: 10.1038/s41598-021-84492-3. [PMID: 33658580]
Balasubramani Gl, Rinky Rajput, Manish Gupta, Pradeep Dahiya, Jitendra K Thakur, Rakesh Bhatnagar, Abhinav Grover. Structure-based drug repurposing to inhibit the DNA gyrase of Mycobacterium tuberculosis. The Biochemical journal. 2020 11; 477(21):4167-4190. doi: 10.1042/bcj20200462. [PMID: 33030198]
Junjie Li, Keda Yu, Da Pang, Changqin Wang, Jun Jiang, Suisheng Yang, Yunjiang Liu, Peifen Fu, Yuan Sheng, Guojun Zhang, Yali Cao, Qi He, Shude Cui, Xijing Wang, Guosheng Ren, Xinzheng Li, Shiyou Yu, Pengxi Liu, Xiang Qu, Jinhai Tang, Ouchen Wang, Zhimin Fan, Guoqin Jiang, Jin Zhang, Jiandong Wang, Hongwei Zhang, Shui Wang, Jianguo Zhang, Feng Jin, Nanyan Rao, Binlin Ma, Pingqing He, Binghe Xu, Zhigang Zhuang, Jianfeng Wang, Qiang Sun, Xiaofeng Guo, Miao Mo, Zhimin Shao. Adjuvant Capecitabine With Docetaxel and Cyclophosphamide Plus Epirubicin for Triple-Negative Breast Cancer (CBCSG010): An Open-Label, Randomized, Multicenter, Phase III Trial. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2020 06; 38(16):1774-1784. doi: 10.1200/jco.19.02474. [PMID: 32275467]
Bernhard Tribukait. Early prediction of pathologic response to neoadjuvant treatment of breast cancer: use of a cell-loss metric based on serum thymidine kinase 1 and tumour volume. BMC cancer. 2020 May; 20(1):440. doi: 10.1186/s12885-020-06925-y. [PMID: 32423477]
Liangliang Bi, Huaxing Zhang, Ruoling Han, Wei Chen, Na Zhao. Application of a combination of echocardiographic techniques in an experimental model of epirubicin-induced cardiotoxicity. The international journal of cardiovascular imaging. 2020 May; 36(5):841-854. doi: 10.1007/s10554-020-01777-w. [PMID: 32034566]
Shujun Li, Yahai Liang, Yanxia Wu, Zhong Huang, Yanming Lin, Zhixiong Yang, Hualin Chen, Aibing Wu. A comparative study on etoposide combined with lobaplatin or cisplatin in the first-line treatment of extensive-stage small cell lung cancer. Journal of B.U.ON. : official journal of the Balkan Union of Oncology. 2020 May; 25(3):1490-1496. doi: NULL. [PMID: 32862595]
Mariann Gyöngyösi, Dominika Lukovic, Katrin Zlabinger, Andreas Spannbauer, Alfred Gugerell, Noemi Pavo, Denise Traxler, Dietmar Pils, Gerald Maurer, Andras Jakab, Martin Riesenhuber, Andreas Pircher, Johannes Winkler, Jutta Bergler-Klein. Liposomal doxorubicin attenuates cardiotoxicity via induction of interferon-related DNA damage resistance. Cardiovascular research. 2020 04; 116(5):970-982. doi: 10.1093/cvr/cvz192. [PMID: 31346605]
Ming Jing, Xiao-Jie Bi, Xue-Min Yao, Fuyi Cai, Jing-Jing Liu, Min Fu, Liang Kong, Xin-Ze Liu, Lu Zhang, Si-Yu He, Lian-Qun Jia, Xue-Tao Li. Enhanced antitumor efficacy using epirubicin and schisandrin B co-delivery liposomes modified with PFV via inhibiting tumor metastasis. Drug development and industrial pharmacy. 2020 Apr; 46(4):621-634. doi: 10.1080/03639045.2020.1742145. [PMID: 32162988]
Junhui Sun, Guanhui Zhou, Xiaoxi Xie, Wenjiang Gu, Jing Huang, Dedong Zhu, Wenhao Hu, Qinming Hou, Changsheng Shi, Tiefeng Li, Xin Zhang, Wenbin Ji, Shihong Ying, Zhiyi Peng, Jian Zhou, Zhihai Yu, Jiansong Ji, Haijun Du, Xiaohua Guo, Jian Fang, Jun Han, Huanhai Xu, Zhichao Sun, Wenqiang Yu, Guoliang Shao, Xia Wu, Hongjie Hu, Ling Li, Jiaping Zheng, Jun Luo, Yutang Chen, Guohong Cao, Tingyang Hu. Efficacy and Safety of Drug-Eluting Beads Transarterial Chemoembolization by CalliSpheres® in 275 Hepatocellular Carcinoma Patients: Results From the Chinese CalliSpheres® Transarterial Chemoembolization in Liver Cancer (CTILC) Study. Oncology research. 2020 Feb; 28(1):75-94. doi: 10.3727/096504019x15662966719585. [PMID: 31558180]
Tetsuya Masada, Toshihiro Tanaka, Hideyuki Nishiofuku, Yasushi Fukuoka, Ryosuke Taiji, Takeshi Sato, Shota Tatsumoto, Kiyoyuki Minamiguchi, Nagaaki Marugami, Kimihiko Kichikawa. Use of a Glass Membrane Pumping Emulsification Device Improves Systemic and Tumor Pharmacokinetics in Rabbit VX2 Liver Tumor in Transarterial Chemoembolization. Journal of vascular and interventional radiology : JVIR. 2020 Feb; 31(2):347-351. doi: 10.1016/j.jvir.2019.06.015. [PMID: 31542274]
Liang Kong, Fu-Yi Cai, Xue-Min Yao, Ming Jing, Min Fu, Jing-Jing Liu, Si-Yu He, Lu Zhang, Xin-Ze Liu, Rui-Jun Ju, Xue-Tao Li. RPV-modified epirubicin and dioscin co-delivery liposomes suppress non-small cell lung cancer growth by limiting nutrition supply. Cancer science. 2020 Feb; 111(2):621-636. doi: 10.1111/cas.14256. [PMID: 31777993]
Xiang Li, Qian Zou, Jing Zhang, Peng Zhang, Xiong Zhou, Satya Siva Kishan Yalamarty, Xinli Liang, Yali Liu, Qin Zheng, Jianqing Gao. Self-Assembled Dual-Targeted Epirubicin-Hybrid Polydopamine Nanoparticles for Combined Chemo-Photothermal Therapy of Triple-Negative Breast Cancer. International journal of nanomedicine. 2020; 15(?):6791-6811. doi: 10.2147/ijn.s260477. [PMID: 32982234]
Natalia Treder, Olga Maliszewska, Ilona Olędzka, Piotr Kowalski, Natalia Miękus, Tomasz Bączek, Ewa Bień, Małgorzata Anna Krawczyk, Elżbieta Adamkiewicz-Drożynska, Alina Plenis. Development and validation of a high-performance liquid chromatographic method with a fluorescence detector for the analysis of epirubicin in human urine and plasma, and its application in drug monitoring. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2020 Jan; 1136(?):121910. doi: 10.1016/j.jchromb.2019.121910. [PMID: 31830661]
Nezhat Jandaghi, Shohreh Jahani, Mohammad Mehdi Foroughi, Maryam Kazemipour, Mehdi Ansari. Cerium-doped flower-shaped ZnO nano-crystallites as a sensing component for simultaneous electrochemical determination of epirubicin and methotrexate. Mikrochimica acta. 2019 12; 187(1):24. doi: 10.1007/s00604-019-4016-2. [PMID: 31807919]
Ai Ch'i Liew, Kok-Khiang Peh, Boon Seang Tan, Wei Zhao, Balamurugan Tangiisuran. Evaluation of chemotherapy-induced toxicity and health-related quality of life amongst early-stage breast cancer patients receiving Chinese herbal medicine in Malaysia. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. 2019 Dec; 27(12):4515-4524. doi: 10.1007/s00520-019-04724-1. [PMID: 30911917]
Neng Wang, Bowen Yang, Gulizeba Muhetaer, Shengqi Wang, Yifeng Zheng, Jiahong Lu, Min Li, Fengxue Zhang, Honglin Situ, Yi Lin, Zhiyu Wang. XIAOPI formula promotes breast cancer chemosensitivity via inhibiting CXCL1/HMGB1-mediated autophagy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2019 Dec; 120(?):109519. doi: 10.1016/j.biopha.2019.109519. [PMID: 31629951]
Jing-Jing Liu, Wei Tang, Min Fu, Xiao-Qing Gong, Liang Kong, Xue-Min Yao, Ming Jing, Fu-Yi Cai, Xue-Tao Li, Rui-Jun Ju. Development of R8 modified epirubicin-dihydroartemisinin liposomes for treatment of non-small-cell lung cancer. Artificial cells, nanomedicine, and biotechnology. 2019 Dec; 47(1):1947-1960. doi: 10.1080/21691401.2019.1615932. [PMID: 31079495]
Qingying Guo, Min Liu, Yanna Zhao, Yushu Wu, Jie Liu, Chang Cai, Yabo Shi, Jun Han. Spectroscopic and cytotoxicity studies on the combined interaction of (-)-epigallocatechin-3-gallate and anthracycline drugs with human serum albumin. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2019 Nov; 222(?):117213. doi: 10.1016/j.saa.2019.117213. [PMID: 31177010]
Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
Klaudia K Brodaczewska, Zofia F Bielecka, Kamila Maliszewska-Olejniczak, Cezary Szczylik, Camillo Porta, Ewa Bartnik, Anna M Czarnecka. Metastatic renal cell carcinoma cells growing in 3D on poly‑D‑lysine or laminin present a stem‑like phenotype and drug resistance. Oncology reports. 2019 Nov; 42(5):1878-1892. doi: 10.3892/or.2019.7321. [PMID: 31545459]
Wenjiao Jiang, Huijie Guo, Dongyuan Su, Hongjiang Xu, Hongmei Gu, Kun Hao. Ameliorative effect of Magnesium Isoglycyrrhizinate on hepatic encephalopathy by Epirubicin. International immunopharmacology. 2019 Oct; 75(?):105774. doi: 10.1016/j.intimp.2019.105774. [PMID: 31351363]
Xu Jing, Chao Sun, Huigang Chen, Jing Sun, Ying Zhang, Jing Wu. Protection of paeonol against epirubicin-induced hepatotoxicity: A metabolomic study. Bioscience trends. 2019 Jul; 13(3):253-260. doi: 10.5582/bst.2019.01105. [PMID: 31231109]
Fengyi Guo, Tian Xia, Yedan Zhang, Xiaotong Ma, Zhongrui Yan, Shaohua Hao, Yali Han, Ruihong Ma, Yuan Zhou, Xue Du. Menstrual blood derived mesenchymal stem cells combined with Bushen Tiaochong recipe improved chemotherapy-induced premature ovarian failure in mice by inhibiting GADD45b expression in the cell cycle pathway. Reproductive biology and endocrinology : RB&E. 2019 Jul; 17(1):56. doi: 10.1186/s12958-019-0499-2. [PMID: 31311554]
Jingxian Gu, Xing Zhang, Ruixia Cui, Jia Zhang, Zhixin Wang, Yifan Jia, Runchen Miao, Yanyan Dong, Xiaohua Ma, Haining Fan, Haijiu Wang, Li Ren, Yiming Li, Wenquan Niu, Jingyao Zhang, Kai Qu, Chang Liu. Prognostic predictors for patients with hepatocellular carcinoma receiving adjuvant transcatheter arterial chemoembolization. European journal of gastroenterology & hepatology. 2019 Jul; 31(7):836-844. doi: 10.1097/meg.0000000000001346. [PMID: 30614882]
Amirhossein Bahreyni, Mohammad Ramezani, Mona Alibolandi, Pirooz Hassanzadeh, Khalil Abnous, Seyed Mohammad Taghdisi. High affinity of AS1411 toward copper; its application in a sensitive aptasensor for copper detection. Analytical biochemistry. 2019 06; 575(?):1-9. doi: 10.1016/j.ab.2019.03.016. [PMID: 30926271]
Laura Martínez-Sogues, Anna Vila, Xavier Roura, Josep Pastor, Rosa Novellas, Alberto Marco, Maria Cuvertoret-Sanz, Jorge Martínez, Laia Solano-Gallego. Hypercalcemia of Malignancy in a Dog Diagnosed With Cholangiocellular Carcinoma. Topics in companion animal medicine. 2019 Jun; 35(?):1-5. doi: 10.1053/j.tcam.2019.02.001. [PMID: 31122681]
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