2,3-Diketo-L-gulonate (BioDeep_00000014568)

Main id: BioDeep_00000005573

 

human metabolite Endogenous


代谢物信息卡片


(4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoic acid

化学式: C6H8O7 (192.027)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(C(C(C(=O)C(=O)C(=O)O)O)O)O
InChI: InChI=1S/C6H8O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-3,7-9H,1H2,(H,12,13)/t2-,3?/m0/s1

描述信息

2,3-Diketo-L-gulonate is an intermediate in Ascorbate and aldarate metabolism. 2,3-Diketo-L-gulonate is produced from Dehydroascorbate and then converted to L-Xylonate via the enzyme Lyases (EC 4.1.1.-). [HMDB]
2,3-Diketo-L-gulonate is an intermediate in Ascorbate and aldarate metabolism. 2,3-Diketo-L-gulonate is produced from Dehydroascorbate and then converted to L-Xylonate via the enzyme Lyases (EC 4.1.1.-).
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同义名列表

10 个代谢物同义名

(4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoic acid; (5S)-4,5,6-trihydroxy-2,3-dioxohexanoic acid; (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate; L-Threo-hexo-2,3-diulosonic acid; L-Threo-2,3-hexodiulosonic acid; 2,3-diketo-L Gulonic acid; 2,3-Diketo-L-gulonic acid; 2,3-Diketogulonic Acid; 2,3-Diketo-L-gulonate; Diketogulonic acid



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

2 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(1)

PathBank(1)

  • Ascorbate Metabolism: Ascorbic acid + Hydrogen Ion + Hydrogen peroxide ⟶ Ascorbic acid + Dehydroascorbic acid + Water

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Rebecca A Dewhirst, Lorna Murray, C Logan Mackay, Ian H Sadler, Stephen C Fry. Characterisation of the non-oxidative degradation pathway of dehydroascorbic acid in slightly acidic aqueous solution. Archives of biochemistry and biophysics. 2020 03; 681(?):108240. doi: 10.1016/j.abb.2019.108240. [PMID: 31883928]
  • Rebecca A Dewhirst, Stephen C Fry. The oxidation of dehydroascorbic acid and 2,3-diketogulonate by distinct reactive oxygen species. The Biochemical journal. 2018 11; 475(21):3451-3470. doi: 10.1042/bcj20180688. [PMID: 30348642]
  • Anna Kärkönen, Rebecca A Dewhirst, C Logan Mackay, Stephen C Fry. Metabolites of 2,3-diketogulonate delay peroxidase action and induce non-enzymic H2O2 generation: Potential roles in the plant cell wall. Archives of biochemistry and biophysics. 2017 04; 620(?):12-22. doi: 10.1016/j.abb.2017.03.006. [PMID: 28315301]
  • Harriet T Parsons, Stephen C Fry. Oxidation of dehydroascorbic acid and 2,3-diketogulonate under plant apoplastic conditions. Phytochemistry. 2012 Mar; 75(?):41-9. doi: 10.1016/j.phytochem.2011.12.005. [PMID: 22226246]
  • Anna Kärkönen, Stephen C Fry. Effect of ascorbate and its oxidation products on H2O2 production in cell-suspension cultures of Picea abies and in the absence of cells. Journal of experimental botany. 2006; 57(8):1633-44. doi: 10.1093/jxb/erj197. [PMID: 16698813]
  • M M Rasulov, I G Kuznetsov, A G Zabozlaev, M G Voronkov. [Oxyferriscorbone: anti-ulcer effect and its possible mechanisms]. Biulleten' eksperimental'noi biologii i meditsiny. 1994 May; 117(5):490-3. doi: ". [PMID: 9296698]
  • P Dostert, M S Benedetti, E Frigerio. Effect of L-dopa, oxyferriscorbone and ferrous iron on in vivo lipid peroxidation. Journal of neural transmission. General section. 1991; 84(1-2):119-28. doi: 10.1007/bf01249115. [PMID: 2054143]
  • M M Rasulov, I G Kuznetsov, S K Suslova, M V Velikaia, M G Voronkov. [Possible mechanisms of anti-ulcer action of silatranes]. Biulleten' eksperimental'noi biologii i meditsiny. 1990 Sep; 110(9):249-52. doi: ". [PMID: 2268706]
  • M Takagi, A Kawajiri, K Nakata, N Morita. Behavior of 3,4-endiol form of 2,3-diketo-gulono-delta-lactone formed from dehydro-L-ascorbic acid in deoxygenated and neutral solution. Journal of nutritional science and vitaminology. 1989 Feb; 35(1):61-70. doi: 10.3177/jnsv.35.61. [PMID: 2738715]
  • S G Vaĭnshteĭn, F A Zvershkhanovskiĭ. [Lipid peroxidation in patients with gastric ulcer and cancer]. Voprosy onkologii. 1984; 30(10):39-41. doi: . [PMID: 6495681]
  • . . . . doi: . [PMID: 21846329]