D-Arginine (BioDeep_00000014496)

 

Secondary id: BioDeep_00000405567

human metabolite PANOMIX_OTCML-2023 Endogenous natural product


代谢物信息卡片


(2R)-2-Amino-5-(carbamimidamido)pentanoic acid

化学式: C6H14N4O2 (174.1117)
中文名称: D-精氨酸
谱图信息: 最多检出来源 Homo sapiens(lipidsearch) 12.51%

分子结构信息

SMILES: C(CC(C(=O)O)N)CN=C(N)N
InChI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t4-/m1/s1

描述信息

D-Arginine, also known as D-2-amino-5-guanidinovaleric acid or (2R)-2-amino-5-guanidinopentanoate, is a member of the class of compounds known as D-alpha-amino acids. D-alpha-Amino acids are alpha amino acids which have the D-configuration of the alpha-carbon atom. D-Arginine is slightly soluble (in water). D-Arginine can be found in human epidermis and platelet tissues. Within the cell, D-arginine is primarily located in the peroxisome. In humans, D-arginine is involved in D-arginine and D-ornithine metabolism. Arginine (abbreviated as Arg or R) is an alpha-amino acid that is used in the biosynthesis of proteins. It is encoded by the codons CGU, CGC, CGA, CGG, AGA, and AGG. It contains an alpha-amino group, an alpha-carboxylic acid group, and a side chain consisting of a 3-carbon aliphatic straight chain ending in a guanidino group. At physiological pH, the carboxylic acid is deprotonated, the amino group is protonated, and the guanidino group is also protonated to give the guanidinium form (-C-(NH2)2+), making arginine a charged, aliphatic amino acid. It is the precursor for the biosynthesis of nitric oxide. D-Arginine is an essential amino acid that is physiologically active in the L-form.
An essential amino acid that is physiologically active in the L-form. [HMDB]

同义名列表

14 个代谢物同义名

(2R)-2-Amino-5-(carbamimidamido)pentanoic acid; (2R)-2-amino-5-carbamimidamidopentanoic acid; (2R)-2-Amino-5-(carbamimidamido)pentanoate; (2R)-2-Amino-5-guanidinopentanoic acid; (R)-2-Amino-5-guanidinopentanoic acid; (2R)-2-Amino-5-guanidinopentanoate; (R)-2-Amino-5-guanidinopentanoate; D-2-Amino-5-guanidinovaleric acid; D-2-Amino-5-guanidinovalerate; D-Arginine; H-D-Arg-OH; D-Arginin; DAR; D-Arginine



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

6 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(6)

PharmGKB(0)

10 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Ryo Nakabayashi, Zhigang Yang, Tomoko Nishizawa, Tetsuya Mori, Kazuki Saito. Top-down Targeted Metabolomics Reveals a Sulfur-Containing Metabolite with Inhibitory Activity against Angiotensin-Converting Enzyme in Asparagus officinalis. Journal of natural products. 2015 May; 78(5):1179-83. doi: 10.1021/acs.jnatprod.5b00092. [PMID: 25922884]
  • Ahmed S Abdel-Moneim, Magdy F El-Kady, Brian S Ladman, Jack Gelb. S1 gene sequence analysis of a nephropathogenic strain of avian infectious bronchitis virus in Egypt. Virology journal. 2006 Sep; 3(?):78. doi: 10.1186/1743-422x-3-78. [PMID: 16987422]
  • Giuseppe Fiermonte, Vincenza Dolce, Laura David, Filippo Maria Santorelli, Carlo Dionisi-Vici, Ferdinando Palmieri, John E Walker. The mitochondrial ornithine transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution of two human isoforms. The Journal of biological chemistry. 2003 Aug; 278(35):32778-83. doi: 10.1074/jbc.m302317200. [PMID: 12807890]
  • Suwit J Somponpun, Celia D Sladek. Osmotic regulation of estrogen receptor-beta in rat vasopressin and oxytocin neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2003 May; 23(10):4261-9. doi: NULL. [PMID: 12764114]