Bisnorbiotin (BioDeep_00000013408)

 

Secondary id: BioDeep_00000606611

human metabolite Endogenous blood metabolite


代谢物信息卡片


3-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazolidin-4-yl]propanoic acid

化学式: C8H12N2O3S (216.0568602)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 16.91%

分子结构信息

SMILES: C1C2C(C(S1)CCC(=O)O)NC(=O)N2
InChI: InChI=1S/C8H12N2O3S/c11-6(12)2-1-5-7-4(3-14-5)9-8(13)10-7/h4-5,7H,1-3H2,(H,11,12)(H2,9,10,13)/t4-,5-,7-/m0/s1

描述信息

Bisnorbiotin is a natural biotin metabolite in human urine. (PMID 9039841). The urinary excretion of Bisnorbiotin a increased with biotin administration. (PMID 9022537).
Bisnorbiotin is a natural biotin metabolite in human urine. (PMID 9039841)

同义名列表

8 个代谢物同义名

3-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazolidin-4-yl]propanoic acid; [3AS-(3aa,4b,6aa)]-hexahydro-2-oxo-1H-thieno[3,4-D]imidazole-4-propanoic acid; 3-[(3aS,4S,6aR)-2-oxo-hexahydrothieno[3,4-d]imidazolidin-4-yl]propanoic acid; [3AS-(3aa,4b,6aa)]-hexahydro-2-oxo-1H-thieno[3,4-D]imidazole-4-propanoate; 1H-Thieno[3,4-d]imidazole-4-propionic acid, hexahydro-2-oxo-; hexahydro-2-oxo-1H-thieno[3,4-D]Imidazole-4-propionic acid; D-Allobisnorbiotin; Bisnorbiotin



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ian L Gunsolus, Matthew Matias, John Prostko, Phaedre Mohr, Lori J Sokoll. Prevalence of Detectable Biotin in Five US Emergency Department Patient Cohorts. Clinical biochemistry. 2021 Jul; 93(?):26-32. doi: 10.1016/j.clinbiochem.2021.03.009. [PMID: 33771568]
  • Cydne A Perry, Allyson A West, Antoinette Gayle, Lauren K Lucas, Jian Yan, Xinyin Jiang, Olga Malysheva, Marie A Caudill. Pregnancy and lactation alter biomarkers of biotin metabolism in women consuming a controlled diet. The Journal of nutrition. 2014 Dec; 144(12):1977-84. doi: 10.3945/jn.114.194472. [PMID: 25122647]
  • Donald M Mock. Adequate intake of biotin in pregnancy: why bother?. The Journal of nutrition. 2014 Dec; 144(12):1885-6. doi: 10.3945/jn.114.203356. [PMID: 25320191]
  • Wendy M Sealey, April M Teague, Shawna L Stratton, Donald M Mock. Smoking accelerates biotin catabolism in women. The American journal of clinical nutrition. 2004 Oct; 80(4):932-5. doi: 10.1093/ajcn/80.4.932. [PMID: 15447901]
  • Donald M Mock, Cindy L Henrich, Nadine Carnell, Nell I Mock. Indicators of marginal biotin deficiency and repletion in humans: validation of 3-hydroxyisovaleric acid excretion and a leucine challenge. The American journal of clinical nutrition. 2002 Nov; 76(5):1061-8. doi: 10.1093/ajcn/76.5.1061. [PMID: 12399279]
  • Sara C Rathman, Stephen Eisenschenk, Robert J McMahon. The abundance and function of biotin-dependent enzymes are reduced in rats chronically administered carbamazepine. The Journal of nutrition. 2002 Nov; 132(11):3405-10. doi: 10.1093/jn/132.11.3405. [PMID: 12421859]
  • D M Mock, N I Mock, R P Nelson, K A Lombard. Disturbances in biotin metabolism in children undergoing long-term anticonvulsant therapy. Journal of pediatric gastroenterology and nutrition. 1998 Mar; 26(3):245-50. doi: 10.1097/00005176-199803000-00002. [PMID: 9523856]
  • D M Mock, M E Dyken. Biotin catabolism is accelerated in adults receiving long-term therapy with anticonvulsants. Neurology. 1997 Nov; 49(5):1444-7. doi: 10.1212/wnl.49.5.1444. [PMID: 9371938]
  • K S Wang, N I Mock, D M Mock. Biotin biotransformation to bisnorbiotin is accelerated by several peroxisome proliferators and steroid hormones in rats. The Journal of nutrition. 1997 Nov; 127(11):2212-6. doi: 10.1093/jn/127.11.2212. [PMID: 9349849]
  • D M Mock, D D Stadler. Conflicting indicators of biotin status from a cross-sectional study of normal pregnancy. Journal of the American College of Nutrition. 1997 Jun; 16(3):252-7. doi: 10.1080/07315724.1997.10718682. [PMID: 9176832]
  • D M Mock, D D Stadler, S L Stratton, N I Mock. Biotin status assessed longitudinally in pregnant women. The Journal of nutrition. 1997 May; 127(5):710-6. doi: 10.1093/jn/127.5.710. [PMID: 9164991]
  • N I Mock, M I Malik, P J Stumbo, W P Bishop, D M Mock. Increased urinary excretion of 3-hydroxyisovaleric acid and decreased urinary excretion of biotin are sensitive early indicators of decreased biotin status in experimental biotin deficiency. The American journal of clinical nutrition. 1997 Apr; 65(4):951-8. doi: 10.1093/ajcn/65.4.951. [PMID: 9094878]
  • D M Mock, N I Mock. Serum concentrations of bisnorbiotin and biotin sulfoxide increase during both acute and chronic biotin supplementation. The Journal of laboratory and clinical medicine. 1997 Mar; 129(3):384-8. doi: 10.1016/s0022-2143(97)90187-6. [PMID: 9042824]
  • D M Mock, K S Wang, G L Kearns. The pig is an appropriate model for human biotin catabolism as judged by the urinary metabolite profile of radioisotope-labeled biotin. The Journal of nutrition. 1997 Feb; 127(2):365-9. doi: 10.1093/jn/127.2.365. [PMID: 9039841]
  • D M Mock, G M Heird. Urinary biotin analogs increase in humans during chronic supplementation: the analogs are biotin metabolites. The American journal of physiology. 1997 Jan; 272(1 Pt 1):E83-5. doi: 10.1152/ajpendo.1997.272.1.e83. [PMID: 9038855]
  • K S Wang, A Patel, D M Mock. The metabolite profile of radioisotope-labeled biotin in rats indicates that rat biotin metabolism is similar to that in humans. The Journal of nutrition. 1996 Jul; 126(7):1852-7. doi: 10.1093/jn/126.7.1852. [PMID: 8683347]
  • D M Mock, G L Lankford, N I Mock. Biotin accounts for only half of the total avidin-binding substances in human serum. The Journal of nutrition. 1995 Apr; 125(4):941-6. doi: 10.1093/jn/125.4.941. [PMID: 7722698]
  • D M Mock, G L Lankford, J Cazin. Biotin and biotin analogs in human urine: biotin accounts for only half of the total. The Journal of nutrition. 1993 Nov; 123(11):1844-51. doi: 10.1093/jn/123.11.1844. [PMID: 8229299]