DCVC (BioDeep_00000013369)

 

Secondary id: BioDeep_00001870907


代谢物信息卡片


S-(trans-1,2-Dichlorovinyl)-L-cysteine

化学式: C5H7Cl2NO2S (214.9574542)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(C(C(=O)O)N)SC(=CCl)Cl
InChI: InChI=1S/C5H7Cl2NO2S/c6-1-4(7)11-2-3(8)5(9)10/h1,3H,2,8H2,(H,9,10)/b4-1-/t3-/m0/s1

描述信息

同义名列表

2 个代谢物同义名

S-(trans-1,2-Dichlorovinyl)-L-cysteine; DCVC



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Elana R Elkin, Dave Bridges, Sean M Harris, Rita Karen Loch-Caruso. Exposure to Trichloroethylene Metabolite S-(1,2-Dichlorovinyl)-L-cysteine Causes Compensatory Changes to Macronutrient Utilization and Energy Metabolism in Placental HTR-8/SVneo Cells. Chemical research in toxicology. 2020 06; 33(6):1339-1355. doi: 10.1021/acs.chemrestox.9b00356. [PMID: 31951115]
  • Elana R Elkin, Dave Bridges, Rita Loch-Caruso. The trichloroethylene metabolite S-(1,2-dichlorovinyl)-L-cysteine induces progressive mitochondrial dysfunction in HTR-8/SVneo trophoblasts. Toxicology. 2019 11; 427(?):152283. doi: 10.1016/j.tox.2019.152283. [PMID: 31476333]
  • Elana R Elkin, Sean M Harris, Rita Loch-Caruso. Trichloroethylene metabolite S-(1,2-dichlorovinyl)-l-cysteine induces lipid peroxidation-associated apoptosis via the intrinsic and extrinsic apoptosis pathways in a first-trimester placental cell line. Toxicology and applied pharmacology. 2018 01; 338(?):30-42. doi: 10.1016/j.taap.2017.11.006. [PMID: 29129777]
  • B van de Water, J P Zoeteweij, J F Nagelkerke. Alkylation-induced oxidative cell injury of renal proximal tubular cells: involvement of glutathione redox-cycle inhibition. Archives of biochemistry and biophysics. 1996 Mar; 327(1):71-80. doi: 10.1006/abbi.1996.0094. [PMID: 8615698]
  • Y Kato, Y Asano, A J Cooper. Inactivation of brain and kidney aspartate aminotransferases by S-(1,2,-dichlorovinyl)-L-cysteine and by S-(1,1,2,2,-tetrafluoroethyl)-L-cysteine. Developmental neuroscience. 1996; 18(5-6):505-14. doi: 10.1159/000111447. [PMID: 8940625]
  • B van de Water, J P Zoeteweij, H J de Bont, J F Nagelkerke. Inhibition of succinate:ubiquinone reductase and decrease of ubiquinol in nephrotoxic cysteine S-conjugate-induced oxidative cell injury. Molecular pharmacology. 1995 Nov; 48(5):928-37. doi: . [PMID: 7476924]
  • J W Davis, D P Blakeman, R A Jolly, W H Packwood, G J Kolaja, T W Petry. S-(1,2-dichlorovinyl)-L-cysteine-induced nephrotoxicity in the New Zealand white rabbit: characterization of proteinuria and examination of the potential role of oxidative injury. Toxicologic pathology. 1995 Jul; 23(4):487-97. doi: 10.1177/019262339502300405. [PMID: 7501960]
  • Q Chen, T W Jones, J L Stevens. Early cellular events couple covalent binding of reactive metabolites to cell killing by nephrotoxic cysteine conjugates. Journal of cellular physiology. 1994 Nov; 161(2):293-302. doi: 10.1002/jcp.1041610214. [PMID: 7525611]
  • B Van de Water, J J Jaspers, D H Maasdam, G J Mulder, J F Nagelkerke. In vivo and in vitro detachment of proximal tubular cells and F-actin damage: consequences for renal function. The American journal of physiology. 1994 Nov; 267(5 Pt 2):F888-99. doi: 10.1152/ajprenal.1994.267.5.f888. [PMID: 7977793]
  • J W Davis, T W Petry. Inhibition of S-(1,2-dichlorovinyl)-L-cysteine-induced lipid peroxidation by antioxidants in rabbit renal cortical slices: dissociation of lipid peroxidation and toxicity. Journal of biochemical toxicology. 1994 Jun; 9(3):121-30. doi: 10.1002/jbt.2570090303. [PMID: 7983677]
  • C E Groves, P J Hayden, E A Lock, R G Schnellmann. Differential cellular effects in the toxicity of haloalkene and haloalkane cysteine conjugates to rabbit renal proximal tubules. Journal of biochemical toxicology. 1993 Mar; 8(1):49-56. doi: 10.1002/jbt.2570080108. [PMID: 8492303]
  • Q Chen, K Yu, J L Stevens. Regulation of the cellular stress response by reactive electrophiles. The role of covalent binding and cellular thiols in transcriptional activation of the 70-kilodalton heat shock protein gene by nephrotoxic cysteine conjugates. The Journal of biological chemistry. 1992 Dec; 267(34):24322-7. doi: NULL. [PMID: 1447182]
  • Q Chen, K Yu, N J Holbrook, J L Stevens. Activation of the growth arrest and DNA damage-inducible gene gadd 153 by nephrotoxic cysteine conjugates and dithiothreitol. The Journal of biological chemistry. 1992 Apr; 267(12):8207-12. doi: NULL. [PMID: 1569075]
  • P J Hayden, C J Welsh, Y Yang, W H Schaefer, A J Ward, J L Stevens. Formation of mitochondrial phospholipid adducts by nephrotoxic cysteine conjugate metabolites. Chemical research in toxicology. 1992 Mar; 5(2):232-7. doi: 10.1021/tx00026a013. [PMID: 1643252]
  • Q Chen, T W Jones, P C Brown, J L Stevens. The mechanism of cysteine conjugate cytotoxicity in renal epithelial cells. Covalent binding leads to thiol depletion and lipid peroxidation. The Journal of biological chemistry. 1990 Dec; 265(35):21603-11. doi: . [PMID: 2254317]
  • W Beuter, C Cojocel, W Müller, H H Donaubauer, D Mayer. Peroxidative damage and nephrotoxicity of dichlorovinylcysteine in mice. Journal of applied toxicology : JAT. 1989 Jun; 9(3):181-6. doi: 10.1002/jat.2550090308. [PMID: 2745925]
  • L H Lash, M W Anders. Mechanism of S-(1,2-dichlorovinyl)-L-cysteine- and S-(1,2-dichlorovinyl)-L-homocysteine-induced renal mitochondrial toxicity. Molecular pharmacology. 1987 Oct; 32(4):549-56. doi: NULL. [PMID: 3670284]
  • L H Lash, M W Anders. Cytotoxicity of S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine in isolated rat kidney cells. The Journal of biological chemistry. 1986 Oct; 261(28):13076-81. doi: . [PMID: 2875994]
  • A C Buck. Disorders of micturition in bacterial prostatitis. Proceedings of the Royal Society of Medicine. 1975 Aug; 68(8):508-11. doi: NULL. [PMID: 681]