Thiacetamid (BioDeep_00000012744)
Secondary id: BioDeep_00001867805
human metabolite blood metabolite Volatile Flavor Compounds
代谢物信息卡片
Acetic acid thioamide
化学式: C2H5NS (75.014269)
中文名称: 硫代乙酰胺
谱图信息:
最多检出来源 Mus musculus(blood) 84.62%
分子结构信息
SMILES: CC(=N)S
InChI: InChI=1S/C2H5NS/c1-2(3)4/h1H3,(H2,3,4)
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:32497
- KEGG: C19302
- KEGGdrug: D70870
- PubChem: 2723949
- HMDB: HMDB0258996
- Metlin: METLIN73014
- ChEMBL: CHEMBL38737
- Wikipedia: Thioacetamide
- MeSH: Thioacetamide
- chemspider: 2006126
- CAS: 62-55-5
- PMhub: MS000027073
- PubChem: 124489974
- KNApSAcK: 32497
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Qiong Liu, Xin Ba, Liang Han, Jiahui Yan, Zhe Chen, Kai Qin, Shenghao Tu, Pan Shen. Dahuang-Wumei decoction protects against hepatic encephalopathy in mice: Behavioural, biochemical, and molecular evidence.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Jun; 128(?):155419. doi:
10.1016/j.phymed.2024.155419. [PMID: 38522314] - Syed Afroz Ali, Ashok Kumar Datusalia. Protective effects of Tinospora cordifolia miers extract against hepatic and neurobehavioral deficits in thioacetamide-induced hepatic encephalopathy in rats via modulating hyperammonemia and glial cell activation.
Journal of ethnopharmacology.
2024 Apr; 323(?):117700. doi:
10.1016/j.jep.2023.117700. [PMID: 38176666] - Himanshu Goel, Richard L Printz, Venkat R Pannala, Mohamed Diwan M AbdulHameed, Anders Wallqvist. Probing Liver Injuries Induced by Thioacetamide in Human In Vitro Pooled Hepatocyte Experiments.
International journal of molecular sciences.
2024 Mar; 25(6):. doi:
10.3390/ijms25063265. [PMID: 38542239] - Haodong Zhang, Jian Xu. Unveiling thioacetamide-induced toxicity: Multi-organ damage and omitted bone toxicity.
Human & experimental toxicology.
2024 Jan; 43(?):9603271241241807. doi:
10.1177/09603271241241807. [PMID: 38531387] - Nidhi Sharma, Ramakrishna Sistla, Sai Balaji Andugulapati. Yohimbine ameliorates liver inflammation and fibrosis by regulating oxidative stress and Wnt/β-catenin pathway.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2023 Nov; 123(?):155182. doi:
10.1016/j.phymed.2023.155182. [PMID: 37952411] - Tianhui Gao, Liting Lin, Qingsong Yang, Zongping Zhu, Shuyi Wang, Tian Xie, Wan Liao. The raw and vinegar-processed Curcuma phaeocaulis Val. ameliorate TAA-induced zebrafish liver injury by inhibiting TLR4/MyD88/NF-κB signaling pathway.
Journal of ethnopharmacology.
2023 Sep; 319(Pt 2):117246. doi:
10.1016/j.jep.2023.117246. [PMID: 37778523] - - Syeda Nuzhat Fatima Zaidi, - Zoya. Effect of lycopene supplementation on lipid profile, blood glucose and electrolyte homeostasis in thioacetamide induced liver cirrhosis.
Pakistan journal of pharmaceutical sciences.
2023 Jul; 36(4):1177-1182. doi:
. [PMID: 37599493] - Reham M Essam, Mariam A Saadawy, Mahitab Gamal, Rania M Abdelsalam, Ayman E El-Sahar. Lactoferrin averts neurological and behavioral impairments of thioacetamide-induced hepatic encephalopathy in rats via modulating HGMB1/TLR-4/MyD88/Nrf2 pathway.
Neuropharmacology.
2023 May; 236(?):109575. doi:
10.1016/j.neuropharm.2023.109575. [PMID: 37201650] - Hyoung-Yun Han, Se-Myo Park, Je-Won Ko, Jung-Hwa Oh, Sang Kyum Kim, Tae-Won Kim. Integrated transcriptomic analysis of liver and kidney after 28 days of thioacetamide treatment in rats.
Toxicological research.
2023 Apr; 39(2):201-211. doi:
10.1007/s43188-022-00156-y. [PMID: 37008694] - Devaraj Ezhilarasan. Molecular mechanisms in thioacetamide-induced acute and chronic liver injury models.
Environmental toxicology and pharmacology.
2023 Apr; 99(?):104093. doi:
10.1016/j.etap.2023.104093. [PMID: 36870405] - Murat Fatih Sökmen, Murat İspiroğlu, Kadir Gişi, Abdulkadir Yasir Bahar, Ergül Belge Kurutaş, Bülent Kantarçeken. Effects of Arum dioscoridis Extract on Hepatic Toxicity Caused by Thioacetamide in Rats.
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology.
2023 03; 34(3):254-261. doi:
10.5152/tjg.2023.211051. [PMID: 36635913] - Usama W Hawas, Mohamed A El-Ansari, Abeer F Osman, Asmaa F Galal, Lamia T Abou El-Kassem. Flavonoid constituents and protective efficacy of Citrus reticulate (Blanco) leaves ethanolic extract on thioacetamide-induced liver injury rats.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.
2023 Mar; 28(2):160-167. doi:
10.1080/1354750x.2022.2151645. [PMID: 36420657] - Omayma Ar Abo-Zaid, Fatma Sm Moawed, Effat Soliman Ismail, Esraa S A Ahmed. β-Sitosterol mitigates hepatocyte apoptosis by inhibiting endoplasmic reticulum stress in thioacetamide-induced hepatic injury in γ-irradiated rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2023 Feb; 172(?):113602. doi:
10.1016/j.fct.2023.113602. [PMID: 36610474] - Fat-Moon Suk, Fang-Yu Hsu, Yi-Chieh Lee, Tzu-Lang Chen, Wan-Chun Chiu, Yi-Jen Liao. Dietary oxidized frying oil activates hepatic stellate cells and accelerates the severity of carbon tetrachloride- and thioacetamide-induced liver fibrosis in mice.
The Journal of nutritional biochemistry.
2023 Jan; 115(?):109267. doi:
10.1016/j.jnutbio.2023.109267. [PMID: 36641072] - Xinyuan Lai, Chuanyun Li, Chengang Xiang, Zihang Pan, Kai Zhang, Lei Wang, Bingqing Xie, Junning Cao, Jihang Shi, Juan Deng, Shichun Lu, Hongkui Deng, Hui Zhuang, Tong Li, Yan Shi, Kuanhui Xiang. Generation of functionally competent hepatic stellate cells from human stem cells to model liver fibrosis in vitro.
Stem cell reports.
2022 11; 17(11):2531-2547. doi:
10.1016/j.stemcr.2022.09.010. [PMID: 36270282] - Eman A R Abdelghffar, Heba A S El-Nashar, Shaimaa Fayez, Wael A Obaid, Omayma A Eldahshan. Ameliorative effect of oregano (Origanum vulgare) versus silymarin in experimentally induced hepatic encephalopathy.
Scientific reports.
2022 10; 12(1):17854. doi:
10.1038/s41598-022-20412-3. [PMID: 36284120] - Iriny M Ayoub, Marawan A El-Baset, Mai M Elghonemy, Samir A E Bashandy, Fatma A A Ibrahim, Omar A H Ahmed-Farid, Abd El-Nasser G El Gendy, Sherif M Afifi, Tuba Esatbeyoglu, Abdel Razik H Farrag, Mohamed A Farag, Abdelsamed I Elshamy. Chemical Profile of Cyperus laevigatus and Its Protective Effects against Thioacetamide-Induced Hepatorenal Toxicity in Rats.
Molecules (Basel, Switzerland).
2022 Oct; 27(19):. doi:
10.3390/molecules27196470. [PMID: 36235007] - Bojan Jorgačević, Sanja Stanković, Jelena Filipović, Janko Samardžić, Danijela Vučević, Tatjana Radosavljević. Betaine Modulating MIF-Mediated Oxidative Stress, Inflammation and Fibrogenesis in Thioacetamide-Induced Nephrotoxicity.
Current medicinal chemistry.
2022 08; 29(31):5254-5267. doi:
10.2174/0929867329666220408102856. [PMID: 35400322] - Nabil Mohamed Selim, Mina Michael Melk, Farouk Rasmy Melek, Dalia Osama Saleh, Mansour Sobeh, Seham S El-Hawary. Phytochemical profiling and anti-fibrotic activities of Plumbago indica L. and Plumbago auriculata Lam. in thioacetamide-induced liver fibrosis in rats.
Scientific reports.
2022 06; 12(1):9864. doi:
10.1038/s41598-022-13718-9. [PMID: 35701526] - Ali M El-Hagrassi, Abeer F Osman, Mostafa E El-Naggar, Noha A Mowaad, Sahar Khalil, Manal A Hamed. Phytochemical constituents and protective efficacy of Schefflera arboricola L. leaves extract against thioacetamide-induced hepatic encephalopathy in rats.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.
2022 Jun; 27(4):375-394. doi:
10.1080/1354750x.2022.2048892. [PMID: 35234557] - Mustafa Ghanim, Johnny Amer, Ahmad Salhab, Nidal Jaradat. Ecballium elaterium improved stimulatory effects of tissue-resident NK cells and ameliorated liver fibrosis in a thioacetamide mice model.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Jun; 150(?):112942. doi:
10.1016/j.biopha.2022.112942. [PMID: 35429743] - Aliah R Alshanwani, Hanan Hagar, Sameerah Shaheen, Ahlam M Alhusaini, Maha M Arafah, Laila M Faddah, Fatima Mb Alharbi, Arun K Sharma, Amel Fayed, Amira M Badr. A promising antifibrotic drug, pyridoxamine attenuates thioacetamide-induced liver fibrosis by combating oxidative stress, advanced glycation end products, and balancing matrix metalloproteinases.
European journal of pharmacology.
2022 May; 923(?):174910. doi:
10.1016/j.ejphar.2022.174910. [PMID: 35339478] - Xiaoli Jin, Yang Li, Jianghua Li, Linyan Cheng, Yetao Yao, Hao Shen, Bili Wang, Jun Ren, Hang Ying, Jian Xu. Acute bone damage through liver-bone axis induced by thioacetamide in rats.
BMC pharmacology & toxicology.
2022 05; 23(1):29. doi:
10.1186/s40360-022-00568-4. [PMID: 35526079] - L Cheng, Y Li, Y Yao, X Jin, H Ying, B Xu, J Xu. Toxic effects of thioacetamide-induced femoral damage in New Zealand white rabbits by activating the p38/ERK signaling pathway.
Physiological research.
2022 04; 71(2):285-295. doi:
10.33549/physiolres.934803. [PMID: 35275703] - Ji-Youn Lim, Woon-Won Jung, Woojin Kim, Kyoung-Sik Moon, Donggeun Sul. Nephrotoxicity evaluation and proteomic analysis in kidneys of rats exposed to thioacetamide.
Scientific reports.
2022 04; 12(1):6837. doi:
10.1038/s41598-022-11011-3. [PMID: 35477741] - Ahmed A Mohamed, Randa A Zaghloul, Amr M Abdelghany, Amal M El Gayar. Selenium nanoparticles and quercetin suppress thioacetamide-induced hepatocellular carcinoma in rats: Attenuation of inflammation involvement.
Journal of biochemical and molecular toxicology.
2022 Apr; 36(4):e22989. doi:
10.1002/jbt.22989. [PMID: 35179263] - Linyan Cheng, Xiaoli Jin, Hao Shen, Xuanwei Chen, Jin Chen, Bin Xu, Jian Xu. Icariin attenuates thioacetamide‑induced bone loss via the RANKL‑p38/ERK‑NFAT signaling pathway.
Molecular medicine reports.
2022 Apr; 25(4):. doi:
10.3892/mmr.2022.12642. [PMID: 35169865] - Amal M H Ghanim, Mahmoud R T Farag, Mahitab A Anwar, Nada A M Ali, Mohammed A Hawas, Hend M E Elsallab, Walaa A Elhendawy, Lina A Basyouni, Ola A Refaey, Khaled E Zaki, Noha A M Ali, Heba A Metwaly. Taurine alleviates kidney injury in a thioacetamide rat model by mediating Nrf2/HO-1, NQO-1, and MAPK/NF-κB signaling pathways.
Canadian journal of physiology and pharmacology.
2022 Apr; 100(4):352-360. doi:
10.1139/cjpp-2021-0488. [PMID: 34695366] - Rehab S Abdelrahman, Ghada S El-Tanbouly. Protocatechuic acid protects against thioacetamide-induced chronic liver injury and encephalopathy in mice via modulating mTOR, p53 and the IL-6/ IL-17/ IL-23 immunoinflammatory pathway.
Toxicology and applied pharmacology.
2022 04; 440(?):115931. doi:
10.1016/j.taap.2022.115931. [PMID: 35202709] - Jinbiao Chen, Ngan Ching Cheng, Jade A Boland, Ken Liu, James G Kench, D Neil Watkins, Sofia Ferreira-Gonzalez, Stuart J Forbes, Geoffrey W McCaughan. Deletion of kif3a in CK19 positive cells leads to primary cilia loss, biliary cell proliferation and cystic liver lesions in TAA-treated mice.
Biochimica et biophysica acta. Molecular basis of disease.
2022 04; 1868(4):166335. doi:
10.1016/j.bbadis.2021.166335. [PMID: 34973373] - Heba A Metwaly, Abdulrahman M El-Eraky, Eman E Ibrahim, Khaled K Kandil, Mohamed A El-Sayed, Nayra M El-Tabakh, Amr M Motawea, Helmi A Ali, Maher Z Jabban, Mona E Mahmoud, Walaa H Abdelfattah, Mohammad A Elmorsy, Amal M H Ghanim. Vanillin attenuates thioacetamide-induced renal assault by direct and indirect mediation of the TGFβ, ERK and Smad signalling pathways in rats.
Cell biochemistry and function.
2022 Mar; 40(2):175-188. doi:
10.1002/cbf.3686. [PMID: 35092082] - XiaoLi Jin, Yang Li, Yayang Yang, Hao Shen, Jin Chen, Bin Xu, Jian Xu. Thioacetamide promotes osteoclast transformation of bone marrow macrophages by influencing PI3K/AKT pathways.
Journal of orthopaedic surgery and research.
2022 Jan; 17(1):53. doi:
10.1186/s13018-022-02938-4. [PMID: 35093114] - Renata L Goto, Mariana B Tablas, Gabriel B Prata, Sara G Espírito Santo, Ana Angélica H Fernandes, Bruno Cogliati, Luis F Barbisan, Guilherme R Romualdo. Vitamin D3 supplementation alleviates chemically-induced cirrhosis-associated hepatocarcinogenesis.
The Journal of steroid biochemistry and molecular biology.
2022 01; 215(?):106022. doi:
10.1016/j.jsbmb.2021.106022. [PMID: 34774723] - Wael Mahmoud Aboulthana, Nagwa Ibrahim Omar, Enas Ahmed Hasan, Kawkab A Ahmed, Ahmed Mahmoud Youssef. Assessment of the Biological Activities of Egyptian Purslane (Portulaca oleracea) Extract after Incorporating Metal Nanoparticles, in Vitro and in Vivo Study.
Asian Pacific journal of cancer prevention : APJCP.
2022 Jan; 23(1):287-310. doi:
10.31557/apjcp.2022.23.1.287. [PMID: 35092399] - Lalita Shahgond, Chirag Patel, Khushboo Thakur, Dipta Sarkar, Sanjeev Acharya, Priyanshi Patel. Therapeutic potential of probiotics - Lactobacillus plantarum UBLP40 and Bacillus clausii UBBC07 on thioacetamide-induced acute hepatic encephalopathy in rats.
Metabolic brain disease.
2022 01; 37(1):185-195. doi:
10.1007/s11011-021-00862-w. [PMID: 34731397] - Vichununt Kerdput, Kritsakorn Kanjanapongkul, Arunporn Itharat, Ratchadaporn Pramong, Wouter H Lamers, Theodorus B M Hakvoort, Aldo Jongejan, Wisuit Pradidarcheep. Molecular Changes Following Induction of Hepatocellular Carcinoma by Diethylnitrosamine and Thioacetamide, and Subsequent Treatment with Dioscorea membranacea Extract.
International journal of medical sciences.
2022; 19(12):1806-1815. doi:
10.7150/ijms.72987. [PMID: 36313224] - Sarwan W Bradosty, Saber W Hamad, Nabaz Fisal Shakir Agha, Faiyaz Khudaboddin Shaikh, Nadir Mustafa Qadir Nanakali, Peshawa Yunis Aziz, Nur'Ain Salehen, Faruk Suzergoz, Mahmood Ameen Abdulla. In vivo hepatoprotective effect of Morinda elliptica stem extract against liver fibrosis induced by thioacetamide.
Environmental toxicology.
2021 Dec; 36(12):2404-2413. doi:
10.1002/tox.23353. [PMID: 34436826] - Amal M H Ghanim, Nancy S Younis, Heba A Metwaly. Vanillin augments liver regeneration effectively in Thioacetamide induced liver fibrosis rat model.
Life sciences.
2021 Dec; 286(?):120036. doi:
10.1016/j.lfs.2021.120036. [PMID: 34637793] - Patric Schyman, Richard L Printz, Venkat R Pannala, Mohamed Diwan M AbdulHameed, Shanea K Estes, Chiyo Shiota, Kelli Lynn Boyd, Masakazu Shiota, Anders Wallqvist. Genomics and metabolomics of early-stage thioacetamide-induced liver injury: An interspecies study between guinea pig and rat.
Toxicology and applied pharmacology.
2021 11; 430(?):115713. doi:
10.1016/j.taap.2021.115713. [PMID: 34492290] - Geng-Ruei Chang, Wei-Li Lin, Tzu-Chun Lin, Huei-Jyuan Liao, Yu-Wen Lu. The Ameliorative Effects of Saikosaponin in Thioacetamide-Induced Liver Injury and Non-Alcoholic Fatty Liver Disease in Mice.
International journal of molecular sciences.
2021 Oct; 22(21):. doi:
10.3390/ijms222111383. [PMID: 34768813] - Shingo Oda, Yuka Hirabuki, Taiki Takeuchi, Takumi Kagawa, Tsuyoshi Yokoi. Plasma miR-218a-5p as a biomarker for acute cholestatic liver injury in rats and investigation of its pathophysiological roles.
Journal of applied toxicology : JAT.
2021 10; 41(10):1537-1552. doi:
10.1002/jat.4144. [PMID: 33565098] - Kexin Wang, Yunyun Deng, June Zhang, Bo Cheng, Yong Huang, Yunlong Meng, Keyuan Zhong, Guanghua Xiong, Jing Guo, Yi Liu, Huiqiang Lu. Toxicity of thioacetamide and protective effects of quercetin in zebrafish (Danio rerio) larvae.
Environmental toxicology.
2021 Oct; 36(10):2062-2072. doi:
10.1002/tox.23323. [PMID: 34227734] - Heba M A Khalil, Hesham A Eliwa, Riham A El-Shiekh, Asmaa K Al-Mokaddem, Marwa Hassan, Azza M Tawfek, Walaa H El-Maadawy. Ashwagandha (Withania somnifera) root extract attenuates hepatic and cognitive deficits in thioacetamide-induced rat model of hepatic encephalopathy via induction of Nrf2/HO-1 and mitigation of NF-κB/MAPK signaling pathways.
Journal of ethnopharmacology.
2021 Sep; 277(?):114141. doi:
10.1016/j.jep.2021.114141. [PMID: 33905819] - Sudarma Bogahawaththa, Suranga P Kodithuwakku, Kavindra K Wijesundera, Eranga H Siriweera, Lalith Jayasinghe, Waruna L Dissanayaka, Jayanthe Rajapakse, Chandana B Herath, Tadayuki Tsujita, Missaka P B Wijayagunawardane. Anti-Fibrotic and Anti-Angiogenic Activities of Osbeckia octandra Leaf Extracts in Thioacetamide-Induced Experimental Liver Cirrhosis.
Molecules (Basel, Switzerland).
2021 Aug; 26(16):. doi:
10.3390/molecules26164836. [PMID: 34443423] - Sérgio Luiz Borges de Souza, Gustavo Augusto Ferreira Mota, Cristina Schmitt Gregolin, Milena do Nascimento, Renata Azevedo Melo Luvizotto, Silmeia Garcia Zanati Bazan, Mário Mateus Sugizaki, Luis Fernando Barbisan, Antonio Carlos Cicogna, André Ferreira do Nascimento. Exercise Training Attenuates Cirrhotic Cardiomyopathy.
Journal of cardiovascular translational research.
2021 08; 14(4):674-684. doi:
10.1007/s12265-020-09997-0. [PMID: 32246321] - Dalia O Saleh, Dina F Mansour, Ahmed M Fayez. Thioacetamide-induced acute hepatic encephalopathy: central vs peripheral effect of Allicin.
Metabolic brain disease.
2021 08; 36(6):1331-1340. doi:
10.1007/s11011-021-00695-7. [PMID: 33765229] - Haili Wang, Jinying Che, Kai Cui, Wenyue Zhuang, He Li, Jinghui Sun, Jianguang Chen, Chunmei Wang. Schisantherin A ameliorates liver fibrosis through TGF-β1mediated activation of TAK1/MAPK and NF-κB pathways in vitro and in vivo.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2021 Jul; 88(?):153609. doi:
10.1016/j.phymed.2021.153609. [PMID: 34126414] - Nancy S Younis, Amal M H Ghanim, Mohammad A Elmorsy, Heba A Metwaly. Taurine ameliorates thioacetamide induced liver fibrosis in rats via modulation of toll like receptor 4/nuclear factor kappa B signaling pathway.
Scientific reports.
2021 06; 11(1):12296. doi:
10.1038/s41598-021-91666-6. [PMID: 34112866] - Somayeh Hajipour, Alireza Sarkaki, Mahin Dianat, Mohammad Rashno, Laaya Sadat Khorsandi, Yaghoob Farbood. The effects of thymoquinone on memory impairment and inflammation in rats with hepatic encephalopathy induced by thioacetamide.
Metabolic brain disease.
2021 06; 36(5):991-1002. doi:
10.1007/s11011-021-00688-6. [PMID: 33620578] - Tao Li, GuangYue Su, YuQing Zhao. Anti-hepatic fibrosis effects of AD-2 affecting the Raf-MEK signaling pathway and inflammatory factors in thioacetamide-induced liver injury.
Journal of food science.
2021 Jun; 86(6):2753-2765. doi:
10.1111/1750-3841.15731. [PMID: 33928646] - Bo Cui, Zhe Yang, Shuning Wang, Mengnan Guo, Qianqian Li, Qiuhua Zhang, Xiuli Bi. The protective role of protocatechuic acid against chemically induced liver fibrosis in vitro and in vivo.
Die Pharmazie.
2021 05; 76(5):232-238. doi:
10.1691/ph.2021.0909. [PMID: 33964998] - Syeda Nuzhat Fatima, Javeria Masood. Fenugreek seeds attenuate thioacetamide induced liver damage.
Pakistan journal of pharmaceutical sciences.
2021 May; 34(3):933-942. doi:
NULL. [PMID: 34602416] - Ming-Yang Tsai, Wei-Cheng Yang, Chuen-Fu Lin, Chao-Min Wang, Hsien-Yueh Liu, Chen-Si Lin, Jen-Wei Lin, Wei-Li Lin, Tzu-Chun Lin, Pei-Shan Fan, Kuo-Hsiang Hung, Yu-Wen Lu, Geng-Ruei Chang. The Ameliorative Effects of Fucoidan in Thioacetaide-Induced Liver Injury in Mice.
Molecules (Basel, Switzerland).
2021 Mar; 26(7):. doi:
10.3390/molecules26071937. [PMID: 33808318] - Syeda Nuzhat Fatima Zaidi, Muhammad Madni. Protective role of coffee supplementation in liver cirrhosis: Study in rats.
Pakistan journal of pharmaceutical sciences.
2021 Mar; 34(2):591-597. doi:
NULL. [PMID: 34275834] - Nehal A Afifi, A Ramadan, Emad Y Erian, Ahmed A Sedik, Mohamed M Amin, Azza Hassan, Dalia O Saleh. Synergistic effect of aminoguanidine and l-carnosine against thioacetamide-induced hepatic encephalopathy in rats: behavioral, biochemical, and ultrastructural evidence.
Canadian journal of physiology and pharmacology.
2021 Mar; 99(3):332-347. doi:
10.1139/cjpp-2020-0212. [PMID: 32721224] - Salwa A Ibrahim, Mervat Z Mohamed, Nashwa F El-Tahawy, Aly M Abdelrahman. Antifibrotic effects of bezafibrate and pioglitazone against thioacetamide-induced liver fibrosis in albino rats.
Canadian journal of physiology and pharmacology.
2021 Mar; 99(3):313-320. doi:
10.1139/cjpp-2020-0159. [PMID: 32721217] - Somayeh Hajipour, Yaghoob Farbood, Mahin Dianat, Mohammad Rashno, Laya Sadat Khorsandi, Alireza Sarkaki. Thymoquinone improves behavioral and biochemical deficits in hepatic encephalopathy induced by thioacetamide in rats.
Neuroscience letters.
2021 02; 745(?):135617. doi:
10.1016/j.neulet.2020.135617. [PMID: 33421492] - Pei-Chang Lee, Yun-Chen Hsieh, Teh-Ia Huo, Ueng-Cheng Yang, Chao-Hsiung Lin, Chung-Pin Li, Yi-Hsiang Huang, Ming-Chih Hou, Han-Chieh Lin, Kuei-Chuan Lee. Active Vitamin D3 Treatment Attenuated Bacterial Translocation via Improving Intestinal Barriers in Cirrhotic Rats.
Molecular nutrition & food research.
2021 02; 65(3):e2000937. doi:
10.1002/mnfr.202000937. [PMID: 33258263] - Chittapon Jantararussamee, Siripa Rodniem, Malai Taweechotipatr, Udomsri Showpittapornchai, Wisuit Pradidarcheep. Hepatoprotective Effect of Probiotic Lactic Acid Bacteria on Thioacetamide-Induced Liver Fibrosis in Rats.
Probiotics and antimicrobial proteins.
2021 02; 13(1):40-50. doi:
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European journal of pharmacology.
2021 Jan; 891(?):173652. doi:
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BioMed research international.
2021; 2021(?):6631415. doi:
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Digestive diseases and sciences.
2021 01; 66(1):131-142. doi:
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PloS one.
2021; 16(11):e0260507. doi:
10.1371/journal.pone.0260507. [PMID: 34843587] - Mi-Rae Shin, Min Ju Kim, Jin A Lee, Seong-Soo Roh. Effect of Uncaria rhynchophylla against Thioacetamide-Induced Acute Liver Injury in Rat.
Canadian journal of gastroenterology & hepatology.
2021; 2021(?):5581816. doi:
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Biomolecules.
2020 12; 10(12):. doi:
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Bioorganic chemistry.
2020 12; 105(?):104444. doi:
10.1016/j.bioorg.2020.104444. [PMID: 33197852] - Shady M Abd El-Halim, Ghada A Abdelbary, Maha M Amin, Mohamed Y Zakaria, Hesham A Shamsel-Din, Ahmed B Ibrahim. Stabilized oral nanostructured lipid carriers of Adefovir Dipivoxil as a potential liver targeting: Estimation of liver function panel and uptake following intravenous injection of radioiodinated indicator.
Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences.
2020 Dec; 28(2):517-532. doi:
10.1007/s40199-020-00355-8. [PMID: 32564282] - Yevgeniya I Shurubor, Arthur J L Cooper, Andrey B Krasnikov, Elena P Isakova, Yulia I Deryabina, M Flint Beal, Boris F Krasnikov. Changes of Coenzyme A and Acetyl-Coenzyme A Concentrations in Rats after a Single-Dose Intraperitoneal Injection of Hepatotoxic Thioacetamide Are Not Consistent with Rapid Recovery.
International journal of molecular sciences.
2020 Nov; 21(23):. doi:
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Physiological research.
2020 11; 69(5):835-845. doi:
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Life sciences.
2020 Nov; 261(?):118458. doi:
10.1016/j.lfs.2020.118458. [PMID: 32961231] - S S El-Hawary, E M Abd El-Kader, M A Rabeh, G A Abdel Jaleel, M A Arafat, Tanja Schirmeister, Usama Ramadan Abdelmohsen. Eliciting callus culture for production of hepatoprotective flavonoids and phenolics from Sequoia sempervirens (D. Don Endl).
Natural product research.
2020 Nov; 34(21):3125-3129. doi:
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Microbial biotechnology.
2020 11; 13(6):1860-1876. doi:
10.1111/1751-7915.13629. [PMID: 32652882] - Min Jiang, Ben-Wen Cui, Yan-Ling Wu, Yu Zhang, Yue Shang, Jian Liu, Hong-Xu Yang, Chun-Ying Qiao, Zi-Ying Zhan, Huan Ye, Quan Jin, Ji-Xing Nan, Li-Hua Lian. P2X7R orchestrates the progression of murine hepatic fibrosis by making a feedback loop from macrophage to hepatic stellate cells.
Toxicology letters.
2020 Oct; 333(?):22-32. doi:
10.1016/j.toxlet.2020.07.023. [PMID: 32721574] - Ayah M H Gowifel, Mona G Khalil, Somaia A Nada, Sanaa A Kenawy, Kawkab A Ahmed, Maha M Salama, Marwa M Safar. Combination of pomegranate extract and curcumin ameliorates thioacetamide-induced liver fibrosis in rats: impact on TGF-β/Smad3 and NF-κB signaling pathways.
Toxicology mechanisms and methods.
2020 Oct; 30(8):620-633. doi:
10.1080/15376516.2020.1801926. [PMID: 32718261] - Ying-Hsien Kao, Yu-Chun Lin, Po-Huang Lee, Chia-Wei Lin, Po-Han Chen, Tzong-Shyuan Tai, Yo-Chen Chang, Ming-Huei Chou, Chih-Yang Chang, Cheuk-Kwan Sun. Infusion of Human Mesenchymal Stem Cells Improves Regenerative Niche in Thioacetamide-Injured Mouse Liver.
Tissue engineering and regenerative medicine.
2020 10; 17(5):671-682. doi:
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Naunyn-Schmiedeberg's archives of pharmacology.
2020 10; 393(10):1887-1898. doi:
10.1007/s00210-020-01896-0. [PMID: 32430618] - Syeda Nuzhat Fatima Zaidi, Javeria Masood. The protective effect of fenugreek seeds extract supplementation on glucose and lipid profile in thioacetamide induced liver damage in rats.
Pakistan journal of pharmaceutical sciences.
2020 Sep; 33(5):2003-2008. doi:
NULL. [PMID: 33824107] - Wei Su, Yang Tai, Shi-Hang Tang, Yan-Ting Ye, Chong Zhao, Jin-Hang Gao, Bi-Guang Tuo, Cheng-Wei Tang. Celecoxib attenuates hepatocyte apoptosis by inhibiting endoplasmic reticulum stress in thioacetamide-induced cirrhotic rats.
World journal of gastroenterology.
2020 Jul; 26(28):4094-4107. doi:
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Pakistan journal of pharmaceutical sciences.
2020 Jul; 33(4):1519-1525. doi:
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Chemico-biological interactions.
2020 Jun; 324(?):109098. doi:
10.1016/j.cbi.2020.109098. [PMID: 32278740] - Guilherme R Romualdo, Elizangela Dos Anjos Silva, Tereza C Da Silva, Thiago P A Aloia, Marina S Nogueira, Inar A De Castro, Mathieu Vinken, Luís F Barbisan, Bruno Cogliati. Burdock (Arctium lappa L.) root attenuates preneoplastic lesion development in a diet and thioacetamide-induced model of steatohepatitis-associated hepatocarcinogenesis.
Environmental toxicology.
2020 Apr; 35(4):518-527. doi:
10.1002/tox.22887. [PMID: 31804025] - Meryem Sayan, Derya Karabulut, Saim Özdamar. Assessment of the protective and therapeutic effect of melatonin against thioacetamide-induced acute liver damage.
Journal of biochemical and molecular toxicology.
2020 Apr; 34(4):e22450. doi:
10.1002/jbt.22450. [PMID: 31967703] - Min Pang, Yu Shan, Fei-Fei Wang, Shu-Xian Yang, Li-Yong Li, Li Cao. [Protective effect of water extracts of Orychophragmus violaceus seeds on TAA-induced acute liver injury in mice].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2020 Mar; 45(6):1399-1405. doi:
10.19540/j.cnki.cjcmm.20191112.405. [PMID: 32281354] - E Koblihová, I Mrázová, Z Vaňourková, H Maxová, S Kikerlová, Z Husková, M Ryska, J Froněk, Z Vernerová. Pharmacological stimulation of Wnt/beta-catenin signaling pathway attenuates the course of thioacetamide-induced acute liver failure.
Physiological research.
2020 02; 69(1):113-126. doi:
10.33549/physiolres.934071. [PMID: 31852203] - Xiaoming Sun, Yi Lv, Lu Huang, Hao Gao, Chaoran Ren, Jingjing Li, Man Bie, Wei Li, Kazuo Koike, Kwok-Fai So, Jia Xiao. Pro-inflammatory cytokines serve as communicating molecules between the liver and brain for hepatic encephalopathy pathogenesis and Lycium barbarum polysaccharides protection.
Journal of ethnopharmacology.
2020 Feb; 248(?):112357. doi:
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Biochemical and biophysical research communications.
2020 02; 522(2):381-387. doi:
10.1016/j.bbrc.2019.11.100. [PMID: 31761320] - Yu Miao, Yanling Wu, Yingjin Jin, Mengze Lei, Jixing Nan, Xue Wu. Benzoquinone derivatives with antioxidant activity inhibit activated hepatic stellate cells and attenuate liver fibrosis in TAA-induced mice.
Chemico-biological interactions.
2020 Feb; 317(?):108945. doi:
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Neuroscience letters.
2020 01; 718(?):134750. doi:
10.1016/j.neulet.2020.134750. [PMID: 31926175] - Mona Abd El-Latif El-Ghazaly, Engy Refaat Rashed, Ghada Mahmoud Shafey, Hala Fahmy Zaki, Amina Salem Attia. Amelioration of thioacetamide-induced hepatic encephalopathy in rats by low-dose gamma irradiation.
Environmental science and pollution research international.
2020 Jan; 27(1):334-343. doi:
10.1007/s11356-019-06934-w. [PMID: 31786756] - Akika Fukawa, Shunsuke Baba, Kaori Iwasawa, Makoto Yamaguchi, Akira Hosono. Dietary α-Lactalbumin protects against thioacetamide-induced liver cirrhosis by maintaining gut-liver axis function in rats.
Bioscience, biotechnology, and biochemistry.
2020 Jan; 84(1):171-177. doi:
10.1080/09168451.2019.1660613. [PMID: 31476130] - Jae Hyun Han, Ok-Hee Kim, Sang Chul Lee, Kee-Hwan Kim, Jung Hyun Park, Jae Im Lee, Kyung Hee Lee, Ha-Eun Hong, Haeyeon Seo, Ho Joong Choi, Ji Hyeon Ju, Say-June Kim. A Novel Hepatic Anti-Fibrotic Strategy Utilizing the Secretome Released from Etanercept-Synthesizing Adipose-Derived Stem Cells.
International journal of molecular sciences.
2019 Dec; 20(24):. doi:
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Journal of tissue engineering and regenerative medicine.
2019 12; 13(12):2131-2141. doi:
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Scientific reports.
2019 11; 9(1):17497. doi:
10.1038/s41598-019-53977-7. [PMID: 31767905] - Hye-Young Seo, So-Hee Lee, Ji-Ha Lee, Yu Na Kang, Young-Keun Choi, Jae Seok Hwang, Keun-Gyu Park, Byoung Kuk Jang, Mi-Kyung Kim. Clusterin Attenuates Hepatic Fibrosis by Inhibiting Hepatic Stellate Cell Activation and Downregulating the Smad3 Signaling Pathway.
Cells.
2019 11; 8(11):. doi:
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Environmental toxicology and pharmacology.
2019 Nov; 72(?):103240. doi:
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The Journal of surgical research.
2019 11; 243(?):165-172. doi:
10.1016/j.jss.2019.05.020. [PMID: 31177036] - Ahmed Abdelmoniem Mousa, Hala Ali Ibrahim El-Gansh, Mabrouk Attia Abd Eldaim, Mostafa Abd El-Gaber Mohamed, Azza Hassan Morsi, Hesham Saad El Sabagh. Protective effect of Moringa oleifera leaves ethanolic extract against thioacetamide-induced hepatotoxicity in rats via modulation of cellular antioxidant, apoptotic and inflammatory markers.
Environmental science and pollution research international.
2019 Nov; 26(31):32488-32504. doi:
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Environmental science and pollution research international.
2019 Oct; 26(29):29930-29945. doi:
10.1007/s11356-019-06158-y. [PMID: 31407268] - Xiaohui Wang, Ting Fu, Junqiao Wang, Changyuan Wang, Kexin Liu, Jingjing Wu, Huijun Sun, Xiaodong Ma, Pengyuan Sun, Qiang Meng. Hepatoprotection of yangonin against hepatic fibrosis in mice via farnesoid X receptor activation.
International immunopharmacology.
2019 Oct; 75(?):105833. doi:
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