N-NITROSODIETHANOLAMINE (BioDeep_00000012732)

 

Secondary id: BioDeep_00001868126

human metabolite blood metabolite Volatile Flavor Compounds natural product


代谢物信息卡片


2-[(2-hydroxyethyl)(nitroso)amino]ethan-1-ol

化学式: C4H10N2O3 (134.069139)
中文名称: N-亚硝基二乙醇胺
谱图信息: 最多检出来源 Homo sapiens(blood) 7.82%

分子结构信息

SMILES: C(CO)N(CCO)N=O
InChI: InChI=1S/C4H10N2O3/c7-3-1-6(5-9)2-4-8/h7-8H,1-4H2

描述信息

D009676 - Noxae > D002273 - Carcinogens

同义名列表

6 个代谢物同义名

2-[(2-hydroxyethyl)(nitroso)amino]ethan-1-ol; 2,2-(Nitrosoimino)diethanol; N-NITROSODIETHANOLAMINE; Diethanolnitrosamine; N-Nitrosodiethanolamine; N-Nitrosodiethanolamine



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

10 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Shakil A Saghir, Kathy A Brzak, Dan A Markham, Michael J Bartels, William T Stott. Investigation of the formation of N-nitrosodiethanolamine in B6C3F1 mice following topical administration of triethanolamine. Regulatory toxicology and pharmacology : RTP. 2005 Oct; 43(1):10-8. doi: 10.1016/j.yrtph.2005.04.002. [PMID: 15905009]
  • C Thirunavukkarasu, D Sakthisekaran. Effect of dietary selenite on N-nitrosodiethylamine-induced and phenobarbital promoted multistage hepatocarcinogenesis in rat: reflection in some minerals. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2003 Nov; 57(9):416-21. doi: 10.1016/j.biopha.2003.08.023. [PMID: 14652167]
  • P Ducos, R Gaudin. N-nitrosodiethanolamine urinary excretion in workers exposed to aqueous metalworking fluids. International archives of occupational and environmental health. 2003 Oct; 76(8):591-7. doi: 10.1007/s00420-003-0465-2. [PMID: 13680243]
  • W T Stott, M J Bartels, K A Brzak, M Mar, D A Markham, C M Thornton, S H Zeisel. Potential mechanisms of tumorigenic action of diethanolamine in mice. Toxicology letters. 2000 Apr; 114(1-3):67-75. doi: 10.1016/s0378-4274(99)00197-6. [PMID: 10713470]
  • S Monarca, G Scassellati-Sforzolini, F Donato, G Angeli, B Spiegelhalder, C Fatigoni, R Pasquini. Biological monitoring of workers exposed to N-nitrosodiethanolamine in the metal industry. Environmental health perspectives. 1996 Jan; 104(1):78-82. doi: 10.1289/ehp.9610478. [PMID: 8834865]
  • J Fuchs, J Burg, J G Hengstler, U Bolm-Audorff, F Oesch. DNA damage in mononuclear blood cells of metal workers exposed to N-nitrosodiethanolamine in synthetic cutting fluids. Mutation research. 1995 Mar; 342(1-2):95-102. doi: 10.1016/0165-1218(95)90094-2. [PMID: 7885399]
  • F Oesch, J G Hengstler, M Arand, J Fuchs. Detection of primary DNA damage: applicability to biomonitoring of genotoxic occupational exposure and in clinical therapy. Pharmacogenetics. 1995; 5 Spec No(?):S118-22. doi: 10.1097/00008571-199512001-00012. [PMID: 7581480]
  • A R Tricker, T Kälble, R Preussmann. Comparative metabolism and urinary excretion of N-mononitrosopiperazine and N,N'-dinitrosopiperazine in the rat. Cancer letters. 1991 Aug; 59(2):165-9. doi: 10.1016/0304-3835(91)90182-h. [PMID: 1884373]
  • M Ahotupa, V Bussacchini-Griot, J C Béréziat, A M Camus, H Bartsch. Rapid oxidative stress induced by N-nitrosamines. Biochemical and biophysical research communications. 1987 Aug; 146(3):1047-54. doi: 10.1016/0006-291x(87)90753-4. [PMID: 3619914]
  • B Spiegelhalder, J Müller, H Drasche, R Preussmann. N-nitrosodiethanolamine excretion in metal grinders. IARC scientific publications. 1987; ?(84):550-2. doi: NULL. [PMID: 3679442]
  • J G Farrelly, B J Thomas, W Lijinsky. Metabolism and cellular interactions of N-nitrosodiethanolamine. IARC scientific publications. 1987; ?(84):87-90. doi: NULL. [PMID: 2445676]
  • C J Michejda, S R Koepke, M B Kroeger-Koepke, W Bosan. Recent findings on the metabolism of beta-hydroxyalkylnitrosamines. IARC scientific publications. 1987; ?(84):77-82. doi: NULL. [PMID: 3316003]
  • A Maekawa, H Onodera, H Tanigawa, K Furuta, J Kanno, C Matsuoka, T Ogiu, Y Hayashi. Lack of carcinogenicity of triethanolamine in F344 rats. Journal of toxicology and environmental health. 1986; 19(3):345-57. doi: 10.1080/15287398609530933. [PMID: 3772984]
  • W Lijinsky, R M Kovatch. Induction of liver tumors in rats by nitrosodiethanolamine at low doses. Carcinogenesis. 1985 Dec; 6(12):1679-81. doi: 10.1093/carcin/6.12.1679. [PMID: 4064244]
  • M Bonfanti, M G Castelli, R Fanelli, L Airoldi. Enterohepatic recycling of N-nitrosodiethanolamine in rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1985 Nov; 23(11):1011-3. doi: 10.1016/0278-6915(85)90252-2. [PMID: 4076928]
  • B Löfberg, H Tjälve. Autoradiography of [14C]N-nitrosodiethanolamine in Sprague-Dawley rats. Cancer letters. 1985 Mar; 26(2):129-37. doi: 10.1016/0304-3835(85)90018-7. [PMID: 3919936]
  • L Airoldi, A Macri, M Bonfanti, M Bonati, R Fanelli. Kinetics and bioavailability of N-nitrosodiethanolamine after intravenous and cutaneous administration to rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1984 Feb; 22(2):133-8. doi: 10.1016/0278-6915(84)90093-0. [PMID: 6538162]
  • W Lijinsky, M D Reuber. Dose-response study with N-nitrosodiethanolamine in F344 rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1984 Jan; 22(1):23-6. doi: 10.1016/0278-6915(84)90047-4. [PMID: 6537933]
  • B Spiegelhalder, R Preussmann, M Hartung. Biological monitoring in the metal working industry. IARC scientific publications. 1984; ?(57):943-6. doi: NULL. [PMID: 6533079]
  • D Hoffman, A Rivenson, J D Adams, A Juchatz, N Vinchkoski, S S Hecht. Effects of route of administration and dose on the carcinogenicity of N-nitrosodiethanolamine in the Syrian golden hamster. Cancer research. 1983 Jun; 43(6):2521-4. doi: NULL. [PMID: 6850574]
  • L Airoldi, M Bonfanti, E Benfenati, P Tavecchia, R Fanelli. Identification of an acidic metabolite of N-nitrosodiethanolamine isolated from rat urine. Biomedical mass spectrometry. 1983 May; 10(5):334-7. doi: 10.1002/bms.1200100505. [PMID: 6860779]
  • R Preussmann, M Habs, H Habs, D Schmähl. Carcinogenicity of N-nitrosodiethanolamine in rats at five different dose levels. Cancer research. 1982 Dec; 42(12):5167-71. doi: NULL. [PMID: 7139619]
  • E J Lethco, W C Wallace, E Brouwer. The fate of N-nitrosodiethanolamine after oral and topical administration to rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1982 Aug; 20(4):401-6. doi: 10.1016/s0278-6915(82)80104-x. [PMID: 6890019]
  • W Lijinsky, A M Losikoff, E B Sansone. Penetration of rat skin by N-nitrosodiethanolamine and N-nitrosomorpholine. Journal of the National Cancer Institute. 1981 Jan; 66(1):125-7. doi: . [PMID: 6935453]
  • E B Sansone, A M Losikoff, W Lijinsky. The penetration of rat skin by some nitrosamines of environmental importance. IARC scientific publications. 1980; ?(31):705-16. doi: NULL. [PMID: 7228292]
  • R Preussmann, G Würtele, G Eisenbrand, B Spiegelhalder. Urinary excretion of N-nitrosodiethanolamine administered orally to rats. Cancer letters. 1978 Apr; 4(4):207-9. doi: 10.1016/s0304-3835(78)94512-3. [PMID: 647660]