Nitrogen mustard N-oxide (BioDeep_00000012729)
Secondary id: BioDeep_00001868994
human metabolite blood metabolite Volatile Flavor Compounds
代谢物信息卡片
Merck frosst brand OF mechlorethamine hydrochloride
化学式: C5H11Cl2NO (171.0217656)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 50%
分子结构信息
SMILES: CN(=O)(CCCl)CCCl
InChI: InChI=1S/C5H11Cl2NO/c1-8(9,4-2-6)5-3-7/h2-5H2,1H3
描述信息
D000970 - Antineoplastic Agents > D018906 - Antineoplastic Agents, Alkylating > D009588 - Nitrogen Mustard Compounds
D009676 - Noxae > D011042 - Poisons > D002619 - Chemical Warfare Agents
D009676 - Noxae > D000477 - Alkylating Agents
D009676 - Noxae > D007509 - Irritants
同义名列表
32 个代谢物同义名
Merck frosst brand OF mechlorethamine hydrochloride; 2-chloro-N-(2-chloroethyl)-N-methylethanamine oxide; Merck brand OF mechlorethamine hydrochloride; Hydrochloride N-oxide, mechlorethamine; N-Oxide, mechlorethamine hydrochloride; Mechlorethamine hydrochloride N oxide; Mechlorethamine hydrochloride N-oxide; Hydrochloride, mechlorethamine; Bis(2-chloroethyl)methylamine; Mechlorethamine hydrochloride; N-Oxide, nitrogen mustard; Nitrogen mustard N-oxide; Nitrogen mustard N oxide; Mechlorethamine N-oxide; Mechlorethamine N oxide; Mechlorethamine oxide; Methylchlorethamine; Nitrogen mustard; Nitrogranulogen; mechlorethamine; Chlorethazine; Chlormethine; Caryolysine; Mustargen; Nitromin; Cloramin; Embichin; NSC-762; Mustine; Mitomen; NSC 762; Nitrogen mustard N-oxide
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:82354
- KEGG: C19274
- PubChem: 9335
- HMDB: HMDB0255650
- Metlin: METLIN72992
- ChEMBL: CHEMBL502759
- MeSH: Mechlorethamine
- CAS: 126-85-2
- PMhub: MS000027057
- PubChem: 124489946
- KNApSAcK: 82354
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Haichang Li, Zhongguang Li, Xiuchun Li, Chuanxi Cai, Serena Li Zhao, Robert E Merritt, Xinyu Zhou, Tao Tan, Valerie Bergdall, Jianjie Ma. MG53 Mitigates Nitrogen Mustard-Induced Skin Injury.
Cells.
2023 07; 12(14):. doi:
10.3390/cells12141915. [PMID: 37508578] - Jaclynn A Meshanni, Jordan M Lee, Kinal N Vayas, Rachel Sun, Chenghui Jiang, Grace L Guo, Andrew J Gow, Jeffrey D Laskin, Debra L Laskin. Suppression of lung oxidative stress, inflammation and fibrosis following nitrogen mustard exposure by the selective farnesoid X receptor agonist obeticholic acid.
The Journal of pharmacology and experimental therapeutics.
2023 May; ?(?):. doi:
10.1124/jpet.123.001557. [PMID: 37188530] - Alexa Murray, Tanvi Banota, Grace L Guo, Ley Cody Smith, Jaclynn A Meshanni, Jordan Lee, Bo Kong, Elena V Abramova, Michael Goedken, Andrew J Gow, Jeffrey D Laskin, Debra L Laskin. Farnesoid X receptor regulates lung macrophage activation and injury following nitrogen mustard exposure.
Toxicology and applied pharmacology.
2022 11; 454(?):116208. doi:
10.1016/j.taap.2022.116208. [PMID: 35998709] - Benediktus N Hapsianto, Naoshi Kojima, Ryoji Kurita, Hitoshi Yamagata, Hiroyuki Fujita, Teruo Fujii, Soo Hyeon Kim. Direct Capture and Amplification of Small Fragmented DNAs Using Nitrogen-Mustard-Coated Microbeads.
Analytical chemistry.
2022 05; 94(21):7594-7600. doi:
10.1021/acs.analchem.2c00531. [PMID: 35578745] - Angela Cruz-Hernandez, Ryan P Mendoza, Kathleen Nguyen, Anna Harder, Christopher M Evans, Alison K Bauer, Neera Tewari-Singh, Jared M Brown. Mast Cells Promote Nitrogen Mustard-Mediated Toxicity in the Lung Associated With Proinflammatory Cytokine and Bioactive Lipid Mediator Production.
Toxicological sciences : an official journal of the Society of Toxicology.
2021 10; 184(1):127-141. doi:
10.1093/toxsci/kfab107. [PMID: 34453837] - Andrea DeSantis-Rodrigues, Rita A Hahn, Peihong Zhou, Michael Babin, Kathy K H Svoboda, Yoke-Chen Chang, Donald R Gerecke, Marion K Gordon. SM1997 downregulates mustard-induced enzymes that disrupt corneal epithelial attachment.
Anatomical record (Hoboken, N.J. : 2007).
2021 09; 304(9):1974-1983. doi:
10.1002/ar.24597. [PMID: 33554453] - Alessandro Venosa, L Cody Smith, Andrew J Gow, Helmut Zarbl, Jeffrey D Laskin, Debra L Laskin. Macrophage activation in the lung during the progression of nitrogen mustard induced injury is associated with histone modifications and altered miRNA expression.
Toxicology and applied pharmacology.
2021 07; 423(?):115569. doi:
10.1016/j.taap.2021.115569. [PMID: 33971176] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Haley Clark, Barbara Pereira Vera, Zijing Zhang, Lynae M Brayboy. MDR-1 function protects oocyte mitochondria against the transgenerational effects of nitrogen mustard exposure.
Reproductive toxicology (Elmsford, N.Y.).
2020 12; 98(?):252-259. doi:
10.1016/j.reprotox.2020.10.010. [PMID: 33164761] - Buddhadeb Chandra, Kanchan Sinha Roy, Mahabul Shaik, Chandrakant Waghmare, RamaRao Golime, Meehir Palit. Gas chromatography-tandem mass spectrometry-based detection of half nitrogen mustards in plasma as a new biomarker of nitrogen mustard exposure.
Analytical methods : advancing methods and applications.
2020 09; 12(36):4447-4456. doi:
10.1039/d0ay00916d. [PMID: 32856667] - Mai Otsuka, Hajime Miyaguchi, Masanobu Uchiyama. Analysis of nitrogen mustard degradation products via post-pentafluorobenzoylation liquid chromatography-tandem mass spectrometry.
Journal of chromatography. A.
2020 Aug; 1625(?):461306. doi:
10.1016/j.chroma.2020.461306. [PMID: 32709349] - Yi-Hua Jan, Diane E Heck, Debra L Laskin, Jeffrey D Laskin. DNA damage signaling in the cellular responses to mustard vesicants.
Toxicology letters.
2020 Jun; 326(?):78-82. doi:
10.1016/j.toxlet.2020.03.008. [PMID: 32173488] - Buddhadeb Chandra, Kanchan Sinha Roy, Mahabul Shaik, Chandrakant Waghmare, Meehir Palit. Mass spectral studies of silyl derivatives of partially hydrolyzed products of nitrogen mustards: Important markers of nitrogen mustard exposure.
Rapid communications in mass spectrometry : RCM.
2020 Feb; 34(3):e8586. doi:
10.1002/rcm.8586. [PMID: 31509283] - Yulia Kaluzhny, Miriam W Kinuthia, Allison M Lapointe, Thoa Truong, Mitchell Klausner, Patrick Hayden. Oxidative stress in corneal injuries of different origin: Utilization of 3D human corneal epithelial tissue model.
Experimental eye research.
2020 01; 190(?):107867. doi:
10.1016/j.exer.2019.107867. [PMID: 31705899] - Alessandro Venosa, Ley Cody Smith, Alexa Murray, Tanvi Banota, Andrew J Gow, Jeffrey D Laskin, Debra L Laskin. Regulation of Macrophage Foam Cell Formation During Nitrogen Mustard (NM)-Induced Pulmonary Fibrosis by Lung Lipids.
Toxicological sciences : an official journal of the Society of Toxicology.
2019 12; 172(2):344-358. doi:
10.1093/toxsci/kfz187. [PMID: 31428777] - Mai Otsuka, Hajime Miyaguchi, Masanobu Uchiyama. Analysis of degradation products of nitrogen mustards via hydrophilic interaction liquid chromatography-tandem mass spectrometry.
Journal of chromatography. A.
2019 Sep; 1602(?):199-205. doi:
10.1016/j.chroma.2019.05.015. [PMID: 31109745] - Yuan Yang, Li Zhao, Li Xiao, Yumei Liang, Chang Wang, Xiao Fu, Xuejing Zhu, Shuguang Yuan, Jianling Zhu, Xiaoping Zhu, Yinghong Liu, Jun Li, Jian Luo, Fuyou Liu, Lin Sun. Chlormethine Hydrochloride is Not Inferior to Tacrolimus in Treating Steroid-Resistant Nephrotic Syndrome.
Kidney & blood pressure research.
2018; 43(1):68-79. doi:
10.1159/000486911. [PMID: 29402844] - Georgia Charkoftaki, James V Jester, David C Thompson, Vasilis Vasiliou. Nitrogen mustard-induced corneal injury involves the sphingomyelin-ceramide pathway.
The ocular surface.
2018 01; 16(1):154-162. doi:
10.1016/j.jtos.2017.11.004. [PMID: 29129753] - Irene Ojini, Alison Gammie. Rapid Identification of Chemoresistance Mechanisms Using Yeast DNA Mismatch Repair Mutants.
G3 (Bethesda, Md.).
2015 Jul; 5(9):1925-35. doi:
10.1534/g3.115.020560. [PMID: 26199284] - Dileep Kumar, Neera Tewari-Singh, Chapla Agarwal, Anil K Jain, Swetha Inturi, Rama Kant, Carl W White, Rajesh Agarwal. Nitrogen mustard exposure of murine skin induces DNA damage, oxidative stress and activation of MAPK/Akt-AP1 pathway leading to induction of inflammatory and proteolytic mediators.
Toxicology letters.
2015 Jun; 235(3):161-71. doi:
10.1016/j.toxlet.2015.04.006. [PMID: 25891025] - Dinesh G Goswami, Dileep Kumar, Neera Tewari-Singh, David J Orlicky, Anil K Jain, Rama Kant, Raymond C Rancourt, Deepanshi Dhar, Swetha Inturi, Chapla Agarwal, Carl W White, Rajesh Agarwal. Topical nitrogen mustard exposure causes systemic toxic effects in mice.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.
2015 Feb; 67(2):161-70. doi:
10.1016/j.etp.2014.11.006. [PMID: 25481215] - Maria A Pino, Magdalena Pietka-Ottlik, Blase Billack. Selected ebselen analogs reduce mechlorethamine toxicity in vitro.
Cutaneous and ocular toxicology.
2014 Mar; 33(1):32-41. doi:
10.3109/15569527.2013.794818. [PMID: 23734969] - Erlong Zhang, Shenglin Luo, Xu Tan, Chunmeng Shi. Mechanistic study of IR-780 dye as a potential tumor targeting and drug delivery agent.
Biomaterials.
2014 Jan; 35(2):771-8. doi:
10.1016/j.biomaterials.2013.10.033. [PMID: 24148240] - Ruijin Zheng, Iris Po, Vladimir Mishin, Adrienne T Black, Diane E Heck, Debra L Laskin, Patrick J Sinko, Donald R Gerecke, Marion K Gordon, Jeffrey D Laskin. The generation of 4-hydroxynonenal, an electrophilic lipid peroxidation end product, in rabbit cornea organ cultures treated with UVB light and nitrogen mustard.
Toxicology and applied pharmacology.
2013 Oct; 272(2):345-55. doi:
10.1016/j.taap.2013.06.025. [PMID: 23845594] - Jennifer A Kanakry, Hailun Li, Lan L Gellert, M Victor Lemas, Wen-son Hsieh, Fangxin Hong, King L Tan, Randy D Gascoyne, Leo I Gordon, Richard I Fisher, Nancy L Bartlett, Patrick Stiff, Bruce D Cheson, Ranjana Advani, Thomas P Miller, Brad S Kahl, Sandra J Horning, Richard F Ambinder. Plasma Epstein-Barr virus DNA predicts outcome in advanced Hodgkin lymphoma: correlative analysis from a large North American cooperative group trial.
Blood.
2013 May; 121(18):3547-53. doi:
10.1182/blood-2012-09-454694. [PMID: 23386127] - Zeki Ilker Kunak, Enis Macit, Hakan Yaren, Halil Yaman, Erdinc Cakir, Ibrahim Aydin, Turker Turker, Yasemin Gulcan Kurt, Ayhan Ozcan, Bulent Uysal, Salim Isbilir, Emin Ozgur Akgul, Tuncer Cayci, Ahmet Korkmaz, Levent Kenar. Protective effects of melatonin and S-methylisothiourea on mechlorethamine induced nephrotoxicity.
The Journal of surgical research.
2012 Jun; 175(1):e17-23. doi:
10.1016/j.jss.2011.11.002. [PMID: 22261582] - Muntha K Reddy, Grier Mills, Christopher Nixon, Shane A Wyatt, Timothy R Croley. High-throughput sample preparation and simultaneous column regeneration liquid chromatography-tandem mass spectrometry method for determination of nitrogen mustard metabolites in human urine.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2011 Aug; 879(24):2383-8. doi:
10.1016/j.jchromb.2011.06.029. [PMID: 21764395] - Levent Kenar, Orkun Alp. Determination of nitrogen mustard hydrolysis products in rat urine samples using GC-MS.
Journal of chromatographic science.
2011 May; 49(5):361-4. doi:
10.1093/chromsci/49.5.361. [PMID: 21549026] - Manoj Sharma, S C Pant, J C Pant, R Vijayaraghavan. Nitrogen and sulphur mustard induced histopathological observations in mouse visceral organs.
Journal of environmental biology.
2010 Nov; 31(6):891-905. doi:
NULL. [PMID: 21506473] - Manoj Sharma, R Vijayaraghavan, K Ganesan. Comparison of toxicity of selected mustard agents by percutaneous and subcutaneous routes.
Indian journal of experimental biology.
2008 Dec; 46(12):822-30. doi:
NULL. [PMID: 19245179] - Hai-Chen Wu, Hagan Bayley. Single-molecule detection of nitrogen mustards by covalent reaction within a protein nanopore.
Journal of the American Chemical Society.
2008 May; 130(21):6813-9. doi:
10.1021/ja8004607. [PMID: 18444650] - De-Ying Zhang, Da-Wei He, Guang-Hui Wei, Xing Liu, Tao Lin, Xu-Liang Li. [Phyllanthus urinaria extract promotes N-cadherin expression in nitrogen mustard-disrupted testicular tissues in vivo].
Zhonghua nan ke xue = National journal of andrology.
2008 May; 14(5):396-400. doi:
". [PMID: 18572855] - Emmanuel Laffitte, Jean-Pierre Venetz, John-David Aubert, Michel A Duchosal, Renato G Panizzon, Manuel Pascual. Mycosis fungoides in a lung transplant recipient with advanced ciclosporin nephropathy: management with mechlorethamine and subsequent renal transplantation.
Dermatology (Basel, Switzerland).
2008; 217(1):87-8. doi:
10.1159/000128283. [PMID: 18446031] - Maria A Pino, Blase Billack. Reduction of vesicant toxicity by butylated hydroxyanisole in A-431 skin cells.
Cutaneous and ocular toxicology.
2008; 27(3):161-72. doi:
10.1080/15569520802092070. [PMID: 18988086] - Thong-Hiang Yeo, Mer-Lin Ho, Weng-Keong Loke. Development of a liquid chromatography-multiple reaction monitoring procedure for concurrent verification of exposure to different forms of mustard agents.
Journal of analytical toxicology.
2008 Jan; 32(1):51-6. doi:
10.1093/jat/32.1.51. [PMID: 18269793] - Robert D van Beek, Marij Smit, Marry M van den Heuvel-Eibrink, Frank H de Jong, Friederike G Hakvoort-Cammel, Cor van den Bos, Henk van den Berg, Rob F A Weber, Rob Pieters, Sabine M P F de Muinck Keizer-Schrama. Inhibin B is superior to FSH as a serum marker for spermatogenesis in men treated for Hodgkin's lymphoma with chemotherapy during childhood.
Human reproduction (Oxford, England).
2007 Dec; 22(12):3215-22. doi:
10.1093/humrep/dem313. [PMID: 17981817] - Robert D van Beek, Marry M van den Heuvel-Eibrink, Joop S E Laven, Frank H de Jong, Axel P N Themmen, Friederike G Hakvoort-Cammel, Cor van den Bos, Henk van den Berg, Rob Pieters, Sabine M P F de Muinck Keizer-Schrama. Anti-Mullerian hormone is a sensitive serum marker for gonadal function in women treated for Hodgkin's lymphoma during childhood.
The Journal of clinical endocrinology and metabolism.
2007 Oct; 92(10):3869-74. doi:
10.1210/jc.2006-2374. [PMID: 17726078] - Muharrem Ucar, Ahmet Korkmaz, Russel J Reiter, Hakan Yaren, Sükrü Oter, Bülent Kurt, Turgut Topal. Melatonin alleviates lung damage induced by the chemical warfare agent nitrogen mustard.
Toxicology letters.
2007 Sep; 173(2):124-31. doi:
10.1016/j.toxlet.2007.07.005. [PMID: 17765411] - Hakan Yaren, Hakan Mollaoglu, Bulent Kurt, Ahmet Korkmaz, Sukru Oter, Turgut Topal, Turan Karayilanoglu. Lung toxicity of nitrogen mustard may be mediated by nitric oxide and peroxynitrite in rats.
Research in veterinary science.
2007 Aug; 83(1):116-22. doi:
10.1016/j.rvsc.2006.11.004. [PMID: 17196628] - Loverro Giuseppe, Guarini Attilio, Di Naro Edoardo, Giacomantonio Loredana, Lavopa Cristina, Liso Vincenzo. Ovarian function after cancer treatment in young women affected by Hodgkin disease (HD).
Hematology (Amsterdam, Netherlands).
2007 Apr; 12(2):141-7. doi:
10.1080/10245330600954072. [PMID: 17454195] - Xiao-Hong Fu, Shu-Sen Wang, Yan Huang, Bo Wang, Hui-Qiang Huang, Li Zhang, Xiao-Fei Sun, Rui-Hua Xu, Tong-Yu Lin. [Feasibility study of application of international prognostic score on prediction of prognosis for advanced Hodgkin's lymphoma].
Ai zheng = Aizheng = Chinese journal of cancer.
2006 Aug; 25(8):1013-8. doi:
NULL. [PMID: 16965685] - Isaac Ohsawa, Yasuo Seto. Determination of nitrogen mustard hydrolysis products, ethanolamines by gas chromatography-mass spectrometry after tert-butyldimethylsilyl derivatization.
Journal of chromatography. A.
2006 Jul; 1122(1-2):242-8. doi:
10.1016/j.chroma.2006.04.076. [PMID: 16707130] - Sharon W Lemire, John R Barr, David L Ashley, Carl T Olson, Timothy L Hayes. Quantitation of biomarkers of exposure to nitrogen mustards in urine from rats dosed with nitrogen mustards and from an unexposed human population.
Journal of analytical toxicology.
2004 Jul; 28(5):320-6. doi:
10.1093/jat/28.5.320. [PMID: 15239850] - Magdalena Dyduch, Jan Skolyszewski, Stanislaw Korzeniowski, Andrzej Sokolowski. Analysis of treatment results in advanced Hodgkin's disease: the case for adjuvant radiotherapy.
International journal of radiation oncology, biology, physics.
2003 Jul; 56(3):634-43. doi:
10.1016/s0360-3016(03)00129-9. [PMID: 12788168] - Maryse Rapp, Isabelle Giraud, Jean-Claude Maurizis, Marie-Josèphe Galmier, Jean-Claude Madelmont. Synthesis and in vivo biodisposition of [14C]-quaternary ammonium-melphalan conjugate, a potential cartilage-targeted alkylating drug.
Bioconjugate chemistry.
2003 Mar; 14(2):500-6. doi:
10.1021/bc020031e. [PMID: 12643763] - Sharon W Lemire, David L Ashley, Antonia M Calafat. Quantitative determination of the hydrolysis products of nitrogen mustards in human urine by liquid chromatography-electrospray ionization tandem mass spectrometry.
Journal of analytical toxicology.
2003 Jan; 27(1):1-6. doi:
10.1093/jat/27.1.1. [PMID: 12587675] - Gregory M Chronowski, Richard B Wilder, Susan L Tucker, Chul S Ha, Andreas H Sarris, Fredrick B Hagemeister, Ibrahim Barista, Mark A Hess, Fernando Cabanillas, James D Cox. An elevated serum beta-2-microglobulin level is an adverse prognostic factor for overall survival in patients with early-stage Hodgkin disease.
Cancer.
2002 Dec; 95(12):2534-8. doi:
10.1002/cncr.10998. [PMID: 12467067] - R Zanotti, A Trolese, A Ambrosetti, G Nadali, C Visco, M M Ricetti, F Benedetti, G Pizzolo. Serum levels of soluble CD30 improve International Prognostic Score in predicting the outcome of advanced Hodgkin's lymphoma.
Annals of oncology : official journal of the European Society for Medical Oncology.
2002 Dec; 13(12):1908-14. doi:
10.1093/annonc/mdf333. [PMID: 12453859] - Daan Noort, Albert G Hulst, Rob Jansen. Covalent binding of nitrogen mustards to the cysteine-34 residue in human serum albumin.
Archives of toxicology.
2002 Mar; 76(2):83-8. doi:
10.1007/s00204-001-0318-2. [PMID: 11914777] - Narin Apisarnthanarax, Rakshandra Talpur, Madeleine Duvic. Treatment of cutaneous T cell lymphoma: current status and future directions.
American journal of clinical dermatology.
2002; 3(3):193-215. doi:
10.2165/00128071-200203030-00006. [PMID: 11978140] - D Molin, B Glimelius, C Sundström, P Venge, G Enblad. The serum levels of eosinophil cationic protein (ECP) are related to the infiltration of eosinophils in the tumours of patients with Hodgkin's disease.
Leukemia & lymphoma.
2001 Jul; 42(3):457-65. doi:
10.3109/10428190109064602. [PMID: 11699410] - A M Miller, A R McPhaden, R M Wadsworth, C L Wainwright. Inhibition by leukocyte depletion of neointima formation after balloon angioplasty in a rabbit model of restenosis.
Cardiovascular research.
2001 Mar; 49(4):838-50. doi:
10.1016/s0008-6363(00)00304-7. [PMID: 11230984] - L Purzyc, I Calkosinski. The influence of mechlorethamine on the activity of ecto-ATPase of rat lymphocytes.
Annales pharmaceutiques francaises.
2001 Feb; 59(1):33-9. doi:
. [PMID: 11223577] - L Soriano Guillén , M T Muñoz Calvo , J Pozo Román , T Contra Gómez , M Buño Soto , J Argente Oliver . [Changes in gonadal function in post-pubertal male survivors of acute lymphoblastic leukemia and Hodgkin's disease].
Anales espanoles de pediatria.
2000 Oct; 53(4):318-23. doi:
NULL. [PMID: 11083980] - P G Gobbi, C Broglia, R Bertè, M P Petrilli, S Molica, F Angrilli, E Iannitto, M L Ghirardelli, N Di Renzo, L Cavanna, E Ascari. Lomustine and melphalan cannot be replaced by cyclophosphamide and etoposide without reducing efficacy in MOPPEBVCAD chemotherapy for advanced Hodgkin's disease.
Haematologica.
2000 Jul; 85(7):722-8. doi:
NULL. [PMID: 10897124] - T Fujimoto, T Nakamura, T Ikeda, K Takagi. Potent protective effects of melatonin on experimental spinal cord injury.
Spine.
2000 Apr; 25(7):769-75. doi:
10.1097/00007632-200004010-00003. [PMID: 10751286] - Q Luo, A K Cheung, C D Kamerath, L G Reimer, J K Leypoldt. Increased protein loss during peritonitis associated with peritoneal dialysis is neutrophil dependent.
Kidney international.
2000 Apr; 57(4):1736-42. doi:
10.1046/j.1523-1755.2000.00019.x. [PMID: 10760110] - S Rappeneau, A Baeza-Squiban, C Jeulin, F Marano. Protection from cytotoxic effects induced by the nitrogen mustard mechlorethamine on human bronchial epithelial cells in vitro.
Toxicological sciences : an official journal of the Society of Toxicology.
2000 Mar; 54(1):212-21. doi:
10.1093/toxsci/54.1.212. [PMID: 10746948] - V M Kovalenko, T F Byshovets', Iu I Hubs'kyĭ, Ie L Levyts'kyĭ, H M Shaiakhmetova, O M Marchenko, O S Voloshyna, H A Saĭfetdinova, V O Okhrimenko, H V Donchenko. [Correcting influence of vitamin E short chain derivatives on lipid peroxidation, liver cell membrane, and chromatin structure when rats are exposed to embichin].
Ukrains'kyi biokhimichnyi zhurnal (1999 ).
2000 Mar; 72(2):56-60. doi:
". [PMID: 10979582] - Y He, W Guo, C Zhang, H Zhu, Z Zhang. [Clinical effects of intra-arterial nitrogen mustard (NH2) chemotherapy during operation for oral cancer].
Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology.
2000 Feb; 18(1):34-6. doi:
NULL. [PMID: 12539359] - T Fujimoto, T Nakamura, T Ikeda, Y Taoka, K Takagi. Effects of EPC-K1 on lipid peroxidation in experimental spinal cord injury.
Spine.
2000 Jan; 25(1):24-9. doi:
10.1097/00007632-200001010-00006. [PMID: 10647156] - C S Chim, Y L Kwong, A K Lie, C K Lee, F C Ho, R Liang. Advanced stage and unfavorable Hodgkin's disease in the Chinese-a 20-year experience.
American journal of hematology.
1999 Jul; 61(3):159-63. doi:
10.1002/(sici)1096-8652(199907)61:3<159::aid-ajh1>3.0.co;2-g. [PMID: 10398307] - M Delain, G Cartron, M Bout, L Benboubker, C Linassier, J P Lamagnere, P Colombat. Intensive therapy with autologous stem cell transplantation as first-line therapy in poor-risk Hodgkin's disease and analysis of predictive factors of outcome.
Leukemia & lymphoma.
1999 Jul; 34(3-4):305-13. doi:
10.3109/10428199909050955. [PMID: 10439367] - N Harada, K Okajima, K Murakami, H Isobe, W Liu. Gastric prostacyclin (PGI2) prevents stress-induced gastric mucosal injury in rats primarily by inhibiting leukocyte activation.
Prostaglandins & other lipid mediators.
1999 Jul; 57(5-6):291-303. doi:
10.1016/s0090-6980(98)00077-x. [PMID: 10480484] - K Warzocha, J Bienvenu, P Ribeiro, I Moullet, C Dumontet, E M Neidhardt-Berard, B Coiffier, G Salles. Plasma levels of tumour necrosis factor and its soluble receptors correlate with clinical features and outcome of Hodgkin's disease patients.
British journal of cancer.
1998 Jun; 77(12):2357-62. doi:
10.1038/bjc.1998.391. [PMID: 9649158] - S Viviani, E Camerini, V Bonfante, A Santoro, M Balzarotti, M Fornier, L Devizzi, P Verderio, P Valagussa, G Bonadonna. Soluble interleukin-2 receptors (sIL-2R) in Hodgkin's disease: outcome and clinical implications.
British journal of cancer.
1998 Mar; 77(6):992-7. doi:
10.1038/bjc.1998.163. [PMID: 9528846] - Z Blumenfeld, M Ritter, Z Shen-Orr, K Shariki, M Ben-Shahar, N Haim. Inhibin A concentrations in the sera of young women during and after chemotherapy for lymphoma: correlation with ovarian toxicity.
American journal of reproductive immunology (New York, N.Y. : 1989).
1998 Jan; 39(1):33-40. doi:
10.1111/j.1600-0897.1998.tb00331.x. [PMID: 9458932] - L V Boĭtsova. [Protective role of the glutathione system in rat organs after administration of embiquine].
Ukrainskii biokhimicheskii zhurnal (1978).
1998 Jan; 70(1):113-7. doi:
NULL. [PMID: 9848151] - S S Kulkarni, P S Sastry, T K Saikia, P M Parikh, R Gopal, S H Advani. Gonadal function following ABVD therapy for Hodgkin's disease.
American journal of clinical oncology.
1997 Aug; 20(4):354-7. doi:
10.1097/00000421-199708000-00006. [PMID: 9256888] - E Ziółko. [A trial of applying an oily suspension of bleomycin endolymphatically in patients with Hodgkin's disease of the extraperitoneal lymph nodes].
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego.
1997 Jul; 3(13):8-9. doi:
NULL. [PMID: 9432303] - L V Boĭtsova. [Role of glutathione antiperoxide system in the mechanism of cytotoxic action of embichin].
Ukrainskii biokhimicheskii zhurnal (1978).
1997 Jul; 69(4):99-103. doi:
. [PMID: 9583131] - K R Imrie, B Sheridan, R Colwill, M Crump, A K Stewart, J McCrae, R Danish, D Sutton, F Romeyer, A Keating. A phase I study of interleukin-6 after autologous bone marrow transplantation for patients with poor prognosis Hodgkin's disease.
Leukemia & lymphoma.
1997 May; 25(5-6):555-63. doi:
10.3109/10428199709039044. [PMID: 9250827] - K Murakami, K Okajima, M Uchiba, M Johno, T Nakagaki, H Okabe, K Takatsuki. Activated protein C prevents LPS-induced pulmonary vascular injury by inhibiting cytokine production.
The American journal of physiology.
1997 Feb; 272(2 Pt 1):L197-202. doi:
10.1152/ajplung.1997.272.2.l197. [PMID: 9124369] - M Uchiba, K Okajima. Antithrombin III (AT III) prevents LPS-induced pulmonary vascular injury: novel biological activity of AT III.
Seminars in thrombosis and hemostasis.
1997; 23(6):583-90. doi:
10.1055/s-2007-996140. [PMID: 9469634] - O I Lebed, V V Zhirnov, A I Luik, B S Braver-Chernobulskaya, V G Yartsev, V G Kuzin. Character of structural disturbances caused by chloroalkylamines in the model and erythrocyte membranes.
Ukrainskii biokhimicheskii zhurnal (1978).
1996 Nov; 68(6):68-76. doi:
". [PMID: 9226829] - J Heikens, H Behrendt, R Adriaanse, A Berghout. Irreversible gonadal damage in male survivors of pediatric Hodgkin's disease.
Cancer.
1996 Nov; 78(9):2020-4. doi:
10.1002/(sici)1097-0142(19961101)78:9<2020::aid-cncr25>3.0.co;2-y. [PMID: 8909325] - F Cervantes, J Briones, M Bruguera, C Font, J M Grau, C Rozman, E Montserrat. Hodgkin's disease presenting as a cholestatic febrile illness: incidence and main characteristics in a series of 421 patients.
Annals of hematology.
1996 Jun; 72(6):357-60. doi:
10.1007/s002770050186. [PMID: 8767104] - J Skretkowicz, M Sekulska, M Danilewicz, M Wagrowska-Danilewicz, P Polakowski. Effect of some anticancer drugs and combined chemotherapy on renal toxicity.
Biological signals.
1996 Jan; 5(1):51-8. doi:
10.1159/000109173. [PMID: 8739323] - L X Cubeddu, D T O'Connor, I Hoffmann, R J Parmer. Plasma chromogranin A marks emesis and serotonin release associated with dacarbazine and nitrogen mustard but not with cyclophosphamide-based chemotherapies.
British journal of cancer.
1995 Oct; 72(4):1033-8. doi:
10.1038/bjc.1995.457. [PMID: 7547218] - A M Gulick, W E Fahl. Forced evolution of glutathione S-transferase to create a more efficient drug detoxication enzyme.
Proceedings of the National Academy of Sciences of the United States of America.
1995 Aug; 92(18):8140-4. doi:
10.1073/pnas.92.18.8140. [PMID: 7667259] - K Neumann, D J Wallace, C Azen, S Nessim, M Fichman, A L Metzger, J R Klinenberg. Lupus in the 1980s: III. Influence of clinical variables, biopsy, and treatment on the outcome in 150 patients with lupus nephritis seen at a single center.
Seminars in arthritis and rheumatism.
1995 Aug; 25(1):47-55. doi:
10.1016/s0049-0172(95)80017-4. [PMID: 8525390] - J W Wilson, A E Wakeling, I D Morris, J A Hickman, C Dive. MCF-7 human mammary adenocarcinoma cell death in vitro in response to hormone-withdrawal and DNA damage.
International journal of cancer.
1995 May; 61(4):502-8. doi:
10.1002/ijc.2910610413. [PMID: 7759156] - T D Quinn, H C Polk, M J Edwards. Hyperthermic isolated limb perfusion increases circulating levels of inflammatory cytokines.
Cancer immunology, immunotherapy : CII.
1995 Apr; 40(4):272-75. doi:
10.1007/bf01519902. [PMID: 7750126] - B Obminska-Domoradzka, M Switała, J Debowy, T Garbuliński. Effects of levamisole, DTC and low-dose mechlorethamine on humoral response of SRBC-immunized rabbits exposed to cold stress.
Zentralblatt fur Veterinarmedizin. Reihe B. Journal of veterinary medicine. Series B.
1995 Mar; 42(1):12-8. doi:
10.1111/j.1439-0450.1995.tb00676.x. [PMID: 7483896] - M Bendandi, A Zaccaria, P L Zinzani, G Visani, V Stefanati, F Cantagalli, A Mancino, S Macchi, F Simoncelli, S Tura. Factor VIII inhibitor prior to and during secondary acute nonlymphocytic leukemia in a patient with cured Hodgkin's disease.
Leukemia & lymphoma.
1995 Feb; 16(5-6):511-3. doi:
10.3109/10428199509054441. [PMID: 7540464] - S T Clark, J A Radford, D Crowther, R Swindell, S M Shalet. Gonadal function following chemotherapy for Hodgkin's disease: a comparative study of MVPP and a seven-drug hybrid regimen.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
1995 Jan; 13(1):134-9. doi:
10.1200/jco.1995.13.1.134. [PMID: 7799013] - J A Delmez, S H Safdar, J M Kissane. The successful treatment of recurrent nephrotic syndrome with the MOPP regimen in a patient with a remote history of Hodgkin's disease.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
1994 May; 23(5):743-6. doi:
10.1016/s0272-6386(12)70288-3. [PMID: 8172220] - A K Siwicki, M Dunier. Effects of lindane exposure on rainbow trout (Oncorhynchus mykiss) immunity. II. In vitro restoration of antibody-secreting cells and lymphocyte proliferation activity by nitrogranulogen after in vivo immunosuppression due to lindane.
Ecotoxicology and environmental safety.
1994 Apr; 27(3):316-23. doi:
10.1006/eesa.1994.1025. [PMID: 7519550] - C Aguirre, J M Rodríguez-Sasiain, R Calvo. Decrease in penbutolol protein binding as a consequence of treatment with some alkylating agents.
Cancer chemotherapy and pharmacology.
1994; 34(1):86-8. doi:
10.1007/bf00686119. [PMID: 8174208] - G Goldman, R Welbourn, J M Klausner, L Kobzik, C R Valeri, D Shepro, H B Hechtman. Leukocytes mediate acid aspiration-induced multiorgan edema.
Surgery.
1993 Jul; 114(1):13-20. doi:
NULL. [PMID: 8395089] - S Khan, J J Ramwani, P J O'Brien. Hepatocyte toxicity of mechlorethamine and other alkylating anticancer drugs. Role of lipid peroxidation.
Biochemical pharmacology.
1992 May; 43(9):1963-7. doi:
10.1016/0006-2952(92)90639-z. [PMID: 1596284] - J Imiela, M Nowaczyk, R Małecki, A Górski. [Successful nitrogranulogen treatment of severe nephrotic syndrome in glomerulonephritis--case report].
Polskie Archiwum Medycyny Wewnetrznej.
1992 Mar; 87(3):225-7. doi:
NULL. [PMID: 1523150] - G Goldman, R Welbourn, J M Klausner, C R Valeri, D Shepro, H B Hechtman. Oxygen free radicals are required for ischemia-induced leukotriene B4 synthesis and diapedesis.
Surgery.
1992 Mar; 111(3):287-93. doi:
NULL. [PMID: 1311874] - M Switała, B Obmińska-Domoradzka, J Debowy. Stimulatory effect of low doses of mechlorethamine on humoral response of ovalbumin-immunized rabbits--comparison with levamisole.
Polish journal of pharmacology and pharmacy.
1992 Mar; 44(2):153-60. doi:
NULL. [PMID: 1409115] - A M Oza, T S Ganesan, M Dorreen, P W Johnson, J Waxman, W Gregory, J Lim, J Wright, L Dadiotis, V Barbounis. Patterns of survival in patients with advanced Hodgkin's disease (HD) treated in a single centre over 20 years.
British journal of cancer.
1992 Mar; 65(3):429-37. doi:
10.1038/bjc.1992.88. [PMID: 1558800] - I N White, A Cahill, A Davies, P Carthew. Acute lesions in rats caused by 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233) or nitromin: a comparison with rates of reduction in microsomal systems from target organs.
Archives of toxicology.
1992; 66(2):100-6. doi:
10.1007/bf02342502. [PMID: 1605723] - E Malinowski. Effects of acetylsalicylic acid, chlormethine and glucose on cow's mammary gland.
Archivum veterinarium Polonicum.
1992; 32(3-4):55-64. doi:
NULL. [PMID: 1339575] - J Cummings, A MacLellan, J F Smyth, P B Farmer. Determination of reactive nitrogen mustard anticancer drugs in plasma by high-performance liquid chromatography using derivatization.
Analytical chemistry.
1991 Aug; 63(15):1514-9. doi:
10.1021/ac00015a004. [PMID: 1952082] - Z Rancewicz, J Imiela, J Juskowa, R Małecki, A Górski. [The immunobiological effects of nitrogranulogen. I. Effect of nitrogranulogen on laboratory and clinical parameters in patients with primary glomerulopathies].
Polskie Archiwum Medycyny Wewnetrznej.
1991 Aug; 86(2):68-74. doi:
. [PMID: 1775393]