4-Methylimidazole (BioDeep_00000012721)

 

Secondary id: BioDeep_00001867995

human metabolite blood metabolite Volatile Flavor Compounds natural product


代谢物信息卡片


4-Methylimidazole oxalate (1:1)

化学式: C4H6N2 (82.05309559999999)
中文名称: 4-甲基咪唑
谱图信息: 最多检出来源 Homo sapiens(blood) 87.5%

分子结构信息

SMILES: CC1=CN=CN1
InChI: InChI=1S/C4H6N2/c1-4-2-5-3-6-4/h2-3H,1H3,(H,5,6)

描述信息

同义名列表

12 个代谢物同义名

4-Methylimidazole oxalate (1:1); 4-Methylimidazole, ion(1-); 4-Methylimidazole hydride; 5-methyl-1H-imidazole; 4(5)-Methylimidazole; 4-Methylimidazole; 5-Methylimidazole; 4-Me-i; 4-MEI; 4MI; 4-Methylimidazole; 4-Methylimidazole



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

15 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Timothy R Fennell, Scott L Watson, Suraj Dhungana, Rodney W Snyder. Metabolism of 4-methylimidazole in Fischer 344 rats and B6C3F1 mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2019 Jan; 123(?):181-194. doi: 10.1016/j.fct.2018.10.032. [PMID: 30316845]
  • Balakrishnan Rekha, Ganesan Velmurugan, Allen J Freddy, Sivakumar Anusha, Tharmarajan Ramprasath, Karuppusamy V Karthik, Shanmugarajan Suresh, Prerna Kulshrestha, Gilles Mithieux, Alexander R Lyon, Govindan Sadasivam Selvam, Subbiah Ramasamy. Chronic intake of 4-Methylimidazole induces Hyperinsulinemia and Hypoglycaemia via Pancreatic Beta Cell Hyperplasia and Glucose Dyshomeostasis. Scientific reports. 2018 11; 8(1):17037. doi: 10.1038/s41598-018-35071-6. [PMID: 30451881]
  • Marion Raters, Paul W Elsinghorst, Stephanie Goetze, Anna Dingel, Reinhard Matissek. Determination of 2-Methylimidazole, 4-Methylimidazole, and 2-Acetyl-4-(1,2,3,4-tetrahydroxybutyl)imidazole in Licorice Using High-Performance Liquid Chromatography-Tandem Mass Spectrometry Stable-Isotope Dilution Analysis. Journal of agricultural and food chemistry. 2015 Jul; 63(25):5930-4. doi: 10.1021/acs.jafc.5b01493. [PMID: 26073294]
  • Kutti R Vinothkumar. Structure of rhomboid protease in a lipid environment. Journal of molecular biology. 2011 Mar; 407(2):232-47. doi: 10.1016/j.jmb.2011.01.029. [PMID: 21256137]
  • Po Chan, Joel Mahler, Greg Travlos, Abraham Nyska, M Wenk. Induction of thyroid lesions in 14-week toxicity studies of 2 and 4-methylimidazole in Fischer 344/N rats and B6C3F1 mice. Archives of toxicology. 2006 Mar; 80(3):169-80. doi: 10.1007/s00204-005-0018-4. [PMID: 16180012]
  • Dermot F McGinnity, James Tucker, Steve Trigg, Robert J Riley. Prediction of CYP2C9-mediated drug-drug interactions: a comparison using data from recombinant enzymes and human hepatocytes. Drug metabolism and disposition: the biological fate of chemicals. 2005 Nov; 33(11):1700-7. doi: 10.1124/dmd.105.005884. [PMID: 16081671]
  • P C Chan. NTP technical report on the toxicity studies of 2- and 4-Methylimidazole (CAS No. 693-98-1 and 822-36-6) administered in feed to F344/N rats and B6C3F1 mice. Toxicity report series. 2004 Apr; ?(67):1-G12. doi: . [PMID: 15146214]
  • Benjamin Quest, Wolfgang Gärtner. Chromophore selectivity in bacterial phytochromes: dissecting the process of chromophore attachment. European journal of biochemistry. 2004 Mar; 271(6):1117-26. doi: 10.1111/j.1432-1033.2004.04015.x. [PMID: 15009190]
  • R Zamora, M Alaiz, F J Hidalgo. Modification of histidine residues by 4,5-epoxy-2-alkenals. Chemical research in toxicology. 1999 Jul; 12(7):654-60. doi: 10.1021/tx980218n. [PMID: 10409406]
  • K Uchida, O T Khor, T Oya, T Osawa, Y Yasuda, T Miyata. Protein modification by a Maillard reaction intermediate methylglyoxal. Immunochemical detection of fluorescent 5-methylimidazolone derivatives in vivo. FEBS letters. 1997 Jun; 410(2-3):313-8. doi: 10.1016/s0014-5793(97)00610-8. [PMID: 9237653]
  • J H Yuan, L T Burka. Toxicokinetics of 4-methylimidazole in the male F344 rat. Xenobiotica; the fate of foreign compounds in biological systems. 1995 Aug; 25(8):885-94. doi: 10.3109/00498259509061901. [PMID: 8779228]
  • P Nielsen, C Friis, I Kraul, C E Olsen. Disposition of 4-methylimidazole in goats and heifers. Research in veterinary science. 1993 Jan; 54(1):72-9. doi: 10.1016/0034-5288(93)90014-7. [PMID: 8434152]
  • S Vind, I Søondergaard, L K Poulsen, U G Svendsen, B Weeke. Comparison of methods for intestinal histamine application: histamine in enterosoluble capsules or via a duodeno-jenunal tube. Influence of fast and histamine-restrictive diet. Allergy. 1991 Apr; 46(3):191-5. doi: 10.1111/j.1398-9995.1991.tb00569.x. [PMID: 2058814]
  • E Karangwa, G E Mitchell, R E Tucker. High-performance liquid chromatographic determination of 4-methylimidazole in sheep plasma and in ammoniated tall fescue hay. Journal of chromatography. 1990 Oct; 532(1):105-13. doi: 10.1016/s0378-4347(00)83756-1. [PMID: 2079523]
  • G A Worth, P M King, W G Richards. Theoretical calculation of tautomer equilibria in solution: 4-(5-)methylimidazole. Biochimica et biophysica acta. 1989 Oct; 993(1):134-6. doi: 10.1016/0304-4165(89)90154-2. [PMID: 2804121]
  • G Di Minno, V Bertelé, C Cerletti, G de Gaetano, M J Silver. Arachidonic acid induces human platelet-fibrin retraction: the role of platelet cyclic endoperoxides. Thrombosis research. 1982 Feb; 25(4):299-306. doi: 10.1016/0049-3848(82)90230-4. [PMID: 6803385]