Chloranil (BioDeep_00000012496)

 

Secondary id: BioDeep_00001867694

human metabolite blood metabolite


代谢物信息卡片


2,3,5,6-Tetrachloro-2,5-cyclohexadiene-1,4-dione

化学式: C6Cl4O2 (243.86524200000002)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 0.15%

分子结构信息

SMILES: C1(=C(C(=O)C(=C(C1=O)Cl)Cl)Cl)Cl
InChI: InChI=1S/C6Cl4O2/c7-1-2(8)6(12)4(10)3(9)5(1)11

描述信息

D016573 - Agrochemicals
D010575 - Pesticides

同义名列表

20 个代谢物同义名

2,3,5,6-Tetrachloro-2,5-cyclohexadiene-1,4-dione; tetrachlorocyclohexa-2,5-diene-1,4-dione; 2,3,5,6-Tetrachlorobenzo-1,4-quinone; 2,3,5,6-Tetrachloro-1,4-benzoquinone; 2,3,5,6-Tetrachloro-p-benzoquinone; 2,3,5,6-Tetrachlor-1,4-benzochinon; tetrachloro-1,4-Benzoquinone; tetrachloro 1,4 Benzoquinone; Tetrachloroparabenzoquinone; Tetrachloro-p-benzoquinone; Tetrachlorobenzoquinone; alpha-Chloranil; p-Chloranil; a-Chloranil; Α-chloranil; Chloranil; Coversan; Spergon; Vulklor; Reranil



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(0)

代谢反应

1 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(1)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Fayaz Ali Larik, Aamer Saeed, Danish Shahzad, Muhammad Faisal, Hesham El-Seedi, Haroon Mehfooz, Pervaiz Ali Channar. Synthetic approaches towards the multi target drug spironolactone and its potent analogues/derivatives. Steroids. 2017 02; 118(?):76-92. doi: 10.1016/j.steroids.2016.12.010. [PMID: 28041953]
  • Juanli Fu, Qiong Shi, Xiufang Song, Zixuan Liu, Yawen Wang, Yuxin Wang, Erqun Song, Yang Song. From the Cover: Tetrachlorobenzoquinone Exerts Neurological Proinflammatory Activity by Promoting HMGB1 Release, Which Induces TLR4 Clustering within the Lipid Raft. Toxicological sciences : an official journal of the Society of Toxicology. 2016 10; 153(2):303-15. doi: 10.1093/toxsci/kfw124. [PMID: 27413111]
  • Demei Xu, Lihua Hu, Xiaomin Xia, Jianbo Song, Lingrui Li, Erqun Song, Yang Song. Tetrachlorobenzoquinone induces acute liver injury, up-regulates HO-1 and NQO1 expression in mice model: the protective role of chlorogenic acid. Environmental toxicology and pharmacology. 2014 May; 37(3):1212-20. doi: 10.1016/j.etap.2014.04.022. [PMID: 24816176]
  • Ali A Ensafi, Maryam Dadkhah, H Karimi-Maleh. Determination of isoproterenol and uric acid by voltammetric method using carbon nanotubes paste electrode and p-chloranil. Colloids and surfaces. B, Biointerfaces. 2011 May; 84(1):148-54. doi: 10.1016/j.colsurfb.2010.12.028. [PMID: 21256720]
  • Maria K Parr, Gregor Fusshöller, Nils Schlörer, Georg Opfermann, Hans Geyer, Grigory Rodchenkov, Wilhelm Schänzer. Detection of Δ6-methyltestosterone in a 'dietary supplement' and GC-MS/MS investigations on its urinary metabolism. Toxicology letters. 2011 Mar; 201(2):101-4. doi: 10.1016/j.toxlet.2010.11.018. [PMID: 21134425]
  • Ahmed Khudhair Hassan, Bahruddin Saad, Sulaiman Ab Ghani, Rohana Adnan, Afidah Abdul Rahim, Norariza Ahmad, Marina Mokhtar, Suham Tawfiq Ameen, Suad Mustafa Al-Araji. Ionophore-based potentiometric sensors for the flow-injection determination of promethazine hydrochloride in pharmaceutical formulations and human urine. Sensors (Basel, Switzerland). 2011; 11(1):1028-42. doi: 10.3390/s110101028. [PMID: 22346617]
  • Haiming Yang, Meguru Tezuka. Mineralization of aqueous pentachlorophenolate by anodic contact glow discharge electrolysis. Journal of environmental sciences (China). 2011; 23(6):1044-9. doi: 10.1016/s1001-0742(10)60512-8. [PMID: 22066230]
  • Ai-Zhen Xiong, Li Yang, Fang Zhang, Xue-Jing Yang, Chang-Hong Wang, Zheng-Tao Wang. Determination of total retronecine esters-type hepatotoxic pyrrolizidine alkaloids in plant materials by pre-column derivatization high-performance liquid chromatography. Biomedical chromatography : BMC. 2009 Jun; 23(6):665-71. doi: 10.1002/bmc.1172. [PMID: 19277972]
  • Ben-Zhan Zhu, Guo-Qiang Shan. Potential mechanism for pentachlorophenol-induced carcinogenicity: a novel mechanism for metal-independent production of hydroxyl radicals. Chemical research in toxicology. 2009 Jun; 22(6):969-77. doi: 10.1021/tx900030v. [PMID: 19408893]
  • Xiangjiu He, Dong Liu, Rui Hai Liu. Sodium borohydride/chloranil-based assay for quantifying total flavonoids. Journal of agricultural and food chemistry. 2008 Oct; 56(20):9337-44. doi: 10.1021/jf070954+. [PMID: 18798633]
  • Susan Sadeghi, Esmat Karimi. Spectrophotometric determination of rifampicin through chelate formation and charge transfer complexation in pharmaceutical preparation and biological fluids. Chemical & pharmaceutical bulletin. 2006 Aug; 54(8):1107-12. doi: 10.1248/cpb.54.1107. [PMID: 16880653]
  • Siobhan M O'Sullivan, Ronan M McCarthy, Melissa A Vargo, Roberta F Colman, David Sheehan. Chemical modification at subunit 1 of rat kidney Alpha class glutathione transferase with 2,3,5,6-tetrachloro-1,4-benzoquinone: close structural connectivity between glutathione conjugation activity and non-substrate ligand binding. Biochemical pharmacology. 2006 May; 71(11):1629-36. doi: 10.1016/j.bcp.2006.03.002. [PMID: 16620786]
  • Ahmed M Osman, Sjef Boeren. Studies on the DT-diaphorase-catalysed reaction employing quinones as substrates: evidence for a covalent modification of DT-diaphorase by tetrachloro-p-benzoquinone. Chemico-biological interactions. 2004 Jan; 147(1):99-108. doi: 10.1016/j.cbi.2003.10.006. [PMID: 14726156]
  • S R Kim, J Y Lee, M Y Lee, S M Chung, O N Bae, J H Chung. Association of quinone-induced platelet anti-aggregation with cytotoxicity. Toxicological sciences : an official journal of the Society of Toxicology. 2001 Jul; 62(1):176-82. doi: 10.1093/toxsci/62.1.176. [PMID: 11399805]
  • C H Tsai, P H Lin, S Waidyanatha, S M Rappaport. Characterization of metabolic activation of pentachlorophenol to quinones and semiquinones in rodent liver. Chemico-biological interactions. 2001 Mar; 134(1):55-71. doi: 10.1016/s0009-2797(00)00318-5. [PMID: 11248222]
  • M Dahlhaus, E Almstadt, P Henschke, S Lüttgert, K E Appel. Oxidative DNA lesions in V79 cells mediated by pentachlorophenol metabolites. Archives of toxicology. 1996; 70(7):457-60. doi: 10.1007/s002040050299. [PMID: 8740541]
  • J J Mertens, J H Temmink, P J van Bladeren, T W Jones, H H Lo, S S Lau, T J Monks. Inhibition of gamma-glutamyl transpeptidase potentiates the nephrotoxicity of glutathione-conjugated chlorohydroquinones. Toxicology and applied pharmacology. 1991 Aug; 110(1):45-60. doi: 10.1016/0041-008x(91)90288-p. [PMID: 1678558]
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  • K J Beales, W D Cooper, D D Eley. Protein quinone complexes. Bovine plasma albumin and halogenated p-quinones. Journal of bioenergetics and biomembranes. 1978 Aug; 10(3-4):101-8. doi: 10.1007/bf00743055. [PMID: 233517]
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