2,6-Diiodo-4-nitrophenol (BioDeep_00000012257)

 

Secondary id: BioDeep_00001868693

human metabolite blood metabolite


代谢物信息卡片


phenol, 2,6-diiodo-4-nitro-

化学式: C6H3I2NO3 (390.8202)
中文名称: 2,6-二碘-4-硝基苯酚
谱图信息: 最多检出来源 Homo sapiens(blood) 100%

分子结构信息

SMILES: C1=C(C=C(C(=C1I)O)I)[N+](=O)[O-]
InChI: InChI=1S/C6H3I2NO3/c7-4-1-3(9(11)12)2-5(8)6(4)10/h1-2,10H

描述信息

C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C250 - Antihelminthic Agent

同义名列表

7 个代谢物同义名

phenol, 2,6-diiodo-4-nitro-; 2,6-Diiodo-4-nitrophenol; 2,6-Diiod-4-nitrophenol; Disophenol; Syngamix; Ancylol; Disophenol



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • V T Soccol, C Sotomaior, F P Souza, E A Castro, M C Pessôa Silva, V Milczewski. Occurrence of resistance to anthelmintics in sheep in Paraná State, Brazil. The Veterinary record. 1996 Oct; 139(17):421-2. doi: 10.1136/vr.139.17.421. [PMID: 8923717]
  • R K Reinecke, I L De Villiers, G Joubert. Studies on Haemonchus contortus. XI. The effect of a bovine strain of Trichostrongylus axei in Merinos on natural pastures heavily infested with H. contortus. The Onderstepoort journal of veterinary research. 1984 Mar; 51(1):71-9. doi: NULL. [PMID: 6462634]
  • M Kumar, A Maru, S P Pachauri. Role of serum enzymes in evaluating flukicidal action of disophenol in Fasciola-affected buffaloes. The British veterinary journal. 1983 May; 139(3):262-4. doi: 10.1016/s0007-1935(17)30494-3. [PMID: 6860928]
  • G A Schad, M R Page. Ancylostoma caninum: adult worm removal, corticosteroid treatment, and resumed development of arrested larvae in dogs. Experimental parasitology. 1982 Dec; 54(3):303-9. doi: 10.1016/0014-4894(82)90039-x. [PMID: 7151941]
  • R K Reinecke, C Bruckner, I L De Villiers. Studies on Haemonchus contortus. V. Chemoprophylaxis and its effect on worm egg counts and the haematocrit. The Onderstepoort journal of veterinary research. 1981 Dec; 48(4):235-8. doi: NULL. [PMID: 7345391]
  • R K Reinecke, C Bruckner, I L de Villiers. A residual anthelmintic 2,6-diiodo-4-nitrophenol (Disophenol). Methods of testing its anthelmintic efficacy. Journal of the South African Veterinary Association. 1981 Sep; 52(3):195-201. doi: NULL. [PMID: 7310790]
  • G W Hutchinson. Anthelmintic treatment of prepatent stephanuriasis with flubendazole, levamisole and disophenol and the effects on liver-specific serum enzymes. Research in veterinary science. 1981 Mar; 30(2):175-80. doi: NULL. [PMID: 6454945]
  • R Soetedjo, D Beriajaya, A W Henderson, J D Kelly. Use of disophenol for the control of Haemonchus contortus in sheep in West Java, Indonesia. Tropical animal health and production. 1980 Nov; 12(4):198-202. doi: 10.1007/bf02236616. [PMID: 7456119]
  • E T Lyons, K C Kim, M C Keyes. Variable activity of disophenol against hookworms and lice of northern fur seal pups on St. Paul Island, Alaska. Journal of wildlife diseases. 1980 Jan; 16(1):53-7. doi: 10.7589/0090-3558-16.1.53. [PMID: 7373724]
  • K B Sinclair, R K Prichard. The use of disophenol in studies of the pathogenicity of the arrested fourth-stage larvae of Haemonchus contortus in the sheep. Research in veterinary science. 1975 Sep; 19(2):232-4. doi: NULL. [PMID: 1166136]
  • J A KAISER. STUDIES ON THE TOXICITY OF DISOPHENOL (2,6-DIIODO-4-NITROPHENOL) TO DOGS AND RODENTS PLUS SOME COMPARISONS WITH 2,4-DINITROPHENOL. Therapie der Gegenwart. 1964 Mar; 103(?):232-44. doi: 10.1016/0041-008x(64)90108-5. [PMID: 14129994]