Cyclic pyranopterin monophosphate (BioDeep_00000012160)

 

Secondary id: BioDeep_00001868329

human metabolite


代谢物信息卡片


(4aR,5aR,11aR,12aS)-2,10,12,12-tetrahydroxy-8-imino-4,4a,5a,6,7,8,11,11a,12,12a-decahydro-2H-1,3,5-trioxa-6,7,9,11-tetraaza-2lambda5-phosphatetracen-2-one

化学式: C10H14N5O8P (363.05799740000003)
中文名称:
谱图信息: 最多检出来源 Macaca mulatta(otcml) 16.67%

分子结构信息

SMILES: C1C2C(C(C3C(O2)NC4=C(N3)C(=O)NC(=N4)N)(O)O)OP(=O)(O1)O
InChI: InChI=1S/C10H14N5O8P/c11-9-14-6-3(7(16)15-9)12-4-8(13-6)22-2-1-21-24(19,20)23-5(2)10(4,17)18/h2,4-5,8,12,17-18H,1H2,(H,19,20)(H4,11,13,14,15,16)/t2-,4-,5+,8-/m1/s1

描述信息

Cyclic pyranopterin monophosphate, also known as cpmp or precursor z, hydrated, belongs to pyranopterins and derivatives class of compounds. Those are pterin derivatives in which a pyran ring is fused either to the pyrimidine ring or the pyrazine ring of the pterin moiety. Cyclic pyranopterin monophosphate is slightly soluble (in water) and an extremely strong acidic compound (based on its pKa). Cyclic pyranopterin monophosphate can be found in a number of food items such as european cranberry, vaccinium (blueberry, cranberry, huckleberry), peanut, and dill, which makes cyclic pyranopterin monophosphate a potential biomarker for the consumption of these food products. Cyclic pyranopterin monophosphate exists in all living organisms, ranging from bacteria to humans. Cyclic pyranopterin monophosphate (cPMP) is an experimental treatment for molybdenum cofactor deficiency type A, which was developed by José Santamaría-Araujo and Guenter Schwarz at the German universities TU Braunschweig and the University of Cologne .
A - Alimentary tract and metabolism > A16 - Other alimentary tract and metabolism products > A16A - Other alimentary tract and metabolism products > A16AX - Various alimentary tract and metabolism products
Cyclic pyranopterin monophosphate is part of the Cofactor biosynthesis, Folate biosynthesis, and Sulfur relay system pathways. It is a substrate for: Molybdopterin synthase catalytic subunit.
C78272 - Agent Affecting Nervous System

同义名列表

13 个代谢物同义名

(4aR,5aR,11aR,12aS)-2,10,12,12-tetrahydroxy-8-imino-4,4a,5a,6,7,8,11,11a,12,12a-decahydro-2H-1,3,5-trioxa-6,7,9,11-tetraaza-2lambda5-phosphatetracen-2-one; (4aR,5aR,11aR,12aS)-2,10,12,12-tetrahydroxy-8-imino-4,4a,5a,6,7,11,11a,12a-octahydro-1,3,5-trioxa-6,7,9,11-tetraaza-2lambda5-phosphatetracen-2-one; Cyclic pyranopterin monophosphoric acid; Cyclic pyranopterin monophoshic acid; Cyclic pyranopterin phosphoric acid; Cyclic pyranopterin monophosphate; Cyclic pyranopterin monophoshate; Cyclic pyranopterin phosphate; Precursor Z, hydrated; Fosdenopterin; precursor Z; CPMP CPD; CPMP



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

4 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(4)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Thomas W Hercher, Joern Krausze, Sven Hoffmeister, Dagmar Zwerschke, Thomas Lindel, Wulf Blankenfeldt, Ralf R Mendel, Tobias Kruse. Insights into the Cnx1E catalyzed MPT-AMP hydrolysis. Bioscience reports. 2020 01; 40(1):. doi: 10.1042/bsr20191806. [PMID: 31860061]
  • Inga Kruse, Andrew E Maclean, Lionel Hill, Janneke Balk. Genetic dissection of cyclic pyranopterin monophosphate biosynthesis in plant mitochondria. The Biochemical journal. 2018 01; 475(2):495-509. doi: 10.1042/bcj20170559. [PMID: 29247140]
  • Avadh Kumar, Borislav Dejanovic, Florian Hetsch, Marcus Semtner, Debora Fusca, Sita Arjune, Jose Angel Santamaria-Araujo, Aline Winkelmann, Scott Ayton, Ashley I Bush, Peter Kloppenburg, Jochen C Meier, Guenter Schwarz, Abdel Ali Belaidi. S-sulfocysteine/NMDA receptor-dependent signaling underlies neurodegeneration in molybdenum cofactor deficiency. The Journal of clinical investigation. 2017 12; 127(12):4365-4378. doi: 10.1172/jci89885. [PMID: 29106383]
  • Ralf R Mendel, Silke Leimkühler. The biosynthesis of the molybdenum cofactors. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. 2015 Mar; 20(2):337-47. doi: 10.1007/s00775-014-1173-y. [PMID: 24980677]
  • Ralf R Mendel. The molybdenum cofactor. The Journal of biological chemistry. 2013 May; 288(19):13165-72. doi: 10.1074/jbc.r113.455311. [PMID: 23539623]