1,2,3,4,6,7,8-Heptachlorodibenzo-P-dioxin (BioDeep_00000012078)

 

Secondary id: BioDeep_00001868176

human metabolite blood metabolite Volatile Flavor Compounds


代谢物信息卡片


1,2,3,4,6,7,8-HEPTACHLORODIBENZO-P-DIOXIN

化学式: C12HCl7O2 (421.77962560000003)
中文名称: 1,2,3,4,6,7,8-七氯二苯并-对-二恶英
谱图信息: 最多检出来源 Homo sapiens(blood) 66.67%

分子结构信息

SMILES: C1=C2C(=C(C(=C1Cl)Cl)Cl)OC3=C(O2)C(=C(C(=C3Cl)Cl)Cl)Cl
InChI: InChI=1S/C12HCl7O2/c13-2-1-3-10(7(17)4(2)14)21-12-9(19)6(16)5(15)8(18)11(12)20-3/h1H

描述信息

D009676 - Noxae > D013723 - Teratogens > D000072317 - Polychlorinated Dibenzodioxins

同义名列表

9 个代谢物同义名

1,2,3,4,6,7,8-HEPTACHLORODIBENZO-P-DIOXIN; 1,2,3,4,6,7,8-Heptachlorodibenzodioxin; 1,2,3,4,6,7,8-heptachlorooxanthrene; heptachlorodibenzo-P-dioxin; 1,2,3,4,6,7,8-HPCDD; PCDD 73; HPCDD; HCDD; 1,2,3,4,6,7,8-Heptachlorodibenzodioxin



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yin-Hui Leong, Nurul Izzati Azmi, Mohamed Isa Abdul Majid, Sheng Wen. Exposure and risk assessment of polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and dioxin-like polychlorinated biphenyls (dl-PCBs) for primiparous mothers and breastfed infants in Penang, Malaysia. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2021 Aug; 38(8):1416-1426. doi: 10.1080/19440049.2021.1922758. [PMID: 34014804]
  • Matthew Ryan Smith, Collynn F Woeller, Karan Uppal, Thomas H Thatcher, Douglas I Walker, Philip K Hopke, Patricia Rohrbeck, Timothy M Mallon, Pamela L Krahl, Mark J Utell, Young-Mi Go, Dean P Jones. Associations of Benzo(ghi)perylene and Heptachlorodibenzo-p-dioxin in Serum of Service Personnel Deployed to Balad, Iraq, and Bagram, Afghanistan Correlates With Perturbed Amino Acid Metabolism in Human Lung Fibroblasts. Journal of occupational and environmental medicine. 2019 12; 61 Suppl 12(?):S35-S44. doi: 10.1097/jom.0000000000001669. [PMID: 31800449]
  • Xiaoyan Xia, Alesia Carroll-Haddad, Nicole Brown, Mark J Utell, Col Timothy M Mallon, Philip K Hopke. Polycyclic Aromatic Hydrocarbons and Polychlorinated Dibenzo-p-Dioxins/Dibenzofurans in Microliter Samples of Human Serum as Exposure Indicators. Journal of occupational and environmental medicine. 2016 08; 58(8 Suppl 1):S72-9. doi: 10.1097/jom.0000000000000743. [PMID: 27501107]
  • Karin I van Ede, Konrad P J Gaisch, Martin van den Berg, Majorie B M van Duursen. Differential relative effect potencies of some dioxin-like compounds in human peripheral blood lymphocytes and murine splenic cells. Toxicology letters. 2014 Apr; 226(1):43-52. doi: 10.1016/j.toxlet.2014.01.026. [PMID: 24472611]
  • Yury I Chernyak, Andrey A Shelepchikov, Efim S Brodsky, Jean A Grassman. PCDD, PCDF, and PCB exposure in current and former firefighters from Eastern Siberia. Toxicology letters. 2012 Aug; 213(1):9-14. doi: 10.1016/j.toxlet.2011.09.021. [PMID: 21979175]
  • Lisa A Rodenburg, Songyan Du, Hui Lui, Jia Guo, Nicole Oseagulu, Donna E Fennell. Evidence for dechlorination of polychlorinated biphenyls and polychlorinated dibenzo-p-dioxins and -furans in wastewater collection systems in the New York metropolitan area. Environmental science & technology. 2012 Jun; 46(12):6612-20. doi: 10.1021/es300560q. [PMID: 22568653]
  • J S Lim, H-K Son, S-K Park, D R Jacobs, D-H Lee. Inverse associations between long-term weight change and serum concentrations of persistent organic pollutants. International journal of obesity (2005). 2011 May; 35(5):744-7. doi: 10.1038/ijo.2010.188. [PMID: 20820170]
  • Hirokazu Uemura, Kokichi Arisawa, Mineyoshi Hiyoshi, Atsushi Kitayama, Hidenobu Takami, Fusakazu Sawachika, Satoru Dakeshita, Kentaro Nii, Hiroshi Satoh, Yoshio Sumiyoshi, Kenji Morinaga, Kazunori Kodama, Taka-ichiro Suzuki, Masaki Nagai, Tsuguyoshi Suzuki. Prevalence of metabolic syndrome associated with body burden levels of dioxin and related compounds among Japan's general population. Environmental health perspectives. 2009 Apr; 117(4):568-73. doi: 10.1289/ehp.0800012. [PMID: 19440495]
  • Duk-Hee Lee, David R Jacobs, Miquel Porta. Association of serum concentrations of persistent organic pollutants with the prevalence of learning disability and attention deficit disorder. Journal of epidemiology and community health. 2007 Jul; 61(7):591-6. doi: 10.1136/jech.2006.054700. [PMID: 17568050]
  • Sonia Lucía Blanco, Cristina Sobrado, Corina Quintela, Santiago Cabaleiro, José Carlos González, Juan M Vieites. Dietary uptake of dioxins (PCDD/PCDFs) and dioxin-like PCBs in Spanish aquacultured turbot (Psetta maxima). Food additives and contaminants. 2007 Apr; 24(4):421-8. doi: 10.1080/02652030601064821. [PMID: 17454116]
  • Duk-Hee Lee, In-Kyu Lee, Kyungeun Song, Michael Steffes, William Toscano, Beth A Baker, David R Jacobs. A strong dose-response relation between serum concentrations of persistent organic pollutants and diabetes: results from the National Health and Examination Survey 1999-2002. Diabetes care. 2006 Jul; 29(7):1638-44. doi: 10.2337/dc06-0543. [PMID: 16801591]
  • James J Collins, Robert A Budinsky, Carol J Burns, Les L Lamparski, Michael L Carson, Greg D Martin, Michael Wilken. Serum dioxin levels in former chlorophenol workers. Journal of exposure science & environmental epidemiology. 2006 Jan; 16(1):76-84. doi: 10.1038/sj.jea.7500439. [PMID: 16015278]
  • Mary S Wolff, Susan L Teitelbaum, Paul J Lioy, Regina M Santella, Richard Y Wang, Robert L Jones, Kathleen L Caldwell, Andreas Sjödin, Wayman E Turner, Wei Li, Panos Georgopoulos, Gertrud S Berkowitz. Exposures among pregnant women near the World Trade Center site on 11 September 2001. Environmental health perspectives. 2005 Jun; 113(6):739-48. doi: 10.1289/ehp.7694. [PMID: 15929898]
  • James Dahlgren, Raphael Warshaw, Randy D Horsak, Frank M Parker, Harpreet Takhar. Exposure assessment of residents living near a wood treatment plant. Environmental research. 2003 Jun; 92(2):99-109. doi: 10.1016/s0013-9351(02)00064-6. [PMID: 12854689]
  • S Kumagai, S Koda, T Miyakita, M Ueno. Polychlorinated dibenzo-p-dioxin and dibenzofuran concentrations in serum samples of workers at intermittently burning municipal waste incinerators in Japan. Occupational and environmental medicine. 2002 Jun; 59(6):362-8. doi: 10.1136/oem.59.6.362. [PMID: 12040109]
  • Ulla Simanainen, Jouni T Tuomisto, Jouko Tuomisto, Matti Viluksela. Structure-activity relationships and dose responses of polychlorinated dibenzo-p-dioxins for short-term effects in 2,3,7,8-tetrachlorodibenzo-p-dioxin-resistant and -sensitive rat strains. Toxicology and applied pharmacology. 2002 May; 181(1):38-47. doi: 10.1006/taap.2002.9386. [PMID: 12030841]
  • M Viluksela, B U Stahl, L S Birnbaum, K K Rozman. Subchronic/chronic toxicity of a mixture of four chlorinated dibenzo-p-dioxins in rats. II. Biochemical effects. Toxicology and applied pharmacology. 1998 Jul; 151(1):70-8. doi: 10.1006/taap.1998.8412. [PMID: 9705888]
  • M Viluksela, B U Stahl, L S Birnbaum, K K Rozman. Subchronic/chronic toxicity of 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin (HpCDD) in rats. Part II. Biochemical effects. Toxicology and applied pharmacology. 1997 Oct; 146(2):217-26. doi: 10.1006/taap.1997.8240. [PMID: 9344889]
  • M Viluksela, B U Stahl, K K Rozman. Subchronic (13-week) toxicity of heptachlorodibenzo-p-dioxin in male Sprague-Dawley rats. Chemosphere. 1994 Nov; 29(9-11):2381-93. doi: 10.1016/0045-6535(94)90407-3. [PMID: 7850387]
  • L W Weber, M Lebofsky, B U Stahl, A Kettrup, K Rozman. Comparative toxicity of four chlorinated dibenzo-p-dioxins (CDDs) and their mixture. Part III: Structure-activity relationship with increased plasma tryptophan levels, but no relationship to hepatic ethoxyresorufin o-deethylase activity. Archives of toxicology. 1992; 66(7):484-8. doi: 10.1007/bf01970673. [PMID: 1332652]
  • N I Kerkvliet, J A Brauner. Mechanisms of 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin (HpCDD)-induced humoral immune suppression: evidence of primary defect in T-cell regulation. Toxicology and applied pharmacology. 1987 Jan; 87(1):18-31. doi: 10.1016/0041-008x(87)90080-9. [PMID: 3492063]