1,2,3,7,8-Pentachlorodibenzo-P-dioxin (BioDeep_00000012074)

 

Secondary id: BioDeep_00001868333

human metabolite blood metabolite Volatile Flavor Compounds


代谢物信息卡片


1,2,3,7,8-PENTACHLORODIBENZO-P-DIOXIN

化学式: C12H3Cl5O2 (353.85756879999997)
中文名称: 1,2,3,7,8-五氯二苯并-对-二恶英
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=C2C(=CC(=C1Cl)Cl)OC3=C(C(=C(C=C3O2)Cl)Cl)Cl
InChI: InChI=1S/C12H3Cl5O2/c13-4-1-7-8(2-5(4)14)19-12-9(18-7)3-6(15)10(16)11(12)17/h1-3H

描述信息

D009676 - Noxae > D013723 - Teratogens > D000072317 - Polychlorinated Dibenzodioxins

同义名列表

7 个代谢物同义名

1,2,3,7,8-PENTACHLORODIBENZO-P-DIOXIN; 1,2,3,7,8-Pentachlorodibenzodioxin; 1,2,3,7,8-pentachlorooxanthrene; 1,2,3,7,8-PeCDD; PCDD 54; PeCDD; 1,2,3,7,8-Pentachlorodibenzodioxin



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Wenjing Tian, Hualing Fu, Tuan Xu, Sherry Li Xu, Zhiling Guo, Jijing Tian, Wuqun Tao, Heidi Qunhui Xie, Bin Zhao. SLC6A19 is a novel putative gene, induced by dioxins via AhR in human hepatoma HepG2 cells. Environmental pollution (Barking, Essex : 1987). 2018 Jun; 237(?):508-514. doi: 10.1016/j.envpol.2018.02.079. [PMID: 29522993]
  • Jung-Wei Chang, Hsiu-Ling Chen, Huey-Jen Su, Ching-Chang Lee. Abdominal Obesity and Insulin Resistance in People Exposed to Moderate-to-High Levels of Dioxin. PloS one. 2016; 11(1):e0145818. doi: 10.1371/journal.pone.0145818. [PMID: 26752053]
  • Karin I van Ede, Konrad P J Gaisch, Martin van den Berg, Majorie B M van Duursen. Differential relative effect potencies of some dioxin-like compounds in human peripheral blood lymphocytes and murine splenic cells. Toxicology letters. 2014 Apr; 226(1):43-52. doi: 10.1016/j.toxlet.2014.01.026. [PMID: 24472611]
  • Karin I van Ede, Patrik L Andersson, Konrad P J Gaisch, Martin van den Berg, Majorie B M van Duursen. Comparison of intake and systemic relative effect potencies of dioxin-like compounds in female rats after a single oral dose. Archives of toxicology. 2014 Mar; 88(3):637-46. doi: 10.1007/s00204-013-1186-2. [PMID: 24363026]
  • Karin I van Ede, Patrik L Andersson, Konrad P J Gaisch, Martin van den Berg, Majorie B M van Duursen. Comparison of intake and systemic relative effect potencies of dioxin-like compounds in female mice after a single oral dose. Environmental health perspectives. 2013 Jul; 121(7):847-53. doi: 10.1289/ehp.1206336. [PMID: 23674508]
  • Yongbin Yang, Zhengtao Liu, Minghui Zheng, Yanyan Zhao, Liang Wang, Wei Sun, Feng Xiao. The acute lethality and endocrine effect of 1,2,3,7,8-PeCDD in juvenile goldfish (Carassius auratus) in vivo. Journal of environmental sciences (China). 2008; 20(2):240-5. doi: 10.1016/s1001-0742(08)60037-6. [PMID: 18574967]
  • L A P Hoogenboom, J C H Van Eijkeren, M J Zeilmaker, M J B Mengelers, R Herbes, J Immerzeel, W A Traag. A novel source for dioxins present in recycled fat from gelatin production. Chemosphere. 2007 Jun; 68(5):814-23. doi: 10.1016/j.chemosphere.2007.02.032. [PMID: 17397901]
  • Sonia Lucía Blanco, Cristina Sobrado, Corina Quintela, Santiago Cabaleiro, José Carlos González, Juan M Vieites. Dietary uptake of dioxins (PCDD/PCDFs) and dioxin-like PCBs in Spanish aquacultured turbot (Psetta maxima). Food additives and contaminants. 2007 Apr; 24(4):421-8. doi: 10.1080/02652030601064821. [PMID: 17454116]
  • Larry L Needham, Daniel Q Naiman, Donald G Patterson, Judy S LaKind. Assigning concentration values for dioxin and furan congeners in human serum when measurements are below limits of detection: an observational approach. Chemosphere. 2007 Mar; 67(3):439-47. doi: 10.1016/j.chemosphere.2006.09.078. [PMID: 17109932]
  • James J Collins, Kenneth Bodner, Carol J Burns, Robert A Budinsky, Les L Lamparski, Michael Wilken, Greg D Martin, Michael L Carson. Body mass index and serum chlorinated dibenzo-p-dioxin and dibenzofuran levels. Chemosphere. 2007 Jan; 66(6):1079-85. doi: 10.1016/j.chemosphere.2006.06.063. [PMID: 16919309]
  • Dorothea F K Rawn, Donald S Forsyth, John J Ryan, Kenneth Breakell, Victor Verigin, Helen Nicolidakis, Stephen Hayward, Patrick Laffey, Henry B S Conacher. PCB, PCDD and PCDF residues in fin and non-fin fish products from the Canadian retail market 2002. The Science of the total environment. 2006 Apr; 359(1-3):101-10. doi: 10.1016/j.scitotenv.2005.04.021. [PMID: 15913708]
  • Mitsunobu Okuyama, Norihiro Kobayashi, Wakako Takeda, Takako Anjo, Yasuhiko Matsuki, Junichi Goto, Akira Kambegawa, Shinjiro Hori. Enzyme-linked immunosorbent assay for monitoring toxic dioxin congeners in milk based on a newly generated monoclonal anti-dioxin antibody. Analytical chemistry. 2004 Apr; 76(7):1948-56. doi: 10.1021/ac0303620. [PMID: 15053656]
  • Ulla Simanainen, Jouni T Tuomisto, Jouko Tuomisto, Matti Viluksela. Structure-activity relationships and dose responses of polychlorinated dibenzo-p-dioxins for short-term effects in 2,3,7,8-tetrachlorodibenzo-p-dioxin-resistant and -sensitive rat strains. Toxicology and applied pharmacology. 2002 May; 181(1):38-47. doi: 10.1006/taap.2002.9386. [PMID: 12030841]
  • K G Orloff, D Hewitt, S Metcalf, S Kathman, M Lewin, W Turner. Dioxin exposure in a residential community. Journal of exposure analysis and environmental epidemiology. 2001 Sep; 11(5):352-8. doi: 10.1038/sj.jea.7500175. [PMID: 11687908]
  • C Y Chen, J T Hamm, J R Hass, L S Birnbaum. Disposition of polychlorinated dibenzo-p-dioxins, dibenzofurans, and non-ortho polychlorinated biphenyls in pregnant long evans rats and the transfer to offspring. Toxicology and applied pharmacology. 2001 Jun; 173(2):65-88. doi: 10.1006/taap.2001.9143. [PMID: 11384209]
  • X Gao, D S Son, P F Terranova, K K Rozman. Toxic equivalency factors of polychlorinated dibenzo-p-dioxins in an ovulation model: validation of the toxic equivalency concept for one aspect of endocrine disruption. Toxicology and applied pharmacology. 1999 Jun; 157(2):107-16. doi: 10.1006/taap.1999.8649. [PMID: 10366543]
  • L W Weber, M Lebofsky, B U Stahl, A Kettrup, K Rozman. Comparative toxicity of four chlorinated dibenzo-p-dioxins (CDDs) and their mixture. Part III: Structure-activity relationship with increased plasma tryptophan levels, but no relationship to hepatic ethoxyresorufin o-deethylase activity. Archives of toxicology. 1992; 66(7):484-8. doi: 10.1007/bf01970673. [PMID: 1332652]
  • K Randerath, K L Putman, E Randerath, G Mason, M Kelley, S Safe. Organ-specific effects of long term feeding of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 1,2,3,7,8-pentachlorodibenzo-p-dioxin on I-compounds in hepatic and renal DNA of female Sprague-Dawley rats. Carcinogenesis. 1988 Dec; 9(12):2285-9. doi: 10.1093/carcin/9.12.2285. [PMID: 3191574]