all-trans-5,6-Epoxyretinoic acid (BioDeep_00000011348)

 

Secondary id: BioDeep_00001874824

human metabolite Endogenous blood metabolite


代谢物信息卡片


(2E,4E,6E,8E)-3,7-dimethyl-9-{2,2,6-trimethyl-7-oxabicyclo[4.1.0]heptan-1-yl}nona-2,4,6,8-tetraenoic acid

化学式: C20H28O3 (316.2038338)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 2.04%

分子结构信息

SMILES: C12(OC1(C)CCCC2(C)C)/C=C/C(/C)=C/C=C/C(/C)=C/C(=O)O
InChI: InChI=1S/C20H28O3/c1-15(8-6-9-16(2)14-17(21)22)10-13-20-18(3,4)11-7-12-19(20,5)23-20/h6,8-10,13-14H,7,11-12H2,1-5H3,(H,21,22)/b9-6+,13-10+,15-8+,16-14+

描述信息

all-trans-5,6-Epoxyretinoic acid, also known as 5,6-epoxy-atRA, is classified as a member of the retinoids. Retinoids are oxygenated derivatives of 3,7-dimethyl-1-(2,6,6-trimethylcyclohex-1-enyl)nona-1,3,5,7-tetraene and derivatives thereof. all-trans-5,6-Epoxyretinoic acid is considered to be a practically insoluble (in water) and a weak acidic compound. all-trans-5,6-Epoxyretinoic acid is an isoprenoid lipid molecule. all-trans-5,6-Epoxyretinoic acid can be found primarily in human kidney and liver tissues; and in blood and urine. Within a cell, all-trans-5,6-epoxyretinoic acid is primarily located in the cytoplasm, in the extracellular space, or near the membrane.
A human metabolite taken as a putative food compound of mammalian origin [HMDB]
D020011 - Protective Agents > D000975 - Antioxidants > D002338 - Carotenoids

同义名列表

12 个代谢物同义名

(2E,4E,6E,8E)-3,7-dimethyl-9-{2,2,6-trimethyl-7-oxabicyclo[4.1.0]heptan-1-yl}nona-2,4,6,8-tetraenoic acid; all-trans-5,6-Epoxy-5,6-dihydroretinoic acid; all-trans-5,6-Epoxy-5,6-dihydroretinoate; 5,6-Epoxyretinoic acid, (13-cis)-isomer; 5,6-Epoxyretinoic acid, sodium salt; 5,6-Epoxy-5,6-dihydro-retinoic acid; 5,6-Epoxy-5,6-dihydroretinoic acid; all-trans-5,6-Epoxyretinoic acid; 5,6-Epoxy-5,6-dihydro-retinoate; all-trans-5,6-Epoxyretinoate; 5,6-Epoxyretinoic acid; 5,6-Epoxy-atRA



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

9 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(9)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • S M Swanson, J X Jiang, Y S Chang, N J De Souza, J M Pezzuto. A rapid and sensitive bioassay involving cultured rat glioma cells to screen for substances capable of elevating intracellular cyclic AMP concentration. Journal of natural products. 1988 Sep; 51(5):929-36. doi: 10.1021/np50059a019. [PMID: 2849641]
  • . Endogenous metabolites of vitamin A and a test for functional activity of 5,6-epoxyretinoic acid. Nutrition reviews. 1983 Sep; 41(9):289-92. doi: 10.1111/j.1753-4887.1983.tb07205.x. [PMID: 6358966]
  • J L Napoli, H Khalil, A M McCormick. Metabolism of 5,6-epoxyretinoic acid in vivo: isolation of a major intestinal metabolite. Biochemistry. 1982 Apr; 21(8):1942-9. doi: 10.1021/bi00537a038. [PMID: 7082654]
  • A M McCormick, J L Napoli. Identification of 5,6-epoxyretinoic acid as an endogenous retinol metabolite. The Journal of biological chemistry. 1982 Feb; 257(4):1730-5. doi: . [PMID: 7056740]
  • H F DeLuca, M Zile, W K Sietsema. The metabolism of retinoic acid to 5,6-epoxyretinoic acid, retinoyl-beta-glucuronide, and other polar metabolites. Annals of the New York Academy of Sciences. 1981 Feb; 359(?):25-36. doi: 10.1111/j.1749-6632.1981.tb12734.x. [PMID: 6942675]
  • A M McCormick, J L Napoli, S Yoshizawa, H F DeLuca. 5,6-epoxyretinoic acid is a physiological metabolite of retinoic acid in the rat. The Biochemical journal. 1980 Feb; 186(2):475-81. doi: 10.1042/bj1860475. [PMID: 7378063]