4-Hydroxy-2,3,3',4',5-pentachlorobiphenyl (BioDeep_00000009872)

 

Secondary id: BioDeep_00001877052

human metabolite blood metabolite Industrial Pollutants


代谢物信息卡片


2,3,3,4,5-pentachloro-[1,1-biphenyl]-4-ol

化学式: C12H5Cl5O (339.87830299999996)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=C(C=C1C2=CC(=C(C(=C2Cl)Cl)O)Cl)Cl)Cl
InChI: InChI=1S/C12H5Cl5O/c13-7-2-1-5(3-8(7)14)6-4-9(15)12(18)11(17)10(6)16/h1-4,18H

描述信息

D004785 - Environmental Pollutants > D011078 - Polychlorinated Biphenyls

同义名列表

7 个代谢物同义名

2,3,3,4,5-pentachloro-[1,1-biphenyl]-4-ol; 4-Hydroxy-2,3,5,3,4-pentachlorobiphenyl; 2,3,3,4,5-pentachloro-4-Hydroxybiphenyl; 4-Hydroxy-2,3,3,4,5-pentachlorobiphenyl; 4-OH-2,3,5,3,4-Pentachlorobiphenyl; 2,3,3,4,5-Pentachloro-4-biphenylol; 4-OH-PeCB2



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mari Ochiai, Midori Iida, Tetsuro Agusa, Kohki Takaguchi, Satoshi Fujii, Kei Nomiyama, Hisato Iwata. Effects of 4-Hydroxy-2,3,3',4',5-Pentachlorobiphenyl (4-OH-CB107) on Liver Transcriptome in Rats: Implication in the Disruption of Circadian Rhythm and Fatty Acid Metabolism. Toxicological sciences : an official journal of the Society of Toxicology. 2018 09; 165(1):118-130. doi: 10.1093/toxsci/kfy123. [PMID: 29788408]
  • David G Levitt. Quantitative relationship between the octanol/water partition coefficient and the diffusion limitation of the exchange between adipose and blood. BMC clinical pharmacology. 2010 Jan; 10(?):1. doi: 10.1186/1472-6904-10-1. [PMID: 20055995]
  • Britta Fängström, Lotta Hovander, Anders Bignert, Ioannis Athanassiadis, Linda Linderholm, Philippe Grandjean, Pál Weihe, Ake Bergman. Concentrations of polybrominated diphenyl ethers, polychlonnated biphenyls, and polychlorobiphenylols in serum from pregnant Faroese women and their children 7 years later. Environmental science & technology. 2005 Dec; 39(24):9457-63. doi: 10.1021/es0513032. [PMID: 16475322]
  • Hans E Purkey, Satheesh K Palaninathan, Kathleen C Kent, Craig Smith, Stephen H Safe, James C Sacchettini, Jeffery W Kelly. Hydroxylated polychlorinated biphenyls selectively bind transthyretin in blood and inhibit amyloidogenesis: rationalizing rodent PCB toxicity. Chemistry & biology. 2004 Dec; 11(12):1719-28. doi: 10.1016/j.chembiol.2004.10.009. [PMID: 15610856]
  • Ilonka A T M Meerts, Hellmuth Lilienthal, Saske Hoving, Johannes H J van den Berg, Bert M Weijers, Ake Bergman, Jan H Koeman, Abraham Brouwer. Developmental exposure to 4-hydroxy-2,3,3',4',5-pentachlorobiphenyl (4-OH-CB107): long-term effects on brain development, behavior, and brain stem auditory evoked potentials in rats. Toxicological sciences : an official journal of the Society of Toxicology. 2004 Nov; 82(1):207-18. doi: 10.1093/toxsci/kfh252. [PMID: 15310863]
  • Ilonka A T M Meerts, Saske Hoving, Johannes H J van den Berg, Bert M Weijers, Hans J Swarts, Eline M van der Beek, Ake Bergman, Jan H Koeman, Abraham Brouwer. Effects of in utero exposure to 4-hydroxy-2,3,3',4',5-pentachlorobiphenyl (4-OH-CB107) on developmental landmarks, steroid hormone levels, and female estrous cyclicity in rats. Toxicological sciences : an official journal of the Society of Toxicology. 2004 Nov; 82(1):259-67. doi: 10.1093/toxsci/kfh251. [PMID: 15310862]
  • T Malmberg, J Hoogstraate, A Bergman, E Klasson Wehler. Pharmacokinetics of two major hydroxylated polychlorinated biphenyl metabolites with specific retention in rat blood. Xenobiotica; the fate of foreign compounds in biological systems. 2004 Jun; 34(6):581-9. doi: 10.1080/00498250410001713078. [PMID: 15277017]
  • Mattias Oberg, Andreas Sjödin, Helena Casabona, Ingrid Nordgren, Eva Klasson-Wehler, Helen Håkansson. Tissue distribution and half-lives of individual polychlorinated biphenyls and serum levels of 4-hydroxy-2,3,3',4',5-pentachlorobiphenyl in the rat. Toxicological sciences : an official journal of the Society of Toxicology. 2002 Dec; 70(2):171-82. doi: 10.1093/toxsci/70.2.171. [PMID: 12441362]
  • Ilonka A T M Meerts, Yvonne Assink, Peter H Cenijn, Johannes H J Van Den Berg, Bert M Weijers, Ake Bergman, Jan H Koeman, Abraham Brouwer. Placental transfer of a hydroxylated polychlorinated biphenyl and effects on fetal and maternal thyroid hormone homeostasis in the rat. Toxicological sciences : an official journal of the Society of Toxicology. 2002 Aug; 68(2):361-71. doi: 10.1093/toxsci/68.2.361. [PMID: 12151632]
  • T Sinjari, P O Darnerud. Hydroxylated polychlorinated biphenyls: placental transfer and effects on thyroxine in the foetal mouse. Xenobiotica; the fate of foreign compounds in biological systems. 1998 Jan; 28(1):21-30. doi: 10.1080/004982598239722. [PMID: 9493316]