Tiapamil (BioDeep_00000009565)

 

Secondary id: BioDeep_00001875852

human metabolite blood metabolite Volatile Flavor Compounds


代谢物信息卡片


2-(3,4-dimethoxyphenyl)-2-(3-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}propyl)-1lambda6,3lambda6-dithiane-1,1,3,3-tetrone

化学式: C26H37NO8S2 (555.1960482000001)
中文名称: 噻帕米
谱图信息: 最多检出来源 Homo sapiens(blood) 92.59%

分子结构信息

SMILES: CN(CCCC1(S(=O)(=O)CCCS1(=O)=O)C2=CC(=C(C=C2)OC)OC)CCC3=CC(=C(C=C3)OC)OC
InChI: InChI=1S/C26H37NO8S2/c1-27(15-12-20-8-10-22(32-2)24(18-20)34-4)14-6-13-26(36(28,29)16-7-17-37(26,30)31)21-9-11-23(33-3)25(19-21)35-5/h8-11,18-19H,6-7,12-17H2,1-5H3

描述信息

C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent > C333 - Calcium Channel Blocker
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
C93038 - Cation Channel Blocker

同义名列表

10 个代谢物同义名

2-(3,4-dimethoxyphenyl)-2-(3-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}propyl)-1lambda6,3lambda6-dithiane-1,1,3,3-tetrone; N-[2-(3,4-Dimethoxyphenyl)ethyl]-3-[2-(3,4-dimethoxyphenyl)-1,1,3 ,3-tetraoxido-1,3-dithian-2-yl]-N-methyl-1-propanamine; N-(3,4-Dimethoxyphenethyl)-2-(3,4-dimethoxyphenyl)-N-methyl-m-dithian-2-propylamin-1,1,3,3-tetroxide hydrochloride; Hydrochloride, dimeditiapramine; Dimeditiapramine hydrochloride; Hydrochloride, tiapamil; Tiapamil hydrochloride; Dimeditiapramine; Tiapamil; Tiapamil



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Milan Nobilis, Zuzana Vybíralová, Barbora Szotáková, Květa Sládková, Martin Kuneš, Zbyněk Svoboda. High-performance liquid chromatographic determination of tiapride and its phase I metabolite in blood plasma using tandem UV photodiode-array and fluorescence detection. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2011 Dec; 879(32):3845-52. doi: 10.1016/j.jchromb.2011.10.032. [PMID: 22100559]
  • S I M Zayed. Differential pulse anodic voltammetric determination of tiapride hydrochloride in pharmaceutical preparation and human urine using carbon paste electrodes. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. 2011; 27(5):535. doi: 10.2116/analsci.27.535. [PMID: 21558662]
  • Prasad B Phapale, Hae Won Lee, Mi-Sun Lim, Sook Jin Seong, Eun-Hee Kim, Jeonghyeon Park, Miran Lee, Sung-Kyu Hwang, Young-Ran Yoon. Liquid chromatography-tandem mass spectrometry quantification of levosulpiride in human plasma and its application to bioequivalence study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2010 Aug; 878(24):2280-5. doi: 10.1016/j.jchromb.2010.06.036. [PMID: 20656570]
  • Inako Okamoto, Kumiko Ohkubo, Hironobu Kawashima, Hiroshi Ideguchi, Junko Ono. [Case of enzyme-linked immunoglobulin with persistent elevation of lactate dehydrogenase activity in serum by administration of an anti-psychotic drug]. Rinsho byori. The Japanese journal of clinical pathology. 2008 Aug; 56(8):671-7. doi: NULL. [PMID: 18800622]
  • Fadia H Metwally, Mohammad Abdelkawy, Nada S Abdelwahab. Stability-indicating methods for determination of tiapride in pure form, pharmaceutical preparation, and human plasma. Journal of AOAC International. 2007 Nov; 90(6):1554-65. doi: NULL. [PMID: 18193732]
  • Fadia Hussein Metwally. Membrane sensors for the selective determination of tiapride in presence of its degradation products. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2007 Aug; 127(8):1267-73. doi: 10.1248/yakushi.127.1267. [PMID: 17666880]
  • Jianguo Li, Fengjuan Zhao, Huangxian Ju. Simultaneous electrochemiluminescence determination of sulpiride and tiapride by capillary electrophoresis with cyclodextrin additives. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2006 May; 835(1-2):84-9. doi: 10.1016/j.jchromb.2006.03.017. [PMID: 16569516]
  • G A Petroianu, M Y Hasan, S M Nurulain, K Arafat, M Shafiullah, R Sheen. Tiapride pre-treatment in acute exposure to paraoxon: comparison of effects of administration at different points-in-time in rats. Molecular and cellular biochemistry. 2006 Apr; 285(1-2):79-86. doi: 10.1007/s11010-005-9057-7. [PMID: 16479322]
  • A B Skorniakov, R A Kalekin, D S Lazarian. [Identification of haloperidol and tiapride in the urine with thin layer chromatography]. Sudebno-meditsinskaia ekspertiza. 2006 Mar; 49(2):37-9. doi: NULL. [PMID: 16826845]
  • G A Petroianu, M Y Hasan, K Arafat, S M Nurulain, A Schmitt. Weak inhibitors protect cholinesterases from strong inhibitors (paraoxon): in vitro effect of tiapride. Journal of applied toxicology : JAT. 2005 Nov; 25(6):562-7. doi: 10.1002/jat.1097. [PMID: 16193528]
  • G A Petroianu, A Schmitt, K Arafat, M Y Hasan. Weak inhibitors protect cholinesterases from stronger inhibitors (dichlorvos): in vitro effect of tiapride. International journal of toxicology. 2005 Mar; 24(2):79-86. doi: 10.1080/10915810590921360. [PMID: 16036766]
  • Koh Iwasaki, Takuma Satoh-Nakagawa, Masahiro Maruyama, Yasutake Monma, Miyako Nemoto, Naoki Tomita, Haruko Tanji, Hironori Fujiwara, Takashi Seki, Masahiko Fujii, Hiroyuki Arai, Hidetada Sasaki. A randomized, observer-blind, controlled trial of the traditional Chinese medicine Yi-Gan San for improvement of behavioral and psychological symptoms and activities of daily living in dementia patients. The Journal of clinical psychiatry. 2005 Feb; 66(2):248-52. doi: 10.4088/jcp.v66n0214. [PMID: 15705012]
  • Ya Moon, In Bok Paek, Hui-Hyun Kim, Hye Young Ji, Hye Won Lee, Hyoung-Geun Park, Hye Suk Lee. Determination of tiapride in human plasma using hydrophilic interaction liquid chromatography-tandem mass spectrometry. Archives of pharmacal research. 2004 Sep; 27(9):901-5. doi: 10.1007/bf02975840. [PMID: 15473657]
  • Nathalie Bock, Gunther H Moll, Maike Wicker, Jürgen Pilz, Eckart Rüther, Tobias Banaschewski, Gerald Huether, Aribert Rothenberger. Early administration of tiapride to young rats without long-lasting changes in the development of the dopaminergic system. Pharmacopsychiatry. 2004 Jul; 37(4):163-7. doi: 10.1055/s-2004-827171. [PMID: 15467972]
  • P Gimeno Fernández, J A Pérez Andújar, J Gómez Nieto, E Domínguez Nieto. [Rhabdomyolysis in transplantation patients]. Revista espanola de anestesiologia y reanimacion. 2003 Jun; 50(6):307-8. doi: NULL. [PMID: 12940222]
  • Nicole Kotzailias, Josef Finsterer, Susanne Aull, Hans-Georg Eichler, Barbara Pratscher, Bernd Jilma. Influence of tiapride on platelet counts in healthy volunteers and patients with movement disorders. Progress in neuro-psychopharmacology & biological psychiatry. 2003 Jun; 27(4):595-9. doi: 10.1016/s0278-5846(03)00046-0. [PMID: 12787844]
  • P Virgili, M C Gal. [Porphyria variegata. Apropos of a case]. L'Encephale. 1995 Nov; 21(6):467-71. doi: NULL. [PMID: 8674472]
  • J F Eliason, H Ramuz, T Yoshikubo, T Ishikawa, T Yamamoto, T Tsuruo. Novel dithiane analogues of tiapamil with high activity to overcome multidrug resistance in vitro. Biochemical pharmacology. 1995 Jul; 50(2):187-96. doi: 10.1016/0006-2952(95)00115-g. [PMID: 7632162]
  • A Kamizono, N Inotsume, K Miyamoto, K Ueda, T Miyakawa, H Arimoto, M Nakano. Determination of sultopride and tiapride in serum by gas chromatography using a surface ionisation detector. Journal of chromatography. 1991 Jun; 567(1):113-20. doi: 10.1016/0378-4347(91)80315-4. [PMID: 1918238]
  • Y A Ding, S M Shieh. Antihypertensive and metabolic effects of tiapamil. Journal of clinical pharmacology. 1990 Mar; 30(3):262-6. doi: 10.1002/j.1552-4604.1990.tb03470.x. [PMID: 2312781]
  • S Slaiman. Anti-hypertensive treatment and serum lipids. The Practitioner. 1989 Aug; 233(1473):1054. doi: NULL. [PMID: 2690054]
  • D Hartmann, N O Lunell, G Friedrich, A Rane. Excretion of tiapamil in breast milk. British journal of clinical pharmacology. 1988 Aug; 26(2):183-6. doi: 10.1111/j.1365-2125.1988.tb03385.x. [PMID: 3207555]
  • D R Abernethy, J B Schwartz. Pharmacokinetics of calcium antagonists under development. Clinical pharmacokinetics. 1988 Jul; 15(1):1-14. doi: 10.2165/00003088-198815010-00001. [PMID: 3042243]
  • Y A Ding, S M Shieh, S P Yang, P K Sung. Long-term effect of tiapamil in essential hypertension. Journal of cardiovascular pharmacology. 1988 Mar; 11(3):339-43. doi: 10.1097/00005344-198803000-00012. [PMID: 2452928]
  • J A Apud, C Masotto, A Monopoli, E Ongini, A C Rovescalli, G Racagni. Effects of repeated tiapride administration on anterior pituitary dopamine receptors and prolactin release in the rat. Pharmacological research communications. 1987 Feb; 19(2):119-29. doi: 10.1016/0031-6989(87)90002-6. [PMID: 3588649]
  • T Norman, E Chiu, R H James, M S Gregory. Single oral dose pharmacokinetics of tiapride in patients with Huntington's disease. European journal of clinical pharmacology. 1987; 32(6):583-6. doi: 10.1007/bf02455992. [PMID: 2958291]
  • G L Duan, M L Lu, B L Wu. [Reverse phase high performance liquid chromatographic determination of tiapride in plasma and urine]. Yao xue xue bao = Acta pharmaceutica Sinica. 1986 Dec; 21(12):917-21. doi: NULL. [PMID: 3591332]
  • R A Roos, E A Van der Velde, O J Buruma, F A de Wolff. Assessment of the therapeutic range of tiapride in patients with tardive dyskinesia. Journal of neurology, neurosurgery, and psychiatry. 1986 Sep; 49(9):1055-8. doi: 10.1136/jnnp.49.9.1055. [PMID: 3760895]
  • K Laederach, P Weidmann, F Lauener, A Gerber, W H Ziegler. Comparative acute effects of the calcium channel blockers tiapamil, nisoldipine, and nifedipine on blood pressure and some regulatory factors in normal and hypertensive subjects. Journal of cardiovascular pharmacology. 1986 Mar; 8(2):294-302. doi: 10.1097/00005344-198603000-00011. [PMID: 2422467]
  • R A Roos, E J de Haas, O J Buruma, F A de Wolff. Pharmacokinetics of tiapride in patients with tardive dyskinesia and Huntington's disease. European journal of clinical pharmacology. 1986; 31(2):191-4. doi: 10.1007/bf00606657. [PMID: 2948825]
  • P H Hinderling, M Eckert, S Gasic, H G Eichler, R Pötzi, P Heizmann. Comparative pharmacokinetics and cardiovascular effects of tiapamil in healthy volunteers and patients with hepatic cirrhosis. European journal of clinical pharmacology. 1986; 31(4):397-404. doi: 10.1007/bf00613513. [PMID: 3816918]
  • J Ribstein, J P Cristol, F Elkik, A Mimran. Renal effects of calcium blockade by tiapamil in normal and hypertensive subjects. Journal of hypertension. Supplement : official journal of the International Society of Hypertension. 1985 Dec; 3(3):S165-7. doi: . [PMID: 2856696]
  • A Nardoni, V Di Piazza, E Marchetti, O Geatti, P Cedaro, L Lattuada. [Changes in the circadian rhythm of urinary cyclic adenosine monophosphate during the alcoholic withdrawal syndrome and related neurobiological correlations]. Minerva medica. 1985 Sep; 76(34-35):1535-40. doi: NULL. [PMID: 2993962]
  • O Stucker, R Trouvé, G Nahas. [Analgesic effect of tiapride in healthy volunteers]. L'Encephale. 1985 Sep; 11(5):221-3. doi: NULL. [PMID: 4085410]
  • A Perényi, M Arató, G Bagdy, E Frecska, R Szücs. Tiapride in the treatment of tardive dyskinesia: a clinical and biochemical study. The Journal of clinical psychiatry. 1985 Jun; 46(6):229-31. doi: NULL. [PMID: 2860098]
  • W Greil, S Auberger, H Haag, E Rüther. Tiapride: effects on tardive dyskinesia and on prolactin plasma concentrations. Neuropsychobiology. 1985; 14(1):17-22. doi: 10.1159/000118195. [PMID: 3906426]
  • P Heizmann, G Wendt, R Von Alten, K Zinapold, C Buser. Determination of tiapamil and of its two main metabolites in plasma and in urine by high-performance liquid chromatography. Journal of chromatography. 1984 Sep; 310(1):119-27. doi: 10.1016/0378-4347(84)80073-0. [PMID: 6501509]
  • M Eckert, H Pozenel, B Pillat. Pharmacokinetics and hemodynamic effects of tiapamil: exercise performance, thallium stress scintigraphy, and radionuclide ventriculography. Journal of clinical pharmacology. 1984 Apr; 24(4):165-73. doi: 10.1002/j.1552-4604.1984.tb01826.x. [PMID: 6725618]
  • J Lessem, A Bellinetto. Interaction between digoxin and the calcium antagonists nicardipine and tiapamil. Clinical therapeutics. 1983; 5(6):595-602. doi: . [PMID: 6627286]
  • E Rey, P d'Athis, M O Richard, D de Lauture, G Olive. Pharmacokinetics of tiapride and absolute bioavailability of three extravascular forms. International journal of clinical pharmacology, therapy, and toxicology. 1982 Feb; 20(2):62-7. doi: NULL. [PMID: 7061180]
  • J C Aschoff, D Claus, W D Hetzel. [Tiapride therapy of centrally produced dyskinesia. Examination of the serum levels of protein, LH and FSH (author's transl)]. Arzneimittel-Forschung. 1982; 32(3):286-9. doi: NULL. [PMID: 6805485]
  • G Wendt. Pharmacokinetics and metabolism of tiapamil. Cardiology. 1982; 69 Suppl(?):68-78. doi: 10.1159/000173539. [PMID: 7151085]
  • J Lessem. Tiapamil in the treatment of lidocaine-resistant ventricular arrhythmias complicating acute myocardial infarction. Cardiology. 1982; 69 Suppl(?):199-208. doi: 10.1159/000173556. [PMID: 7151080]
  • G G Rogers, C Rosendorff, C J Shimell, A Coull. Effects of tiapamil on haemodynamics and myocardial salvage during myocardial infarction in the baboon. Cardiology. 1982; 69 Suppl(?):58-67. doi: 10.1159/000173538. [PMID: 7151084]
  • C Gennari, R Nami, M Pizzuti, G D'Ascenzo, C Bianchini. [Effects of tiapride infusion on plasma levels of beta-endorphin, prolactin and dopamine in patients with pain from cancer (author's transl)]. La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris. 1981 Apr; 57(15-16):795-800. doi: NULL. [PMID: 6269192]
  • C Gennari, R Nami, M Pizzuti, G D'Ascenzo, C Bianchini. Effects of tiapride infusion on plasma levels of beta-endorphin, prolactin and dopamine in patients with pain from cancer. Pathologie-biologie. 1981 Feb; 29(2):105-10. doi: NULL. [PMID: 6262702]
  • K Lindvall, G Cocco, G Wendt, D Chu, P Heizmann. Serial M-mode echocardiography in evaluation of the cardiovascular effects of tiapamil and their relationship to plasma levels in patients with coronary heart disease. International journal of cardiology. 1981; 1(1):15-24. doi: 10.1016/0167-5273(81)90042-5. [PMID: 7333712]