Epanolol (BioDeep_00000008861)

 

Secondary id: BioDeep_00000859054

human metabolite blood metabolite


代谢物信息卡片


N-(2-{[3-(2-cyanophenoxy)-2-hydroxypropyl]amino}ethyl)-2-(4-hydroxyphenyl)acetamide

化学式: C20H23N3O4 (369.16884780000004)
中文名称: 依泮洛尔
谱图信息: 最多检出来源 Homo sapiens(blood) 66.67%

分子结构信息

SMILES: C1=CC=C(C(=C1)C#N)OCC(CNCCNC(=O)CC2=CC=C(C=C2)O)O
InChI: InChI=1S/C20H23N3O4/c21-12-16-3-1-2-4-19(16)27-14-18(25)13-22-9-10-23-20(26)11-15-5-7-17(24)8-6-15/h1-8,18,22,24-25H,9-11,13-14H2,(H,23,26)

描述信息

C - Cardiovascular system > C07 - Beta blocking agents > C07A - Beta blocking agents > C07AB - Beta blocking agents, selective
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013566 - Sympathomimetics
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
Same as: D06646

同义名列表

7 个代谢物同义名

N-(2-{[3-(2-cyanophenoxy)-2-hydroxypropyl]amino}ethyl)-2-(4-hydroxyphenyl)acetamide; N-(2-((3-(2-Cyanophenoxy)-2-hydroxypropyl)amino)ethyl)-4-hydroxyphenylacetamide; 292EPANOLOL; ICI141292; Epanolol; Visacor; ICI 141



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • D Taverner, I G Mackay, K Craig, M L Watson. The effects of selective beta-adrenoceptor antagonists and partial agonist activity on renal function during exercise in normal subjects and those with moderate renal impairment. British journal of clinical pharmacology. 1991 Sep; 32(3):387-91. doi: 10.1111/j.1365-2125.1991.tb03917.x. [PMID: 1685667]
  • H Vandenbosch, J Piessens, H De Geest. Effects of a single oral administration of Epanolol on exercise tolerance in patients with stable effort angina pectoris. Acta cardiologica. 1991; 46(1):11-25. doi: . [PMID: 1674394]
  • I D Cockshott, J McAinsh, S Norris. Pharmacokinetic and pharmacodynamic studies in man with an antianginal agent 'Visacor'. Biopharmaceutics & drug disposition. 1990 Apr; 11(3):253-63. doi: 10.1002/bdd.2510110310. [PMID: 1970266]
  • J Hosie, A K Scott, J C Petrie, I D Cockshott. Pharmacokinetics of epanolol after acute and chronic oral dosing in elderly patients with stable angina pectoris. British journal of clinical pharmacology. 1990 Mar; 29(3):333-7. doi: 10.1111/j.1365-2125.1990.tb03644.x. [PMID: 1968755]
  • R Marlier, J McAinsh, I D Cockshott. Pharmacokinetics of epanolol in elderly patients with stable angina pectoris. Arzneimittel-Forschung. 1990 Feb; 40(2 Pt 1):142-4. doi: NULL. [PMID: 1970734]
  • M S Laher, P Crome, G S Rakhra, S I Ankier, I D Cockshott. ICI 141,292 (epanolol)--pharmacokinetics after single and repeated oral administration in the elderly with moderate renal impairment. European journal of clinical pharmacology. 1990; 39(1):71-4. doi: 10.1007/bf02657061. [PMID: 1980462]
  • R A Lefebvre, M G Bogaert, D Duprez. Investigation of possible pharmacokinetic and pharmacodynamic interactions between epanolol and digoxin. European journal of clinical pharmacology. 1990; 38(5):505-7. doi: 10.1007/bf02336692. [PMID: 1974206]
  • I D Cockshott. Pharmacokinetics of epanolol (ICI 141,292) in healthy young volunteers and comparative data in elderly patients with angina and subjects with renal or hepatic impairment. Drugs. 1989; 38 Suppl 2(?):10-7. doi: 10.2165/00003495-198900382-00005. [PMID: 2575975]
  • G Simon, V J Wittig. Antihypertensive and hormonal responses to beta-blockade with intrinsic sympathomimetic activity: pindolol versus epanolol. Journal of cardiovascular pharmacology. 1987 Nov; 10(5):543-7. doi: 10.1097/00005344-198711000-00008. [PMID: 2447403]
  • R G Wilcox, T Bennett, I A Macdonald, F Broughton Pipkin, P H Baylis. Post-exercise hypotension: the effects of epanolol or atenolol on some hormonal and cardiovascular variables in hypertensive men. British journal of clinical pharmacology. 1987 Aug; 24(2):151-62. doi: 10.1111/j.1365-2125.1987.tb03156.x. [PMID: 2887189]
  • W Reid, D J Ewing, J D Harry, H J Smith, J M Neilson, B F Clarke. Effects of beta-adrenoceptor blockade on heart rate and physiological tremor in diabetics with autonomic neuropathy. A comparative study of epanolol, atenolol and pindolol. British journal of clinical pharmacology. 1987 Apr; 23(4):383-9. doi: 10.1111/j.1365-2125.1987.tb03066.x. [PMID: 2883987]
  • I G Mackay, A M Macnicol, H J Smith, A D Cumming, M L Watson. Intrinsic sympathomimetic activity of cardioselective beta-adrenoceptor blockers and effects on renal function. British journal of clinical pharmacology. 1985 Sep; 20(3):197-203. doi: 10.1111/j.1365-2125.1985.tb05061.x. [PMID: 2864052]
  • J McAinsh, R P Smith, R A Ferguson. Absolute bioavailability study in the dog with Visacor, a new cardioselective beta blocking drug with intrinsic sympathomimetic activity. European journal of drug metabolism and pharmacokinetics. 1984 Apr; 9(2):129-39. doi: 10.1007/bf03189616. [PMID: 6146530]
  • H J Smith, S E Halliday, D C Earl, D Stribling. Effects of selective (beta-1 and beta-2) and nonselective beta adrenoceptor antagonists on the cardiovascular and metabolic responses to isoproterenol: comparison with ICI 141,292. The Journal of pharmacology and experimental therapeutics. 1983 Jul; 226(1):211-6. doi: . [PMID: 6134820]
  • L Giuliani, G Carmignani, E Belgrano, P Puppo. Transcatheter arterial embolization in urological tumors: the use of isobutyl-2-cyanoacrylate. The Journal of urology. 1979 May; 121(5):630-4. doi: 10.1016/s0022-5347(17)56913-x. [PMID: 439260]