Sulconazole (BioDeep_00000006657)

 

Secondary id: BioDeep_00001868696

human metabolite blood metabolite


代谢物信息卡片


1-(2-{[(4-chlorophenyl)methyl]sulfanyl}-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole

化学式: C18H15Cl3N2S (396.00214800000003)
中文名称: 舒康唑
谱图信息: 最多检出来源 Mentha canadensis(plant) 48.28%

分子结构信息

SMILES: C1=CC(=CC=C1CSC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl)Cl
InChI: InChI=1S/C18H15Cl3N2S/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21/h1-9,12,18H,10-11H2

描述信息

D - Dermatologicals > D01 - Antifungals for dermatological use > D01A - Antifungals for topical use > D01AC - Imidazole and triazole derivatives
D000890 - Anti-Infective Agents > D000935 - Antifungal Agents
C254 - Anti-Infective Agent > C514 - Antifungal Agent

同义名列表

9 个代谢物同义名

1-(2-{[(4-chlorophenyl)methyl]sulfanyl}-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole; 1-{2-[(4-chlorobenzyl)sulphanyl]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole; 1-(beta-(4-Chlorobenzylthio)-24-dichlorophenethyl)imidazole; Sulconazole, mononitrate, (+-)-isomer; Sulconazole mononitrate; Sulconazole nitrate; sulconazole; Exelderm; Myk



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ayesha Samee, Faisal Usman, Tanveer A Wani, Mudassir Farooq, Hamid Saeed Shah, Ibrahim Javed, Hassan Ahmad, Riffat Khan, Seema Zargar, Safina Kausar. Sulconazole-Loaded Solid Lipid Nanoparticles for Enhanced Antifungal Activity: In Vitro and In Vivo Approach. Molecules (Basel, Switzerland). 2023 11; 28(22):. doi: 10.3390/molecules28227508. [PMID: 38005230]
  • Ann R Holmes, Mikhail V Keniya, Irena Ivnitski-Steele, Brian C Monk, Erwin Lamping, Larry A Sklar, Richard D Cannon. The monoamine oxidase A inhibitor clorgyline is a broad-spectrum inhibitor of fungal ABC and MFS transporter efflux pump activities which reverses the azole resistance of Candida albicans and Candida glabrata clinical isolates. Antimicrobial agents and chemotherapy. 2012 Mar; 56(3):1508-15. doi: 10.1128/aac.05706-11. [PMID: 22203607]
  • Yasuto Kido, Pär Matsson, Kathleen M Giacomini. Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. Journal of medicinal chemistry. 2011 Jul; 54(13):4548-58. doi: 10.1021/jm2001629. [PMID: 21599003]
  • Wen-Ding Hsu, Shuei-Liong Lin, Felin-Lin Wu, Chih-Kang Chiang, Kwan-Dun Wu. Topical antifungal treatment cures exit-site fungal infection. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2002 Oct; 40(4):E15. doi: 10.1053/ajkd.2002.35757. [PMID: 12324936]
  • Laura Kragie, Stephanie D Turner, Christopher J Patten, Charles L Crespi, David M Stresser. Assessing pregnancy risks of azole antifungals using a high throughput aromatase inhibition assay. Endocrine research. 2002 Aug; 28(3):129-40. doi: 10.1081/erc-120015045. [PMID: 12489563]
  • B Hercelin, M Delaunay-Vantrou, F Alamichel, M Mazza, J P Marty. Pharmacokinetics of cutaneous Sulconazole nitrate in the hairless rat: absorption, excretion, tissue concentrations. European journal of drug metabolism and pharmacokinetics. 1993 Apr; 18(2):149-54. doi: 10.1007/bf03188789. [PMID: 8243497]
  • T J Franz, P Lehman. Percutaneous absorption of sulconazole nitrate in humans. Journal of pharmaceutical sciences. 1988 Jun; 77(6):489-91. doi: 10.1002/jps.2600770605. [PMID: 3171926]
  • M Fass, B Zaro, M Chaplin, S Matin. Reversed-phase high-pressure liquid chromatographic analysis of sulconazole in plasma. Journal of pharmaceutical sciences. 1981 Dec; 70(12):1338-40. doi: 10.1002/jps.2600701212. [PMID: 7320848]