Chlorphenesin (BioDeep_00000006633)

 

Secondary id: BioDeep_00001868034

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


3-(4-Chlorophenoxy)-1,2-propanediol

化学式: C9H11ClO3 (202.0396686)
中文名称: 3-(4-氯苯氧基)-1,2-丙二醇
谱图信息: 最多检出来源 Homo sapiens(blood) 0.3%

分子结构信息

SMILES: C1=CC(=CC=C1OCC(CO)O)Cl
InChI: InChI=1S/C9H11ClO3/c10-7-1-3-9(4-2-7)13-6-8(12)5-11/h1-4,8,11-12H,5-6H2

描述信息

Chlorphenesin is only found in individuals that have used or taken this drug. It is a centrally acting muscle relaxant. Its mode of action is unknown. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1203)The mechanism of action of chlorphenesin is not well defined, and its effects are measured mainly by subjective responses. It is known that chlorphenesin acts in the central nervous system (CNS) rather than directly on skeletal muscle.
D - Dermatologicals > D01 - Antifungals for dermatological use > D01A - Antifungals for topical use
D018373 - Peripheral Nervous System Agents > D009465 - Neuromuscular Agents
C254 - Anti-Infective Agent > C28394 - Topical Anti-Infective Agent
D002491 - Central Nervous System Agents

同义名列表

19 个代谢物同义名

3-(4-Chlorophenoxy)-1,2-propanediol; p-Chlorophenyl-alpha-glyceryl ether; Glycerol alpha-p-chlorophenyl ether; 3-(p-Chlorophenoxy)-1,2-propanediol; 3-(4-chlorophenoxy)propane-1,2-diol; 3-(p-Chlorophenoxy)propane-1,2-diol; Glycerol a-p-chlorophenyl ether; p-Chlorophenyl-a-glyceryl ether; Glycerol α-p-chlorophenyl ether; p-Chlorophenyl-α-glyceryl ether; p-Chlorophenyl glyceryl ether; alpha-Glyceryl ether; Chlorphenesinum; p-Chlorophenyl; Chlorphenesine; Chlorophenesin; chlorphenesin; Clorfenesina; Chlorphenesin



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ana Rubio, Christian Görgens, Oliver Krug, Masato Okano, Matthew Fedoruk, Brian Ahrens, Hans Geyer, Mario Thevis. Chromatographic-mass spectrometric analysis of the urinary metabolite profile of chlorphenesin observed after dermal application of chlorphenesin-containing sunscreen. Rapid communications in mass spectrometry : RCM. 2021 Dec; 35(21):e9183. doi: 10.1002/rcm.9183. [PMID: 34431558]
  • Jingyi Wang, Yang Liu, Wendy R Kam, Ying Li, David A Sullivan. Toxicity of the cosmetic preservatives parabens, phenoxyethanol and chlorphenesin on human meibomian gland epithelial cells. Experimental eye research. 2020 07; 196(?):108057. doi: 10.1016/j.exer.2020.108057. [PMID: 32387382]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • M Sasajima, H Aihara, F Akiyama, K Tsuchida, S Otomo. [A pharmacological study of chlorphenesin carbamate. Tolerance to chlorphenesin carbamate (author's transl)]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 1977 Apr; 73(3):347-58. doi: 10.1254/fpj.73.347. [PMID: 410705]
  • W A Hook, R P Siraganian. Complement-induced histamine release from human basophils. III. Effect of pharmacologic agents. Journal of immunology (Baltimore, Md. : 1950). 1977 Feb; 118(2):679-84. doi: . [PMID: 65434]
  • R G Stoll, K A DeSante, E Novak, R E Monovich, A R DiSanto. Chlorphenesin carbamate serum levels during subchronic administration to human (normal) volunteers. Journal of clinical pharmacology. 1974 Oct; 14(10):520-4. doi: 10.1002/j.1552-4604.1974.tb01366.x. [PMID: 4610015]
  • D G Kaiser, S R Shaw. GLC determination of chlorphenesin carbamate in serum. Journal of pharmaceutical sciences. 1974 Jul; 63(7):1094-7. doi: 10.1002/jps.2600630713. [PMID: 4852199]
  • J F Douglas, J A Stockage, N B Smith. Gas chromatographic determination of chlorphenesin in plasma. Journal of pharmaceutical sciences. 1970 Jan; 59(1):107-8. doi: 10.1002/jps.2600590122. [PMID: 5411312]
  • J Edelson, J F Douglas, B J Ludwig. Chlorphenesin metabolism in the rat and dog. Biochemical pharmacology. 1969 Oct; 18(10):2331-8. doi: 10.1016/0006-2952(69)90347-5. [PMID: 5403973]
  • R M O'Dell, J P Jarrell, J U Schlegel. Renal distrubution of sulfisoxazole in canine kidney. Current therapeutic research, clinical and experimental. 1969 May; 11(5):307-15. doi: NULL. [PMID: 4977404]
  • D R Buhler, H Harpootlian. Metabolism of 3-(p-chlorophenoxy)-2-methoxypropyl carbamate in the rat. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 1967 Jun; 125(2):469-71. doi: 10.3181/00379727-125-32122. [PMID: 6028566]
  • R C Thomas, D R Buhler, G J Ikeda. Preparation of tritium-labeled compounds. II. Chlorphenesin carbamate by exposure to tritium gas and determination of intramolecular distribution of tritium. Journal of pharmaceutical sciences. 1967 Apr; 56(4):507-11. doi: 10.1002/jps.2600560417. [PMID: 6034550]
  • F M Berger, G Fukui, B J Ludwig, S Margolin. Selective suppression of penicillin hypersensitivity by certain phenoxy propanediols. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 1967 Jan; 124(1):303-10. doi: 10.3181/00379727-124-31728. [PMID: 6017786]
  • D R Buhler, H Harpootlian, R L Johnston. The absorption, excretion, and metabolism of chlorphenesin carbamate in the dog. Biochemical pharmacology. 1966 Oct; 15(10):1507-21. doi: 10.1016/0006-2952(66)90196-1. [PMID: 5971806]
  • D R BUHLER. CHARACTERIZATION OF THE GLUCURONIDE CONJUGATE OF CHLORPHENESIN CARBAMATE FROM THE RAT AND FROM MAN. Biochemical pharmacology. 1965 Mar; 14(?):371-3. doi: 10.1016/0006-2952(65)90208-x. [PMID: 14314338]
  • D R BUHLER. THE METABOLISM OF CHLORPHENESIN CARBAMATE. The Journal of pharmacology and experimental therapeutics. 1964 Aug; 145(?):232-41. doi: NULL. [PMID: 14214422]