Propoxycaine (BioDeep_00000006626)

 

Secondary id: BioDeep_00001868428

human metabolite blood metabolite


代谢物信息卡片


2-(Diethylamino)ethyl 4-amino-2-propoxybenzoic acid

化学式: C16H26N2O3 (294.1943)
中文名称: 丙氧卡因
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCOC1=C(C=CC(=C1)N)C(=O)OCCN(CC)CC
InChI: InChI=1S/C16H26N2O3/c1-4-10-20-15-12-13(17)7-8-14(15)16(19)21-11-9-18(5-2)6-3/h7-8,12H,4-6,9-11,17H2,1-3H3

描述信息

D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C245 - Anesthetic Agent

同义名列表

8 个代谢物同义名

2-(Diethylamino)ethyl 4-amino-2-propoxybenzoic acid; 2-(diethylamino)ethyl 4-amino-2-propoxybenzoate; Hydrochloride, propoxycaine; Propoxycaine hydrochloride; Propoxyprocaine; Propoxycaine; Propoxycaine; Propoxycaine



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Qian Wen, Tingjun Fan, Suran Bai, Yunlong Sui. Cytotoxicity of proparacaine to human corneal endothelial cells in vitro. The Journal of toxicological sciences. 2015 Aug; 40(4):427-36. doi: 10.2131/jts.40.427. [PMID: 26165639]
  • Yu-Chih Hou, I-Jong Wang, Fung-Rong Hu. Ring keratitis associated with topical abuse of a dilute anesthetic after refractive surgery. Journal of the Formosan Medical Association = Taiwan yi zhi. 2009 Dec; 108(12):967-72. doi: 10.1016/s0929-6646(10)60011-3. [PMID: 20040463]
  • Jong-Hwa Lee, Dong-Il Kim, Hun Mun, Sung-Key Lee, Jong-Sun Park, Jong-Ho Kim, Jang-Hoon Lee, Yi-Hoon Park, Young-Chan Jeon, Ung-Chan Yoon, Moon-Kyung Bae, Hye-Ock Jang, W Gibson Wood, Il Yun. The effect of propoxycaine.HCl on the physical properties of neuronal membranes. Chemistry and physics of lipids. 2008 Jul; 154(1):19-25. doi: 10.1016/j.chemphyslip.2008.03.009. [PMID: 18407836]
  • Mario Suwalsky, Carlos Schneider, Beryl Norris, Fernando Villena, Hernán Cárdenas, Francisco Cuevas, Carlos P Sotomayor. The local anesthetic proparacaine modifies sodium transport in toad skin and perturbs the structures of model and cell membranes. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2002 Sep; 57(9-10):930-8. doi: 10.1515/znc-2002-9-1029. [PMID: 12440736]
  • T M Zollman, R M Bragg, D A Harrison. Clinical effects of oleoresin capsicum (pepper spray) on the human cornea and conjunctiva. Ophthalmology. 2000 Dec; 107(12):2186-9. doi: 10.1016/s0161-6420(00)00463-2. [PMID: 11097593]
  • R L Grant, D Acosta. Comparative toxicity of tetracaine, proparacaine and cocaine evaluated with primary cultures of rabbit corneal epithelial cells. Experimental eye research. 1994 Apr; 58(4):469-78. doi: 10.1006/exer.1994.1040. [PMID: 7925683]
  • A H Krauss, D F Woodward. An atypical vasopermeability response to leukotrienes in the iris-ciliary body. Prostaglandins. 1991 Jun; 41(6):559-70. doi: 10.1016/0090-6980(91)90061-j. [PMID: 1647045]
  • P E Hopper, C J Murphy, E C Feldman, R W Nelson, G D Bottoms, C E Franti. Serum glucose and insulin responses to an insulin-containing ophthalmic solution administered topically in clinically normal cats. American journal of veterinary research. 1991 Jun; 52(6):903-7. doi: NULL. [PMID: 1883093]
  • F Gusovsky, Y Nishizawa, W Padgett, E T McNeal, K Rice, C H Kim, C R Creveling, J W Daly. Voltage-dependent sodium channels in synaptoneurosomes: studies with 22Na+ influx and [3H]saxitoxin and [3H]batrachotoxinin-A 20-alpha-benzoate binding. Effects of proparacaine isothiocyanate. Brain research. 1990 Jun; 518(1-2):101-6. doi: 10.1016/0006-8993(90)90959-f. [PMID: 1697206]
  • H Brewitt, E Bonatz, H Honegger. Morphological changes of the corneal epithelium after application of topical anaesthetic ointments. Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde. 1980; 180(4):198-206. doi: 10.1159/000308974. [PMID: 7443191]
  • H Brewitt, H Honegger. [The influence of local anesthetics on corneal epithelium. A scanning electron microscopic study (author's transl)]. Klinische Monatsblatter fur Augenheilkunde. 1978 Sep; 173(3):347-54. doi: . [PMID: 750708]
  • R N Rosenberg, D J Dalessio, J Tremblay, D Woodman. Kinetics of acetylcholine synthesis and hydrolysis in myasthenia gravis. Science (New York, N.Y.). 1971 Aug; 173(3997):644-5. doi: 10.1126/science.173.3997.644. [PMID: 5564597]