Oxyphencyclimine (BioDeep_00000006618)

 

Secondary id: BioDeep_00001868409

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


(1-methyl-1,4,5,6-tetrahydropyrimidin-2-yl)methyl 2-cyclohexyl-2-hydroxy-2-phenylacetate

化学式: C20H28N2O3 (344.20998180000004)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(urine) 35.56%

分子结构信息

SMILES: CN1CCCN=C1COC(=O)C(c1ccccc1)(C1CCCCC1)O
InChI: InChI=1S/C20H28N2O3/c1-22-14-8-13-21-18(22)15-25-19(23)20(24,16-9-4-2-5-10-16)17-11-6-3-7-12-17/h2,4-5,9-10,17,24H,3,6-8,11-15H2,1H3

描述信息

Oxyphencyclimine is only found in individuals that have used or taken this drug. It is an anticholinergic drug (trade name Daricon) used in treating peptic ulcers.Oxyphencyclimine binds the muscarinic acetylcholine receptor. It may block all three types of muscarinic receptors including M-1 receptors in the CNS and ganglia, M-2 receptors in the heart (vagus) and M-3 receptors at the parasympathetic NEJ system. The muscarinic acetylcholine receptors mediate various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Oxphencyclimine inhibits vagally mediated reflexes by antagonizing the action of acetylcholine. This in turn reduces the secretion of gastric acids in the stomach.
A - Alimentary tract and metabolism > A03 - Drugs for functional gastrointestinal disorders > A03A - Drugs for functional gastrointestinal disorders > A03AA - Synthetic anticholinergics, esters with tertiary amino group
C78272 - Agent Affecting Nervous System > C66880 - Anticholinergic Agent > C29704 - Antimuscarinic Agent
C78272 - Agent Affecting Nervous System > C29698 - Antispasmodic Agent

同义名列表

7 个代谢物同义名

(1-methyl-1,4,5,6-tetrahydropyrimidin-2-yl)methyl 2-cyclohexyl-2-hydroxy-2-phenylacetate; Oxyphencyclimine monohydrochloride; Oxyphencyclimine hydrochloride; Oxyphencyclimine, (+-)-isomer; Oxiphencycliminum; oxyphencyclimine; Oxyphencyclimine



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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Plant Reactome(0)

INOH(0)

PlantCyc(0)

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1 个相关的物种来源信息

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