Mivacurium (BioDeep_00000006530)
Main id: BioDeep_00000831776
Secondary id: BioDeep_00001868432
human metabolite blood metabolite
代谢物信息卡片
Mivacurium mixture of isomers
化学式: C58H80N2O14+2 (1028.560926)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COc1cc2c(cc1OC)C(Cc1cc(OC)c(OC)c(OC)c1)[N+](C)(CCCOC(=O)CCC=CCCC(=O)OCCC[N+]1(C)CCc3cc(OC)c(OC)cc3C1Cc1cc(OC)c(OC)c(OC)c1)CC2
InChI: InChI=1S/C58H80N2O14/c1-59(25-21-41-35-47(63-3)49(65-5)37-43(41)45(59)29-39-31-51(67-7)57(71-11)52(32-39)68-8)23-17-27-73-55(61)19-15-13-14-16-20-56(62)74-28-18-24-60(2)26-22-42-36-48(64-4)50(66-6)38-44(42)46(60)30-40-33-53(69-9)58(72-12)54(34-40)70-10/h13-14,31-38,45-46H,15-30H2,1-12H3/q+2/b14-13+/t45-,46-,59?,60?/m1/s1
描述信息
D018373 - Peripheral Nervous System Agents > D009465 - Neuromuscular Agents > D009466 - Neuromuscular Blocking Agents
M - Musculo-skeletal system > M03 - Muscle relaxants > M03A - Muscle relaxants, peripherally acting agents
C78272 - Agent Affecting Nervous System > C66880 - Anticholinergic Agent > C66886 - Nicotinic Antagonist
同义名列表
2 个代谢物同义名
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:6958
- KEGG: C07550
- PubChem: 5281042
- PubChem: 104803
- DrugBank: DB01226
- ChEMBL: CHEMBL1182833
- MeSH: Mivacurium
- CAS: 133814-19-4
- PMhub: MS000019582
- PubChem: 9753
- CAS: 106791-40-6
- NIKKAJI: J283.273I
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Bryant W Cornelius, Todd M Jacobs. Pseudocholinesterase Deficiency Considerations: A Case Study.
Anesthesia progress.
2020 09; 67(3):177-184. doi:
10.2344/anpr-67-03-16. [PMID: 32992329] - Ruifeng Zeng, Xiulan Liu, Jing Zhang, Ning Yin, Jian Fei, Shan Zhong, Zhiyong Hu, Miaofeng Hu, Mazhong Zhang, Bo Li, Jun Li, Qingquan Lian, Wangning ShangGuan. The efficacy and safety of mivacurium in pediatric patients.
BMC anesthesiology.
2017 04; 17(1):58. doi:
10.1186/s12871-017-0350-2. [PMID: 28415988] - Herve Delacour, Sofya Lushchekina, Isabelle Mabboux, Franck Ceppa, Patrick Masson, Lawrence M Schopfer, Oksana Lockridge. Characterization of a novel butyrylcholinesterase point mutation (p.Ala34Val), "silent" with mivacurium.
Biochemical pharmacology.
2014 Dec; 92(3):476-83. doi:
10.1016/j.bcp.2014.09.014. [PMID: 25264279] - Zhou Xiang, Qu Yan-Liang, Song Xiao-Yang, Zhang Yan-Hui, Chen Min, Gan Guo-Shen, Wu Ming-Chun, Luo Zhong-Bing, Wang Qing-Li, Hu Guang-Jun, Qin Ming-Zhe, Tao Jun. Effects of promethazine or dexamethasone pretreatment on mivacurium-induced histamine release in children.
Paediatric anaesthesia.
2014 Mar; 24(3):322-6. doi:
10.1111/pan.12305. [PMID: 24238032] - Herve Delacour, Sofya Lushchekina, Isabelle Mabboux, Aurore Bousquet, Franck Ceppa, Lawrence M Schopfer, Oksana Lockridge, Patrick Masson. Characterization of a novel BCHE "silent" allele: point mutation (p.Val204Asp) causes loss of activity and prolonged apnea with suxamethonium.
PloS one.
2014; 9(7):e101552. doi:
10.1371/journal.pone.0101552. [PMID: 25054547] - Mehmet Tercan, Esra Mercanoglu Efe, Gurkan Turker, Fatma Nur Kaya, Belgin Yavascaoglu, Yesim Ozarda, Elif Basagan Mogol. Do metoclopramide and ondansetrone alter mivacurium-induced neuromuscular blockade? - a randomised trial.
Brazilian journal of anesthesiology (Elsevier).
2014 Jan; 64(1):35-9. doi:
10.1016/j.bjane.2013.04.008. [PMID: 24565386] - Marc Zoller, Stefan Walther. [Residual relaxant block due to pseudocholinesterase deficiency - First manifestation in an elderly patient].
Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS.
2014 Jan; 49(1):8-11. doi:
10.1055/s-0033-1363907. [PMID: 24446003] - D Dillon, P Lee. Patient information sheet for plasma cholinesterase deficiency.
Anaesthesia.
2013 Oct; 68(10):1085. doi:
10.1111/anae.12429. [PMID: 24047308] - Martijn Boon, Christian H Martini, Leon P H J Aarts, Rob F M Bevers, Albert Dahan. Effect of variations in depth of neuromuscular blockade on rating of surgical conditions by surgeon and anesthesiologist in patients undergoing laparoscopic renal or prostatic surgery (BLISS trial): study protocol for a randomized controlled trial.
Trials.
2013 Mar; 14(?):63. doi:
10.1186/1745-6215-14-63. [PMID: 23452344] - P E Dubois, M Gourdin, J Jamart, S M Broka, P Eucher, A D'Hollander. Early and late parameters describing the offset of neuromuscular blockade are highly intercorrelated.
Acta anaesthesiologica Scandinavica.
2012 Jan; 56(1):76-82. doi:
10.1111/j.1399-6576.2011.02596.x. [PMID: 22150409] - T-H Han, J A J Martyn. Neuromuscular pharmacodynamics of mivacurium in adults with major burns.
British journal of anaesthesia.
2011 May; 106(5):675-9. doi:
10.1093/bja/aer023. [PMID: 21354998] - R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479. [PMID: 18426954] - M A Cheong, K S Kim, G S Lee. The pharmacodynamics of mivacurium in the rabbit with carbon tetrachloride-induced liver disease.
European journal of anaesthesiology.
2007 Sep; 24(9):789-95. doi:
10.1017/s0265021507000397. [PMID: 17462115] - P E Pendeville, F Lois, J-L Scholtes. A comparison of intubation conditions and time-course of action with rocuronium and mivacurium for day case anaesthesia.
European journal of anaesthesiology.
2007 Jun; 24(6):546-50. doi:
10.1017/s0265021506002341. [PMID: 17241507] - Emad S Osman, Hanan F Khafagy, Khalda G Radwan, Abdullah M Desouky. Role of cholinesterase activity on pharmacodynamics of mivacurium preceded by pancuronium in elderly and young adults.
Journal of the Egyptian Society of Parasitology.
2007 Apr; 37(1):243-55. doi:
. [PMID: 17580581] - J Barrio, G San Miguel, I Molina, I Asensio, F Gramuntell, V García. [Clinical effect of mivacurium in morbidly obese patients].
Revista espanola de anestesiologia y reanimacion.
2006 May; 53(5):297-300. doi:
. [PMID: 16827069] - Doris Østergaard, Jørgen Viby-Mogensen, Søren N Rasmussen, Mona R Gätke, France Varin. Pharmacokinetics and pharmacodynamics of mivacurium in patients phenotypically homozygous for the atypical plasma cholinesterase variant: effect of injection of human cholinesterase.
Anesthesiology.
2005 Jun; 102(6):1124-32. doi:
10.1097/00000542-200506000-00011. [PMID: 15915024] - C Motamed, K Kirov, X Combes, P Feiss, P Duvaldestin. Interaction between mivacurium and pancuronium: impact of the order of administration.
European journal of clinical pharmacology.
2005 May; 61(3):175-7. doi:
10.1007/s00228-005-0905-x. [PMID: 15824913] - N El Ayass, Ph Hendrickx. Decreased mivacurium infusion rate and delayed neuromuscular recovery after metoclopramide: a randomized double blind placebo-controlled study.
European journal of anaesthesiology.
2005 Mar; 22(3):197-201. doi:
10.1017/s0265021505000347. [PMID: 15852992] - Lisa C Pic. Novel pharmacological approaches for the antagonism of neuromuscular blockade.
AANA journal.
2005 Feb; 73(1):37-40. doi:
. [PMID: 15727282] - J Rieder, P Lirk, F Bodrogi, M Sawires, G Gruber, G Hoffmann. Cisatracurium, but not mivacurium, induces apoptosis in human umbilical vein endothelial cells in vitro.
European journal of anaesthesiology.
2005 Jan; 22(1):16-9. doi:
10.1017/s0265021505000049. [PMID: 15816567] - S Schiere, J H Proost, J Roggeveld, M Wierda. An interstitial compartment is necessary to link the pharmacokinetics and pharmacodynamics of mivacurium.
European journal of anaesthesiology.
2004 Nov; 21(11):882-91. doi:
10.1017/s0265021504000237. [PMID: 15717705] - A K Karabulut, R Reisli, I I Uysal, J B Celik, T Ziylan. An investigation of non-depolarizing muscle relaxants on embryonic development in cultured rat embryos.
European journal of anaesthesiology.
2004 Sep; 21(9):715-24. doi:
10.1017/s0265021504009081. [PMID: 15595584] - John J Savarese, Matthew R Belmont, Mir A Hashim, Robert A Mook, Eric E Boros, Vicente Samano, Sanjay S Patel, Paul L Feldman, Jan-Ake I Schultz, Michael McNulty, Timothy Spitzer, Douglas L Cohn, Philip Morgan, William B Wastila. Preclinical pharmacology of GW280430A (AV430A) in the rhesus monkey and in the cat: a comparison with mivacurium.
Anesthesiology.
2004 Apr; 100(4):835-45. doi:
10.1097/00000542-200404000-00013. [PMID: 15087618] - Ahtsham Niazi, Irene E Leonard, Breda O'Kelly. Prolonged neuromuscular blockade as a result of malnutrition-induced pseudocholinesterase deficiency.
Journal of clinical anesthesia.
2004 Feb; 16(1):40-2. doi:
10.1016/j.jclinane.2003.02.010. [PMID: 14984858] - Branka Surina, Drazen Nosso, Zoran Siftar, Zlata Flegar-Mestrić, Vera Simeon-Rudolf. Cholinesterase unit establishment and issuing of >>Warning Cards<< for carriers of suxamethonium sensitive serum butyrylcholinesterase variants.
Collegium antropologicum.
2004; 28 Suppl 2(?):297-304. doi:
NULL. [PMID: 15571104] - D Østergaard, J Viby-Mogensen, S N Rasmussen, M R Gätke, N A Pedersen, L T Skovgaard. Pharmacokinetics and pharmacodynamics of mivacurium in patients phenotypically heterozygous for the usual and atypical plasma cholinesterase variants (UA).
Acta anaesthesiologica Scandinavica.
2003 Nov; 47(10):1219-25. doi:
10.1046/j.1399-6576.2003.00243.x. [PMID: 14616318] - T Ledowski, H Wulf, K Ahrens, M Weindlmayr-Goettel, H G Kress, G Geldner, J Scholz. Neuromuscular block and relative concentrations of mivacurium isomers under isoflurane versus propofol anaesthesia.
European journal of anaesthesiology.
2003 Oct; 20(10):821-5. doi:
10.1017/s0265021503001327. [PMID: 14580052] - Cyrus Motamed, Riad Menad, Robert Farinotti, Krassen Kirov, Xavier Combes, Daniel Bouleau, Pierre Feiss, Philippe Duvaldestin. Potentiation of mivacurium blockade by low dose of pancuronium: a pharmacokinetic study.
Anesthesiology.
2003 May; 98(5):1057-62. doi:
10.1097/00000542-200305000-00006. [PMID: 12717125] - R G Rohling, K M Rentsch, B Beck-Schimmer, T Fuchs-Buder. Risk of recurarization during retransfusion of autologous blood withdrawn after injection of muscle relaxants: a comparison of rocuronium and mivacurium.
Journal of clinical anesthesia.
2003 Mar; 15(2):85-90. doi:
10.1016/s0952-8180(02)00519-6. [PMID: 12719045] - J Laurin, F Donati, F Varin. Stereoselective in vitro degradation pattern of mivacurium in human plasma.
British journal of anaesthesia.
2002 Dec; 89(6):832-8. doi:
10.1093/bja/aef270. [PMID: 12453925] - Haolin Ma, Xinliang Zhuang. Selection of neuromuscular blocking agents in patients undergoing renal transplantation under general anesthesia.
Chinese medical journal.
2002 Nov; 115(11):1692-6. doi:
NULL. [PMID: 12609090] - J A J Martyn, Y Chang, N G Goudsouzian, S S Patel. Pharmacodynamics of mivacurium chloride in 13- to 18-yr-old adolescents with thermal injury.
British journal of anaesthesia.
2002 Oct; 89(4):580-5. doi:
10.1093/bja/aef234. [PMID: 12393359] - Samia Ezzine, François Donati, France Varin. Mivacurium arteriovenous gradient during steady state infusion in anesthetized patients.
Anesthesiology.
2002 Sep; 97(3):622-9. doi:
10.1097/00000542-200209000-00016. [PMID: 12218529] - Bhiken Naik, Steven Hirshhorn, Vikas R Dharnidharka. Prolonged neuromuscular block due to cholinesterase depletion by plasmapheresis.
Journal of clinical anesthesia.
2002 Aug; 14(5):381-4. doi:
10.1016/s0952-8180(02)00382-3. [PMID: 12208445] - Franck Ceppa, Stephane Gidenne, Alain Benois, Eleonore Fontan, Pascal Burnat. Rapid identification of atypical variant of plasma butyrylcholinesterase by PCR.
Clinical chemistry and laboratory medicine.
2002 Aug; 40(8):799-801. doi:
10.1515/cclm.2002.138. [PMID: 12392308] - Doris ØStergaard, M Ibsen, L Skovgaard, J Viby-Mogensen. Plasma cholinesterase activity and duration of action of mivacurium in phenotypically normal patients.
Acta anaesthesiologica Scandinavica.
2002 Jul; 46(6):679-83. doi:
10.1034/j.1399-6576.2002.460608.x. [PMID: 12059891] - Doris ØStergaard, J Viby-Mogensen, N A Pedersen, H Holm, L T Skovgaard. Pharmacokinetics and pharmacodynamics of mivacurium in young adult and elderly patients.
Acta anaesthesiologica Scandinavica.
2002 Jul; 46(6):684-91. doi:
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Anaesthesia and intensive care.
2002 Jun; 30(3):360-3. doi:
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Acta anaesthesiologica Scandinavica.
2002 May; 46(5):512-8. doi:
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European journal of anaesthesiology.
2002 Apr; 19(4):240-62. doi:
10.1017/s0265021502000418. [PMID: 12074414] - Walid Habre, Barna Babik, Michel Chalier, Ferenc Peták. Role of endogenous histamine in altered lung mechanics in rabbits.
Anesthesiology.
2002 Feb; 96(2):409-15. doi:
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Der Anaesthesist.
2002 Feb; 51(2):134-41. doi:
10.1007/s00101-001-0276-3. [PMID: 11963306] - C Motamed, K Kirov, X Combes, G Dhonneur, P Duvaldestin. Effect of metoclopramide on mivacurium-induced neuromuscular block.
Acta anaesthesiologica Scandinavica.
2002 Feb; 46(2):214-6. doi:
10.1034/j.1399-6576.2002.460217.x. [PMID: 11942874] - C Hofer, M P Zalunardo, A Zollinger. Total intravenous anaesthesia in a patient with familial hypokalaemic periodic paralysis.
Anaesthesia.
2001 Nov; 56(11):1082-5. doi:
10.1046/j.1365-2044.2001.02268.x. [PMID: 11703241] - M C Theroux, J B Rose, S Iyengar, M S Katz. Succinylcholine pretreatment using gallamine or mivacurium during rapid sequence induction in children: a randomized, controlled study.
Journal of clinical anesthesia.
2001 Jun; 13(4):287-92. doi:
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Journal of pharmacokinetics and pharmacodynamics.
2001 Feb; 28(1):7-25. doi:
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Annales francaises d'anesthesie et de reanimation.
2000 Nov; 19(9):649-53. doi:
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Anesthesia and analgesia.
2000 Sep; 91(3):732-5. doi:
10.1097/00000539-200009000-00044. [PMID: 10960409] - D S McGehee, M D Krasowski, D L Fung, B Wilson, G A Gronert, J Moss. Cholinesterase inhibition by potato glycoalkaloids slows mivacurium metabolism.
Anesthesiology.
2000 Aug; 93(2):510-9. doi:
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Journal of the Formosan Medical Association = Taiwan yi zhi.
2000 Aug; 99(8):656-8. doi:
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Anesthesiology.
2000 Jun; 92(6):1581-7. doi:
10.1097/00000542-200006000-00014. [PMID: 10839906] - J Szenohradszky, D Fogarty, H Kirkegaard-Nielsen, R Brown, M L Sharma, D M Fisher. Effect of edrophonium and neostigmine on the pharmacokinetics and neuromuscular effects of mivacurium.
Anesthesiology.
2000 Mar; 92(3):708-14. doi:
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Anesthesiology.
2000 Jan; 92(1):31-7. doi:
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Anesthesia and analgesia.
1999 Dec; 89(6):1579-82. doi:
10.1097/00000539-199912000-00052. [PMID: 10589654] - M Blobner, R Busley, R Mann, S Jelen-Esselborn, E Kochs. [Neuromuscular recovery following mivacurium is predictable in patients with severe systemic disease prognoses].
Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS.
1999 Oct; 34(10):638-41. doi:
10.1055/s-1999-218. [PMID: 10548961] - L J Smith, W S Schwark, D R Cook, P F Moon, A L Looney. Pharmacokinetic variables of mivacurium chloride after intravenous administration in dogs.
American journal of veterinary research.
1999 Sep; 60(9):1051-4. doi:
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American journal of veterinary research.
1999 Sep; 60(9):1047-50. doi:
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Yonsei medical journal.
1999 Aug; 40(4):371-6. doi:
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Anesthesiology.
1999 Jul; 91(1):119-26. doi:
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British journal of anaesthesia.
1999 Apr; 82(4):542-5. doi:
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Clinical pharmacokinetics.
1999 Mar; 36(3):169-89. doi:
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Der Anaesthesist.
1999 Mar; 48(3):157-62. doi:
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Journal of biochemical and molecular toxicology.
1999; 13(2):113-8. doi:
10.1002/(sici)1099-0461(1999)13:2<113::aid-jbt7>3.0.co;2-8. [PMID: 9890196] - N Nijs, P Duvaldestin, V Slavov, G Dhonneur. Is the recovery profile of mivacurium independent of the rate of decay of its plasma concentration in patients with normal plasma cholinesterase activity?.
Acta anaesthesiologica Scandinavica.
1998 Nov; 42(10):1175-9. doi:
10.1111/j.1399-6576.1998.tb05272.x. [PMID: 9834800] - P Davies, M Landy. Suxamethonium and mivacurium sensitivity from pregnancy-induced plasma cholinesterase deficiency.
Anaesthesia.
1998 Nov; 53(11):1109-11. doi:
10.1046/j.1365-2044.1998.00581.x. [PMID: 10023281] - L E Vanlinthout, C F Bartels, O Lockridge, K Callens, L H Booij. Prolonged paralysis after a test dose of mivacurium in a patient with atypical serum cholinesterase.
Anesthesia and analgesia.
1998 Nov; 87(5):1199-202. doi:
10.1097/00000539-199811000-00042. [PMID: 9806709] - J C Bevan, E J Reimer, M F Smith, Scheepers L deV, H S Bridge, G R Martin, D R Bevan. Decreased mivacurium requirements and delayed neuromuscular recovery during sevoflurane anesthesia in children and adults.
Anesthesia and analgesia.
1998 Oct; 87(4):772-8. doi:
10.1097/00000539-199810000-00006. [PMID: 9768768] - D W Green, M Fisher, I Sockalingham. Mivacurium compared with succinylcholine in children with liver disease.
British journal of anaesthesia.
1998 Sep; 81(3):463-5. doi:
10.1093/bja/81.3.463. [PMID: 9861140] - T M Beaufort, V Nigrovic, J H Proost, M C Houwertjes, J M Wierda. Inhibition of the enzymic degradation of suxamethonium and mivacurium increases the onset time of submaximal neuromuscular block.
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