Enflurane (BioDeep_00000006519)

human metabolite blood metabolite Chemicals and Drugs Volatile Flavor Compounds

代谢物信息卡片

2-Chloro-1,1,2-trifluoroethyl difluoromethyl ether

化学式: C3H2ClF5O (183.97143319999998)
中文名称: 易使宁
谱图信息: 最多检出来源 Homo sapiens(blood) 25%

分子结构信息

SMILES: C(C(F)(F)OC(F)F)(Cl)F
InChI: InChI=1S/C3H2ClF5O/c4-1(5)3(8,9)10-2(6)7/h1-2H

描述信息

Enflurane is only found in individuals that have used or taken this drug. It is an extremely stable inhalation anesthetic that allows rapid adjustments of anesthesia depth with little change in pulse or respiratory rate. [PubChem]Enflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Enflurane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. It also appears to bind the D subunit of ATP synthase and NADH dehydogenase. Enflurane also binds to and angonizes the GABA receptor, the large conductance Ca²⁺ activated potassium channel, the glycine receptor, and antagonizes the glutamate receptor receptor. These yield a decreased depolarization and therefore, tissue excitability which results in anesthesia.
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
N - Nervous system > N01 - Anesthetics > N01A - Anesthetics, general > N01AB - Halogenated hydrocarbons
C78272 - Agent Affecting Nervous System > C245 - Anesthetic Agent

同义名列表

20 个代谢物同义名

2-Chloro-1,1,2-trifluoroethyl difluoromethyl ether; 2-chloro-1-(difluoromethoxy)-1,1,2-trifluoroethane; Baxter anaesthesia brand OF enflurane; AstraZeneca brand OF enflurane; Anesthetic compound no. 347; Zeneca brand OF enflurane; Abbott brand OF enflurane; Pisa brand OF enflurane; Methylflurether; Anesthetic 347; Compound 347; enflurane; Enlirane; Ohio 347; Ethrane; Alyrane; Enfran; Efrane; Etran; Enflurane

数据库引用编号

19 个数据库交叉引用编号

ChEBI: CHEBI:4792
KEGG: C07516
KEGGdrug: D83877
KEGGdrug: D00543
PubChem: 3226
HMDB: HMDB0014373
Metlin: METLIN2534
DrugBank: DB00228
ChEMBL: CHEMBL1257
Wikipedia: Enflurane
MeSH: Enflurane
chemspider: 3113
CAS: 132998-91-5
CAS: 13838-16-9
PMhub: MS000019568
PubChem: 9719
NIKKAJI: J3.127E
RefMet: Enflurane
KNApSAcK: 4792

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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PharmGKB(0)

1 个相关的物种来源信息

9606 - Homo sapiens: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Małgorzata Kupczewska-Dobecka. [Health hazards resulting from occupational exposure to enfluran - overview of tests and analysis of admissible concentration values]. Medycyna pracy. 2022 Feb; 73(1):51-69. doi: 10.13075/mp.5893.01204. [PMID: 35129537]
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