Clorazepate (BioDeep_00000006380)

 

Secondary id: BioDeep_00001868283

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


7-Chloro-2,3-dihydro-2,2-dihydroxy-5-phenyl-1H-1,4-benzodiazepine-3-carboxylic acid

化学式: C16H11ClN2O3 (314.0458)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 35.98%

分子结构信息

SMILES: C1=CC=C(C=C1)C2=NC(C(=O)NC3=C2C=C(C=C3)Cl)C(=O)O
InChI: InChI=1S/C16H11ClN2O3/c17-10-6-7-12-11(8-10)13(9-4-2-1-3-5-9)19-14(16(21)22)15(20)18-12/h1-8,14H,(H,18,20)(H,21,22)

描述信息

Clorazepate is only found in individuals that have used or taken this drug. It is a water-soluble benzodiazepine derivative effective in the treatment of anxiety. It has also muscle relaxant and anticonvulsant actions. [PubChem]Benzodiazepines bind nonspecifically to benzodiazepine receptors BNZ1, which mediates sleep, and BNZ2, which affects affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABAA) receptors, this enhances the effects of GABA by increasing GABA affinity for the GABA receptor. Binding of the inhibitory neurotransmitter GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell.
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014151 - Anti-Anxiety Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic > C1012 - Benzodiazepine
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
D018377 - Neurotransmitter Agents > D018682 - GABA Agents > D018757 - GABA Modulators
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants

同义名列表

15 个代谢物同义名

7-Chloro-2,3-dihydro-2,2-dihydroxy-5-phenyl-1H-1,4-benzodiazepine-3-carboxylic acid; 7-Chloro-2,3-dihydro-2,2-dihydroxy-5-phenyl-1H-1,4-benzodiazepine-3-carboxylate; 7-chloro-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepine-3-carboxylic acid; Monopotassium, clorazepate; Clorazepate monopotassium; Chlorazepate, dipotassium; Dipotassium chlorazepate; Dipotassium, clorazepate; Clorazepate dipotassium; Clorazepic acid; Chlorazepate; clorazepate; Tranxilium; Tranxene; Clorazepate



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 ALB, CA1, CYP2E1, FERMT1, GZMB, POMC
Peripheral membrane protein 2 CYP1B1, CYP2E1
Endosome membrane 1 CLCN5
Endoplasmic reticulum membrane 2 CYP1B1, CYP2E1
Nucleus 2 ALB, GZMB
cytosol 6 ALB, CA1, CLCN5, FERMT1, GZMB, SCLY
dendrite 2 HTR2C, NECTIN1
centrosome 1 ALB
Cell membrane 5 CLCN5, HTR2C, KCNT1, NECTIN1, TNFRSF1A
ruffle membrane 1 FERMT1
Multi-pass membrane protein 4 CACNA1I, CLCN5, HTR2C, KCNT1
Golgi apparatus membrane 2 CLCN5, TNFRSF1A
Synapse 1 HTR2C
cell junction 1 FERMT1
cell surface 1 TNFRSF1A
Golgi apparatus 3 ALB, CLCN5, SCLY
Golgi membrane 3 CLCN5, INS, TNFRSF1A
lysosomal membrane 1 CLCN5
mitochondrial inner membrane 1 CYP2E1
synaptic vesicle 1 CLCN5
Cytoplasm, cytosol 1 SCLY
plasma membrane 7 CACNA1I, CLCN5, HTR2C, IFNLR1, KCNT1, NECTIN1, TNFRSF1A
Membrane 8 CACNA1I, CLCN5, CYP1B1, GZMB, IFNLR1, KCNT1, NECTIN1, TNFRSF1A
extracellular exosome 3 ALB, CA1, SHBG
endoplasmic reticulum 1 ALB
extracellular space 6 ALB, CXCL8, IL5, INS, POMC, TNFRSF1A
adherens junction 1 NECTIN1
mitochondrion 1 CYP1B1
protein-containing complex 1 ALB
intracellular membrane-bounded organelle 3 CYP1B1, CYP2E1, GZMB
Microsome membrane 2 CYP1B1, CYP2E1
Single-pass type I membrane protein 3 IFNLR1, NECTIN1, TNFRSF1A
Secreted 9 ALB, CXCL8, GZMB, IL5, INS, POMC, SHBG, TNFRSF1A, TRH
extracellular region 10 ALB, CXCL8, GZMB, IL5, INS, NECTIN1, POMC, SHBG, TNFRSF1A, TRH
hippocampal mossy fiber to CA3 synapse 1 NECTIN1
anchoring junction 1 ALB
Early endosome 1 CLCN5
apical part of cell 1 CLCN5
presynaptic active zone membrane 1 NECTIN1
Mitochondrion inner membrane 1 CYP2E1
Membrane raft 1 TNFRSF1A
focal adhesion 1 FERMT1
Cell junction, adherens junction 1 NECTIN1
secretory granule 2 POMC, TRH
receptor complex 1 TNFRSF1A
ciliary basal body 1 ALB
cell periphery 1 FERMT1
cytoskeleton 1 FERMT1
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 1 ALB
endosome lumen 1 INS
Presynaptic cell membrane 1 NECTIN1
secretory granule lumen 2 INS, POMC
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 ALB, INS
platelet alpha granule lumen 1 ALB
voltage-gated calcium channel complex 1 CACNA1I
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 GZMB
apical junction complex 1 NECTIN1
cell-cell contact zone 1 NECTIN1
catalytic complex 1 SCLY
Cytolytic granule 1 GZMB
cytolytic granule lumen 1 GZMB
growth cone membrane 1 NECTIN1
tumor necrosis factor receptor superfamily complex 1 TNFRSF1A
G protein-coupled serotonin receptor complex 1 HTR2C
ciliary transition fiber 1 ALB
interleukin-28 receptor complex 1 IFNLR1
[Isoform Alpha]: Cell membrane 1 NECTIN1
[Isoform Delta]: Cell membrane 1 NECTIN1
[Isoform Gamma]: Secreted 1 NECTIN1


文献列表

  • X Laqueille, C Launay, A Dervaux, M Kanit. [Abuse of alcohol and benzodiazepine during substitution therapy in heroin addicts: a review of the literature]. L'Encephale. 2009 Jun; 35(3):220-5. doi: 10.1016/j.encep.2008.05.005. [PMID: 19540407]
  • R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals. 2008 Jul; 36(7):1385-405. doi: 10.1124/dmd.108.020479. [PMID: 18426954]
  • A M Gil Tejedor, P Fernández Hernando, J S Durand Alegría. A rapid fluorimetric screening method for the 1,4-benzodiazepines: determination of their metabolite oxazepam in urine. Analytica chimica acta. 2007 May; 591(1):112-5. doi: 10.1016/j.aca.2007.03.055. [PMID: 17456431]
  • G Malgorn, B Leboucher, P Harry, A Turcant, L Catala, J L Giniès. [Benzodiazepine poisoning in a neonate: clinical and toxicokinetic evaluation following enterodialysis with activated charcoal]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie. 2004 Jul; 11(7):819-21. doi: 10.1016/j.arcped.2004.03.122. [PMID: 15234378]
  • Henri Arouko, Marie-Dominique Matray, Coralie Bragança, Jean-Pierre Mpaka, Laure Chinello, Françoise Castaing, Christine Bartou, Daniel Poisot. [Voluntary poisoning by ingestion of Datura stramonium. Another cause of hospitalization in youth seeking strong sensations]. Annales de medecine interne. 2003 Jun; 154 Spec No 1(?):S46-50. doi: ". [PMID: 12910033]
  • A Sánchez-Romero, R García-Delgado, J A Durán-Quintana. [Can treatment associated with ticlopidine and nifedipine increase serum levels of phenobarbital?]. Revista de neurologia. 2003 Mar; 36(5):433-4. doi: NULL. [PMID: 12640596]
  • K Amano, S Katsuragi, J Takamatsu, A Ogata, C Miyazaki, M Deshimaru, T Miyakawa. Differences between the tolerance characteristics of two anticonvulsant benzodiazepines in the amygdaloid-kindled rat. Life sciences. 2001 Jul; 69(9):1049-55. doi: 10.1016/s0024-3205(01)01187-0. [PMID: 11508647]
  • N Moore, C Pierfitte, F Pehourcq, R Lagnaoui, B Bégaud. Comparison of patient questionnaires, medical records, and plasma assays in assessing exposure to benzodiazepines in elderly subjects. Clinical pharmacology and therapeutics. 2001 Jun; 69(6):445-50. doi: 10.1067/mcp.2001.116147. [PMID: 11406742]
  • R Nibler, E Weninger, W D Illner. [Prolonged post-anesthesia recovery in hemodialysis-induced hypothyroidism]. Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS. 1998 Dec; 33(12):810-2. doi: 10.1055/s-2007-994862. [PMID: 9893921]
  • J Haginaka, N Kanasugi. Enantioselectivity of bovine serum albumin-bonded columns produced with isolated protein fragments. II. Characterization of protein fragments and chiral binding sites. Journal of chromatography. A. 1997 May; 769(2):215-23. doi: 10.1016/s0021-9673(97)00025-3. [PMID: 9188181]
  • P Virgili, M C Gal. [Porphyria variegata. Apropos of a case]. L'Encephale. 1995 Nov; 21(6):467-71. doi: NULL. [PMID: 8674472]
  • A B Joseph, B A Wroblewski. Potentially toxic serum concentrations of desipramine after discontinuation of valproic acid. Brain injury. 1993 Sep; 7(5):463-5. doi: 10.3109/02699059309029690. [PMID: 8401488]
  • S D Forrester, J R Wilcke, J D Jacobson, K R Dyer. Effects of a 44-day administration of phenobarbital on disposition of clorazepate in dogs. American journal of veterinary research. 1993 Jul; 54(7):1136-8. doi: . [PMID: 8368611]
  • W Kułak, W Sobaniec, M Sobaniec-Lotowska. Inhibition of lipid peroxidation in rat brain by nifedipine and clorazepate after electrically induced seizures. Materia medica Polona. Polish journal of medicine and pharmacy. 1993 Jan; 25(1):33-5. doi: ". [PMID: 8412340]
  • S A Brown, S D Forrester. Serum disposition of oral clorazepate from regular-release and sustained-delivery tablets in dogs. Journal of veterinary pharmacology and therapeutics. 1991 Dec; 14(4):426-9. doi: 10.1111/j.1365-2885.1991.tb00858.x. [PMID: 1774820]
  • S D Forrester, S A Brown, G E Lees, S M Hartsfield. Disposition of clorazepate in dogs after single- and multiple-dose oral administration. American journal of veterinary research. 1990 Dec; 51(12):2001-5. doi: NULL. [PMID: 2085227]
  • R Scherkl, D Kurudi, H H Frey. Clorazepate in dogs: tolerance to the anticonvulsant effect and signs of physical dependence. Epilepsy research. 1989 Mar; 3(2):144-50. doi: 10.1016/0920-1211(89)90042-9. [PMID: 2565230]
  • H H Frey, R Scherkl. Clorazepate, correlation between metabolism and anticonvulsant activity. European journal of pharmacology. 1988 Dec; 158(3):213-6. doi: 10.1016/0014-2999(88)90069-6. [PMID: 2908106]
  • J A Squella, R Becerra, L J Nunez-Vergara. Polarography: a new tool in the elucidation of drug-albumin interactions. Biochemical pharmacology. 1987 Oct; 36(20):3531-3. doi: 10.1016/0006-2952(87)90337-6. [PMID: 2890353]
  • H R Ochs, D J Greenblatt, A Locniskar, J Weinbrenner. Influence of propranolol coadministration or cigarette smoking on the kinetics of desmethyldiazepam following intravenous clorazepate. Klinische Wochenschrift. 1986 Dec; 64(23):1217-21. doi: 10.1007/bf01734459. [PMID: 2879960]
  • R Lossius, P Dietrichson, P K Lunde. Effect of clorazepate in spasticity and rigidity: a quantitative study of reflexes and plasma concentrations. Acta neurologica Scandinavica. 1985 Mar; 71(3):190-4. doi: 10.1111/j.1600-0404.1985.tb03187.x. [PMID: 2859728]
  • A Bertler, S Lindgren, J O Magnusson, H Malmgren. Intramuscular bioavailability of chlorazepate as compared to diazepam. European journal of clinical pharmacology. 1985; 28(2):229-30. doi: 10.1007/bf00609698. [PMID: 2859206]
  • P Mormede, R Dantzer, A Perio. Relationship of the effects of the benzodiazepine derivative clorazepate on corticosterone secretion with its behavioural actions. Antagonism by Ro 15-1788. Pharmacology, biochemistry, and behavior. 1984 Dec; 21(6):839-43. doi: 10.1016/s0091-3057(84)80062-3. [PMID: 6151666]
  • R I Shader, R J Pary, J S Harmatz, S Allison, A Locniskar, D J Greenblatt. Plasma concentrations and clinical effects after single oral doses of prazepam, clorazepate, and diazepam. The Journal of clinical psychiatry. 1984 Oct; 45(10):411-3. doi: . [PMID: 6148339]
  • H R Ochs, D J Greenblatt, B Verburg-Ochs, A Locniskar. Comparative single-dose kinetics of oxazolam, prazepam, and clorazepate: three precursors of desmethyldiazepam. Journal of clinical pharmacology. 1984 Oct; 24(10):446-51. doi: 10.1002/j.1552-4604.1984.tb01817.x. [PMID: 6150943]
  • P Colin, G Sirois, J Lelorier. Cimetidine interaction with dipotassium clorazepate disposition in the anesthetized dog. Archives internationales de pharmacodynamie et de therapie. 1984 Mar; 268(1):12-24. doi: NULL. [PMID: 6145392]
  • L Dennerstein, A Callan, G Warne, J Montalto, J Brown, G Burrows, A Fulton, M Notelovitz. The effects of benzodiazepines on hormones in women with idiopathic hirsutism. Progress in neuro-psychopharmacology & biological psychiatry. 1984; 8(1):11-7. doi: 10.1016/0278-5846(84)90131-3. [PMID: 6145182]
  • H R Ochs, H W Rauh, D J Greenblatt, H J Kaschell. Clorazepate dipotassium and diazepam in renal insufficiency: serum concentrations and protein binding of diazepam and desmethyldiazepam. Nephron. 1984; 37(2):100-4. doi: 10.1159/000183222. [PMID: 6145109]
  • T Mimaki, T Tagawa, J Ono, J Tanaka, H Terada, N Itoh, H Yabuuchi. Antiepileptic effect and serum levels of clorazepate on children with refractory seizures. Brain & development. 1984; 6(6):539-44. doi: 10.1016/s0387-7604(84)80097-2. [PMID: 6152517]
  • M L Jack, W A Colburn. Pharmacokinetic model for diazepam and its major metabolite desmethyldiazepam following diazepam administration. Journal of pharmaceutical sciences. 1983 Nov; 72(11):1318-23. doi: 10.1002/jps.2600721120. [PMID: 6417322]
  • D R Abernethy, D J Greenblatt, M Divoll, R I Shader. Prolonged accumulation of diazepam in obesity. Journal of clinical pharmacology. 1983 Aug; 23(8-9):369-76. doi: 10.1002/j.1552-4604.1983.tb02750.x. [PMID: 6415130]
  • J R Castillo-Ferrando, A Carrasco Prieto, F De La Torre Brasas. Effects of benzodiazepines on digoxin tissue concentrations and plasma protein binding. The Journal of pharmacy and pharmacology. 1983 Jul; 35(7):462-3. doi: 10.1111/j.2042-7158.1983.tb04324.x. [PMID: 6136591]
  • P Colin, G Sirois, J Lelorier. High-performance liquid chromatography determination of dipotassium clorazepate and its major metabolite nordiazepam in plasma. Journal of chromatography. 1983 Apr; 273(2):367-77. doi: 10.1016/s0378-4347(00)80957-3. [PMID: 6134746]
  • G Olive, E Rey. [Benzodiazepines and pregnancy. Transplacental passage, labor and lactation]. L'Encephale. 1983; 9(4 Suppl 2):87B-96B. doi: NULL. [PMID: 6144535]
  • A Bertler, S Lindgren, J O Magnusson, H Malmgren. Pharmacokinetics of chlorazepate after intravenous and intramuscular administration. Psychopharmacology. 1983; 80(3):236-9. doi: 10.1007/bf00436160. [PMID: 6137019]
  • D R Abernethy, D J Greenblatt, M Divoll, R I Shader. Prolongation of drug half-life due to obesity: studies of desmethyldiazepam (clorazepate). Journal of pharmaceutical sciences. 1982 Aug; 71(8):942-4. doi: 10.1002/jps.2600710827. [PMID: 6811726]
  • H R Ochs, E Steinhaus, A Locniskar, M Knüchel, D J Greenblatt. Desmethyldiazepam kinetics after intravenous, intramuscular, and oral administration of clorazepate dipotassium. Klinische Wochenschrift. 1982 Apr; 60(8):411-5. doi: 10.1007/bf01735933. [PMID: 6124654]
  • R I Shader, D A Ciraulo, D J Greenblatt, J S Harmatz. Steady-state plasma desmethyldiazepam during long-term clorazepate use: effects of antacids. Clinical pharmacology and therapeutics. 1982 Feb; 31(2):180-3. doi: 10.1038/clpt.1982.28. [PMID: 6120059]
  • M Staak, A Moosmayer, K Besserer, K Speidel, A Kleinschmidt. [Pharmacokinetic studies after oral and parenteral application of dipotassium chlorazepate (author's transl)]. Arzneimittel-Forschung. 1982; 32(3):272-5. doi: . [PMID: 6123331]
  • B H Dvorchik. Drug disposition during pregnancy. International journal of biological research in pregnancy. 1982; 3(3):129-37. doi: NULL. [PMID: 7174143]
  • T R Norman, A Fulton, G D Burrows, K P Maguire. Pharmacokinetics of N-desmethyldiazepam after a single oral dose of clorazepate: the effect of smoking. European journal of clinical pharmacology. 1981; 21(3):229-33. doi: 10.1007/bf00627925. [PMID: 6119204]
  • R I Shader, D J Greenblatt, D A Ciraulo, M Divoll, J S Harmatz, A Georgotas. Effect of age and sex on disposition of desmethyldiazepam formed from its precursor clorazepate. Psychopharmacology. 1981; 75(2):193-7. doi: 10.1007/bf00432186. [PMID: 6119726]
  • A Bertler, S Lindgren, H Malmgren. Pharmacokinetics of dipotassium chlorazepate in patients after repeated 50 mg oral doses. Psychopharmacology. 1980; 71(2):165-7. doi: 10.1007/bf00434406. [PMID: 6108593]
  • D Haidukewych, E A Rodin, R Davenport. Monitoring clorazepate dipotassium as desmethyldiazepam in plasma by electron-capture gas--liquid chromatography. Clinical chemistry. 1980 Jan; 26(1):142-4. doi: NULL. [PMID: 6101311]
  • M Staak, H Strohm, W Nusser, G Raff. [Mnemic disturbances following experimental alcohol-tranquilizer application (author's transl)]. Zeitschrift fur Rechtsmedizin. Journal of legal medicine. 1980; 84(3):167-78. doi: 10.1007/bf01866568. [PMID: 6108026]
  • P Jatlow, K Dobular, D Bailey. Serum diazepam concentrations in overdose. Their significance. American journal of clinical pathology. 1979 Oct; 72(4):571-7. doi: 10.1093/ajcp/72.4.571. [PMID: 40432]
  • E Rey, P d'Athis, P Giraux, D de Lauture, J M Turquais, J Chavinie, G Olive. Pharmacokinetics of clorazepate in pregnant and non-pregnant women. European journal of clinical pharmacology. 1979 Apr; 15(3):175-80. doi: 10.1007/bf00563102. [PMID: 37089]
  • M Guerre-Millo, E Rey, J C Challier, J M Turquais, P d'Athis, G Olive. Transfer in vitro of three benzodiazepines across the human placenta. European journal of clinical pharmacology. 1979 Apr; 15(3):171-3. doi: 10.1007/bf00563101. [PMID: 37088]
  • A S Troupin, P Friel, A J Wilensky, L Morretti-Ojemann, R H Levy, P Feigl. Evaluation of clorazepate (Tranxene) as an anticonvulsant--a pilot study. Neurology. 1979 Apr; 29(4):458-66. doi: 10.1212/wnl.29.4.458. [PMID: 35767]
  • D J Greenblatt, R I Shader, J S Harmatz, A Georgotas. Self-rated sedation and plasma concentrations of desmethyldiazepam following single doses of clorazepate. Psychopharmacology. 1979; 66(3):289-90. doi: 10.1007/bf00428321. [PMID: 43553]
  • B Cuparencu, J Horák, M Cucuianu, N Hâncu, S Negrea, E Seuşan, J Vincze. Effects of some benzodiazepine derivatives on fibrinolysis and serum lipids in normolipidaemic rats and in humans. Atherosclerosis. 1978 Dec; 31(4):435-41. doi: 10.1016/0021-9150(78)90139-9. [PMID: 31894]
  • R I Shader, A Georgotas, D J Greenblatt, J S Harmatz, M D Allen. Impaired absorption of desmethyldiazepam from clorazepate by magnesium aluminum hydroxide. Clinical pharmacology and therapeutics. 1978 Sep; 24(3):308-15. doi: 10.1002/cpt1978243308. [PMID: 28870]
  • G H Sokol, D J Greenblatt, B L Lloyd, A Georgotas, M D Allen, J S Harmatz, T W Smith, R I Shader. Effect of abdominal radiation therapy on drug absorption in humans. Journal of clinical pharmacology. 1978 Aug; 18(8-9):388-96. doi: 10.1002/j.1552-4604.1978.tb02454.x. [PMID: 29058]
  • K K Kaistha, R Tadrus. Thin-layer detection of diazepam and/or chilordiazepoxide alone or in combination with major drugs of abuse in drug abuse urine screening programs. Journal of chromatography. 1978 Jul; 154(2):211-8. doi: 10.1016/s0021-9673(00)98462-0. [PMID: 681472]
  • A J Wilensky, R H Levy, A S Troupin, L Moretti-Ojemann. Clorazepate kinetics in treated epileptics. Clinical pharmacology and therapeutics. 1978 Jul; 24(1):22-30. doi: 10.1002/cpt197824122. [PMID: 26493]
  • D J Greenblatt. Determination of desmethyldiazepam in plasma by electron-capture GLC: application to pharmacokinetic studies of clorazepate. Journal of pharmaceutical sciences. 1978 Mar; 67(3):427-9. doi: 10.1002/jps.2600670347. [PMID: 25328]
  • P Coassolo, C Briand, M Bourdeaux, J C Sari. Microcalorimetric method to determine competitive binding. Action of a psychotropic drug (dipotassium chlorazepate) on L-tryptophan . human serum albumin complex. Biochimica et biophysica acta. 1978 Feb; 538(3):512-20. doi: 10.1016/0304-4165(78)90412-9. [PMID: 23863]
  • E Rey, J M Turquais, G Olive. [Determination of dipotassium clorazepate in the plasma by gas chromatography (author's transl)]. Annales de biologie clinique. 1978; 36(4):355-8. doi: NULL. [PMID: 32817]
  • M Staak, A Moosmayer. [Pharmacokinetic studies on interactions between dipotassium clorazepate and alcohol after oral application (author's transl)]. Arzneimittel-Forschung. 1978; 28(7):1187-91. doi: . [PMID: 39573]
  • S H Curry, R Whelpton, A N Nicholson, C M Wright. Behavioural and pharmacokinetic studies in the monkey (Macaca mulatta) with diazepam, nordiazepam and related 1,4-benzodiazepines. British journal of pharmacology. 1977 Nov; 61(3):325-30. doi: 10.1111/j.1476-5381.1977.tb08423.x. [PMID: 412540]
  • R V Magnus, B C Dean, S H Curry. Clorazepate: double blind crossover comparison of a single nightly dose with diazepam thrice daily in anxiety. Diseases of the nervous system. 1977 Oct; 38(10):819-21. doi: . [PMID: 20284]
  • A H Chun, P J Carrigan, D J Hoffman, R P Kershner, J D Stuart. Effect of antacids on absorption of clorazepate. Clinical pharmacology and therapeutics. 1977 Sep; 22(3):329-35. doi: 10.1002/cpt1977223329. [PMID: 19188]
  • C Post, S Lindgren, A Bertler, H Malmgren. Pharmacokinetics of N-desmethyldiazepam in healthy volunteers after single daily doses of dipotassium chlorazepate. Psychopharmacology. 1977 Jul; 53(2):105-9. doi: 10.1007/bf00426477. [PMID: 19801]
  • J A Wada. Pharmacological prophylaxis in the kindling model of epilepsy. Archives of neurology. 1977 Jul; 34(7):389-95. doi: 10.1001/archneur.1977.00500190023003. [PMID: 406881]
  • M A Brooks, M R Hackman, R E Weinfeld, T Macasieb. Determination of clorazepate and its major metabolites in blood and urine by electron capture gas-liquid chromatography. Journal of chromatography. 1977 May; 135(1):123-31. doi: 10.1016/s0021-9673(00)86308-6. [PMID: 16029]
  • P J Carrigan, G C Chao, W M Barker, D J Hoffman, A H Chun. Steady-state bioavailability of two clorazepate dipotassium dosage forms. Journal of clinical pharmacology. 1977 Jan; 17(1):18-28. doi: 10.1002/j.1552-4604.1977.tb04582.x. [PMID: 13089]
  • F Rubio-Donnadieu, J Gutiérrez, T Flores. [Treatment of epileptic crisis with chlorazepate dipotassium. Clinical study of 48 patients with the determination of serum levels of nordiazepam]. Neurologia, neurocirugia, psiquiatria. 1977; 18(2-3 Suppl):317-23. doi: . [PMID: 29249]
  • M Wretlind, A Pilbrant, A Sundwall, J Vessman. Disposition of three benzodiazepines after single oral administration in man. Acta pharmacologica et toxicologica. 1977 Jan; 40 Suppl 1(1):28-39. doi: NULL. [PMID: 15399]
  • J Horák, B Cuparencu, M Cucuianu, A Opincaru, E Seusan, I Vincze. Effects of some benzodiazepine derivatives on Triton WR-1339-Induced hyperlipidaemia in rats. Atherosclerosis. 1976 Jul; 24(1-2):81-97. doi: 10.1016/0021-9150(76)90066-6. [PMID: 8063]
  • D J Hoffman, A H Chun. GLC determination of plasma drug levels after oral administration of clorazepate potassium salts. Journal of pharmaceutical sciences. 1975 Oct; 64(10):1668-71. doi: 10.1002/jps.2600641017. [PMID: 241829]
  • W F Smyth, B Leo. A spectral and polarographic study of potassium chlorazepate. Analytica chimica acta. 1975 Jun; 76(2):289-97. doi: 10.1016/s0003-2670(01)85400-3. [PMID: 238425]